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넙치 Viral Hemorrhagic Septicemia Virus (VHSV) 저항성 관련 양적형질 유전자좌(QTL) 분석
이희건,윤상원,이다인,박종원,정효선,김주란,양혜림,이승환,이정호 한국동물유전육종학회 2022 한국동물유전육종학회지 Vol.6 No.3
Olive flounder (Paralichthys olivaceus) is one of the most produced fish, accounting for 46.2% (37,240 metric tons) of total fish farming yield in Korea. Flounder is vulnerable to viral hemorrhagic septicemia (VHS) which makes fish farmers struggle. Viral Hemorrhagic Septicemia Virus (VHSV) is an RNA virus sustaining its infectivity, especially at low temperatures (8-15°C). In order to minimize the damage from VHSV, several studies were conducted. However, the genetic factor of resistance to VHSV is not well known to date. Quantitative trait loci (QTL) analysis is an efficient analysis in aspects of detecting loci that influence quantitative traits. We conducted a quantitative trait locus (QTL) analysis by constructing a genetic linkage group. 23 linkage groups were constructed and it’s reliable according to the previous study that suggested flounder has 2n=48 chromosome. Bivariate phenotypes (dead/alive) were adapted and 5 pseudo markers were identified as QTL. A total of 7 markers were nearby 5 pseudo markers, located in linkage groups 8, 13, and 16. Although it can be more delicately accurate results if the bivariate phenotype information were fixed by extra environment effects, those markers are valuable to be candidates for representing the resistance of VHSV in terms of flounder.
의과대학생과 수련의에서 진화 이론에 대한 수용과 이해에 관한 예비 연구: 의약계열 전공자와 비의약계열 전공자와의 비교
이희건,김민숙,김원,손보경,박한선 대한신경정신의학회 2022 신경정신의학 Vol.61 No.3
Objectives Evolutionary theory is an important biological principle that can be applied in biology and medicine. On the other hand, education on evolution is not widely conducted in medical education. Therefore, this study compared the acceptance and understanding of the concept of evolutionary theory between young medical majors and non-medical majors. Methods From January to September 2021, participants with a medicine major, a humanities and social science major, and an engineering and natural science major were recruited online. They answered questionnaires about their acceptance, understanding, and interest in evolutionary theory and their religiousness. Results Two hundred and fifty participants were recruited: 50 in the medicine group, 57 in the humanities and social science group, 123 in the engineering and natural science group, and 20 other majors. The analysis showed that the acceptance and understanding of the evolutionary theory were lower in the medicine group than in the other groups. Conclusion This is the first study to compare the acceptance and understanding of evolutionary theory between the medical majors and non-medical majors in Korea. This result suggests that the education about evolution is very poor and needs to be strengthened in medical education.
잔류 용매 제거를 위한 (+)-dihydromyricetin의 에탄올 전처리 건조
이희건 ( Hee-gun Lee ),김진현 ( Jin-hyun Kim ) 한국화학공학회 2022 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.60 No.2
본 연구에서는 정제된(+)-dihydromyricetin로부터 잔류 용매를 효과적으로 제거할 수 있는 건조 방법을 개발하였다. 에탄올 전 처리를 통한 회전 증발(rotary evaporation)에 의해 잔류 아세톤 농도를 ICH 규정치(5,000 ppm) 이하로 효율적으로 제거하였다. 또한 잔류 에탄올 역시 물 첨가를 통한 회전 증발로 ICH 규정치(5,000 ppm)를 충족시켰으며 잔류 수분 함량은 4% 이내였다. 모든 건조 온도(35, 45, 55 ℃)에서 잔류 용매는 건조 초기에 급격히 제거되었으며 건조 효율은 건조 온도가 높을수록 증가하였다. 건조 메커니즘 조사 결과, 에탄올 전 처리에 의한 잔류 용매 제거는 아세톤-에탄올 혼합물의 높은 증기압과 아세톤-에탄올 간의 수소 결합과 연관됨을 알 수 있었다. In this study, a drying method that can effectively remove residual solvent from (+)-dihydromyricetin was developed. Residual acetone concentration was efficiently removed below ICH-specified value (5,000 ppm) by simple rotary evaporation with ethanol pretreatment. In addition, the residual ethanol met the ICH-specified value (5,000 ppm) by simple rotary evaporation through the addition of water, and the residual moisture also met the specified value (<4%) for active pharmaceutical ingredients. At all the drying temperature (35, 45, and 55 ℃), a large amount of the residual solvent was initially removed during the drying, and the drying efficiency increased when increasing the drying temperature. Removal of residual solvent by ethanol pretreatment was shown to be related to high vapor pressure of acetone-ethanol mixture and hydrogen bonding between acetone and ethanol.