개 심장사상충(Dirofilaria immitis) 진단을 위한 항원성 조사 및 단크론항체 생산

이철순,지차호,Lee, Cheol-soon,Jee, Cha-ho 대한수의학회 2000 大韓獸醫學會誌 Vol.40 No.1

In order to diagnose canine heartworm infection by antigen capture ELISA, the crude somatic(S), partial somatic(below 45kDa) and excretory/secretory(E/S) antigen of adult heartworm were identified and the antigenicity was examined by silver stain, immunoblot and ELISA. Then, production of monoclonal antibody to specific antigen carried out in this experiment. The bands to S antigen and E/S antigen were recognized between 10 and 200kDa and common bands were recognized strongly 14, 18, 28, 43kDa by silver stain. By western blot analysis, fractions to S antigen were recognized 14, 16, 18, 20, 24, 28, 32, 43, 50, 55kDa, etc. and only a 14kDa to E/S antigen in positive sera which were positive in modified Knott's test and necropsy. In ELISA, the positive sera reacted to antigens(SA, $SA_{45}$, E/S) were significantly different from negative sera by Student's t-test(p<0.05). Four hybridoma cell lines(14, 16, 17, 32kDa) than produce specific monoclonal antibodies for these antigens were obtained by immunizing BALB/c mice with a partially purified somatic antigen (below 45kDa) preparation, by fusing spleen cells with SP2/O cell myeloma cells, and by screening cell culture supernatants for antibody. In these results, it was confirmed that partial somatic antigen(below 45kDa) or E/S antigen can be used for serologic diagnosis of heartworm infection and monoclonal antibody reacting with specific antigen(14kDa) can be used for antigen capture ELISA in prepatent period of canine heartworm infection.

해외시장 개척주력

이철순,Lee, Cheol-Sun (사)한국포장협회 2006 包裝界 Vol.153 No.-

노인에서 COVID-19로 인한 불안감과 관련된 인식

임은지(Eunji Lim),김봉조(Bong-Jo Kim),이철순(Cheol-Soon Lee),차보석(Boseok Cha),이소진(So-Jin Lee),서지영(Jiyeong Seo),최재원(Jae-Won Choi),이영지(Young-Ji Lee),이윤정(Younjung Lee),이동윤(Dongyun Lee) 대한노인정신의학회 2021 노인정신의학 Vol.25 No.1

Objective: To investigate perceptions of coronavirus disease-19 (COVID-19) associated with anxiety caused by the COVID-19 epidemic in the elderly who are vulnerable to mental health problems. Methods: This study used data of a survey on perceptions of COVID-19 and changes in mental health of 1,000 out of residents in a province of Korea in April 2020. The survey included questions about psychological perceptions for COVID-19. Subjects were dived into two groups (<60 and ≥60). Binary logistic regression analyses were performed for evaluating the association between anxiety and perceptions about COVID-19 in each group. Results: Results of binary logistic regression analyses revealed that only ‘fear of getting infected myself’among perceptions for COVID-19 was associated with anxiety in the elderly aged more than 60 years. However, in adults aged less than 60 years, all perceptions for COVID-19 except impairment of performance were associated with such anxiety. Conclusion: We found that the anxiety for COVID-19 in elderly with age over 60 years was associated with ‘fear of getting infected myself’ rather than ‘fear of family or people around them’, unlike adults aged less than 60 years. These results can be applied in strategies for psychological quarantine against COVID-19 among the elderly.

양극성 장애 입원 환자에서 비타민 D와 회복력

김창근(Chang-Geun Kim),김봉조(Bong-Jo Kim),이철순(Cheol-Soon Lee),이소진(So-Jin Lee),이동윤(Dongyun Lee),서지영(Ji-Yeong Seo),최재원(Jae-Won Choi),이영지(Young-Ji Lee),이윤정(Youn Jung Lee),임은지(Eunji Lim),차보석(Boseok Cha) 대한생물치료정신의학회 2021 생물치료정신의학 Vol.27 No.3

Objectives:The purpose of this study was to investigate the relationship between serum vitamin D concentration and resilience in patients hospitalized with bipolar disorder. Methods:Serum vitamin D levels were measured on day 1 of hospitalization in 64 patients with bipolar disorder, who were diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition. The Connor-Davidson Resilience Scale and the Korean version of the Inventory for Depressive Symptomatology (KIDS) were administered to these patients, and symptoms of mania were evaluated using the Young Mania Rating Scale (YMRS). Patients were then categorized into vitamin D sufficient and deficient groups based on a serum vitamin D cut-off of 20 ng/mL. Analysis of covariance (ANCOVA) was performed to compare the resilience between the two groups, and multiple linear regression was performed to determine the association between serum vitamin D levels and resilience. Results:The vitamin D deficiency group had more depressive episodes than the sufficient group (p<0.05). ANCOVA showed that the vitamin D deficient group had significantly lower resilience scores than the sufficient group (p= 0.034). Moreover, multiple regression analyses conducted by controlling age, sex, body mass index, season of blood sampling, KIDS scores, and YMRS scores, showed a significant association between serum vitamin D concentration and resilience in patients with bipolar disorder (p=0.001). Conclusions:This study suggested that vitamin D deficiency is associated with resilience as a protective factor against stress and trauma in patients with bipolar disorder. Further research is warranted to determine the causal relationship between vitamin D levels and resilience.

한국전쟁 휴전 이후 주한미군 잔류정책

이철순(Lee, Chul Soon) 동아시아국제정치학회 2005 국제정치연구 Vol.8 No.1

한국인 집단에서 알코올 의존과 세로토닌 수송체 유전자 다형성의 연관성

이철순(Cheol-Soon Lee),노양덕(Yang-Duck Noh),구준(Joon Gu),박철수(Chul-Soo Park),손진욱(Jin-Wook Shon),한규희(Kyu-Hee Hahn),김봉조(Bong-Jo Kim) 대한생물치료정신의학회 2007 생물치료정신의학 Vol.13 No.2

Objective:Family, twin, and adoption studies have demonstrated that genes play an important role in the development of alcoholism. We investigated the association between alcoholism and the genetic polymorphisms of the serotonin transporter regulatory gene(5-HTTLPR) in Korean population. We also explored the association between the genetic polymorphisms of the 5-HTTLPR and clinical characteristics in patients with alcohol dependence. Methods:The genotype and allele frequencies of the 5-HTTLPR were investigated in 172 control subjects and 162 male hospitalized patients who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition(DSMIV), criteria for alcohol dependence. Several standardized research scales were used for the clinical assessment of alcoholism, including the Alcohol Dependence Scale(ADS), the Beck Depression Inventory, the Beck Anxiety Inventory, and the Obsessive-Compulsive Drinking Scale. Results:We found that the frequency of LL genotype and L allele was higher in patients with alcohol dependence than that of control subjects. Alcoholics with the 5-HTTLPR LS or SS genotypes had a later age of onset (mean age of onset, 29.4 and 32.1 years, respectively) than those with the LL genotype(mean age of onset, 25.9 years;p=.002). Also we found that the polymorphisms of the 5-HTTLPR were associated with the scores of the ADS, but not associated with the scores of the BDI, BAI, and OCDS. Alcoholics with the L allele had an earlier age of onset and higher scores of the BDI than those with the S allele(respectively p=.019, p=.021). The scores of the ADS were higher in patients with the S allele than those with the L allele(p=.002). Conclusion:Our finding suggest that genetic polymorphisms of the 5-HTTLPR may be associated with the development of alcoholism and that the 5-HTTLPR play an important role in the development of the early onset and the severe type of alcoholism.

소련의 북한 정치세력에 대한 정책 : 1945-1948

이철순(Lee Chul Soon) 21세기정치학회 2010 21세기 정치학회보 Vol.20 No.1

This paper examines Soviet policy toward the North Korean political contest from 1945 to 1948. It elaborates which political forces the Soviet Union intended to support and how autonomous Kim Il Sung was from Moscow's intervention. During the first 'genuine coalition'(August 1945- January 1946), the Soviet Communist Party coaligned with nationalist leader Cho Man-sik to build the National United Front. Cho was discarded in January 1946 because he opposed the Moscow conference decision. Simultaneously, Stalin interviewed Kim Il Sung to confirm his loyalty to the Soviet Union before return back to North Korea in September 1945. The Soviet Communist Party supported Kim Il Sung's establishment of the Northern Branch of Korean Communist Party in October 1945 and orchestrated a welcoming rally for Kim on October 14, 1945. The Party made Kim North Korea's de facto leader by appointing him as general secretary of the Northern Branch of Korean Communist Party in mid-December 1945. The next stage, a 'bogus coalition'(January 1946-September 1948), preceded the final emergence of the 'monolithic regime'. The Soviet Communist Party had full confidence in Kim. Stalin summoned Kim and another communist leader, Park Heonyoung to Moscow and interviewed them simultaneously in July 1946. Stalin showed greater trust in Kim than Park at this meeting by letting Kim sit to his right. The Soviet Communist Party further backed Kim in building the North Korean Worker's Party and by intervening heavily in the South-North meeting of April 1948. At this time Stalin's confidant Shtykov actually dominated North Korean politics. In conclusion, North Korean Communist regime was 'satellite regime' under the strong patronage of the Soviet Union and thus Kim had little autonomy from it.

이승만의 대미외교를 통한 국가생존 전략(1895-1953)

이철순 ( Chul Soon Lee ) 서울대학교 한국정치연구소 2012 韓國 政治 硏究 Vol.21 No.3

이 논문은 1895년부터 1953년까지의 이승만의 대미외교를 통한 국가생존 전략을 살펴보는 것을 목적으로 한다. 비록 식민지 시기에 그의 대미외교가 가시적인 성과를 보이지 못했다 하더라도 그는 어려운 여건 속에서 1948년 대한민국을 건국하는 데 성공하였고 자신의 오랜 염원이었던 한미상호방위조약을 1953년에 체결함으로써 한국의 안보를 미국으로부터 문서상으로 보증 받는데 성공하였다. 이러한 의미에서 그의 국가생 존전략은 결과적으로 성공적인 것이었다. 이승만이 대미외교를 수행할 때 지속적으로 사용한 방법은 미국이 1882년 조미수호조약의 거중조정 약속을 지키지 않은 배신행위를 계속해서 지적하는 것이었다. This paper examines Syngman Rhee`s strategy of national survival by U.S. diplomacy from 1875 to 1953. Even though his U.S. diplomacy could not show visible outcome during the Japanese colonial period, he succeeded in establishing the Republic of Korea under the unfavorable conditions and securing a U.S. guarantee of Korea`s national security in writing by singing the R.O.K.-U.S. Mutual Defense Treaty with the U.S. in 1953. Accordingly, his strategy was successful. The method he used in conducting his US diplomacy was to persistently point out the betrayal of U.S. failure to live up to the Treaty of Amity and Commerce of 1882, which stipulated the duty to exert "good offices" to help the other in need.

미국의 자유주의 전통과 한국 정치세력에 대한 정책 (1945∼1960)

이철순(Lee, Chul Soon) 동아시아국제정치학회 2011 국제정치연구 Vol.14 No.2

This paper examines the U. S. policy toward the South Korean Politics from 1945 to 1960. It elaborates whether the U. S. policy reflected the third and the fourth beliefs derived from America"s liberal tradition(“Radicalism and Revolution are Bad.” and Distributing Power is more Important than Accumulating Power.”) or not. Due to the third belief, the U. S. decision makers tried to exclude the extreme left, i. e. the communist regime and extreme right i. e. the authoritarian regime. However, anticommunist authoritarian regime was accepted by them as the second best. Therefore, anti-communist authoritarian Syngman Rhee regime was tolerated by them in 1948 when the South Korean government was established. On the other hand, the fourth belief also had influence upon the U. S. policy. The U. S. policy makers endeavored to build the moderate left-right coalition in 1946 and the coalition of moderate factions of Liberal Party and Democratic Party in the late 1950s. They also made an consistent effort to liberalize the authoritarian Rhee regime to protect its leaning toward dictatorship.

한국전쟁 이전 소련의 위협에 대한 미국의 인식, 1945-1950

이철순(Lee Chul Soon) 한국학중앙연구원 2000 한국학 Vol.23 No.3