웹 서비스 기반 유전체 주석정보 통합검색 시스템 구축

이희전,용환승 한국정보과학회 2004 데이타베이스 연구 Vol.20 No.1

With the rise of active research about various genomes and as a result of its production. a huge genome annotation data has been generated in recent bioinformatics area. In this thesis, to efficientlu solve how to share annotation data, we designed and developed the intergrated retrieval system among decentralized annotation database servers using Web Service to take over object technology and BioDAS which is a great practical example on how to begin the integration process. In order to construct database in retrieval systm, we received genome annotation data via Web Service from decentralized servers. Intergrated retrieval system provided users with expedience by the ability of the meta search and is equipped with easiness of system expansion by providing the fuction of result storing. 최근 바이오인포매틱스 분야에서는 수많은 유전체에 대한 연구들이 활발하게 진행됨에 따라 그에 따른 산출물로 방대한 양의 유전체 주석정보 데이터들이 생겨나고 있다. 본 논문에서는 주석정보 데이터들의 공유문제를 효과적으로 해결하기 위하여 분산 객체기술의 계보를 잇는 웹 서비스 기술과 오늘날 바이오 인포매틱스 분야에서 데이터 통합에 관한 실질적인 방법으로 대두되고 있는 BioDAS개념을 응용하여 분산된 주석정보 데이터베이스 서버들 간의 통합 검색 시스템을 설계, 구현하였다. 통합검색 시스템은 메타 검색 기능을 통해 사용자에게 편의를 제공해 주며 결과 저장기능 제공을 통해 시스템 확장의 용이성을 갖추고 있다.

흉부 대상포진후 신경통 치료 중 발견된 악성 종양 - 증례보고 -

이희전(Hee Jeon Lee),이효근(Hyo Keun Lee),정소영(S 대한통증학회 1995 The Korean Journal of Pain Vol.8 No.1

We experienced two cases of malignancy diagnosed during the treatment of postherpetic neuralgia. One case was a lung cancer and the other case was a pancreatic cancer. Generally, herpes zoster frequently occurred in the patients who have immunosupressive dis- ease, diabetes mellitus, malignancy and tuberculosis, etc. It is necessary to rule out malignancy in the patients who have herpes zoster, especially those patients whth severe eruptive cluster, persisting to the therapy or multifocal pain. So, we must carefully observe and follow up the patients to find out malignancy as well as to diminish the pain.

안 대상포진 환자에서 지속적 경부 경막외차단의 효과 - 증례보고 -

이희전(Hee Jeon Lee),정소영(So Young Chung),이효근 대한통증학회 1995 The Korean Journal of Pain Vol.8 No.1

A 34 year old male patient visited to our neuro-pain clinic with symtoms of a left frontal headache, eyeball throbbing and occipital pain. Two days after the first visit to our clinic, pain was aggrevated and the skin eruption ap- peared on the left forehead. He was diagnosed as raving Herpes Zoster Opthalmicus(HZO). We performed stellate gangli- on block(SGB), but pain did not subsid. So a continuous cervical epidural block was perfomed (CCEB) and it could relieve the pain promptly. In this case, VAS(visual analogue scale) was di- minished from 10 to 3 and the skin eruption was healed 24 days after the treatment with CCEB and SGB. We experienced that CCEB is more effective rather than intermittent SGB in intractable HZO. CCEB should be considered to the treatment of choice in patients with HZO.

제왕절개술 마취의 임상적 고찰

박광원,이희전,전용애,정순미 대한마취과학회 1979 Korean Journal of Anesthesiology Vol.12 No.1

To provide optimal obstetric anesthetic care, it is essential for the anesthetist to know well the maternal physiological alterations produced by pregnancy, labor and paturition, physiology and pharmacology of the fetal placental complex and how these are altered by analgesics and anesthetics (Bonica, 1972). Recently, the tendency to cesarean section has increased; the cesarean section rate was 8.1. (Lee et al., 1974) and 15% (Dripps et al., 1977). Choice of regional or general anesthesia for cesarean section depends on many factors. As, the paturient is considered to have a full stomach, regional anesthesia is advantageous. However, if the indication is fetal distress or maternal hemorrhage, the necessity for rapid delivery overrides all other considerations. For elective cesarean section the choice of anesthesia largely relates to patients condition and physicans preference, although the somewhat. longer time required for delivery in a repeated cesarean section may indicafes regional rather than general anesthesia (Dripps et al., 1977; James et al., 1977). The problem of anesthetic management of cesarean section was fetal depression due to sedatives, analgesics and anesthetics during delivery. In emergency cesarean section, the major problem in general anesthesia is aspiration of gastric contents and in regional anesthesia it is hypotension. Regarding fetal and neonatal depression associated with anesthesia, the effects of general or regional anesthesia or. the neonatal neurobehavioral status have been reported by many authors (Standley et al., 1974; Tronick et al., 1976; Hollmen et al., 1978). Thus we have made a clinical analysis of anesthesia for 300 cases by random sampling among 1725 cesarean sections. including emergency and elective operations, performed from July 1973 to June 1978 in Severance Hospital at Yonsei University College of Medicine. Clinical analysis was made of frequency of cesarean section, age distribution, parity, indication of cesarean section, physical status (A.S.A. classification), premedication, anesthetic method, relationship between Apgar seore and the type of anesthesia, relationship between induction to delivery time and one minute Apgar score, time to initial blood pressure drop after spinal anesthesia, blood loss, the methods of cardiopulmonary resuscitation of the newborn, perinatal mortality and neonatal neurobehavioral states. The result are as follows: 1) The incidence of cesarean aection was 18.4 percent of total deliveries and the tendency is increasing. 2) One minute Apgar score in spinal anesthesia is better than in general anesthesia (0. 01 $lt;p $lt;0 025). 3) Blood loss in spinal anesthesia (566±146ml) is less than in general anesthesia (796 ± 388ml). 4) Blood pressure showed a drop within ten minutes in 83 percent of cases after induction of spinal anesthesia. 5) Perinatal mortality of general anethesia (3. 9%) is more than spinal aneathesia (1.9%) Even tbough clinical results of spinal anesthesia seem to be more favorable than those of general anesthesia, from the above obrvation it may be concluded that choice of anesthesia for cesarean section depends on each maternal condition and only one anestbetic method should not be exclusively used.

경막외 Morphine 주입이 술후 제통 및 동맥혈중 기체분압에 미치는 영향

오흥근,이희전,우남식 대한마취과학회 1980 Korean Journal of Anesthesiology Vol.13 No.2

After the identification by Snyder of specific opiate receptors it the substantia gelatinosa of the posterior horn of the spinal cord, Behar et al. reported that small doses of epidural morphine are effective in treatment of acute and chronic pain. We have administered 3~5 mg of epidural morphine as a single dose with 1.5~2 % lidocaine to 40 patients as a continuous lumber epidural anesthesia and to 20 patients as a single caudal anesthesia. All the patients had remarkable relief of pain and we can confirm that there was no loss of sensation to temperature, touch or pinprick. However the dosage (3. 4 or 5 mg) of morphine administrated did not affect the duration of postoperative pain relief. Arterial blood pressure and heart rate were measured up to 15 minutes after morphine injection at 5 minutes intervals, but were not significantly changed. PaO₂,PaCO₂pH and base excess were also not significantly changed.

고혈압환자 마취관리의 임상적 관찰

김종래,박광원,이희전 대한마취과학회 1979 Korean Journal of Anesthesiology Vol.12 No.4

It has been reported that the number of patients with hypertension increases yearly in the Korean population(Sohn et al, 1968; Lee, 1962; Kang et al, 1989), and this imposes many anesthetic problems during surgery. The etiology of essential hypertension is unknown, but it affects primarily the brain, heart and kindney. The main causes of mortality due to hypertension are cerebrovascular accident. congestive heart failure, myocardial infarction and uremia. For the better anesthetic management of patients with hypertension, it is essential to understand clearly the adrenergic machanism and pharmacologic action of antihypertensive drugs, especially their effects on hemodyamic circulation. About 15 years ago it was generally agreed that antihypertensive medication should be stopped some time before anesthesia and surgery in order to regain the compensatory function of the circulation during anesthesia and surgical stress (Armstrong Davison, 1951; Vadnam et al, 1961. Dingle, 1966). However the present concept is that the better the hypertension is controlled the better the patrent's chances of surviving anesthesia and it is recommended that antihypertensive medication should be continued as close as possible to the time of anesthesia(Brown, 1978). The present study was undertaken to learn the effect of antihypertensive medication, given preoperatively, on the arterial blood pressure during general anesthesia, by reviewing the anesthesia courses of hypertensive patients who were admitted to Severance FIospital from March 1969 to February l978. The patients with hypertension were divided into two groups, one group consisting of 100 patients, who received antihypertensive medication in the preoperative period and the other group, consisting of 100 patients, who had not received antihypertensive medication for the control of high blood pressure preoperatively. Changes of arterial blood pressure during anesthesia were analyzed, and data were compared between two groups. The results are as follows; 1) The number of the patients with hypertension, admitted to the hospital, has been increasing yearly for the past 10 year period(March, 1969 to February 1978). 2) The patients who received antihypertensive medication for preoperative anesthetic management showed less arterial blood pressure fluctuation during general anesthesia, compared to tbe patients who had not received antihypertensive medication (p$lt;0.05). It may be suggested from the above observation that the preoperative control of hypertension is desirable for the maintenance of a stable blood pressure during general anesthesia.

다한증 환자에서 교감신경절 차단의 임상적 고찰

김 찬(Chan Kim),이희전(Hee Jeon Lee),이효근(Hyo Ke 대한통증학회 1996 The Korean Journal of Pain Vol.9 No.1

N/A Two hundred and eighty eight patients suffering from excessive sweating of palms, soles and axillae etc., visited our Neuro-Pain clinic from November 199l to March 1996. The sex ratio was 1:1.2. The third decade of age was the major age group. The onset time of hyperhidrosis was prepubertal period(in 95.1% of them). The provocative factors of exces- sive sweating were tension and stress from interpersonal relationship. They had the family history(30,9%) and the past history treated with herb medication(56.9%), medicine(30.6%), op- eration(1.4%), and no treatment(39.6%). We treated 113 patients by sympathetic ganglion block with pure alcohol. The average times of thoracic sympathetic ganglion block were 2.10eft), 2.4(right) and those of lumbar sympathetic ganglion block were 1.2(left), l.6(right). Average admission period was 14.7 days. Recurrence rate was 7.1%. Most longstanding effec- tive period was 45 months. We conclude from our results that sympathetic ganglion block is one of the most effective treatments for hyperhidrosis owing to its simple technique and low recurrence rate.

Halothane 저혈압 마취가 신장기능에 미치는 영향

송선옥,박양생,정상섭,박광원,이희전,남용택,도종웅 대한마취과학회 1978 Korean Journal of Anesthesiology Vol.11 No.1

Hypotensive anesthesia is widely used in an operation since 1) it minimizes bleeding and provides a good operarion field, 2) it prevents massive hemorrhage in an operation which otherwise involes a large amount of b1ood loss and 3) it is useful in an operation for hypertensive patients. This procedure also involves a number of risks such as delayed awakening, reactionary bleeding, decrease in urine output and tissue hypoxia. The most dangerous complication can be hypoxia especialIy in the vital organs. 1t is therefore necessary to treat dehydration or blood loss before hypotensive anesthesia is induced. Since hypotensive anesthesia was introduced by Gardner (1947) for an operation of olfactory groove meningioma, various methods of deliberate hypotension have been developed. The most common method of hypotensive anesthesia in the present day is to use drugs, such as trmetaphan, nitroprusside and halothane. The effect of hypotensive anesthesia an various physiological functions of animals have been inveatigated ia the past. Giffiths and Gillies (1948) reported that, in the hypotension induced by sympathectomy, an arterial systolic pressure of 32 mmHg is the minimum to overcome peripheral resistance. Chung (19743 observed in the halothane-induced hypotensive dogs that a systolic pressure of 30mmHg was required to assure adequate cerebral oxygenation. In the present study, we have investigated the effect of halothanie-induced hypotension on the renal function of dogs. The arterial systolic pressure was successively reduced to 60 and 30mmHg for 30min. eech, and chaages ia various renal functians were studied during 100min. of the recovety period. The results are summarixed as follows: 1. The systolic blccd pressure was ccmpletely reeovered 80min. after the cessation of halothane inhalation. 2. Average renal blccd flow Cestimated by Cppe) and glomerular filtration rate (estimated by Cg) during the first 20min. of the recovery phase were 26% ind 45% of the control level. However after 100min. of thy reeovery period, repal blqcd flow wasrecovered to 63% and glomerular filtration rate to 74%of the control leveL 3. Average urine flow during the first 20min. of tht rtcovery phase was approximately 40% of the control. 4. U/P osm. ratio was reduced to 90% the control level during the first 20min. of recovery, but it exceeded the control value after 20min. of recovery. 5. Thero was only 24% of the-tml value in the first 20min. of reeavery phese, but there- after it gradually returned to the control level. 6. FEH2O (fractional excretion of N2) was ned eignificantly changed- by halothane inhalation although there was a tendency to slight reduction at the beginnjng of the recovery phase. 7. FEK was 47% of the control value dqring ghe initial phase of recovery, but it returned to the control level after 40min. of the recovery period. 8. FE, and FEH2O were reduced to 56% and 50% of the control level after the hypotensive pericd, but returned to 70% and 82% of the control level after 40min. of the recovery period. These resutts indicate that although tbe systemic blood pressure completely recovered after halothane-induced hypotension, renal hemodynamics are not completely recovered with 100min. of the recovery period. However renal functions are mostly reversible, suggesting that halathane -induced hypotension did not induce irreversible damage of renal tissue.

교감신경절 차단에 의한 동상합병증 환자의 치료 경험 - 증례보고 -

양승곤(Seung Ko Yang),이희전(Hee Jeon Lee),황현정( 대한통증학회 1996 The Korean Journal of Pain Vol.9 No.1

Frostbite involves freezing of tissues and usually affects the distal aspects of the ex- tremities or exposed parts of the face, such as the ears, nose, chin, and cheeks. It pro- duces tissue injury by ice crystal formation between the cells, cellular dehydration, and microvascular occulsion. There are four degrees of frostbite. First degree is accompanied by erythema and edema, second degree, by vesiculation, blistering, and eschar formation, third degree, by hemorrhagic blistering and bluish gray discoloration, and fourth degree, by injury to subcutaneous tissue, muscle, tendon, and bone leading to mottled, dry, black, and necrotic changes We succesafelly treated 2. patients suffering from frostbite by per- forming sympathetic ganglion block with pure alcohol We concluded sympathetic ganglion block is one of the most effective treatments for frostbite.

무릎관절의 통증에 관한 연구

최중립(Joong Rieb Choi),이희전(Hee Jeon Lee),조욱 대한통증학회 1992 The Korean Journal of Pain Vol.5 No.2

N/A It is general knowledge that knee joint pain can be attributed to trauma and degenerative change around the knee joint. However most patients who have suffered from pain or limited range of motion of the knee joint show no definite pathology on X-ray or laboratory examina- tion. We examined 242 patients with knee joint pain and found compression or entrapment of the articular nerve fiber by the tissue around the knee joint resulted in pain in almost all cases. Conclusion: by relieving the compression of the articular nerve fiber with just physical ther- apy and LASER stimulation on the identified trigger points, in conjunction with NSAIDs, mus-cle relaxants, were found to be very effective in the treatment of knee joint pain.