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      • KCI등재

        중국조선족 서신데이터베이스를 통해 본조선족 노인의 위상 - 1980년대 조선족 노인협회를 중심으로 –

        이주미 영남대학교 중국연구센터 2021 중국과 중국학 Vol.- No.43

        This study examines the roles and statuses of the elderly in the Korean-Chinese community through the correspondences of the Korean-Chinese. The old age period is very vague and it is difficult to establish a starting point. However, the nationally established age of retirement is often considered to be the start of the old age period. According to correspondence data of the Korean-Chinese, those ages 55 to 60 were established to be in their retirement period during the 1980s in Korean-Chinese societies and a certain standard of living was guaranteed after retirement. Elderly groups were active with the Senior Citizens Association at the center and their representative activities were embodied in the conveyance of folk customs and traditional etiquette to future generations and in the discovery, collection, and organization of folk art. As the Cultural Revolution came to a close, efforts were actively made to recover the unique culture and traditions of the people to restore their ethnicity and the Senior Citizens Association greatly contributed to the restoration of tradition. The Korean-Chinese elderly played the roles of memory messengers and cultural transmitters and they were also the true enjoyers of traditional art. 이 연구는 중국의 문화대혁명이 끝날 무렵인 1974년부터 한중 수교가 이루 어지는 1992년까지의 조선족 서신을 대상으로 조선족 사회에서 노인이 담당한 역할과 위상에 대해 살핀다. 노년 시기는 매우 모호하여 그 시작점을 정하기 어렵다. 그러나 대체로 국가 정한 은퇴 연령부터 노인으로 취급한다. 조선족 서신 자료에 의하면 80년대에 조선족 사회에서는 55세에서 60세 가량을 퇴직 시기로 정하고 퇴직 이후 일정정도 생활수준을 보장했다. 노인 집단은 노인협회를 중심으로 활동했는데, 그들의 대표적인 활동은 민족의 풍습과 전통 예절을 후대에 전하고 민간예술을 발굴, 수집, 정리하는 일로 구체화되었다. 중국은 10년간의 문화대혁명을 거치면서 소수민족의 자율성을 억압하고 민족의식을 말살하고 전통문화를 유린했다. 이 기간에 민족 예술단체가 해산되고 작가와 예술인이 추방당했음은 주지의 사실이다. 문화대혁명이 끝나자 민족성을 되찾기 위해 민족 고유의 문화와 전통을 복원하려는 노력이 활발해졌 는데, 노인협회가 전통을 복원하는 일에 큰 기여를 한 것이다. 조선족 노인들은 이처럼 기억 전달자, 문화 전승자 역할을 담당하고 있었을 뿐 아니라 전통 예술의 진정한 향유자이기도 했다. 서신데이터베이스 분석에 의하면 조선족 노인들이 아리랑과 같은 민요를 즐겨 부른 이유는 그것이 그들의 취향에 잘부합되었기 때문이다. 이는 조선족 노인들에게 전통문화가 계승해야 하는 것일 뿐 아니라 향유하고 싶은 것임을 분명해 말해준다.

      • KCI등재

        Association Between Serum Uric Acid Level and Metabolic Syndrome

        이주미,김현창,조혜민,오선민,최동필,서일 대한예방의학회 2012 Journal of Preventive Medicine and Public Health Vol.45 No.3

        Objectives: Serum uric acid levels have been reported to be associated with a variety of cardiovascular conditions. However, the direct association between uric acid levels and metabolic syndrome remains controversial. Thus, we evaluated the association of serum uric acid levels and metabolic syndrome in a community-based cohort study in Korea. Methods: We performed cross-sectional analysis of baseline data of 889 males and 1491 females (aged 38 to 87) who participated in baseline examinations of the Korean Genome and Epidemiology Study: Kanghwa study. Blood samples were collected after at least an 8 hour fast. Uric acid quartiles were defined as follows: <4.8, 4.8-<5.6, 5.6-<6.5, ≥6.5mg/dL in males; and <3.8, 3.8- <4.3, 4.3 - <5.1, ≥5.1 mg/dL in females. Metabolic syndrome was defined by the National Cholesterol Education Program Adult Treatment Panel III Criteria with adjusted waist circumference cutoffs (90 cm for males; 80 cm for females). The association between serum uric acid quartiles and metabolic syndrome was assessed using multivariate logistic regression. Results: The odds ratio for having metabolic syndrome in the highest versus lowest quartiles of serum uric acid levels was 2.67 (95% confidence interval [CI], 1.60 to 4.46) in males and 2.14 (95% CI, 1.50 to 3.05) in females after adjusting for age, smoking, alcohol intake, body mass index, total cholesterol, HbA1c, albumin, γ-glutamyltransferase, blood urea nitrogen, and log C-reactive protein. The number of metabolic abnormalities also increased gradually with increasing serum uric acid levels (adjusted p for trend < 0.001 in both sexes). Conclusions: Higher serum uric acid levels are positively associated with the presence of metabolic syndrome in Korean males and females.

      • KCI등재

        DNA methylation of stem cell surface markers in colon cancers

        이주미 한국유전학회 2012 Genes & Genomics Vol.34 No.3

        DNA methylation is considered an important mechanism for inactivation of tumor suppressor genes in the cancer genome. Recent advances in genome-wide analysis technology have identified a number of new genes that are inactivated in cancer and regulated by DNA hypermethylation. This study investigates transcriptional silencing of the CD44, CD34, and EpCAM genes, which are well known as cancer stem cell surface markers in many types of cancer. We examined promoter DNA methylation patterns for CpG island for CD44, CD34, and EpCAM genes in eleven colon cancer cell lines by methylation specific PCR (MSP). LoVo and Colo205 cells showed robust promoter DNA hypermethylation, which strongly correlated with gene re-expression after 5-Aza-2’-deoxycytidine (DAC)treatment. We also confirmed promoter hypermethylation of CD44, CD34, and EpCAM genes by bisulfite sequencing in LoVo cells compared with DNMT1(-/-)DNMT3B(-/-) double knockout (DKO) HCT116 cells and normal colon tissue. This data suggest that the promoter DNA hypermethylation seen in colon cancer is cancer-specific. Taken together, transcriptional silencing of CD44, CD34, and EpCAM gene is caused by promoter DNA hypermethylation of their CpG islands in colon cancer cell lines. Our data might contribute to understanding the biological roles of inactivating cancer stem cell markers in colon cancers.

      • KCI등재
      • KCI등재

        Population pharmacokinetic analysis of the multiple peaks phenomenon in sumatriptan

        이주미,임미선,성숙진,박성민,권미리,한승훈,이성민,김우미,윤영란,유희두 대한임상약리학회 2015 Translational and Clinical Pharmacology Vol.23 No.2

        The objective of this study was to develop a population pharmacokinetic (PK) model for sumatriptan,which frequently shows an atypical absorption profile with multiple peaks. Sumatriptan,a selective agonist for the vascular serotonin (5-HT1) receptor that causes vasoconstriction of thecerebral arteries, is used for the acute treatment of migraine attack with or without aura. Despite itsrelatively high between-subject variability, few reports have addressed PK modeling of sumatriptan. Plasma data obtained after a single 50-mg oral dose of sumatriptan in 26 healthy Korean male subjectswere used. Blood samples were collected 0 (predose), 0.25, 0.5, 0.75, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10,and 12 h after dosing. Plasma sumatriptan concentrations were analyzed using UPLC/MS/MS. PopulationPK analysis was performed using plasma concentration data for sumatriptan with NONMEM(ver. 7.2). A total of 364 concentrations of sumatriptan were captured by a one-compartmentmodel with first-order elimination, and a combined transit compartment model and first-orderabsorption with lag time was successful in describing the PK with multiple peaks in the absorptionphase of sumatriptan. The creatinine clearance as a covariate significantly (P < 0.01) influenced theabsorption fraction (f ). The final model was validated through a visual predictive check and bootstrappingwith no serious model misspecification

      • KCI등재

        일차 마르코프 잡음 환경에서의 국소 최적 검파: 1. 검정 통계량

        이주미,박주호,송익호,권형문,김홍직,윤석호,Lee, Ju-Mi,Park, Ju-Ho,Song, Iic-Ho,Kwon, Hyoung-Moon,Kim, Jong-Jik,Yoon, Seok-Ho 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.10C

        이제까지 국소 최적 검파를 다룬 연구들에서는 대부분 관측을 독립이라 두었다. 독립 관측 모형에서 얻은 검파기는 의존성 잡음 성분이 있는 현대 고속 통신 시스템에서 성능이 쾌 떨어질 수 있다. 이 논문의 1부에서는 곱셈 꼴 잡음과 일차 마르코프 덧셈꼴 잡음이 일어나는 환경에서 알려진 약한 신호를 검파할 때 알맞은 검정 통계량을 자세히 살펴본다. 이어, 2부에서는 여러 검파기의 점근 성능과 유한 표본 크기 성능을 얻고 서로 견주어 보며, 성능을 가장 좋게 하려면 간섭끼리의 의존성을 생각하여 검파기를 꾸며야 함을 보인다. In most of the studies on locally optimum detection assumes independent observations. The use of an independent observation model may cause a considerable performance degradation in detection applications of modern high data rate communication systems exhibiting dependence among interference components. In this paper, we address the detection of weak known signals in multiplicative and first order Markov additive noises. In Part 1, the test statistics of the locally optimum detectors are investigated in detail. In Part 2, the asymptotic and finite sample-size performance of several detectors are obtained and compared, confirming that the dependence among interference components need to be taken into account to maintain performance appropriately.

      • KCI등재

        상보적 교수 이론에 기반한 한국어 읽기 수업 효과 연구- 대학 수학 학습자를 중심으로 -

        이주미,김지애 한국문화융합학회 2019 문화와 융합 Vol.41 No.2

        The purpose of this paper is to discuss the applicability of reciprocal learning activities as a teaching plan for a Korean reading class for academic purposes by applying the reciprocal learning theory, which is a constructivism learning theory used in reading classes for foreign undergraduates currently studying in a university. To this end, we proposed the framework of a reciprocal learning model for a Korean reading class, applied it to the class and examined the effects on learners’ reading abilities by analyzing the results produced in the process. According to the analysis of learners’ midterm and final exam grades, the learners’ overall reading abilities improved in the lecture-based class and personal practice-oriented class. However, good students continued to perform well, while poor students performed poorly. On the other hand, in a class that was composed of lecture-based class, individual practice, and reciprocal learning activities, the learners’ overall reading abilities improved moreover the grades of students with poor reading abilities improved greatly, indicating that reciprocal learning activities not only generally improve learners’ reading abilities but also lead to academic achievement and success. In addition, an analysis of student’s reflection journals showed that reciprocal learning activities improved their reading and learning strategies and have a positive effect on self-efficacy. These result should be applied and analyzed in more academic situations in the future. The result of this study show that reading classes that use reciprocal learning theory are expected to lead student to become active learners in academic situations and to become a method for developing meaningful interactive classes that are centered around learners.

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