http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이찬미,정현아,오상호,Takashi Tanaka,박찬흠,Takako Yokozawa,최재수 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
Aldose reductase (AR) is a key enzyme in thepolyol pathway that is strongly implicated in the pathogenesisof diabetic complications. AR inhibitors have beenproposed as therapeutic agents for diabetic complicationsthrough suppression of sorbitol formation and accumulation. In this study, we evaluated whether two major compounds ofCorni Fructus, loganin and 7-O-galloyl-D-sedoheptulose,had an inhibitory effect on diabetic complications throughAR inhibition. Because the iridoid glycoside loganin and thelow-molecular-weight polyphenol 7-O-galloyl-D-sedoheptuloseshowed marginal inhibitory activities against rat lensAR (RLAR) and human recombinant AR (HRAR) in inhibitionassays, we performed enzyme kinetic analyses andmolecular simulation of the interaction of these two compoundswith AR to further investigate their potential asinhibitors of diabetic complications. In kinetic analysisusing Lineweaver–Burk plots and Dixon plots, loganin and7-O-galloyl-D-sedoheptulose were both mixed inhibitors ofRLAR with inhibition constants (Ki) of 27.99 and128.68 lL, respectively. Moreover, molecular dockingsimulation of both compounds demonstrated negativebinding energies (Autodock 4.0 = -6.7; -7.5 kcal/mol;Fred 2.0 = -59.4; -63.2 kcal/mol) indicating a highaffinity and tight binding capacity for the active site of theenzyme. Iridoid nucleus and aromatic ring systems andglycoside and sedoheptulose moieties were found to bindtightly to the specificity pocket and the anion binding pocketin RLAR through Phe123, His111, Trp21, Tyr49, His111,and Trp112 residues. Our results clearly indicate thatloganin and 7-O-galloyl-D-sedoheptulose have great promisefor the treatment of diabetic complications throughinhibition of AR.
Microbial Contamination Rates of Hospital Privacy Curtains: A Prospective Culture Study
이찬미,고혜연,이효연,오영록,최평균,박완범,김남중 대한의료관련감염관리학회 2021 의료관련감염관리 Vol.26 No.1
Contaminated curtains are a reservoir of microorganisms that can be a source of infection outbreak. In order to investigate the contamination rates of hospital curtains over time, we obtained cultures from 34 hospital privacy curtains and 2 control curtains over 8 weeks. If the cultures revealed over 2.5 colony-forming units (CFU)/cm2 of microorganisms, the curtains were considered contaminated. The burden of microorganisms in the control curtains remained under 0.2 CFU/cm2 during the study period. The cumulative contamination rate of the hospital privacy curtains increased over time (week 2: 15.6%, week 4: 37.0%, and week 8: 55%). The contamination rates of the curtains from the 2-, 4-, 5-, 6-, and 7-bed rooms were 0% (0/1), 0% (0/4), 20% (1/5), 43.8% (7/16), and 100% (3/3), respectively. Methicillin-resistant Staphylococcus aureus was not isolated from either the control or the hospital curtains during the study period. Vancomycin-resistant enterococci was not isolated from the control curtains but was isolated from 11.8% (4/34) of the hospital curtains (week 2: 2, week 4: 1, and week 6: 1). The contamination rate of the hospital curtains increased over time and showed a tendency to rise with an increase in the number of beds in a room.
노르딕 워킹 운동 프로그램이 중년 농촌주민의 신체지표와 주관적 행복감에 미치는 영향
이찬미,박영숙 한국지역사회간호학회 2020 지역사회간호학회지 Vol.31 No.1
Purpose: The purpose of this study was to identify the effect of regular Nordic walking exercise on the physical indicators and subjective happiness of middle-aged rural residents. Methods: A pretest and posttest design with a nonequivalent control group was conducted. The participants of experimental and control group were each 21 subjects from 40 to 64 years old. The Nordic walking exercise program consisted of 24 sessions which were focused on group exercise, and was conducted three times a week for eight weeks. Results: The experimental group showed significant decreases in body mass index (p=.042), body fat (p<.001), and abdominal fat (p=.026). The experimental group showed significant increases in muscle mass of right lower limb (p=.009) and left lower limb (p=.016) but was not statistically significant in right, left upper limbs and body. On the other hand, the control group showed significant decreases in muscle mass of right upper limb (p=.034), left upper limb (p=.038), and body (p=.034). There were no significant differences in systolic blood pressure, diastolic blood pressure, and subjective happiness between the experimental and the control group. Conclusion: The Nordic walking exercise should be actively encouraged to improve health of the middle-aged in rural area.
외식종사원의 직무스트레스와 심리적 안녕감, 직무만족, 이직의도의 관계 : 회복탄력성의 조절효과
이찬미,윤혜현 한국외식경영학회 2019 외식경영연구 Vol.22 No.1
Emotional problems in employees caused by job stress have a negative influence on organizational achievement, such as job avoidance, delay, and degradation in the performance of work and productivity, job dissatisfaction, and furthermore, deteriorate the efficiency of organizations. Thus, psychological health of service employees is considered to be one of important problems for manages in contemporary times. In this study, we set up the research hypotheses, in relation to structural relationship, that job stress would have a negative influence on psychological well-being of the Foodservice employees. Moreover, the moderating effect of resilience was investigated and the research model and hypotheses were validated through empirical analysis. We conducted a survey of employees working in the cooking department, food and beverage department of special first-class hotels and restaurants located in Seoul and Gyeonggi-do region for the empirical research. Based on a total of 300 samples, we examined the reliability, validity, and suitability of the study model, validated 4 major hypotheses and 10 sub-hypotheses, and performed the frequency analysis to examine characteristics of the samples. Aforesaid results of this study have the following meaning and implication: This study was an initial exploratory study investigating the psychological well-being which was lacking in foodservices and provided theoretical basis for the succeeding studies and for establishment of policies necessary to control each element of job stress hindering the psychological well-being of foodservice employees. Thus, the results of this study suggests that HR managers of food companies would need to implement investigation regularly into current status of job stress in the employees and make proactive efforts for effective management of human resources through introduction of psychological counseling programs designed to help promote recovery of psychological well-being and strengthen the resilience in the employees. 본 연구는 국내 외식기업 종사원들을 대상으로 직무스트레스와 심리적 안녕감, 직무만족, 이직의도의 관계에 대해 연구하였으며 더불어, 회복탄력성의 조절효과를 알아보고자 하였다. 실증분석을 위해 서울․경기 지역에 위치한 특1급 호텔 및 기업형 체인레스토랑에서 근무하고 있는 조리부, 식․음료부 종사원을 대상으로 설문조사를 실시, 총 300부 의 표본을 바탕으로 연구모형의 신뢰성 및 타당성, 그리고 적합도를 검토하여 총 4개의 주 가설 및 10개의 하위가설을 검증하였다. 분석결과, 본 연구의 표본 외식종사원들은 직무스트레스 하위 구성요소 네 가지에 대하여 역할갈등, 역할과다, 고객갈등, 역할모호의 순으로 직무환경에서의 스트레스를 크게 느끼는 것으로 나타났다. 또한 직무스트레스가 심리적 안녕감에 미치는 영향에 대하여 분석한 결과, 역할과다를 제외한 모든 요소가 종사원의 심리적 안녕감의 하위요소인 자아수용과 긍정적 대인관계에 유의한 부(-)적 상관을 나타냈다. 심리적 안녕감의 하위요소 중 자아수용은 직무만족에 정(+)의 영향을 미치는 것으로 나타났으나 긍정적 대인관계는 직무만족에 유의한 영향을 나타내지 않았다. 또한 직무만족은 이직의도에 유의한 부(-)의 영향을 나타내는 것으로 조사되었으며 직무스트레스와 심리적안녕감의 관계에서 회복탄력성에 따른 부분적인 조절효과를 확인하였다. 결과적으로 직무스트레스의 경험으로 인한 심리적 안녕감의 저하는 종사원의 직무에 대한 만족의 저하와 이직의도의 증가로 이어지므로 외식기업의 인사 관리자는 종사원들의 직무스트레스에 대한 실태조사를 주기적으로 실시하고 종사원의 심리적 안녕감 회복 및 회복탄력성의 강화를 위한 심리상담 프로그램 등의 도입을 통해 인적자원 관리를 위한 노력을 우선적으로 기울여야 할 필요가 있음을 시사하였다.