정맥용 면역글로불린 투여 후 발생한 무균성 수막염 3례

이준호,송은경,이진아,김남희,김동호,박기원,최은화,이환종,Lee, Joon Ho,Song, Eun Kyoung,Lee, Jin A,Kim, Nam Hee,Kim, Dong Ho,Park, Ki Won,Choi, Eun Hwa,Lee, Hoan Jong 대한소아감염학회 2005 Pediatric Infection and Vaccine Vol.12 No.2

IVIG 투여에 의해 무균성 수막염은 그 기전이 밝혀지지 않았으나 IVIG 투여와 관련된 신경학적 부작용 중 가장 중한 합병증의 하나이다. 저자들은 서울대학교 어린이병원에서 2003년부터 2004년까지 3명의 환아에서 확인된 IVIG 투여와 관련된 무균성 수막염 4례를 경험하여 보고하였다. 3명의 환아는 ITP, 가와사키병, 중증 근무력증으로 기저질환은 각각 상이하였으나 기저질환에 대한 치료를 위해 모두 고용량의 IVIG를 투여받았으며, IVIG를 투여받은 후 1~2일 이내에 심한 두통과 뇌막자극 징후를 보였다. 척수액 소견상 백혈구 수는 $100/{\mu}L$ 미만에서부터 $1,000/{\mu}L$ 이상까지 다양하였으나 주로 다핵구로 구성된 척수액 백혈구 분포를 보였고(66~98%), 세균 배양검사와 장바이러스 배양과 PCR 검사에서 음성 결과를 보였다. 3명의 환아 모두 수막염 발생 2일 후까지는 증상이 호전되었으며, 후유증 및 장애가 없었다. Intravenous immune globulin(IVIG) is widely used for immune thrombocytopenic purpura (ITP), Kawasaki disease and other autoimmune neuromuscular disease. Aseptic meningitis was one of the most serious neurologic complications reported following the use of IVIG. We experienced 4 episodes of aseptic meningitis associated with IVIG usage in 3 patients from 2003 to 2004. Underlying disease of each patients was ITP, Kawasaki disease and myathenia gravis and all of them received high dose IVIG treatment for their underlying disease. Within a days, they started to complain severe headache and diagnosed meningitis by cerebrospinal fluid analysis. Cerebrospinal fluid leukocyte counts varied from 92 to over a thound per microliter with dominance of polymorphonuclear leukocytes. Microbiologic studies revealed no organisms. All of them were free from headache within 2 days and did not suffer any neurological sequelae.

A 37Ch Visible Adaptive Optics System for Wavefront Compensation

이준호,Byung Tae Choi,Eung Cheol Kang,Hae Seog Kho,Ho Jung Cheon,Jae Il Lee,Joon Won Kim,Kyung Muk Lee,Sung Jin Kim,Young Cheol Lee,Young Il Cho 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.1

A visible adaptive system was developed to compensate for phase distortions of a visible (He-Ne) laser. The visible adaptive optics (AO) system consists of 5 subsystems: a Shack-Hartmann wavefront sensor, a deformable membrane mirror of 15 mm with 37 actuators, a high-speed tip/tilt mirror of 20 mm, a position sensor and a control & display unit. The lab-developed Shack-Hartmann sensor was experimentally shown to have a measurement accuracy of better than RMS /50 at 0.6328 μm over the maximum phase distortion that the deformable mirror could generate, i.e., approximately /4. The adaptive optics system operated the deformable mirror at 10 Hz and the tip/tilt mirror at 30 Hz, which were, respectively, closed by the Shack-Hartmann sensor and the position sensor. The closed adaptive optics system was demonstrated to compensate for time-varying wavefront aberrations of PV (Peak-to-Valley) 1.2 μm with a time frequency of 1.4 Hz. The residual RMS wavefront error was shown to be smaller than 0.014 μm, i.e., /45 at 0.6328 μm.

링크식 격발기구 설계에 관한 연구

이준호,여운주,최의중,Lee, Joon-Ho,Yeo, Woon-Joo,Choe, Eui-Jung 한국군사과학기술학회 2009 한국군사과학기술학회지 Vol.12 No.3

In the traditional percussion locks of small arms, a firing pin is struck by a hammer rotating on a single center of rotation, which makes the percussion mechanism simple and reliable. In order to strike the firing pin by the hammer, however, the firing pin should be located within the radius of rotation of the hammer. As the distance between the striking point of the firing pin and the center of rotation of the hammer becomes longer, the radius of rotation of the hammer should also be increased, which results in the increase of the volume and weight of the small arms because the hammer needs the more space for its operation inside of the small arms. In this paper, a link type percussion lock was newly proposed in order to overcome the limitation of designing small arms when using traditional percussion locks, as mentioned above. The link type percussion lock was modeled by using multi-body dynamics software and designed to satisfy the requirements such as striking force level of the hammer exerting on the firing pin enough to detonate the percussion cap of ammunitions and the safety on the accidental drop. It was applied to the newly developed dual-barrel weapon system, in which the weight and overall length are important design factors, and verified by durability test and drop test on the ground.

마이크로웨이브 가열을 이용한 슬래그로부터 인의 용철로의 환원이동에 관한 열역학적 고찰

이준호,김은주,김태영,강윤배,Lee, Joon-Ho,Kim, Eun-Ju,Kim, Tae-Young,Kang, Youn-Bae 한국재료학회 2010 한국재료학회지 Vol.20 No.1

Phosphorus exhibits considerable segregation in steelmaking slag. In order to recover phosphorus from slag to $K_3PO_4$ via molten iron, a carbothermic reaction using microwave heating was suggested recently. The carbothermic reduction of phosphorus from slag to molten iron using microwave heating was carried out at 2073K. However, at this temperature the thermodynamic properties of both slag and molten iron cannot be determined experimentally. Therefore, the computational approach of the so-called CALPHAD method is very useful to understand the transfer of phosphorus from slag to metal and to enhance this reaction. In the present investigation, a theoretical study of the reduction behavior of phosphorus in slag was carried out at much lower temperatures using the recently developed thermodynamic database in the FactSage program. The calculated results showed reasonable accordance with the experimental data; namely, the thermodynamic database could be applied successfully to higher temperature reactions. The current study found that higher temperature and high $SiO_2$ concentration are favorable for the recovery of phosphorus from slag.

정보은닉기법을 적용한 함정 전투체계 소나 영상의 정보관리 방안 연구

이준호,신상호,정기현,유기영,Lee, Joon-Ho,Shin, Sang-Ho,Jung, Ki-Hyun,Yoo, Kee-Young 한국군사과학기술학회 2015 한국군사과학기술학회지 Vol.18 No.6

The SONAR waterfall image(SWI) is used typically to target detection in SONAR operation and is managed with additional data linked in the naval combat system. The SWI and additional data are very important to classify a kind of target. Although additional data of the SWI is essential and must be kept together with the SWI, it was stored separately in the current system. In this paper, we propose an improved information management method in the naval combat system, where additional data can be contained in the SWI together by using information hiding techniques. The experimental results show that the effectiveness of information hiding techniques in the naval combat system. It is demonstrated that the information hiding techniques can be applied to the SWI that can make the naval combat system to be robust and secure.

경화 위축성 태선과 경피증의 감별진단에 있어서 렉틴의 의의

이준호,문두찬,권경술,정태안 ( Joon Ho Lee,Doo Chan Moon,Kyung Sool Kwon,Tae Ahn Chung ) 대한피부과학회 1993 大韓皮膚科學會誌 Vol.31 No.3

Background : Differential diagnosis of lichen sclerosus et atrophicus( SA) and scleroderma is occasionally difficult. Objective : The purpose of this study was to attempt differentiation between the two diseases using imrnunohistochemical stain and lectins. Methods : Paraffin-embeddred sections of 4 cases of LSA and 11 cases of scleroderma were evaluated for this study. Using lectins, such as peanut agglutinin(PNA), siybean agglutinin(SBA), Ulex europaeus agglutinin-I(UEA-I) and Dolichos biflorus agglutinin(DBA) and the avidin-biotin-peroxi-dase complex(ABC) technique, differential lectin binding patterns betv een the two diseases were examined. Results : In the case of LSA, PNA and SBA stained the upper and lower spinous layer of the epidermis, and UEA I also stained the spinous layer of the epidermis weakly, but no DBA was stained. In the case of scleroderma, PNA stained not only the spinous layer but also the basal layer, SBA stained the upper half of the spinous layer but not the lower half of the pinous layer of epidermis. But UEA-I stained the vascular endothelial cells of dermis instead of epidermis, and DBA stained only the basal layer of epidermis. Conclusion : Staining of these 4 lectins on paraffin-embedded sectians using ABC teehnique could be helpful in differenting LSA and scleroderma. (Kor J Dermatol 1993; 31(3): 329-336)

총구화염저감용 소염기 설계에 관한 연구

이준호,채제욱,이성배,김현준,Lee, Joon-Ho,Chae, Je-Wook,Lee, Sung-Bae,Kim, Hyun-Jun 한국군사과학기술학회 2009 한국군사과학기술학회지 Vol.12 No.2

It is known that muzzle flash can be generated by the reaction between the oxygen in the air and unburned gunpowder contained in the propellant gas if a barrel is not long enough to burn gunpowder fully inside of the barrel. A hugh muzzle flash, which is a characteristic of small arms with short barrel length, disturbs a shooter in aiming at the target at night by making the shooter blind for a while and endangers the shooter's life by revealing firing position to enemies. In addition, the heat of muzzle flash can deteriorate the performance of thermal sights, which are attached to small arms for effective night combat. In this paper, flash suppressors of different shapes were designed for a newly developed 5.56mm caliber rifle with short barrel length and the performance of each flash suppressor to reduce the muzzle flash was compared by on-site test firing. Through the test firing, a highly efficient design of flash suppressor for reducing the muzzle flash was identified. The result of the paper can be referred when designing flash suppressors for small arms with short barrel length.

판상형 격간벽 시스템 건물의 반응수정계수

이준호,전용,김진구,Lee, Joon-Ho,Jeon, Yong,Kim, Jin-Koo 대한건축학회 2011 대한건축학회논문집 Vol.27 No.7

In this study seismic performance and response modification factors of rectangular reinforced concrete staggered wall system (SWS) structures were evaluated. To this end, 5, 9, 15, and 25-story SWS structural models were designed and were analyzed by pushover analysis to observe the force-displacement relationship up to failure and the location of plastic deformation. The response modification factor was computed based on the overstrength and the ductility capacities obtained from capacity envelopes. The analysis results showed that the 5- and 9-story SWS structures failed due to yielding of columns and walls located in the lower stories, whereas in the 15- and 25-story structures plastic hinges were more widely distributed throughout the stories. The response modification factors obtained by multiplying overstrength factor and ductility factor increased as the number of stories decreased.

인진쑥 추출물이 다이옥신계 TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin)에 노출된 흰쥐의 간 기능 및 지질대사에 미치는 효과

이준호,장춘뢰,필수초,황석연,Lee, Joon Ho,Zhang, Chun Lei,Bi, Shou Chao,Hwang, Seok Youn 한국영양학회 2013 Journal of Nutrition and Health Vol.46 No.3

This study was conducted in order to investigate the effects of Artemisia capillaris (AC) extract on disorders of hepatic functions and lipid metabolism induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an endocrine disrupter, using male rats (SD, five weeks old) for a period of three weeks. These 37 animals were divided into four groups. AC extract was added as 1.5% or 3% levels to basal diets, respectively. TCDD (40 ug/kg B.W) was administered by intraperitoneal injection into rats after a week from the beginning of the experiment. AC extract alleviated the increase of rat's relative liver weights induced by TCDD. Thymuses of all rats treated with TCDD were apparently shrunken by approximately 80%. Levels of white blood cells (WBC), red blood cells, hemoglobin, and hematocrits were significantly increased by treatment with TCDD, however, WBC tended to decrease by AC extract diets. In hepatic function, the elevation of glutamic oxalacetic transaminase activities by TCDD treatment was diminished by AC extract diets. Serum HDL-cholesterol levels were significantly elevated by AC extract diets. The apparent increase of triglyceride levels of rat livers induced by TCDD was significantly suppressed in the AC extract diet groups. Hepatic cytosolic catalase activities significantly decreased by treatment with TCDD showed a recovering trend by AC extract diets. In histochemical observation, the fat droplets and apoptosis of hepatocytes treated with TCDD were markedly alleviated by AC extract diets. These results indicated that AC could exert recovering effects on some disorders of hepatic functions, lipids metabolism, and antioxidant activities resulting from TCDD treatment.

Kalman filter를 이용한 위치추정 알고리즘의 성능 분석

이준호,조성우,이동근,Lee, Joon-Ho,Cho, Seong-Woo,Lee, Dong-Keun 한국군사과학기술학회 2009 한국군사과학기술학회지 Vol.12 No.6

In this paper, the dependence of the Kalman filter-based emitter location algorithm on the initial estimate is investigated. Given all the LOB data, the initial estimate of the emitter location is obtained from the linear LSE algorithm with the former LOB data. Using the initial estimate, the Kalman filter algorithm is applied with the remaining LOB data to update the initial estimate. It is shown that as the number of data used in the calculation of the initial estimate increases, the accuracy of the final estimate is improved and the total computational complexity of obtaining the initial estimate and the final estimate increases. In addition, the dependence of the performance of the Kalman filter algorithm on the predefined constant is illustrated.