우황청심원 관련 최근 연구 동향 : 국내 논문에 대한 고찰

이제원,백경민,백영두,임은영,장우석,전우현,정인권,Lee, Je-Won,Baek, Kyung-Min,Baek, Young-Doo,Im, Eun-Young,Chang, Woo-Seok,Cheon, Woo-Hyun,Chung, In-Kwon 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.4

Objectives : Woohwangchungsim-won has been used for acute diseases such as cerebrovascular disease (stroke), heart disease. The aim of this study was to determine the effects, significance & necessity of Woohwangchungsim-won in acute stages of these disease by reviewing Korean articles about Woohwangchungsim-won. Methods : Article searches were performed on 8 major Korean web article search engine from January 1980 to August 2010. There were no restrictions on the types of publication, including grey articles. Results : Forty-three articles were included. Twenty one were efficacy tests, thirteen were comparative efficacy tests, eight were toxicity tests, and one was new method development. Eighteen articles were multicenter studies and twenty five were single center studies. Thirty two articles were animal testing, only ten articles were clinical articles. Thirty seven articles presented the composition and quantity of Woohwangchungsim-won, but six did not. Conclusions : The results of Korean articles about Woohwangchungsim-won can not strongly support the effects, significance & necessity of Woohwangchungsim-won. More rigorous studies are required for determination of the effects of Woohwangchungsim-won.

뇌졸중 후 우울증 : 한방 치료에 대한 국내외 최신 문헌 고찰

이제원,이보매나,장우석,황하연,백경민,Lee, Je-Won,Lee, Bo-Mae-Na,Jang, Woo-Seok,Hwang, Ha-Yeon,Baek, Kyung-Min 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.4

Objectives : This study reviews the latest articles in Korea and other countries that studied oriental medicine treatment on poststroke depression. Methods : Korean articles were retrieved from the 9 major Korean web article search engines. Foreign articles were retrieved from PubMed. Article published date was from 2000 up to September 2012. There were no restrictions on the types of publication, but articles not available in full text were excluded. The methodological quality was assessed according to Cochrane's assessment of risk of bias and Newcastle-Ottawa quality assessment scale. Results : Twenty-two articles were included in this study. Eleven articles were published in Korea, the rest were published in China. Nine articles were randomized controlled trials (RCT), one article was a non-randomized study (NRS), four articles were case reports, three articles were cross-sectional studies, two articles were comparative studies. In RCT articles, risk of selection bias and performance bias were generally high, risk of detection bias was unclear. The NRS article took four stars in Newcastle-Ottawa quality assessment. Comparison Hamilton rating scale for depression score between oriental medicine treated group and western medicine treated group revealed that there was no remarkable difference in mean score changes after treatment on PSD. Conclusions : The results of this study suggest that oriental medicine treatment is as effective as western medicine treatment for PSD. In the future, more rigorous oriental medicine treatment studies should be conducted.

Activation of Pro-Apoptotic Multidomain Bcl-2 Family Member Bak and Mitochondria-Dependent Caspase Cascade are Involved in p-Coumaric Acid-Induced Apoptosis in Human Jurkat T Cells

Je Won Lee(이제원),Young Ho Kim(김영호) 한국생명과학회 2011 생명과학회지 Vol.21 No.12

다양한 식용식물에 함유되어 있는 것으로 알려진 phenolic acids의 일종인 p-coumaric acid의 항암활성을 규명하고자, 인체 급성백혈병 T 세포주인 Jurkat T 세포에 대한 p-coumaric acid의 에폽토시스 유도기전을 조사하였다. Jurkat T 세포를 p-coumaric acid (50-150 μM)로 처리한 결과, 세포독성, 에폽토시스-관련 DNA fragmentation, 및 pro-apoptotic multidomain Bcl-2 family member인 Bak의 활성화, Δψm loss, caspase-9, -3, -7, 및 -8의 활성화, 그리고 PARP 분해 등의 여러 에폽토시스-관련 생화학적 현상들이 농도의존적으로 나타났다. 그러나 이러한 에폽토시스-관련 생화학적 현상들은 Jurkat T 세포에 anti-apoptotic Bcl-2 단백질을 과발현할 경우에는 나타나지 않았다. 또한 p-coumaric acid처리에 의해 유도되는 Jurkat T 세포의 에폽토시스에는 necrosis가 수반되지 않는 것으로 확인되었다. Jurkat T 세포를 pan-caspase inhibitor인 z-VAD-fmk를 전처리할 경우, p-coumaric acid 처리에 의해 유도되는 apoptotic sub-G1 peak는 차단되어 나타나지 않았으나 Δψm loss는 여전히 나타났는데, 이는 p-coumaric acid처리에 의한 에폽토시스의 유도에 caspase cascade 활성화가 필수적이며Δψm loss의 downstream 현상임을 나타낸다. 한편, FADD 및caspase-8을 함께 발현하는 Jurkat T 세포주 A3, FADD-결손 Jurkat T 세포주 I2.1, 그리고 caspase-8-결손 Jurkat T 세포주 I9.2의 p-coumaric acid의 세포독성에 대한 감수성은 서로 유사하게 나타났는데, 이는 p-coumaric acid처리에 의한 에폽토시스의 유도가 Fas와 FasL간의 상호작용에 의해 개시되지 않음을 시사한다. p-Coumaric acid의 세포독성은 Jurkat T 세포에 비해 인체 정상 말초혈액 T 세포에서 훨씬 낮게 나타났다. 이러한 결과들은 p-coumaric acid 처리에 의해 유도되는 Jurkat T 세포의 에폽토시스가 Bak 활성화, Δψm loss, caspase-9, -3, -7, 및 -8로 이루어진 caspase cascade의 활성화, 그리고 PARP 분해에 의해 유도되며, 또한 anti-apoptotic 단백질인 Bcl-2의 과발현에 의해서 음성적으로 조절됨을 나타낸다. The apoptogenic effect of p-coumaric acid, a phenolic acid found in various edible plants, on human acute leukemia Jurkat T cells was investigated. Exposure of Jurkat T cells to p-coumaric acid (50-150 μM) caused cytotoxicity and TdT-mediated dUTP nick-end labeling (TUNEL)-positive apoptotic DNA fragmentation along with Bak activation, Δψm loss, activation of caspase-9, -3, -7, and -8, and PARP degradation in a dose-dependent manner. However,these apoptotic events were completely abrogated in Jurkat T cells overexpressing Bcl-2.Under these conditions, necrosis was not accompanied. Pretreatment of the cells with the pan-caspase inhibitor (z-VAD-fmk) could prevent p-coumaric acid-induced sub-G1 peak representing apoptotic cells, whereas it failed to block Δψm loss, indicating that the activation of caspase cascade was prerequisite for p-coumaric acid-induced apoptosis as a downstream event of Δψm loss. FADD- and caspase-8-positive wild-type Jurkat T cell clone A3, FADD-deficient Jurkat T cell clone I2.1, and caspase-8-deficient Jurkat T cell clone I9.2 exhibited similar susceptibilities to the cytotoxicity of p-coumaric acid, excluding an involvement of Fas/FasL system in triggering the apoptosis. The apoptogenic activity of p-coumaric acid is more potent in malignant Jurkat T cells than in normal human peripheral T cells. Together, these results demonstrated that p-coumaric acid-induced apoptogenic activity in Jurkat T cellswas mediated by Bak activation, Δψm loss, and subsequent activation of multiple caspases such as caspase-9, -3, -7, and-8, and PARP degradation, which could be regulated by anti-apoptotic protein Bcl-2.

고 신뢰도 무선센서네트워크를 위한 변조 방식에 따른 성능 분석

이제원(Je-won Lee),이성윤(Sungyoon Lee),김재길(Jae-kil Kim),강호용(Hoyong Kang),전종암(Jong-Arm Jun),안재민(Jae min Ahn) 한국통신학회 2012 한국통신학회 학술대회논문집 Vol.2012 No.6

GNSS 확산부호로써의 Zadoff-Chu 코드 성능 분석

이제원(Lee Je-won),박대순(Park Dae-Soon),김정빈(Kim Jeong-been),김갑진(Kim Kap-jin),송기원(Song Ki-won),안재민(Ahn Jae Min) 한국통신학회 2013 한국통신학회 학술대회논문집 Vol.2013 No.6

고 신뢰도 무선센서네트워크를 위한 송-수신기 설계 및 성능 분석

이제원(Je-won Lee),이성윤(Sungyoon Lee),김재길(Jae-kil Kim),강호용(Hoyong Kang),전종암(Jong-Arm Jun),안재민(Jae-min Ahn) 한국통신학회 2012 한국통신학회 학술대회논문집 Vol.2012 No.2

미용서비스에서 관계혜택유형과 고객만족

이제원(Lee, Je Won),유은희(Yoo, Eun Hee),하홍열(Ha, Hong Youl) 동국대학교 사회과학연구원 2015 사회과학연구 Vol.22 No.2

전환비용이 재구매의도에 미치는 영향에 대하여는 기존연구들에서 많은 조명을 받아왔으나, 고객만족에 대한 전환비용의 조절효과의 역할은 상대적으로 연구가 제한적이었다. 본 연구에서는 미용서비스에서 사회적 관계혜택과 특별우대관계혜택이 고객만족에 영향을 미치는 과정에서 전환비용의 1차 조절효과와 미용실 유형의 2차 조절효과를 분석하였다. 본 연구의 모형을 검증하기 위하여 미용실을 이용하는 20-50대의 남녀 300부의 설문지를 이용하여 위계적 회귀분석을 이용하여 측정하였다. 본 연구의 주요결과는 다음과 같다. 첫째, 미용서비스과정에서 사회적 혜택은 고객만족의 정(+)영향을 미치지 않는 반면, 특별우대혜택은 정(+)의 영향을 미치는 것으로 확인되었다. 둘째, 사회적혜택과 특별우대관계 혜택 모두 고객만족과의 사이에서 전환비용의 조절효과는 유의한 영향을 미치지 못하였다. 셋째, 미용실유형별 전환비용의 조절효과 역시 프랜차이즈미용실과 일반미용실 모두 유의한 효과를 내지 못하였다. 한편 흥미롭게도, 성별, 특별우대관계혜택의 상호작용을 통한 고객만족과의 추가분석에서, 남성이 여성보다 낮은 혜택에서 높은 만족도를 보였으나, 높은 혜택에서는 성별 간의 상대적 만족도의 차이가 미미하였다. 이것은 1회 지출비용은 작지만 정기적이며 방문빈도수가 높은 남성고객에 대한 낮은 특별우대혜택이, 높은 특별우대혜택을 기대하는 여성고객에 비하여 고정고객확보와 유지 및 긍정적 구전효과 등을 이끌어내기에 유리하여, 장기적으로 볼 때 미용실 경영에 긍정적으로 기여할 수 있음을 시사한다. The effect of switching costs on repurchasing has been highlighted by formal researches. However, studies that address the moderating effect of switching costs on customer satisfaction have been relatively limited. Therefore, this study aims at analyzing the first moderating effect of switching costs and the secondary moderating effect of salon types on the process of social and special treatment relational benefits on customer satisfaction in the hair beauty service industry. A professional research firm conducted a survey. A total of 300 questionnaires were distributed to male and female. The proposed hypotheses were analyzed by the hierarchical regression. First, the finding show that social benefits did not give positive effect on customer satisfaction, while preferential treatment benefits gave positive effect. Second, the moderating effect of switching costs did snot have any valid influence upon the relationship between two types of benefits on customer satisfaction. Third, the types of beauty salon did not show valid effect on both franchise beauty salon and typical beauty salon. Finally, in additional analysis of gender and spacial treatment relational benefit on customer satisfaction, male customer appeared higher levels of satisfaction in low benefits rather than female customers, while there was relatively mere difference between male and female in high benefits. The authors discuss insights and provide limitations and further research directions.

SC-FDE 기반 3D-HDTV MISO SFN 지상파 방송망 내 수신 안테나 위치에 따른 수신 성능 분석

이제원(Je-won Lee),이성윤(Sungyoon Lee),신동철(Dong-chul Shin),김재길(Jae-kil Kim),안재민(Jae-min Ahn) 한국통신학회 2011 한국통신학회 학술대회논문집 Vol.2011 No.6

프로야구구단의 시각적 아이덴티티, 구단이미지, 구단평판 간의 관계

이제원(Je Won Lee),고성은(Seong Eun Koh) 한국체육교육학회 2009 한국체육교육학회지 Vol.14 No.2

The purpose of this study is intended to give suggestions for studying visual identity of professional baseball industries which has some effects on team image and team reputation and provide professional baseball industries with the suggestions improving image and deriving positive team reputation. For this research, responses from 313 consumers who was experienced attending or watching the TV baseball game was used. Correlation analysis, CFA, and SEM were used to examine research hypotheses by using SPSS win ver.14.0 and AMOS 5.0. As results was followed. First, visual identity had significant positive (+) influenced on team image(game managing, social responsibility). Second, visual identity had significant positive (+) influenced on team reputation. Third, team image(game managing, social responsibility) had significant positive (+) influenced on team reputation. As indicated above, visual identity have critical effects on team image and team reputation. Accordingly, professional basketball industries must develop their own visual identity and manage team image and team reputation to appeal to consumers and active communication should be made as well.

플랫폼 비즈니스의 소비가치지향과 태도 및 행동의도에 대한 연구

이제원 ( Lee Je-won ) 한국고객만족경영학회 2018 고객만족경영연구 Vol.20 No.3

소비자 행동으로 태도에 대한 전통적 연구들은 온라인 기반의 비즈니스 적용에는 제한적이었고, 플랫폼 비즈니스를 증명하는 것에는 한계가 있었다. 최근 플랫폼 비즈니스의 급속한 성장 과정에서 소비자들의 소비가치에 대한 태도와 행동의도의 영향력 관계를 조사하여 이를 증명하고자 한다. 또한 소비가치와 소비가치에 대한 태도의 조절효과(효용지향 및 쾌락지향)가 태도와 행동의도 간에 미치는 영향력의 관계를 비교한다. 본 연구결과 첫째, 소비가치의 혁신지향, 타인지향, 자기표현지향은 소비가치에 대한 플랫폼 태도에 긍정적인 영향을 주며, 이는 소비자의 행동의도를 촉진시킨다. 둘째, 조절효과에서 효용지향 집단은 혁신지향과 태도의 관계를 강화시키는 반면, 쾌락지향 집단은 통계적인 유의성을 나타내지 못하였다. 셋째, 타인지향과 태도의 관계는 효용지향 집단에서는 관계의 약화를, 쾌락지향 집단에서는 관계를 강화시키는 상반된 결과를 나타내었다. 마지막으로, 자기표현지향과 태도의 관계는, 효용지향 집단에서는 관계 강화를 나타낸 반면, 쾌락지향 집단에서는 관계가 약화되는 조절효과를 나타내었다. 본 연구결과를 기반으로 혁신지향, 타인지향, 자기표현지향 집단은 효용지향과 쾌락지향 집단에서의 조절효과의 차이점이 나타났으며, 이를 통해 소비가치에 대한 태도 및 행동의도 간의 영향력 관계가 존재한다는 것을 증명하였고 연구의 시사점과 한계점을 통해 인터넷 플랫폼 비즈니스 기업들의 실질적 접근방법을 제안하였다. There is very limited research that applied online-based businesses on consumer attitudes, and in turn, it is difficult for the proofs of platform businesses. This study investigates relevant relationships among consumption value, attitudes, and behavioral intentions on platform business. Furthermore, we aim at examining the moderating role between consumption value and attitudes toward consumption value. As a consequence, we investigate how two moderators have an important control effect on three proposed relationships, indicating that there are similarities and differences. First, the findings show that three types of consumption value (innovative orientation, other-orientation, self-expression orientation) have significant influence on attitudes toward consumption value, and then, these impacts result in facilitating behavioral intentions. Second, for the utilitarian orientation group, the relationship between innovative orientation and attitudes improves, whereas for the hedonic orientation group, the same relationship is insignificant. Third, for the utilitarian orientation group, the relationship between other-orientation and attitudes declines, whereas for the hedonic orientation group, the same relationship improves. Finally, while for the utilitarian orientation group, the relationship between self-expression orientation and attitudes enhances, for the hedonic orientation group, the same relationship decreases. In line with these observations, the authors discuss theoretical and practical insights and provides valuable directions for further studies.