정상인과 수면장애 환자군 간의 주간졸림증 비교 및 임상적 의미 분석

이진성,김석주,최종배,정도언,Lee, Jin-Sung,Kim, Seog-Ju,Choi, Jong-Bae,Jeong, Do-Un 대한수면의학회 2002 수면·정신생리 Vol.9 No.2

배 경 : 주간 졸림증은 흔한 증상으로서 수면 습관, 수면 박탈, 그리고 야간 작업 등과 관련된다. 또한 폐쇄성 수면무호흡증과 같은 수면장애의 중요 증상이다. 문헌 조사에 의하면 그간 국내에서 주간 졸림증에 대한 소수의 연구가 있었다. 그러나 다수의 정상대조군과 수면다원기록법을 사용해 확진된 수면장애 환자들 간에 주간 졸림증의 임상적인 특징을 비교한 체계적인 연구는 찾아볼 수 없었다. 본 연구에서는 야간 작업을 하지 않는 직장인, 만성적인 수면 박탈로 인해 주간 졸림증이 심할 것으로 추측되는 의과대학생, 그리고 수면다원기록법을 사용해 확진된 수면장애 환자를 대상으로 주관적인 주간 졸림증의 정도를 비교하였다. 그리고 수면장애 환자에서 주관적인 주간 졸림증과 수면다원검사 변인들 간의 연관성을 조사하였다. 방 법 : 야간 근무를 하지 않는 병원 직원 103명, 의과대학 3학년 학생 137명, 그리고 수면다원검사를 사용해 확진 된 수면장애 환자 518명을 대상으로 하였다. 수면장애에는 폐쇄성 수면무호흡증, 주기성 사지운동증, 불면증, 그리고 기면병을 포함하였다. 주관적인 졸림증의 정도를 한국어로 번안, 제작된 Epworth 졸림증 척도로 측정하여, 정상군과 졸림증군 그리고 수면장애 환자군 사이의 주관적인 졸림증 정도를 비교하였다. 그리고 각 수면 장애 환자군에서 수면 장애가 심한 정도를 반영하는 수면다원검사 변인과 주관적인 졸림증의 연관성을 분석하였다. 결 과 : 정상군, 수면장애 환자군, 의과대학생군 간에는 Epworth 졸림증 척도 점수의 유의한 차이가 있었다(F=68.190, df=5,752, p<0.001). 폐쇄성 수면무호흡증 환자군에서 주관적인 졸림증의 정도는 평균 혈중산소포화도(p=0.062), 호흡장애지수(p=0.807)와 유의한 상관관계가 없었다. 주기성 사지운동증 환자군에서 주기성 사지운동 지수와 졸림증과는 유의한 상관관계가 없었다(p=0.761). 기면병 환자군에서 입면잠복시간 반복검사(MSLT)에서 측정한 평균 입면잠복시간과 졸림증은 유의한 상관관계가 없었다(p=0.055). 결 론 : 주관적인 졸림증의 정도는 정상군, 수면장애 환자군, 그리고 의과대학생군 간에 유의한 차이가 있었다. 그러나 각 수면장애 환자군 내에서 주관적인 졸림증의 정도는 수면장애의 심한 정도를 반영하는 객관적인 수면다원검사 변인과는 상관관계가 없었다. 주관적인 졸림증의 평가가 임상적으로 중요하나 수면다원기록법과 같은 객관적인 평가방법을 대체할 수는 없다는 것을 확인할 수 있었다. Objectives: Daytime sleepiness is a common symptom and is associated with sleep behavior, sleep deprivation, and night shift, etc. It is also one of the most important symptoms of sleep disorders like obstructive sleep apnea (OSA). According to our survey on Korean literature, a few studies have dealt with daytime sleepiness, and we have not been able to locate any study comparing normal subjects with polysomnography-proven sleep disorder patients regarding daytime sleepiness. We aimed at comparing daytime sleepiness among normal healthy daytime workers, medical students being expected to have daytime sleepiness due to chronic sleep deprivation, and patients having sleep disorders diagnosed with polysomnography. We also studied the association between subjective daytime sleepiness and objective polysomnographic findings in patients with sleep disorders. Methods: One hundred three hospital workers, 137 medical students, and patients with sleep disorders were studied. Sleep disorders included OSA, periodic limb movements in sleep (PLMS), insomnia, and narcolepsy. The degree of subjective sleepiness in each group was measured by the Korean version of Epworth sleepiness scale and compared. The relationship between polysomnographic findings reflecting severity of sleep disorder in each patient group and subjective sleepiness was analyzed. As for patients with narcolepsy, the relationship between the mean sleep latency and subjective sleepiness was studied. Results: There was a significant difference of ESS score (F=68.190, dF=5.752, p<0.001) among daytime workers, medical students, and sleep disorder patients. In OSA patient group, the degree of the sleepiness had no significant correlation either with mean O2 satuaration (p=0.062) or with RDI (p=0.807). In PLMS patient group, there was no correlation between periodic limb movement index (PLMI) and subjective sleepiness (p=0.761). In narcolepsy patient group, the subjective sleepiness had no correlation with mean sleep latency measured with MSLT (p=0.055). Conclusion: We found a significant difference of subjective sleepiness among daytime workers, medical students, and patients with sleep disorders. However, no consistent correlation was found between severity of subjective sleepiness and objective polysomnographic findings reflecting severity of each sleep disorder. This research confirms that the evaluation of subjective sleepiness is important clinically, but it cannot substitute the objective measures such as nocturnal polysomnography and MSLT.

수면과 알코올

이진성,김성곤,정우영,양영희,Lee, Jin-Seong,Kim, Sung-Gon,Jung, Woo-Young,Yang, Young-Hui 대한수면의학회 2013 수면·정신생리 Vol.20 No.2

Alcohol has been used as sedatives historically. The effect of alcohol on sleep is different according to its dose, timing of ingestion, and drinking frequency. Sleep problems may play a role in the development and course of alcohol-related disorders. Insomnia in alcohol-dependent patients is common and early treatment of insomnia may reduce the rate of relapse. Sleep apnea, restless legs syndrome, periodic limbs movement disorder, and altered circadian rhythm may be more frequent in this patients. Management of sleep and alcohol problems is important in treating alcohol-related disorder and sleep disorders, respectively.

견사곤충에서 Mariner Transposase-like Element의 분자적 동정

이진성,황재삼,김용성,서동상,Lee, Jin Sung,Hwang, Jae Sam,Kim, Yong Sung,Suh, DongSang 한국생명과학회 1998 생명과학회지 Vol.8 No.4

누에, 멧누에, 천잠 및 작잠에서의 형질전환용 vector 개발을 위한 첫단계로 이미 인간을 포함한 여러 곤충에서 그 존재가 확인된 mariner transposable element가 이들 견사 곤충에 존재하는지의 여부를 탐색하기 위해서 이미 보고된Drosophila mauritiana와 Hyalophora ceropia의 mariner transposase 유전자의 고도로 보존성이 높은 부위에 대한 degenerctive primer pair를 제작하여 이들의 존재 여부를 탐색하였다. 결과적으로 예상되는 약 500bp의 PCR product가 관찰됨에 따라서 모든 견사곤충의 genome에는 maminer-like element(MLE)가 존재한다는 것을 간접적으로 확인할 수 있었다. 이미 cloning된 pBmoMAR를 probe DNA로하여 southern hybridization을 수행한 결과에서도 확인 할 수 있었으며, 각 견사층의 genome내에 high copy로 존재한다는 것을 추정할 수 있었다. 따라서 이와 같은 결과는 견사곤충에서 MLE가 vector system으로써 개발될 수 있는 기초자료로 제공될 수 있을 것이다. As a first step for developing universal genetic transformation vector of dilkmoths., we identified the presence of mariner-like element(MLE) which is one of transposable element discovered from many insects to human species, from Bombyx mori, Bombyx mandarina, Antherae yammamai and Antherae pernyi. We used a degenerative primer pair designed from a transposase gene of Drosophila mauritiana and Hyalophora ceropia MLE. As results, major PCR product of 500bp expected as a part of transposase of MLE was detected from all the slkmoths used of this study using these primer. And hybridization assay using pBmoMAR as a probe DNA that was previously cloned from Bombyx mori by the same primer pair, confirmed the presence of MLE from all the silkmoths. This assay showed also that the endogenous MLE in genome of the silkworm is present as high copy number unlikely Drosophila mauritiana which has 10-20 copy number. This data will be a fundamental genetic information for developing mariner-derived vector to transform the silkmoths and other useful insects.

Large Scale Gap 시험의 전산모사연구

이진성,박정수,이영신,Lee, Jin-Sung,Park, Jung-Su,Lee, Young-Shin 한국군사과학기술학회 2011 한국군사과학기술학회지 Vol.14 No.5

This study describes computational simulation results in 2-dimensional and 3-dimensional space concerning large scale gap test(LSGT) by using commercial hydrocode such as AUTODYN and LS-DYNA to analyze the detonation phenomenons of high explosives. To consider the possibilities of LSGT simulation, we used Lee - Tarver reaction rate model of PBX-9404 and Comp-B which were implemented AUTODYN's material library. Also we have tried the diverse numerical schemes such as Lagrangian, Eulerian and ALE(Arbitary Lagrangian Eulerian), SPH(Smoothed Particle Hydrodynamics) in LSGT simulations. After LSGT simulations, we compared the simulation results with published results to verify the LSGT simulations. According to the LSGT simulations, we have concluded as follows. In 2-dimensional and 3-dimensional space, Lagrangian solver provided the most reliable results based on analysis time and accuracy. When using two hydrocodes in 2-dimensional space, the simulation results are almost same except one explosive model. We have verified the modeling method and simulation results of the LSGT by using the commenrcial hydrocode in this study.

원통형 회전 히트파이프의 내부 유동 및 열전달 특성에 관한 연구

이진성,이재준,김철주,Lee, Jin Sung,Lee, Jae Jun,Kim, Chul Ju 대한기계학회 1998 大韓機械學會論文集B Vol.22 No.9

In order to elucidate the operational characteristics of rotating heat pipes, the internal flow patterns and heat transfer performance are investigated. Flow patterns and its transition are studied with various rotational speeds by visualizing flows established inside a rotating tube. To verify those results of analysis, 2 heat pipes of the same geometries but fill charge rates of 7, 30% were manufactured and submitted to operating tests. Comparison of experimental results on heat transfer rate show a fairly good agreement with the analytical results. The analysis reveals that the optimum charge ratio is ranged in 4~7% depending on the quantity of thermal loads. but the heat pipe with 7% of fill charge ratio reached dry-out limitation at heat flux of $q^{{\prime}{\prime}}=6.2kW/m^2$ lower than that of analytic results. Transition of flow regime was well related to the correlation by Semena & Khmelev on transient centrifugal Froude Number Frc. But hysteresis phenomenon was observed in transition of flow regime, when the rotational speed was stepwisely changed in the way to undergo 1 cycle.

누에에서의 Mariner 유사 전이인자유전자의 동정

이진성,황재삼,김용성,서동상,권오유,Lee, Jin-Sung,Hwang, Jae-Sam,Kim, Yong-Sung,Suh, Dong-Sang,Kwon, O-Yu 한국생명과학회 1998 생명과학회지 Vol.8 No.3

We have cloned an internal fragment of the putative transoisase gene of MLE in the silkworm, Bombyx mori, using PCR method with degenerative oligonucleotide primers designed to represent regions of amino acids encoding transposase. The resulting PCR clone, designed as BmoMAR, cords a partial ORF(152 a.a.) of MLE in which interrupted by five stop codons, and the sequence of its deduced amino acids showed 37% homology with Mos1, an active mariner, from Drosophila mauritiana. Furthermore, the BmoMAR exhibits nucleotide and amino acid homology with 59% and 37% from Apis mellifera and D. mauritiana 7.9 clone, respectively. This result strongly that a MLE is present in the genome of B. mori. 이미 밝혀져 있는 mariner 전이인자의 전이효소를 암호화하는 부위에 대하여 퇴화성 primer를 사용하여 PCR 방법에 의해 누에(Bombyx mori)에서 ariner 유사 전이닌자의 잠정적인 전이효소 부위를 클로닝 하였다. BmoMAR로 망명된 이 PCR 클론으로부터 추론된 아미노산은 152개로 다섯 개의 종결코돈이 삽입되어 있었으며, Drosophila mauritiana의 active Mos 1에 37%의 아미노산 상동성을 보였다. 또한, 기존의 곤충들에서 밝혀진 mariner-like element에 대한 상동성은 DNA 수주에서는 Apis mellifera에 59% 그리고 아미노산 수준에서는 D. mauritiana 7.9 clone에 37% 상동성을 보였다. 이 결과는 mariner-like element가 B. mori에도 존재하고 있지만. 이들 전이인자의 전이효소를 암호화하는 부위에 종결코돈이 발견되는 것으로 보아서 비활성 전이인자 혹은 일존의 selenoprotein으로 추정된다.

규산염계 광물의 급여가 산란계분의 암모니아 발생과 생산성에 미치는 효과

이진성,강성원,윤진아,손용석,Lee, Jin-Sung,Kang, Sung-Won,Yoon, Jin-A,Son, Yong-Suk 한국축산환경학회 2009 축산시설환경학회지 Vol.15 No.3

산란계에 대한 비금속광물의 급여가 계사내 암모니아 발생 및 생산성에 미치는 영향을 평가하기 위하여, 49주령의 갈색 Lohman 종 산란계 1,020수에 대하여 사료용 공시광물로 소디움벤토나이트, 장석 및 세사를 사료섭취량의 2% 수준으로 첨가 급여하면서 분에서 발생하는 암모니아 농도 및 산란율, 난각강도 등을 조사하였다. 소디움벤토나이트 및 장석 급여구는 세사 급여구에 비해 계분에서 발생하는 암모니아 농도를 유의적으로 감소시키고(P<0.05) 계분 내 질소 함량은 증가시킴으로써 이들 규산염광물질의 급여가 암모니아 발생을 억제함을 보여줌과 동시에 친환경 유기질 비료로서의 가능성을 시사하였다. 또한 산란수에 있어서 처리구 간에 통계적으로 유의한 차이는 나타나지 않았으며(p>0.05), 난각강도의 경우 장석 급여군이 유의적으로 낮게 나타났으나(p<0.05) 기존에 보고된 연구결과와 비교해볼 때 우려할 만한 수준은 아닌 것으로 판단된다. 결론적으로 산란계에 대한 규산염계 광물 소디움벤토나이트와 장석의 급여는 생산성에 영향을 미치지 않으면서 계분의 암모니아 발생을 최소화시키는 효과를 발휘하는 것으로 사료된다. This study was conducted to investigate the effects of dietary silicate minerals on ammonia emission from the excreta and performance in laying hens. A total of one thousand and twenty 49 week-old Lohmann brown layers were divided into three treatment groups consisting two replicates of 170 birds each. The experimental diets were containing three kinds of silicate minerals (Sand, Na-bentonite and SY feldspar) added at the level of 2% by top-dressing. Ammonia emission from the excreta was significantly decreased (p<0.05) by the supplementation of Na-bentonite or SY feldspar. N concentration of the excreta was significantly higher (p<0.05) for the hens fed Na-bentonite or SY feldspar compared to those fed sand. However, no significant differences were observed in feed intake and laying performance with over 80% laying rate observed for all the treatments. Egg shell strength was diminished when SY feldspar was added to the diet. As a whole, the results obtained from the experiment indicated that supplementation of Na-bentonite or SY feldspar added at 2% to the laying hen diet should not affect laying performance but help to reduce ammonia from the excreta at the same time.

SPH에서의 Convex Hull 알고리즘 적용연구

이진성,이영신,Lee, Jin-Sung,Lee, Young-Shin 한국군사과학기술학회 2011 한국군사과학기술학회지 Vol.14 No.2

SPH(Smoothed Particle Hydrodynamics) is a gridless Lagrangian technique that is useful as an alternative numerical analysis method used to analyze high deformation problems as well as astrophysical and cosmological problems. In SPH, all points within the support of the kernel are taken as neighbours. The accuracy of the SHP is highly influenced by the method for choosing neighbours from all particle points considered. Typically a linked-list method or tree search method has been used as an effective tool because of its conceptual simplicity, but these methods have some liability in anisotropy situations. In this study, convex hull algorithm is presented as an improved method to eliminate this artifact. A convex hull is the smallest convex set that contains a certain set of points or a polygon. The selected candidate neighbours set are mapped into the new space by an inverse square mapping, and extract a convex hull. The neighbours are selected from the shell of the convex hull. These algorithms are proved by Fortran programs. The programs are expected to use as a searching algorithm in the future SPH program.

약실교환방식의 20 mm 시험용 총열 개발

이진성,이영신,Lee, Jin-Sung,Lee, Young-Shin 한국군사과학기술학회 2011 한국군사과학기술학회지 Vol.14 No.4

A new smooth bore test barrel was developed to be used in sensitivity assessment test for explosives and fragment impact test. The bore diameter of the barrel is 20 mm, and the powder chamber is designed to be replaceable with the 12.7 mm, 20 mm and 30 mm type chamber. The test results showed the wide range of fragment velocity from 400 to 2000 m/s, included the fragment velocity requirement of the fragment impact test(alternate procedure #1) in MIL-STD-2105B. The stability of the bullet trajectory was checked by test shots and the structural safety of the system has been confirmed through the stress analysis and the interior ballistics analysis of the barrel.

수면과 2형 당뇨병

이진성,김성곤,Lee, Jin-Seong,Kim, Sung-Gon 대한수면의학회 2017 수면·정신생리 Vol.24 No.1

Adequate amount and quality of sleep are important for metabolic control in patients with type 2 diabetes. Too short or too long sleep time disrupts glycemic control in both prediabetes and type 2 diabetic patients. Circadian misalignment such as shift work is also associated with an increased risk of developing type 2 diabetes. Clinicians should pay attention to the sleep problems and circadian patterns of patients. However, the pathophysiologic mechanism of the association between sleep and diabetes is likely to be complex and bidirectional. The underlying mechanism remains poorly understood, and further research is warranted.