산증(疝症)의 개념변화(槪念變化)에 대(對)한 연구(硏究) (금원(金元) - 명대(明代))

이주은,오수석,이용태,Lee, Joo-Eun,Oh, Soo-Suk,Lee, Yong-Tae 대한동의생리학회 2006 동의생리병리학회지 Vol.20 No.6

The korean oriental medicine dose not actively apply San syndrome(that is, colic syndrome) to the clinic because its concept is not established concretely even though it has definitely existed as a disease of human being from the time of Naegyeong to these days. Thus the author writes this thesis to establish the concept of San syndrome by the research of literature for the purpose of promoting clinical application. Study on the concept of San syndrome through the statements written by medical practitioners of each period comes to the following conclusions. The concept of San syndrome stated by various medical practitioners does not deviate from that in Hwangjenaegyeong. Most of them simply modify and supplement it. San syndrome refers to the case when the contents of abdominal cavity protrude to outside and when swelling and pain around the genital organs, or fierce pain in abdomen comes with constipation and dysuria. There are three methods of classifications of 7 San syndromes in large. The first one is the classification in Hwangjenaegyeong, the second one is that of So Wonbang, and the third one is that of Jang Jahwa .Among them ,Jang Jahwa's classification has occupied the most influential position since Hwangjenaegyeong, in which, there are seven Sans; Han-San, Su-San, Geun-San, Hyul-San, Gi-San, Ho-San, and Toe-San. On the basis of his classification, the concept of San Syndrome is established by posterity. The causes of San syndrome are claimed in three ways. In Hwangjenaegyeong , Cold and Ki are described. Ju Dangye assorted Damp-Heat. Heo Jun maintained Cold, Ki and Damp-Heat. Ju Dangye made enlargement and progress on the etiology in Hwangjenaegyeong from Cold and Ki to Damp-Heat. Heo Jun reasonably combined Cold, Gi, and Damp-Heat as the pathogen of San syndrome. There are two meridians closely related to San syndrome. in Hwangjenaegyeong, the Conception meridian is designated, Ju Dangye insisted on the Liver meridian of Foot Gyuleum. His theory that the Liver meridian entirely governs San syndrome is accepted by posterity. Ru Young in Myeong dynasty complementarily combined the concept In Hwangje -naegyeong, classifications of Jang Jahwa, and Ju Dangye's theory. He was followed by Gong Jeonghyeon, Lee Cheon, and Heo Jun, and finally related to Jisan in present time. Heo Jun has completed the standard of San syndrome by combining opinions of anterior medical practitioners. He complied with Naegyeong and Yang Sayoung's view in symptoms, and classified into seven categories according to Jang Jahwa's advocation. in the pathogenesis, he followed up Naegyeong in which Cold and Ki were designated as a cause and Ju Dangye's theory that San syndrome was caused by Damp-Heat, congested fluids, retention of undigested food, and stagnated blood. For meridians, he agreed with Ju Dangye's assertion that the Liver meridian entirely governs San syndrome. About Hyungsang of face, Lee Cheon indicated that if the part behind ear was sunken, the person had his kidney hanged below, and if the person had his kidney hanged below, he was susceptible to lumbosacral pain and Ho-San syndromes. Afterwards, Jisan pointed out that persons with the following characteristics in Hyungsang should be considered to have San syndromes; droopy ears, asymmetric wings of nose, unbalanced eyes, curved nose, asymmetric testicles, turned up nose for man, and long nose for woman. By recognizing the concrete features of Hyungsang, Jisan founded Hyungsang medicine, the horizon of oriental medicine.

저출력-장시간 조사와 고출력-단시간 조사에 의한 역치하 레이저 광응고반의 조직학적 변화

이주은,김경환,제승연,이지은,이종수,엄부섭,Joo Eun Lee,Kyeong Hwan Kim,Seung Youn Jea,Ji Eun Lee,Jong Soo Lee,Boo Sup Oum 대한안과학회 2009 대한안과학회지 Vol.50 No.3

Purpose: To compare histopathological and apoptotic changes of ophthalmoscopically similar subthreshold laser burns made by a low power-long duration (LD) and a high power-short duration (SD) subthreshold laser treatment. Methods: Ophthalmoscopically invisible subthreshold laser burns with a 3.0 mm spot size were made using an 810 nm diode laser on the rabbit retina. Lasers were applied for 60 seconds in the LD group, and 1 second in the SD group. Laser power was adjusted to achieve ophthalmoscopically invisible burns just below the threshold. The rabbits were sacrificed at 6, 12, 24, and 72 hours, 1, 2, and 4 weeks after laser treatment. The eyes were processed for light microscopic examination using hematoxylin and eosin (H&E), toluidine blue, and TdT-dUTP terminal nick-end labeling (TUNEL) staining. Eyes were also processed for electron microscopic examination. Results: The changes in the retina were different between the two groups. The LD group showed abundant TUNEL positive cells in all the retinal layers at 6 hours after laser treatment, and distinct histological changes in the outer nuclear layer. Conversely, in the SD group, apoptosis did not occur and histological alteration in the outer nuclear layer was minimal. Conclusions: Subthreshold laser treatment for 1 second reduced damage of the inner retinal layer and did not result in apoptosis in the neurosensory retina while maintaining a similar effect on the RPE and its adjacent region.

산증(疝症)의 개념변화(槪念變化)에 대(對)한 연구(硏究) (내경(內經)- 송대(宋代))

이주은,오수석,이용태,Lee, Joo-Eun,Oh, Soo-Suk,Lee, Yong-Tae 대한동의생리학회 2006 동의생리병리학회지 Vol.20 No.2

The korean oriental medicine dose not actively apply San syndrome(that is, colic syndrome) to the clinic because its concept is not established concretely even though it has definitely existed as a disease of human being from the time of Naegyeong to these days. Thus the author writes this thesis to establish the concept of San syndrome by the research of literature for the purpose of promoting clinical application. Study on the concept of San syndrome through the statements written by medical practitioners of each period comes to the following conclusions. The concept of San syndrome stated by various medical practitioners does not deviate from that in Hwangjenaegyeong. Most of them simply modify and supplement it. San syndrome refers to the case when the contents of abdominal cavity protrude to outside and when swelling and pain around the genital organs, or fierce pain in abdomen comes with constipation and dysuria. There are three methods of classifications of 7 San syndromes in large. The first one is the classification in Hwangjenaegyeong, the second one is that of So Wonbang, and the third one is that of Jang Jahwa .Among them ,Jang Jahwa's classification has occupied the most influential position since Hwangjenaegyeong, in which, there are seven Sans; Han-San, Su-San, Geun-San, Hyul-San, Gi-San, Ho-San, and Toe-San. On the basis of his classification, the concept of San syndrome is established by posterity. The causes of San syndrome are claimed in three ways. In Hwangjenaegyeong , Cold and Ki are described. Ju Dangye asserted Damp-Heat. Heo Jun maintained Cold, Ki and Damp-Heat. Ju Dangye made enlargement and progress on the etiology in Hwangjenaegyeong from Cold and Ki to Damp-Heat. Heo Jun reasonably combined Cold, Gi, and Damp-Heat as the pathogen of San syndrome. There are two meridians closely related to San syndrome. In Hwangjenaegyeong, the Conception meridian is designated, Ju Dangye insisted on the Liver meridian of Foot Gyuleum. His theory that the Liver meridian entirely governs San syndrome is accepted by posterity. Ru Young in Myeong dynasty complementarily combined the concept In Hwangjenaegyeong, classifications of Jang Jahwa, and Ju Dangye's theory. He was followed by Gong Jeonghyeon, Lee Cheon, and Heo Jun, and finally related to Jisan in present time. Heo Jun has completed the standard of San syndrome by combining opinions of anterior medical practitioners. He complied with Naegyeong and Yang Sayoung's view in symptoms, and classified into seven categories according to Jang Jahwa's advocation. In the pathogenesis, he followed up Naegyeong in which Cold and Ki were designated as a cause and Ju Dangye's theory that San syndrome was caused by Damp-Heat, congested fluids, retention of undigested food, and stagnated blood. For meridians, he agreed with Ju Dangye's assertion that the Liver meridian entirely governs San syndrome. About Hyungsang of face, Lee Cheon indicated that if the part behind ear was sunken, the person had his kidney hanged below, and if the person had his kidney hanged below, he was susceptible to lumbosacral pain and Ho-San syndromes. Afterwards, Jisan pointed out that persons with the following characteristics in Hyungsang should be considered to have San syndromes; droopy ears, asymmetric wings of nose, unbalanced eyes, curved nose, asymmetric testicles, turned up nose for man, and long nose for woman. By recognizing the concrete features of Hyungsang, Jisan founded Hyungsang medicine, the horizon of oriental medicine.

Cyanex 572를 사용하여 [Pr, Nd, Sm]/[La]분리에 대한 향류추출공정 설계

이주은,소홍일,장인환,안재우,김홍인,이진영,Lee, Joo-eun,So, Hong-Il,Jang, In-Hwan,Ahn, Jae-Woo,Kim, Hong-in,Lee, Jin-young 한국자원리싸이클링학회 2018 資源 리싸이클링 Vol.27 No.4

추출제로 Cyanex 572를 사용하여 혼합 용액에서 [Pr, Nd, Sm]그룹과 [La]을 분리하기 위하여 Xu Guangxian이 제시한 이론에 의하여 향류추출 공정의 최적 추출 공정 변수를 계산하고자 하였다. 기초실험으로부터 두 그룹의 최적 분리계수는 추출 공정의 경우 16.80, 세정공정에서는 21.48 이었고, 1.0 M Cyanex 572에 의한 희토류 성분의 추출용량은 0.12 M 이었다. 공정 개발에 필요한 추출 단수, 세정 단수, 유량비 등에 대하여 최적 추출비 이론에 의해 계산하였다. 계산 결과 두 그룹의 희토류 분리에 필요한 단수는 추출 7단 및 세정 4단이며, 원료용액, 추출용액 및 세정용액의 유량비는 25 : 5.67 : 12.27 이었다.

계층적 시계열 분석을 이용한 지역별 교통사고 발생건수 예측

이주은,성병찬,Lee, Jooeun,Seong, Byeongchan 한국통계학회 2017 응용통계연구 Vol.30 No.1

The paper introduces bottom-up and optimal combination methods that can analyze and forecast hierarchical time series. These methods allow forecasts at lower levels to be summed consistently to upper levels without any ad-hoc adjustment. They can also potentially improve forecast performance in comparison to independent forecasts. We forecast regional traffic accident counts as time series data in order to identify efficiency gains from hierarchical forecasting. We observe that bottom-up or optimal combination methods are superior to independent methods in terms of forecast accuracy. 본 논문에서는 계층적 시계열 자료 분석을 위한 대표적인 두 가지 방법인 상향식과 최적조합 예측법을 소개한다. 이러한 예측법은 계층적 시계열을 구성하는 모든 계열을 예측해야 하는 독립적 예측과 달리, 임의의 조정 과정이 없이 하위 계층 계열의 예측값의 합은 항상 상위 계층의 예측값과 일치하게 된다. 또한, 독립적 예측과 비교하여 예측력을 향상시킨다. 계층적 예측법의 효율성을 살펴보기 위하여 국내 16개 시도별 남녀 교통사고 발생건수 시계열 자료를 예측하였다. 이를 통하여 교통사고 발생건수에 대한 각 계층의 예측에서 계층적 방법과 독립적 방법의 차이점 및 우수성을 비교하였다.

유치원 급식의 위생관리 실태조사 및 미생물적 품질평가

이주은,최경숙,강영재,곽동경,Lee, Joo-Eun,Choi, Kyung-Sook,Kang, Young-Jae,Kwak, Tong-Kung 한국식품조리과학회 2012 한국식품조리과학회지 Vol.28 No.5

This research aims to audit foodservice sanitation management practices and to assess microbiological quality of foods and their food contact environments in kindergartens. Sanitation auditing was conducted in 10 kindergartens in Seoul, Gyeonggi, and Incheon areas to assess the levels of safety practices. Results revealed that the surveyed kindergartens scored 41.4 out of 100 points, on average. The average scores of each category were 6.4/11 (58.1%) for facilities sanitation, 4.2/12 (35.0%) for equipment sanitation, 2.4/10 (24.0%) for personal hygiene, 5.1/10 (51.0%) for food ingredients management, 6.0/17 (35.3%) for production process, 5.4/10 (54.0%) for environmental sanitation, 2.0/6 (33.3%) for kitchen utensils sanitation, and 2.2/6 (96.7%) for safety management. Microbiological quality of raw, prepared foods, personal sanitation (hands), environmental sanitation, and drinking water were assessed. Total plate counts (TPC) of the following menus exceeded the critical limit: seasoned leek (5 log CFU/g), cucumber (5.0 log CFU/g), panbroiled fish paste (TNTC at $10^4$), tangpyeongchae (5.3 log CFU/g), egg rolls (6.1 log CFU/g), panbroiled sausage (TNTC at $10^4$), and soft tofu pot stew (TNTC at $10^4$). Coliform which exceeded the standard limit were detected from seasoned leek (2 log CFU/g), cucumber (2.5 log CFU/g), panbroiled fish paste (2.0 log CFU/g), egg roll (3.8 log CFU/g), tangpyeongchae (4.0 log CFU/g), panbroiled sausage (2.3 log CFU/g), and soft tofu pot stew (3.7 log CFU/g). For seasoned foods (muchim), S. aureus ranged 2.2~2.9 log CFU/g. In food workers' hands, microbial profiles ranged 3.8~7.9 log CFU/hand for TPC, ND~4.5 log CFU/hand for coliforms, ND~4.7 log CFU/hand for S. aureus, and ND~5.3 log CFU/hand for Enterobacteriaceae. Microbiological profiles of food contact surface of knives, cutting boards, dish-clothes, and trays showed possibilities of cross-contamination. General bacteria were 2.1~4.5 logCFU/ml in 4 purified water samples and E. coli were found in the kitchen of one kindergarten. These results suggested that environmental sanitation management practices need more strict improvement: effective sanitation education methods and practices were strongly required, and more strict sanitation management for cooking utensils and equipment were required.

염산용액에서 Cyanex 572를 사용하여 [Sm]/[Pr, Nd] 분리를 위한 향류추출 공정변수 계산

이주은,소홍일,장인환,안재우,김홍인,이진영,Lee, Joo-eun,So, Hong-il,Jang, In-hwan,Ahn, Jae-woo,Kim, Hong-in,Lee, Jin-young 한국자원리싸이클링학회 2018 資源 리싸이클링 Vol.27 No.5

For the purpose of optimizing the counter current extraction process for separation of [Sm] and [Pr, Nd] group in hydrochloric acid solution using Cyanex 572 as an extractant, the theory of Xu Guangxian was derived for calculating the optimized extraction factors. From the basic batch test result, the separation factor of [Sm]/[Pr, Nd] was 14.59 at pH 1.75 in extraction process and 14.61 at 0.01 M HCl in scrubbing process. The process parameters can be calculated using a theory of optimum extraction ratio. From the result of calculation, the total extraction and scrubbing stage numbers at counter current process were 11 and for maintain extraction ratio the flow rate ratio of feed solution, solvent solution, scrubbing solution was 6.25 : 1.74 : 5.80 using 0.1 M HCl.

아미노글리코사이드계 항생제의 투약간격에 따른 안전성 및 효과

이주은,김호순,신완균,조남춘,Lee, Ju Eun,Kim, Ho Soon,Shin, Wan Gyoon,Cho, Nam Chun 한국임상약학회 1998 한국임상약학회지 Vol.8 No.2

Improved knowledge of the time course of antimicrobial activity should provide useful information for designing optimal dosage regimen. In contrast to $\beta$-lactam, aminoglycosides tend to induce a prolonged postantibiotic effect against aerobic or facultative gram negative rods and clinical outcome was significantly correlated with achieving peak serum concentrations. The objective of this study was to compare the efficacy, safety of e same total daily dose of amikacin and gentamicin given either twice or thrice daily in the treatment of patients. Consecutive patients over 20 years old with a suspected or confirmed infection for which an aminoglycosides was indicated were eligible. Exclusion criteria were known allergy to aminoglycosides, renal impairment, granulocytopenia and pregnancy. Patients were treated with intravenous amikacin 15 mg/kg/day or gentamicin 4.5 mg/kg/day either in two devided or in three devided. Seventy-four patients with infection were enrolled in this study of amikacin twice daily (A2, n=29), gentamicin twice daily (G2, n=8) vs amikacin thrice daily (A3, n=30), gentamicin thrice daily (G3, n=7). Baseline characteristics were comparable in G2 and G3. The clinical cure rate (including partial improve) were $89.0\%\;and\;86.0\%$ in A2 group and A3 group respectively. The bacteriologic cure rate were $99.0\%\;and\;85.7\%$ in A2 group and in A3 group respectively. The clinical and bacteriologic effects were difficult to compare G2 with G3, because of the small numbers of patients. The serum creatinin rose in $3.44\%$ (1 in 29) of patients in the A2 group compared to $13.3\%$ (4 in 30) in e A3 group. Although audiometry was not performed, there was no clinical evidence of ototoxicity in any of the patients. In our opinion, twice-daily regimen of aminoglycosides is more effective and less nephrotoxic than thrice-daily regimen.

「전세계 네트워크를 지속적으로 확장하여 글로벌 종합물류기업으로 성장할 것」

이주은,Lee, Ju-Eun 한국물류협회 2006 물류 Vol.2 No.13

국내 자동차산업의 대표기업은 현대자동차 그룹. 우리나라 수출산업의 효자인 자동차산업은 세계 메이저 자동차기업과 세계시장에서 치열한 판매전쟁을 펼치고 있다. 이전에는 저가전략으로 자동차를 판매하여 왔지만, 지금은 최고의 품질로 경쟁할 수 있는 위치까지 올라서면서, 세계 여러나라의 소비자에게 원하는 시간에 원하는 제품을 제공하고 있다. 국내의 자동차 산업이 최고의 물류품질로 경쟁할 수 있었던 계기는 지난 2001년 2월 22일, 글로비스 주식회사의 탄생에서 시작된다. 그 당시, 각 기업들은 글로벌 경영 전략에 적합한 글로벌 SCM 물류 대응 체제 구축이 필요한 상황이었지만, 국내 물류산업은 세계 수준과 격차가 있었다.우리나라의 수출효자산업인 자동차산업에서도 이러한 문제를 해결하기 위해 설립된 물류회사가 바로 글로비스 주식회사이다. 창립 역사는 짧지만, 매출액 1조 5천억원을 달성하면서 국내 물류산업을 이끌어갈 글로벌 종합물류기업으로 성장하고 있다. 지난해 12월 코스닥 증권시장에 상장되면서 물밑에서 조용히 승천을 준비하던 용이 세상 밖으로 나왔다. 2006년은 글로비스가 세계시장에서 글로벌종합물류기업들을 이끌어 가는 리더기업으로서 그 첫해가 될 것으로 기대한다.국내물류기업의 선두그룹이자 자동차 산업의 글로벌 SCM 물류서비스와 철강, 정유, 화학 등 다양한 분야에서 최적의 물류서비스를 제공하고 있는 글로비스의 이주은 대표이사를 만나본다.

페리다이나믹스 이론 및 적용 소개

이주은,홍정욱,Lee, Ju-Eun,Hong, Jeong-Uk 한국전산구조공학회 2013 전산구조공학 Vol.26 No.4