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( Hyun-ju Kim ),( Hye-jin Yoon ),( Dong-kyo Lee ),( Xian Jin ),( Xiangguo Che ),( Je-yong Choi ) 생화학분자생물학회(구 한국생화학분자생물학회) 2021 BMB Reports Vol.54 No.5
Estrogen-related receptor γ (ERRγ), a member of the orphan nuclear receptor family, is a key mediator in cellular metabolic processes and energy homeostasis. Therefore, ERRγ has become an attractive target for treating diverse metabolic disorders. We recently reported that ERRγ acts as a negative regulator of osteoclastogenesis induced by receptor activator of nuclear factor-κB ligand (RANKL). In the present study, we explored the effects of an ERRγ-specific modulator, GSK5182, on ERRγ-regulated osteoclast differentiation and survival. Interestingly, GSK5182 increased ERRγ protein levels much as does GSK4716, which is an ERRγ agonist. GSK5182 inhibited osteoclast generation from bone-marrow-derived macrophages without affecting cytotoxicity. GSK5182 also attenuated RANKL-mediated expression of c- Fos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), pivotal transcription factors for osteoclastogenesis. Arrested osteoclast differentiation was associated with reduced RANK expression, but not with the M-CSF receptor, c-Fms. GSK5182 strongly blocked the phosphorylation of IκBα, c-Jun N-terminal kinase, and extracellular signal-regulated kinase in response to RANKL. GSK5182 also suppressed NF-κB promoter activity in a dose-dependent manner. In addition to osteoclastogenesis, GSK5182 accelerated osteoclast apoptosis by caspase-3 activation. Together, these results suggest that GSK5182, a synthetic ERRγ modulator, may have potential in treating disorders related to bone resorption. [BMB Reports 2021; 54(5): 266-271]
유채의 지방산조성개량육종에 관한 연구 -제V보 유채재배시기이동에 따른 종실유의 지방산조성변화-
이정일,지하민부,고류겸치,Lee, Jung-Il,Shiga, Toshio,Takayanagi, Kenji 한국작물학회 1975 한국작물학회지 Vol.- No.19
The fatty acid composition of the oil in the rapeseed grown by spring and autumn planting were determined by gas liquid phase chromatography. Erucic acid content of the rapeseed oil grown by autumn planting was higher than that produced by spring planting, but the contents of oleic acid and linoleic acid were lower in autumn planting than those in spring planting. There was significant difference at 1% level between seasonal plantings. The reasons for the different fatty acid compositions were the low integrated temperature, the high amount of precipitation and the short hours of sunshine during the maturing period in autumn planting.
細胞質雄性不稔系統을 利用한 油菜 Heterosis育種開發에 關한 硏究 第1報, 細胞質雄性不稔系統을 利用한 有用形質의 Heterosis 發現과 稔性回復力 調査
J. I. LEE(李正日),T. SHIGA(志賀敏夫),B. S. KWON(權炳善) 한국육종학회 1976 한국육종학회지 Vol.8 No.2
Cytoplasmic male-sterility line was found by Shiga in Japan. We have investigated the degree of heterosis of agronomic characters and ability of fertility restoration of F₁ from the cross between cytoplasmic male-sterilie line and 157 varieties as pollen parents of Korea, Japan and Europe. That result has appeared with highly desirable heterosis, particulary in yielding and most yield component characters except on 1,000 seed weight but plant height was tall and maturing was late. Ability of Fertility restoration of F₁ hybrids from Europe pollen parent varieties was 74% but that of Japanese pollen parent varieties was low as 5%. It seems that high yielding of F₁ from fertility non-restoration varieties may be caused by the polly cross.
油菜의 脂肪酸組成改良育種에 關한 硏究 Ⅶ. O-eurcic acid 遺傳子가 導入된 後代系統의 實用的인 特性과 今後의 問題點
J. I. Lee(李正日),T. Shina(志賀敏夫),K. Takayanagi(高柳謙治) 한국육종학회 1975 한국육종학회지 Vol.7 No.1
Nineteen F₃ lines of non-erucic acid selections from winter × spring crosses, of rape were compared in several agronomic traits. Among the 19 lines tested 3 lines were found to be more productive than check variety Yudal. Maturing time was close to mid-parent but plant height was taller than the tall parent. In yield components, number of branches, number of grains per pod and number of pods per plant was higher than mid-parent but 1,000 grain weight was lower than that of mid-parent.
油菜의 脂肪酸組成改良育種에 關한 硏究 Ⅵ. 油菜登熟中의 脂肪酸合成에 미치는 O-erucic acid 遺傳子의 作用
J. I. Lee(李正日),K. Takayanagi(高柳謙治),T. Shiga(志賀敏夫) 한국육종학회 1974 한국육종학회지 Vol.6 No.2
The process of fatty acid synthesis of high-erucic acid varieties and O-erucic acid variety were investigated during the maturing period of rapeseeds. The fatty acid composition showed highly significant difference between both variety groups around 30 days after flowering Any significant differences in fatty acid composition between two variety groups were not detected in the former period of 30 days after flowering. O-erucic acid variety contained some amount of erucic acid. However, erucic acid synthesis was discontinued in O-erucic acid variety in the later period of 30days after flowering. Rapeseed oil contained much amount of M.G. in the initial stage of maturity (30days after flowering). The amount of erucic acid containing in O-erucic acid variety was ranged from 6 to 37% in M.G. and D.G. gene reaction of O-erucic acid started from the later of 30days after flowering and fatty acid synthesis was significantly different at two stages : initial and late period of maturity in rapeseeds.
이지하(Jeeha Lee) 국문학회 2007 국문학연구 Vol.16 No.-
Heroine Novels have been evaluated reciprocally. There are opinions that these novels show strong consciousness of women because heroines achieve social success against men and deny the role of women under the men s control. On the other hand, some insist Heroine Novels still expose the ideology of Confucian Patriarchy. This paper examines these problems on the viewpoint of the Subject and the Others. In these novels, heroines who struggle with discord between sex and gender establish subjectivity through they deny women s role and dress up as a man. In this case they contribute to show women s capacity and confirm equality between men and women. These novels deserve attention in that point considering circumstances of the late period of Joseon Dynasty which tighten control of women. However these novels have limits not to accomplish subjectivity of general women because heroines can not perceive the trobles as general problems of whole women and they try to overcome personally and neglect somebody to achieve their success. As a result, Heroine Novels have significance in raising attention to women s problems under the strong patriarchy, but at the same time they have limits that can not get thorough recognition of women s condition and proper solutions.
이지하(Lee Jeeha),이희업(Lee Hee-up),이희성(Lee Hisung),강기석(Kang Ki-sok),R. Farabet 한국철도학회 2000 한국철도학회 학술발표대회논문집 Vol.- No.-
Before the complete construction of new high-speed line between Seoul and Pusan, KTX is going to operate on both new high-speed line between Seoul and Daegu and electrified conventional lines between Daegu and Pusan. Then, the wheels of KTX are going to operate on various rails such as KS50N and KS60 of conventional line as well as UIC60 of high-speed line. Also, conventional line will have a mixed traffic mode with various types of trains operating on it, such as Saemaul and Mugunghwa. Hence, this study reviews the wear phenomena of wheels and rails in geometrical point of view by comparing their profiles. The analyses of the results show that because UIC60 rail is designed for KTX, KS50N rail whose profile is similar to that of UIC60 will not have any impact on the shape of wheel wear. On the other hand, KS60 rail is expected to have partial wear on both the flange of KTX wheel and the gauge corner of the rail in the initial stages. However, the operation of the trains whose wheels have 1/20 conicity will cause partial sidewear on the inside of the rail and the movement of the contact point between KTX wheel and the rail toward the inside of the track. As a result, the flange wear of KTX wheel will be reduced and the formation of wear-equilibrium profile will be faster.
이지하(Lee, Jie-ha) 한국지역사회복지학회 2012 한국지역사회복지학 Vol.0 No.41
본 연구는 생태학적 이론을 바탕으로 하여 미국 내, 청소년기 및 청년기 여성의 위험성행동에 영향을 미칠 수 있는 개인, 가족 및 지역사회 관련 요인들을 파악하였다. 생태학적 이론을 구성하는 요소들을 설명함과 동시에 성행동 위험성의 격차를 논의하기 위한 구체적인 변인들을 조사함으로써 본 연구는 소수 인종 여성들의 성행동의 위험성에 관한 두 가지의 기본적인 결과를 제시한다. 첫째, 성행동의 위험분포는 각각 인종별로 상이하며 흑인과 아시아계 여성이 타 인종들에 비해 높은 위험에 처해 있었다. 둘째, 성행동의 위험의 변인들 역시 각각 인종별로 상이하게 나타났다. 특히, 상이한 변인들 중에서 폭음의 역할이 다양한 인종 그룹들을 망라하여 강조되었다. 본 연구 결과는 청소년기 및 청년기 여성의 성행동의 위험성에 영향을 미치는 예측요인을 개인, 가족, 지역사회로 규명해 주고 있으므로, 여성의 성행동의 위험성을 최소화 할 수 있는 다차원적인 노력의 밑거름이 될 수 있을 것으로 사료된다. The primary purpose of this study is to advance our understanding of risky sexual behaviors among racial/ethnic minority females in the United States. This study estimates, among females who differ by racial/ethnic group, the proportions of three outcomes (self-reported STD diagnosis, early sexual debut, and multiple sex partners). Using a framework based on ecological theory, it examines the longitudinal factors associated with these three outcomes among females who differ by racial/ethnic group. Data were derived from the National Longitudinal Study of Adolescent Health, Waves 1 (1995),and 3 (2001); the sample was 6,894 females. Findings indicate that the proportion of risky sexual behaviors, differed by race/ethnicity indicating that African American and Asian American and Pacific Islander (API) females are at high risk. Overall, the results from logistic regression analyses showed that the predictors of STDs, early sexual debut, and multiple sex partners, varied by race/ethnicity. The results also indicate that, among different predictors of STD risks, the role of binge drinking is highlighted across different racial/ethnic groups.