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이철범,송동섭,김혁,김영학,강정호,이재웅,김순길,Lee, Chul-Burm,Song, Dong-Sub,Kim, Hyuk,Kim, Young-Hak,Kang, Jung-Ho,Lee, Jae-Ung,Kim, Sun-Gil 대한흉부심장혈관외과학회 2001 Journal of Chest Surgery (J Chest Surg) Vol.34 No.3
신동맥 사이 또는 신동맥 상부에 위치하는 대부분의 복부대동맥 축착은 흉복부절개의 접근으로 수술한다. 우리는 경흉막 후복막 접근으로 개복을 하지 않고 단측단측 흉복부대동맥의우회술을 시행한 1례의 수술을 소개하고자 한다. 경흉막 후복막 접근은 흉복부대동맥의 시야가 매우 좋으며 개복을 할 때보다 더 쉽게 흉복부대동맥의 우회술을 할 수 있고 복강내 장기를 노출하지 않는 장점이 있다.
이철범,임현수,지행옥,박충기,박용욱,김혁,정원상,김영학,강정호,Lee, Chul-Burm,Lim, Hyoun-Soo,Jee, Heng-Ok,Park, Choong-Ki,Park, Yong-Wook,Kim, Hyuck,Jung, Won-Sang,Kim, Young-Hak,Kang, Jung-Ho 대한흉부심장혈관외과학회 2002 Journal of Chest Surgery (J Chest Surg) Vol.35 No.7
우리는 단순 흉부 방사선 촬영에서 우연히 발견한 47세 여자의 횡격흉막에서 발생한 양성 고립성 섬유성 종양 1례를 보고한다. 단순 흉부 방사선 촬영, 복부 초음파 검사, 전산화 단층 촬영과 자기공명영상으로 주변과 경계가 분명한 다엽성의 흉막 섬유성 종양으로 진단하였다. 우측 개흉 수술시 종괴는 대부분 유착이 없었으나 $5{\times}4$cm 정도의 횡격막 중앙부와 유경으로 붙어 있었다. 붙어 있는 횡격막과 함께 종괴를 완전히 절제하였다. 종양은 $23.5{\times}13.5{\times}8.0$cm 크기였으며, 병리조직학 진단은 양성 섬유성 종양이었고 함께 절제된 횡격막에는 종양세포가 없었다. We present a case of a 47-year-old woman with benign solitary fibrous tumor of the pleura originated in the diaphragm which was discovered incidentally on a chest radiograph. Chest radiograph, sonograph, computed tomographic scan and magnetic resonance image studies proved a well circumscribed and lobulated fibrous tumor of the pleura. During the subsequent right thoracotomy, the tumor was found to be encapsulated and consisted of firm mass. It was connected to the diaphragm with $5{\times}4$cm area by pedicle. Most of the tumor was free of adhesion. It was excised completely together with attached diaphragm. The tumor measured $23.5{\times}13.5{\times}8.0$cm and the pathologic diagnosis was benign solitary fibrous tumor and the attached diaphragm was free of disease.
이철범,함시영,김혁,정원상,김영학,강정호,백홍규,Lee, Chul-Burm,Hahm, Shee-Young,Kim, Hyuk,Jung, Won-Sang,Kim, Young-Hak,Kang, Jung-Ho,Baik, Hong-Kyu 대한기관식도과학회 2000 大韓氣管食道科學會誌 Vol.6 No.1
Background: For the purpose of reducing operating time and rate of anastomotic leakage, we have performed esophagovisceral anastomosis with an EEA stapler using the largest size possible. If any difficulty in the approach of the EEA stapler was encountered one-layer interrupted hand-sewn anastomosis. Because the rate of postoperative benign anastomotic stricture was higher than expected, a retrospective study was done on all patients who underwent esophageal reconstruction. Material and Method: Over a period of 3 years from January 1996 to December 1998, we performed esophageal reconstructions on 30 patients. Patients were divided into two groups ; EEA stapler group(Group Ⅰ) comprised of 21 patients and hand-sewn group(Group Ⅱ) comprised of 9 patients.Result:The hospital mortality was 6.67 %(2/30) and the anastomotic leakage rate was 3.33 %(1/30). Among the discharged patients, the rate of recurrent anastomotic tumor was 3.57 %(1/28) and the rate of benign anastomotic stricture stricture rate was 35 %(7/20) in Group Ⅰ and 12.5 %(1/8) in Group Ⅱ, which was not significant. Conclusion: Although nontumor benign stricture was significantly higher in Group Ⅱ than in Group Ⅰ(p=0.0492), the incidence of anastomotic complications did not differ between the two groups. The one-layer interrupted hand-sewn esophagovisceral anastomosis by maintaining a wide lumen and close approximation of mucosa to mucosal layers with evenly spaced sutures could be one of the preferred surgical method to reduce benign anastomotic strictures.
이철범,정태열,함시영,김혁,정원상,김영학,강정호,지행옥,박용욱,Lee, Chul-Burm,Chung, Tae-Yul,Halm, Shee-Young,Kim, Hyuk,Jung, Won-Sang,Kim, Young-Hak,Kang, Jung-Ho,Jee, Heng-Ok,Park, Yong-Wook 대한흉부심장혈관외과학회 2000 Journal of Chest Surgery (J Chest Surg) Vol.33 No.4
Malignant fibrous histiocytoma(MFH) is a deep-seated pleomorphic sarcoma, which occurs principally as a mass of the extremities, abdominal cavity, or retroperitoneum in adults. However, it only rarely occurs in the chest wall. An 85-year-old man had undeergone excision of a small mass on the right posterior chest wall under local anesthesia 14 months age. However, the lesion did not heal and the mass recurred. He was referred to our hospital after the mass had grown to a size of 10.5$\times$8$\times$4cm with a 3$\times$3cm skin defect. Intraoperative frozen biopsy revealed MFH. An en-bloc wide resection and thin-thickness skin graft from his thigh were performed. Although distant metastasis to the lund developed 14 months later and the patient died 2 months later, there was no local recurrence. Thin-thickness skin graft is a simple method for a wide range skin defect, especially in the old age. He recovered in good condition without any physical disabilities.
정원상,전양빈,전순호,김혁,이철범,김영학,지행옥,서정국,공구,Chung, Won-Sang,Jeon, Yang-Bin,Chun, Soon-Ho,Kim, Hyuk,Lee, Chul-Burm,Kim, Young-Hak,Jee, Heng-Ok,Seo, Jung-Kuk,Kong, Gu 대한흉부심장혈관외과학회 1998 Journal of Chest Surgery (J Chest Surg) Vol.31 No.5
국내에서 심장, 폐이식이 각 대학병원에서 점차 확산 시행되고는 있으나, 이에 따른 기초실험이 뒷받침되지 않고, 큰 동물에서는 많은 실험비용이 들어 보다 적은 동물을 이용하게 되었으나 이 방법은 현미경하의 미세수술기법의 발달과 더불어 발전하게 되었다. 본 연구는 현미경하의 미세수술기법으로 쥐모델에서 복부의 대동맥과 하공정맥에 다른 쥐의 공여심장의 대동맥과 폐동맥을 각각 문합술로 연결하는 방법으로 이식하여 동종이형의 장기이식에 따른 거부반응과 면역억제제를 투여하여 그에 따른 생존율을 비교하고자 하였다. 체중 150∼250 gm의 흰쥐의 심장을 공여 및 이식하는 바, 이소성의 심장이식후 면역억제제를 투여하지 않은 군과 면역억제제를 투여한 군으로 나누고, 각 군에서 복부에 이식된 심장의 박동을 매일 만져보고서 만져지지 않을 경우는 이식된 심장이 거부반응에 따른 것으로 판단하여 이의 생존율을 비교 검토하여본 바, 면역억제제를 투여하지 않은 군에서보다 투여한 군에서 오래 생존하여 동종이형의 이식에서 면역억제제를 투여하므로써 장기이식에 따른 장기성적을 향상시킴을 알 수 있었다. In 1964, Abbott and Colleagues published the world's first heterotopic heart transplantation technique in the rat. Their method established circulation by end-to-end anastomoses of the graft's aorta and pulmonary artery to the recipient's abdominal aorta and Inferior Vena Cava(IVC), respectively. In 1966, Tomita et al altered Abbott's technique by employing end-to-side rather than end-to-end anastomoses, thus eliminating the hind leg paralysis that sometimes resulted from Abbott's technique. In order to prevent postsuture hemorrhage (since 7-0 silk suture was the finest available at that time), Tomita's aortic anastomosis was done with double up-and-down continuous suture technique. A single layer continuous anstomosis effected the pulmonary artery-IVC anastomosis. The availability of Nylon monofilament suture made it possible for Ono and Lindsey to use a single layer suture technique for the aortic end-to-side anastomosis in their modified rat heart transplantation. We observed survival time between control group and Immunosuppression(Cyclosporine administration, 10mg/Kg${\times}$4 times postoperatively) group after heterotopic heart transplantation in the rat model. The cyclosporine adminstration group survived longer than the control group, thus we concluded that cyclosporine was based on Immunosuppressive drugs.
가슴샘 카르시노이드종양의 세침흡인 세포소견 - 1예 보고 -
오영하,장기석,송영수,이철범,박충기,박문향,박용욱,Oh, Young-Ha,Jang, Ki-Seok,Song, Young-Soo,Lee, Chul-Burm,Park, Choong-Ki,Park, Moon-Hyang,Park, Yong-Wook The Korean Society for Cytopathology 2005 대한세포병리학회지 Vol.16 No.1
Carcinoid tumors of the thymus are vanishingly rare, and the characteristic cytologic findings of this condition have never before been reported in Korea. Recently, we encountered a 58-year-old woman who had been suffering from general weakness and weight loss for several months. Radiological imaging revealed a large anterior mediastinal mass. A fine needle aspiration biopsy (FNAB) of the mass showed predominantly scattered single cells, as well as some loose clusters of small cells with scanty cytoplasm. Some of these small cells exhibited plasmacytoid features, with moderately granular cytoplasm. We also discuss the cytological differential diagnosis between thymic carcinoid and other mediastinal tumors.
전순호,정태열,송동섭,김혁,함시영,이철범,강정호,정원상,김영학,지행옥,Chon, Soon-Ho,Chung, Tae-Yul,Song, Dong-Sub,Kim, Hyuck,Hahm, Shee-Young,Lee, Chul-Burm,Kang, Jung-Ho,Chung, Won-Sang,Kim, Yong-Hak,Jee, Heng-Ok 대한흉부심장혈관외과학회 2000 Journal of Chest Surgery (J Chest Surg) Vol.33 No.1
Background: Esophageal perforation is an extremely lethal injury that requires careful management for survival,. Material and Method: We performed a retrospective clinical revi-ew of 14 patients treated for esophageal perforation at the Department of Thoracic and Cardiovascular Surgery hanyang University Hospital between July 1986 and August 1998. Cardiovascular Surgery Hanyang University Hospital between July 1986 and August 1998. Result: The ration between male and female patients was 12:2 and their ages ranged from 9 to 68 years( average: 446 years). Iatrogenic perforations were found in 6 patients(42.9%) spontaneous perforations in 3 patients(21.4%) traumatic perforations in 2 patients(14.3%) and caustic perforations foreign body origin and esophagel cancer in 1 patient (7.1%) each. Four of the patients(28.6%) had esophageal ruptures located cancer in 1 patient (7.1%) each. Four of the patients (28.6%) had esophageal ruptures located in the cervical esophagus and 10 patients (71.4%) in the thoracic esophagus, The most frequent location was in the mid third portion of the esophagus (35.7%) there were also 2 patients(14.3%) in the upper third portion and 3 patients(21.4%) in the lower third portion. Complications encountered included mediastinitis empyema or pleural effusion mediastinal or lung abscess sepsis and aspiration pneumonia. The most frequent complication that occurred was mediastinitis in 9 cases (57%) Three patients underwent conservative treatment. Among the patients who underwent surgical treatment 5 patients underwent primary closure 6 patients underwent open drainage and 2 patients underwent reconstrumction (1 patients had an initial primary closure and 1 patient had an initial open drainage procedure). The mortality rates for those with conservative and surgical treatment were 66.7% (2cases) and 9.1% (1 cases) respec- tively. Conclusion: Perforation of the esophagus although very rare has a high mortality rate and thus aggressive operative therapy is necessary.
김병일,손상태,신성호,정원상,김혁,김영학,강정호,지행옥,이철범,서정국,Kim, Byung-Il,Sohn, Sang-Tae,Shin, Sung-Ho,Chung, Won-Sang,Kim, Hyuk,Kim, Young-Hak,Kang, Jung-Ho,Jee, Heng-Ok,Lee, Chul-Burm,Seo, Jung-Kuk 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.1
배경: 1971년 calne에 의해 계통발생학적으로 조화성과 비조화성으로 분류된 이종이형이식이 발표된 이후, 계통발생학적으로 서로 공통점이 없는 비조화성과 공통점이 있는 조화성의 이종이형이식에서 초급성 거부반응과 촉진된 급성거부반응으로 나누어지나, 이런 조화성의 이종이형의 심장이식시에는 초급성거부반응이 없는 상태로 이종이형의 이식의 연구기회를 제공하게된다. 쥐모델에서의 조화성의 이종이형이식의 생존율을 높이는 현재의 치료법들은 높은 사망율 때문에 많은 연구재에서 이상적이지 못하다. 기존의 사이클로스포린A(Cyclosporine A) 나 새로운 면역억제제인 푸린 합성억제제인(purine synthesis inhibitor) 마이코페놀레이트 모페틸(Mycophenolate Mofetil, RS61443)은 현재 동종이형이식에는 효과적으로 임상에 이용되고 있다. 대상 및 방법: 잡종휜쥐를 수혜군으로 다 자란 생쥐를 기증군으로하여 이를 다시 4개군으로 나누어 제 1군(대조군)은 전처치나 치료약제의 투여가 없었던 군으로, 제 2군은 이식전 7∼10일전에 전처치로써 비장적출술을, 제 3군은 기존의 면역억제제인 사이클로스포린A로 치료한 군으로, 제 4군은 사이클로스포린과 새로운 면역억제제인 마이코페놀레이트 모페틸(RS 61443)을 동시에 투여한 군으로 나누어 각 군간의 술후 생존율을 비교하였다. 결과: 본문의 표와 그림에서 보여 주는 바와 같이 각군간의 생존율의 차이는 없었다. 결론: 본 저자등은 결론적으로 조화성의 이종이형의 이식은 동종이형의 이식의 지난 보고와는 거부반응이 서로 다르며, 기존 혹은 새로운 면역억제제인 마이코페놀레이트 모페틸의 투여도 이들 이종이형의 이식후 생존율을 연장하는데는 효과적이지 못하였다. Background: The transplantation of organs between phylogenetically disparate or harmonious species has invariably failed due to the occurrence of hyperacute rejection or accerelated acute rejection. But, concordant cardiac xenograft offer us an opportunity to study xenotransplantation in the absence of hyperacute rejection. Current therapeutics for the prolongation of survival of rodent concordant xenotransplantation are not ideal with many regimens having a high mortality rate. Cyclosporine A & Mycophenolate Mofetil are new immunosuppresive agent which has been shown to be effective at prolonging survival of allograft, as purine synthesis inhibitor. Material and Method: We used white mongrel rats as recipient and mice as donor, divided 4 groups(n=6), control group(Group 1) has no medication or pretreatment, Group 2 has splenectomy as pretreatment 7∼10 days before transplantation, Group 3 has Cyclosporine A treatment group, Group 4 has combined treatment of Cyclosporine A & Mycophenolate Mofetil(RS 61443). We compared survival time. Reuslt: We can't find significant difference of survival time between each groups. Conclusion: We concluded that rejection of cardiac xenograft was different from rejection of allograft, and new immunossuppresive Agent(Mycophenolate Mofetil, Cyclosporine A) was not effective for prolongation of survival time after cardiac xenograft.