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돼지 마이코플라즈마 폐렴 예방백신의 접종시기별 방어효과에 관한 연구
이함희 ( Ham Hee Lee ),제임스라 ( James Rha ),한정희 ( Jeong Hee Han ) 한국가축위생학회 2008 韓國家畜衛生學會誌 Vol.31 No.3
This study was performed to evaluate the effect of commercial swine mycoplasma vaccine(M+Pac(R),Schering-Plough Animal HealthCo.) at different vaccination time-points. Total 139 piglets were moved to experimental farm after weaning and were randomly allocated to 3 treatment groups and 1 control group. Piglets of 3 treatment groups(A, B and C) were vaccinated twice at 1 and 3 weeks(A group), 3 and 5 weeks (B), and 6 and 8 weeks(C), respectively. All vaccinates showed higher antibody titers compared with nonvaccinates, and maintained to finish(P<0.001). Performance and RBC/WBC count showed no significant difference between groups. Vaccinates at 6-8 weeks showed better effect on decrease of clinical sign compared with vaccinates at 1-3 weeks and 3-5 weeks and nonvaccinates. Also, lung lesion assessment showed significant difference between vaccinates at 3-5 weeks and 6-8 weeks, and nonvaccinates and vaccinates at 1-3 weeks(P<0.05). Vaccinates at 3-5 score in comparison with other groups. In conclusion, these results suggested that vacci-nation at 3-5 weeks or later may be more effective than earlier vaccination.
지영철,한정희,권혁무,정현규,이함희 한국수의병리학회 2002 한국수의병리학회지 Vol.6 No.1
The purpose of this study was to investigate to potective effects against porcine epidemic diarrhea virus (PEDV) infection in piglets by administration of the PEDV antiserum orally at 2 hrs, 24 hrs and 36 hrs after birth. six piglets adiminstered the antiserum were experimentally infected with PEDV at five-day-old. Control group were four piglets infected with PEDV only. Clinical signs and gross, histopathological lesion and immunohistochemical findings were examined. The results obtained were as follows; 1. In clinical signs, piglets of the control group appeared the typical signs of severe watery diarrhea, depression and anorexia but piglets of the PEDV antiserum treated group recovered progressively. In mortality, control group showd 75%, but PEDV antiserum treated group showed 16.7%, respectively. 2. In gross findings, piglets of the control group appeared the typical findings of congestion, distension of lumen, contaning curdes of undigested milk in stomach. But piglets of the PEDV antiserum treated group appeared milder than those of control group. 3. In histopathological findings, piglets of the control group appeared the typical findings of villous atrophy and fusion, congesion, exfoliation, vacuolation, squamation, loss of cilia and proliferation of crypt. But piglets of the PEDV antiserum treated group appeared milder than those of control group. 4. In immunohistochemical findings, piglets of the PEDV antiserum treated group showed more intensive in reaction for IgG and IgG than those of control group. The recation for IgA was stronger than that of IgG. It was concluded that oral administration of PEDV antiserum to piglets was effective in preventing PEDV infection and reduced their mortality.