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갑상샘눈병증 환자의 안와감압술에서 2차원 안와 전산화 단층촬영의 4가지 parameter의 유용성
이종석,이화,장민욱,백세현,이태수,Jong Suk Lee,Hwa Lee,Min Wook Chang,Sehyun Baek,Tae Soo Lee 대한안과학회 2014 대한안과학회지 Vol.55 No.9
Purpose: To present easily measurable 2D orbit computed tomography (CT) reference data that can be used in a preoperative study for orbital decompression and classification of individual orbital morphologies. Methods: The study sample was composed of 77 patients with orbital contusion (42 Asian males + 35 Asian females = 154 orbits) who visited the emergency room of the Korea University Guro Hospital from September 2012 to June 2013. Patients with orbital wall fracture, retrobulbar hemorrhage, or eyeball rupture were excluded. Medical records including 2D orbit or facial bone CT were retrospectively reviewed and 4 orbital parameters (orbital length, OL; globe length, GL; GL/OL ratio and 2D cone angle) were measured. Results: The average OL was 42.53 ± 2.46 mm (35.63-49.09 mm) and average GL was 24.83 ± 1.09 mm (22.75-28.13 mm). The average GL/OL ratio using these 2 parameters was 0.59 ± 0.04 (0.50-0.68). The posterior cone angle was on average, 45.96 ± 5.91° (29.35-60.04°). Conclusions: Simple measurement of 4 parameters using 2D orbit CT and classification of Asian individual orbital morphology may help in the choice of the most effective surgical technique for decompression surgery in thyroid eye disease patients. J Korean Ophthalmol Soc 2014;55(9):1267-1271
이종석,전대근,이수용,김석준,정동환,박현수,Lee, Jong-Seok,Jeon, Dae-Geun,Lee, Soo-Yong,Kim, Sug-Jun,Jung, Dong-Whan,Park, Hyun-Soo 대한근골격종양학회 1997 대한골관절종양학회지 Vol.3 No.2
Twenty hundred and five out of 266 patients who were registered in Korea Cancer Center Hospital from Mar. 1985 to Jan. 1994, were analyzed in the aspect of survival and local recurrence. Fifty one patients were excluded due to inadequate data and follow up. Prognostic factors for survival were evaluated statistically. One hundred and four cases were male, 101 female. Average age was 39.7(range 1 to 77) year with a peak incidence around 4th decade. The most frequent diagnosis was malignant fibrous histiocytoma(MFH)(24.1%). Liposarcoma, synovial sarcoma, rhabdomyosarcoma, malignant peripheral nerve sheath tumor and fibrosarcoma were relatively common diagnostic entities, in decreasing order. In location, extremity was 179(87.3%) and trunk 26(12.7%). Average follow up period was 7.5 years(6 months to 10 years). Actuarial 5 years and 10 years survival rate were 64.0% and 40.8% respectively. In univariate analysis with log-lank test, significant differences in survival rate were noted in histopathological diagnosis, size(10 cm), stage and metastasis. Age, sex, tumor location, tumor depth and local recurrence didn't affect the survival rate. Adjuvant chemotherapy and/or radiotherapy did not affect overall survival rate, but lowered the local recurrence rate when compared with surgery only. Surgical margin did not affect the survival rate, but local recurrence rate was different according to each margin; 5.7% in more than wide; 39.5% in marginal; and 60.0% in intralesional excision. In multivariate analysis for results of univariate analysis with Cox's propotional model, metastasis was a meaningful factor for survival of soft tissue sarcoma.
이종석,위재완,Hye Young Lee,안효실,홍억기 한국생물공학회 2010 Biotechnology and Bioprocess Engineering Vol.15 No.3
Hericium erinaceus is a well known edible and medicinal mushroom used in East-Asia. Recently, H. erinaceus has attracted a lot of attention owing to its antitumor,immuno-modulatory, and cytotoxic effect. It has been postulated that the fruiting body of H. erinaceus contains a polysaccharide that is similar to β-D-glucan,which is known to have antitumor activity against Sarcoma 180. However, optimized liquid culture conditions for enhanced polysaccharide productivity have yet to be developed, which is a necessary step for industrial applications. Therefore, the aim of this study was to determine the optimal liquid culture conditions for maximum polysaccharide production. In shake flask cultures, the optimal concentration of ascorbic acid was found to be 2.0 g/L,which prevented the broth from changing color from yellow to black. The optimal culture conditions were determined to be 23oC, 200 rpm, and a 10% inoculum size, at an uncontrolled initial pH. In addition, the modified medium contained 20 g/L glucose, 10 g/L yeast extract, and 2.0 g/L ascorbic acid. The maximum mycelial biomass and exopolysaccharide (EPS) production in the modified medium containing uracil was 13.43 and 1.26 g/L, respectively.
이종석,전대근,김석준,이수용,박현수,Lee, Jong-Seok,Jeon, Dae-Geun,Kim, Sug-Jun,Lee, Soo-Yong,Park, Hyun-Soo 대한근골격종양학회 1995 대한골관절종양학회지 Vol.1 No.2
Twenty three rhabdomyosarcoma patients who were registered in Korea Cancer Center Hospital from Mar. 1985 to Apr. 1994 were analysed in the aspect of treatment and survival. Thirteen cases were male and 10 female. Average age was 29.5 years(range 1 to 66). Locations of the tumor were as follows: 13 in lower extremity, 6 in upper extremity and 4 in trunk. According to the UICC classification, stage II b was 1 case, stage III a 4, stage III b 10, stage IV a 3 and stage IV b 5. In histological categories, embryonal rhabdomyosarcoma was 7 cases, alveolar 7, pleomorphic 7 and undetermined 2. Average follow up period was 35.3 months(1 tk 7.5 years). Ten cases were continuous disease free, 3 no evidence of disease, 3 alive with disease and 7 died of disease at final follow up. Kaplan-Meier's actuarial 5-year survival rate was 60.3% and 5-year continuous disease free survival rate was 31.4%, Surgical margin was an important factor in local tumor control. Although there was no definite statistical significance, our results suggest chemotherapy and radiation therapy have meaningful roles in reducing local recurrence and improving survival.
골유착성 임프란트에 의해 지지되는 새로운 설계의 Hybrid Prosthesis
이종석,신상완,Lee, J.S.,Shin, S.W. 대한심미치과학회 1999 Journal of the Korean Academy of Esthetic Dentistr Vol.8 No.1
A fixed bridge is preferred as a prosthetic option supported by oral implants. However, it is very difficult to re tore edentulous maxilla with fixed prosthesis in cases with improper position and angulation of fixtures, abnormal jaw relation, and need for proper lip support. Six Br${\aa}$nemark implants were installed in edentulous maxilla opposing mandible with natural dentition. A removable hybrid prosthesis attached to a bar milled by 6 degrees was therefore designed to overcome such disadvantages of fixed prosthesis. Lateral stabilization of removable prosthesis was obtained by framework closely fitting the milled bar. Support for the prosthesis was ensured by three elevated areas on the bar. Two precision attachments(CEKA REVAX) provided appropriate direct and indirect retention without influencing support. A clinical and laboratory procedure was presented.
이종석,전대근,김석준,이수용,양현석,Lee, Jong-Seok,Jeon, Dae-Geun,Kim, Sug-Jun,Lee, Soo-Yong,Yang, Hyun-Seok 대한근골격종양학회 1997 대한골관절종양학회지 Vol.3 No.1
PURPOSE : For the reconstruction of large bone defect after tumor resection, it is possible to reuse the bone involved by tumor with some treatment to it. Several bone-reusing methods have been reported such as autoclaving, low-heat treatment(pasteurization) and intraoperative radiotherapy. We have used extracorporeally radiated autogenous bone graft for reconstruction after tumor resection, and analyzed the periods for junctional union, functional results and complications to know the indications of this method. METHODS : From Dec. 1993 to Sept. 1995, nine patients had taken autogenous bone graft with extracorporeal irradiation. Eight cases were osteosarcoma and 1 giant cell tumor. The graft sites were 5 in femur, 3 proximal tibia and 1 femur and tibia. Stage 3 was 1 case(GCT), Stage IIB 3 and Stage IIIB 5. After wide resection, surrounding soft tissue and intramedullary and extramedullary portion of the tumor were removed. Radiation was done in 5000cGy to the resected bone. Ender nails and bone cement were inserted and filled into the medulla to prevent fracture. RESULTS : Average follow-up period was 12.3(4 to 21) months. Average junctional union period in simple X-ray was 6.5 months in 4 cases. Average functional score following Enneking's criteria was 19(12-27). Complications were as follows ; condylar fractures and femur neck fracture in 4 cases, subluxation of the knee joint 3 and infection 1. Although local recurrence was detected in 1 case, the site of recurrence was not in the radiated bone but surrounding soft tissue. At final follow-up, no recurrence was found in one case(GCT), CDF 2, AWD 2, DOD 3, and died of chemotherapy related sepsis 1. CONCLUSIONS : Extracorporeally radiated bone autograft is considered to be a method for reconstruction of the large bone defect made by tumor resection, especially in the reconstruction around the joint.
충적하천(沖積河川)의 수로양상(水路樣相)에 따른 유사(流砂) 및 흐름특성(特性)
이종석,이대철,배동만,차영기,Lee, Jong Seok,Lee, Dae Cheol,Pai, Dong Man,Cha, Young Kee 대한토목학회 1994 대한토목학회논문집 Vol.14 No.5
This paper aims to develop the numerical model for prediction of the channel migration by analyzing of sediment and flow characteristics with patterns of channel in alluvial rivers. Flow in rivers constitutes to be the meandering or the braided form and rarely straight channel through morphologically stable patterns with mutual actions between the flowing water and bed materials. In order to develop the model for simulation of the channel migration, the channels are divided into two types with positive or negative sign by the direction of curvature radius of the centerline channel ($r_c$). That is, the single bend-channel consists of only one curvature of positive or negative sign and the multi-bend channel consists of two more curvatures of positive or negative sign, respectively. The model analyzes the sediment and flow characteristics under the influence of superelevation, spiral motion, irregularity in bed topography and depth-averaged velocity of channels. For reliability of this model, the single bend-channel and the multi bend channel are compared with experiment data in other models and the measured field data in the Keum-River, respectively. As a result, the both com parisians turn out to be excellent. 본 논문은 충적하천에서 수로의 양상조건에 따른 유사 및 흐름특성을 해석함으로써 수로의 변이를 예측할 수 있는 수치모형을 개발하기 위한 연구이다. 하천의 흐름은 하상 및 제방재료 특성과의 상호작용에 의해 복잡한 관계를 이루면서 수로변이를 통하여 형태학적으로 안정적인 형상을 유지하고 흐르기 때문에 대부분의 경우 직선형수로는 드물고 사행 또는 망류상을 이루고 있다. 본 연구에서는 수로변이를 모의할 수 있는 모형을 개발하기 위해 수로중심선 곡률반경 $r_c$값의 양과 음의 부호수에 따라 수로를 구분 즉, $r_c$의 양 또는 음의 값이 하나 만으로 이루어진 단만곡수로(single-bend channel)와 양과 음이 둘 이상의 값을 갖는 복만곡수로(multi-bend channel)로 구분하여 이들 수로에서의 편수위상승, 나선운동, 하상 및 수심평균유속의 불규칙 현상의 영향에 의한 유사이동과 흐름특성을 해석한다. 단만곡수로는 타 _모형의 실험자료와 복만곡수로는 금강의 매포수위관측소를 시점으로하는 연구구간에서 실측치 현장자료와 비교분석함으로써 본 모형의 적용성을 검증하였으며, 그 결과는 대체로 잘 일치하는 것으로 나타났다.