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Disappearance of Serum Methylated p16 Indicates Longer Survival in Patients with Gastric Cancer
임한기,박중민,지경천,이은주,정은미 대한위암학회 2013 Journal of gastric cancer Vol.13 No.3
Purpose: The aim of this study was to assess clinical correlations with postoperative alteration of p16 DNA methylation, and to clarify whether postoperative changes in the serum DNA methylation status of p16 could be used as a reliable prognostic factor for gastric cancer. Materials and Methods: Fifty-three consecutive gastric adenocarcinoma patients who underwent gastric resection (Chung-Ang University Hospital, Seoul, Korea) were included. DNA methylation of p16 was evaluated by methylation-specific polymerase chain reaction using serum DNA preoperatively and at the 10th postoperative day. The correlation between changes in methylation status and patients’prognosis was analyzed. Results: p16 was methylated in 79.2% of preoperative serum DNA and in 54.7% of postoperative serum DNA, respectively. Methylation in p16 disappeared more frequently in patients who underwent standard D2 lymphadenectomy compared to those who underwent modified D1+ lymphadenectomy (P=0.016). Whereas methylation of preoperative serum DNA was not correlated with survival, patients with postoperative disappearance of p16 methylation showed longer survival than those without postoperative disappearance of p16 methylation in the patients who had gastric cancer with lymph node metastasis (P=0.042). Conclusions: Postoperative disappearance of p16 methylation could be an available prognostic factor for node-positive gastric cancer.
강한기(Han-gi Kang),임상영(Sang-young Lim),최선미(Seon-mi Choi),이동주(Dong-ju Lee) 대한설비공학회 2021 대한설비공학회 학술발표대회논문집 Vol.2021 No.6
Thermal energy storage systems are known to reduce operating costs but to be high in energy usage. This paper aims to organize the development process of thermal energy storage systems and identify market changes. Furthermore, it aims to introduce energy-saving heat storage devices that can be used in zero energy buildings in the future by comparing the actual energy usage of thermal energy storage systems and absorption refrigerator systems.
이상미,임은혁,김한기,김봉문,김창호,노윤정,이현정 한국정책분석평가학회 2016 政策分析評價學會報 Vol.26 No.4
2012년부터 현재까지 추진된 산학협력선도대학(LINC) 육성사업의 목적구조에 기초해서 사업의 효과성을 분석하였다. LINC사업은 대학의 시스템을 산학협력 친화형으로 개선함으로써 산업체 맞춤형 인재를 양성하고 산-학 간 기술의 공유 및 사업화를 촉진할 수 있도록 하는 것이 목적인 사업이다. 사업의 목적구조에 근거하여 LINC사업을 통해 대학의 시스템이 산학협력 친화형으로 개선되었는지, 즉 산학협력 기반조성 효과를 먼저 검증하고, 이후 ‘산업체& 맞춤형&인재양성&효과’와 ‘산-학 간 기술 공유 및 사업화 성과’가 나타나는지를 검토하였다. 각 대학별로 사업참여 이전과 이후의 매년도 성과 데이터를 통합(pooling)하고 일반화추정방정식을 활용하여 사업의 연차별 효과를 검증하였는데, 분석결과 각 부문별로 유의미한 성과가 나타남을 확인하였다.
대퇴골 전자간 골절수술시 압박고 나사 고정과 감마정 고정의 비교
김주오,임한기,오재일,유상문 대한골절학회 2001 대한골절학회지 Vol.14 No.2
Purpose : To compare and analyze the operative results of compression hip screw with those of gamma nail in the treatment of intertrochanteric fracture of femur. Materials and Methods: We performed retrospective analysis of intertrochanteric fracture of femur using the compression hip screws on 16 cases(stable 8 cases, unstable 8 cases) and compared the results with those of 21 cases(stable 5 cases, unstable 16 cases) of Gamma nail fixation. All the 37 cases were operated between April 1992 and May 1997 and followed for minimal 12 months. We permitted earlier weight bearing for the Gamma nail inserted group(1 week vs 3 weeks). We evaluated the operation time, bleeding amount, intraoperative and postoperative complications, bone union time, neck-shaft angle, and functional assessment by follow up radiographs and clinical results. Results: The average operation time was shorter in the Gamma nail group than in the compression hip screw group (97±23.3 compared with 117±35.9 minutes; p$lt;0.05). The average amount of bleeding was lesser in the Gamma nail group than in the compression hip screw group (592 compared with 712 ml: p$lt;0.05). The fracture union time and clinical function of two groups showed no statistically significant difference(p$gt;0.05). During Gamma nail insertion, crack was developed in one femoral shaft which was united after bed rest and delayed weight bearing. Postoperative complications were coxa vara in 3 cases(1 case on Gamma nail, 2 cases on CHS) and cutting out of lag screw in 3 cases(1 case on Gamma nail, 2 cases on CHS), but showed no statistically significant difference between two groups(p=0.781). Conclusion: Early weight bearing can be encouraged for the Gamma nail group and this seemed to be beneficial for the old patients. The Gamma nail fixation is considered as a useful method for the patients with intertrochanteric fracture if it is managed with proper technique.
송광섭,김민정,임한기,홍윤화,박성실,홍창원,Sung Chan Park,손대경,한경수,오재환 대한대장항문학회 2020 Annals of Coloproctolgy Vol.36 No.4
Gastrointestinal graft-versus-host disease (GVHD) is a common complication after hematopoietic stem cell transplantation. Concomitant cytomegalovirus (CMV) enteritis worsens the prognosis of this condition. We report a case of small bowel perforation associated with gastrointestinal GVHD and CMV enteritis in a patient with leukemia who was successfully treated surgically. A 39-year-old man presented with intestinal perforation necessitating emergency surgical intervention. He was diagnosed with T-cell acute lymphoblastic leukemia and developed severe gastrointestinal GVHD and CMV enteritis after hematopoietic stem cell transplantation. His terminal ileum showed a perforation with diffuse wall thinning, and petechiae were observed over long segments of the distal ileum and the proximal colon. Small bowel segmental resection and a subtotal colectomy with a double-barreled ileocolostomy were performed. The patient recovered uneventfully after the operation. Based on reports described in the literature, surgery plays a minor role in the management of gastrointestinal GVHD; however, timely surgical intervention could be effective in selected patients.
김주오,최승준,임한기,유상문 대한골절학회 2001 대한골절학회지 Vol.14 No.4
Purpose: We compared and evaluated the unloading effect and the availability of four different types of lower limb casts. Materials and Methods: The subjects were ten healthy men who had no gait disturbances, neuromuscular disorder, and deformities of lower extremities. The mean age was 25.2years (22-29) and the mean weight was 62.6㎏ (53.9-69.1). The trials consisted of patellar tendon bearing (PTB) casts, short leg casts, long leg extension casts, and long leg 30° flexion casts. In each experiment, ten sets of measurements were taken with all subjects wearing four different types of lower limb casts and walking on a flat surface indoors. The load cell was placed on the sole of the foot and wrapped with casts so that we could measure the pressure of the sole during gait. The percentage of load reduction was calculated by comparing pressure of the soles and the bottom of the casts. Results: The unloading effects of the PTB, the short leg, the long leg extension, and the long leg 30° flexion casts were 23.8%, 19.5%, 25.5%, 27.9% of the loading. No significant difference of unloading effect was demonstrated between each four different types of lower limb casts (P$gt;0.05). Conclusion: Notwithstanding the clinical success of the lower limb casts in below-knee fractures, the unloading effect of the casts was limited and any type of the casts did not show better unloading effects.