아미설프라이드로 유발된 고프로락틴혈증: 예비 연구

이정우,박영민,이승환,강승걸,이분희,박은진,Lee, Jung-Woo,Park, Young-Min,Lee, Seung-Hwan,Kang, Seung-Gul,Lee, Bun-Hee,Park, Eun-Jin 한국정신신체의학회 2011 정신신체의학 Vol.19 No.1

연구목적: 고프로락틴혈증은 항정신병약물로 인한 흔한 부작용이다. 그럼에도 불구하고 이러한 고프로락틴혈증에 대한 임상가들의 관심은 적은 편이다. 왜냐하면 고프로락틴혈증으로 인한 부작용의 심각성이 널리 알려지지 않았기 때문이다. 특히 아미설프라이드로 인한 고프로락틴혈증에 대한 국내 연구는 전무한 실정이다. 본 연구에서는 한국인에서의 아미설프라이드로 인한 프로락틴 수치의 변화를 알아보고자 한다. 방 법: 2008년 1월부터 2010년 12월까지 일산백병원 신경정신과의 외래와 입원 환자 24명을 대상으로 의무기록을 검토하여 자료를 분석하였다. 이를 통해 아미설프라이드 사용 전후의 프로락틴 수치의 변화를 비교하였다. 또한 아미설프라이드 용량, 투약 기간과 프로락틴 수치 변화율과의 상관관계를 통계적으로 분석하였다. 결 과: 아미설프라이드를 투여한 모든 환자에서 고프로락틴혈증이 발생하였다. 아미설프라이드 투여 후의 프로락틴 수치는 투여 전 보다 유의하게 상승하였다(z=-3.702, p=0.000). 아미설프라이드 용량과 프로락틴 상승의 정도는 유의한 상관관계를 보였으나(r=0.61, p=0.002), 아미설프라이드 투여 기간과 프로락틴 상승의 정도는 유의한 상관관계를 보이지 않았다. 또한 아미설프라이드 용량과 프로락틴 수치 변화율은 유의한 상관관계를 보이지 않았다. 결 론: 아미설프라이드를 포함한 항정신병약물은 프로락틴 수치를 증가시켜 장 단기간의 부작용을 발생시킬 수 있다. 따라서 아미설프라이드를 사용하는 임상의는 프로락틴 수치를 정기적으로 측정하여야 하며 고프로락틴혈증과 관련된 부작용을 평가하여야 한다. Objective: Hyperprolactinemia is common side effect associated with antipsychotics use. Nevertheless, hyperprolactinemia is relatively neglected by clinician. Especially, there is no study related to amisulprideinduced hyperprolactinemia in korea. This study aimed to determine whether amisulpride can be induced hyperprolactinemia in Korean psychiatric patients. Methods: This study methodology consisted of a retrospective review of medical charts and prolactin levels. Serum prolactin levels were measured in 24 Korean patients(12 males and 12 females) with psychosis who were treated over 400mg of amisulpride per day. Results: All patients had hyperprolactinemia. Prolactin levels significantly increased after receiving amisulpride(z=-3.702, p=0.000). The prolactin level was significantly higher in females($156.29{\pm}63.75$ng/mL) than in males($69.04{\pm}39.91$ng/mL) after administering amisulpride(p=0.000). There was a correlation between dosage and prolactin levels(r=0.61, p=0.002). However, there was no correlation between duration of treatment and prolactin levels. Conclusions: Antipsychotics, especially amisulpride can increase serum prolactin levels and may results in short and long term side effects. Routine clinical assessment of initial and additional prolactin level and associated symptoms should be done

신경근전기자극에 의한 척수운동신경원의 흥분성 변화

이정우,김태열,이인학,이준희,Lee, Jeong-Woo,Kim, Tae-Youl,Lee, In-Hak,Lee, Joon-Hee 대한임상전기생리학회 2003 대한임상전기생리학회지 Vol.1 No.1

The purpose of this study was to determine the effect of neuromuscular electrical stimulation(NMES) on the alteration of spinal motor neuron excitability. In this article, I would like to experiment on a standard capacity of clinical electrophysiology, a difference in applying methods and a clinical efficiency of NMES by Nerve conduction velocity. We used normal eight subjects without neuromuscular disease and all subjects participated 3 session, which at least 1 week between session. Participants classified according to each group in Antagonist, Agonist, Antagonist-Agonist by the NMES. The test was measured continuously pre test, post-test, post 20 minute test by EMG including H reflex, F wave, motor nerve conduction velocity(MNCV). The following results were obtained; 1. H-reflex latencies and H/M intervals were significantly increased in agonist and antagonist-agonist group(p<.01). 2. H-reflex amplitudes and H/M ratios were significantly decreased in agonist and antagonist-agonist group(p<.01). In agonist group, H-reflex amplitudes and H/M ratios were more significantly decreased than antagonist group. 3. F-wave latencies were significantly increased in agonist and antagonist-agonist group(p<.01). F/M intervals were significantly increased in antagonist-agonist group(p<.01). F wave conduction velocities were significantly increased in agonist and antagonist-agonist group(p<.01) but F/M ratios were not significant. 4. MNCV were significantly decreased in agonist(p<.01). These results lead us to the conclusion that agonist and Antagonist-agonist was significantly decreased excitability of spinal motor neuron. Conversely, Antagonist does not decreased. Therefore, A further direction of this study will be to provide more evidence that NMES have an effect on excitability of spinal motor neurons in UMN syndrome.

집중호우로 인한 한강변 간선도로 침수 피해

이정우,이정은,이동섭,Lee, Jeong-U,Lee, Jeong-Eun,Lee, Dong-Seop 한국수자원학회 2011 물과 미래(한국수자원학회지) Vol.44 No.10

죽산천 주변 암반층 지하수 양수로 인한 하천수 감소 영향 분석

이정우,김남원,정일문,차준호,Lee, Jeongwoo,Kim, Nam Won,Chung, Il Moon,Cha, Joon Ho 한국수자원학회 2015 한국수자원학회논문집 Vol.48 No.9

본 연구에서는 죽산천 주변 지역에 대해 SWAT-MODFLOW 결합모형으로 암반층 지하수 양수에 따른 하천수 감소량을 모의하여 하천-관정 이격거리, 대수층 및 하천바닥층 수리특성 등과의 관계를 파악하고, 양수 위치에 따른 하천수 감소량을 공간적으로 표출하여 그 특징을 분석하였다. 양수정 위치에 따른 하천과의 이격거리, 투수량계수, 저류계수, 하천바닥층 수리전도성 등의 차이로 인해 지하수 양수량 대비 하천수 감소량 비율이 10~90%의 범위를 나타내었으며, 투수량계수가 $10m^2/day$ 보다 크거나 저류계수가 0.1보다 작은 경우 대부분 관정에서 하천수 감소율이 50%를 초과하는 것으로 분석되었다. 암반층에서 지하수를 양수할 경우 5년 동안 평균적으로 53.6%의 하천수 감소율을 나타내어 충적층 양수에 비해 12.9% 만큼 덜 감소하는 것으로 분석되었다. 또한 죽산천 중하류부에서 양수 영향이 비교적 크게 나타나는 것으로 분석되었다. The streamflow depletion due to groundwater pumping from deep aquifer near the Juksan stream has been simulated, in this study, by using the surface water and groundwater integrated model, SWAT-ODFLOW in order to analyze the relationship between the stream depletion and hydraulic properties of aquifer and streambed, and to spatially assess the streamflow depletion. The simulated results showed that the streamflow depletion rate divided by the pumping rate for each well location ranges from 10% to 90% with reflecting the various well-stream distance, transmissivity, storativity, and streambed hydraulic conductance. In particular, the streamflow depletion exceeds about 50% of pumping rate for conditions with transmissivity higher than $10m^2/day$ or storage coefficient lower than 0.1. The simulated results in the form of spatial maps indicated that the spatially averaged percent depletion of streamflow is about 53.6% for five years of pumping which is lower than that for shallow aquifer pumping by 12.9%. From the spatially distributed stream depletion, it was found that higher and more rapid stream depletion to pumping occurs near middle-downstream reach.

핀테크의 거시적 영향

이정우 ( Jung Woo¸ Lee ) 한국지급결제학회 2020 지급결제학회지 Vol.12 No.2

핀테크는 전통적 금융기관에 어떻게 변화를 가져올까? 세계적으로 핀테크가 확대하는 배경의 하나로서 ‘이용자의 가치관의 변용’을 지적할 수 있다. 현재 핀테크로서 제공되는 서비스의 대부분은 ‘이용자의 요청’으로 제공되어 널리 평가되고 있음을 알 수 있다. 미국 투자은행 골드만삭스에 따르면 향후 5-10년 후 미국 내 총 대출액 중 약 1/3에 해당하는 4조 달러가 대체금융서비스로 제공될 것으로 내다 봤다. 융자 분야에서는 결제 트랜잭션 데이터를 이용한 융자 서비스 이외에도 새로운 서비스가 등장하고 있다. 마켓플레이스 렌딩 크라우드 펀딩(Crowd funding)으로 불리는 핀테크 서비스는 전통적인 금융기관이 제공하는 융자 서비스와 다른 형태로 융자를 해주는 서비스로 주목받고 있다. 일찍이 P2P 렌딩이라고도 불린 이러한 서비스는, 대체로 인터넷을 통해서 투자가·대여자와 차주를 연결시켜(매칭), 불특정 다수로부터 비교적 소액으로 자금을 모으는 것이다. 본고는 우선 우리나라의 핀테크 관련 투자가 위와 같은 외국과 비교해 극단적으로 낮다는 점과 사업투자 펀드와 같은 우리나라에 특유한 신규사업에 대한 투자확대의 가능성을 설명한다. 다음은 금융경제 교육의 필요성과 현황에 대해 밝힐 것이다. 마지막으로 핀테크가 각 경제주체에 미치는 영향을 이론적으로 분석하여 거시경제에 미치는 영향에 대해서는 핀테크의 플러스 효과와 마이너스 효과가 있음을 밝히고 그 파급경로를 설명한다. How will FinTech change traditional financial institutions? As one of the backgrounds that FinTech is expanding globally, it can be pointed out ‘change of users’ values.’ It can be seen that most of the services currently provided as FinTech are provided as ‘requests of users’ and are widely evaluated. According to Goldman Sachs, an investment bank in the United States, in the next 5 to 10 years, about a third of the total amount of loans in the United States, or $4 trillion, will be provided as alternative financial services. In the field of financing, new services are emerging in addition to financing services using payment transaction data. Fintech service, called marketplace lending crowd funding, is attracting attention as a service that provides loans in a different form than those provided by traditional financial institutions. These services, also known as peer-to-peer lending, usually connect investors, lenders and borrowers through the Internet (matching), and collect funds in relatively small amounts from an unspecified majority. First of all, this paper explains that Korea’s FinTech-related investment is extremely low compared to those of foreign countries, and the possibility of expanding investment in new businesses unique to Korea such as a business investment fund. The following will reveal the necessity and status of financial economy education. Finally, the effect of FinTech on each economic entity is theoretically analyzed, revealing the positive and negative effects of FinTech on the macroeconomic impact, and explaining its ripple path.

원적외선의 평가기술과 시장동향

이정우,Lee, Jeong-U (사)한국원적외선협회 2001 한국원적외선협회보 Vol.10 No.-

세기변조방사선치료 선량분포 확인을 위한 2차원적 이온전리함 배열의 특성분석

이정우,홍세미,김연래,최경식,정진범,이두현,서태석,Lee, Jeong-Woo,Hong, Se-Mie,Kim, Yon-Lae,Choi, Kyoung-Sik,Jung, Jin-Beom,Lee, Doo-Hyun,Suh, Tae-Suk 한국의학물리학회 2006 의학물리 Vol.17 No.3

본 연구의 목적은 2차원적 이온전리함 배열의 특성을 분석하고 세기변조방사선치료 선량분포 확인의 유용성을 평가하기 위함이다. 본 실험에 사용된 2차원적 이온전리함 배열(MatriXX, Scanditronix-Wellhofer, IBA, Germany)은 $24{\times}24cm^2$ 범위에 1,024개의 평판형 전리함(용적: $0.08cm^3$, 직경: 4.5 mm, 높이: 5 mm, 배열간격: 7.62 mm)이 일정한 간격으로 배열되어있다. MatriXX의 특성분석을 위해 선량 직선성, 선량률 의존도, 출력 계수, 단기 선릉재현성을 분석하였으며, 선량분포 확인의 신뢰도를 평가하기 위해 Varian사의 동적쐐기와 세기변조 방사선치료의 선량분포를 분석하였다. 선량 직선성의 범위는 $1{\sim}800$cGy이었으며, 1% 미만의 오차율을 보였다. 선량률 의존성(범위 $100{\sim}600MU/min$)은 300 Mu/min을 기준으로 했을 때 모든 선량률 범위에서 0.4% 미만의 선량변화를 보였다. 또한, 물팬톰에서 0.1 cc 지두형 전리함으로 측정한 출력계수와 폴리스틸렌 팬톰에서 MatriXX로 측정한 출력계수를 비교하였다. 이 실험의 결과, $3{\times}3{\sim}24{\times}24cm^2$ 범위에서 0.5% 미만의 일치를 나타내었다. 단기 출력재현성 확인을 위하여 15분 간격으로 6회 측정한 결과, 0.5% 내의 차이를 보였다. 동적쐐기와 세기변조 방사선 조사면의 일치성 실험에서도 치료계획장치의 계산값과 필름측정값이 비교적 잘 일치함을 알 수 있었다. 본 연구를 통해 MatriXX의 물리적인 특성을 분석하였으며 세기변조방사선치료의 품질관리를 위한 유용성을 확인하였다. A commercial ion chamber matrix was examined the characteristics and its performance for radiotherapy qualify assurance. The device was the I'mRT 2D-MatriXX (Scanditronix-Wellhofer, Schwarzenbruck, Germany). The 2D-MatriXX device consists of a 1020 vented ion chamber array, arranged in $24{\times}24cm^2$ matrix. Each ion chamber has a volume of $0.08cm^3$, spacing of 0.762 cm and minimum sampling time of 20 ms. For the investigation of the characteristics, dose linearity, output factor, short-term reproducibility and dose rate dependency were tested. In the testing of dose linearity. It has shown a good signal linearity within 1% in the range of $1{\sim}800$cGy. Dose rate dependency was found to be lower than 0.4% (Range: 100-600 Mu/min) relative to a dose rate of 300 Mu/min as a reference. Output factors matched very well within 0.5% compared with commissioned beam data using a ionization chamber (CC01, Scanditronix-Wellhofer, Schwarzenbruck, Germany) in the range of field sizes $3{\times}3{\sim}24{\times}24cm^2$. Short-term reproducibility (6 times with a interval of 15 minute) was also shown a good agreement within 0.5%, when the temperature and the pressure were corrected by each time of measurement. in addition, we compared enhanced dynamic wedge (EDW, Varian, Palo Alto, USA) profiles from calculated values in the radiation planning system with those from measurements of the MatriXX. Furthermore, anon-uniform IMRT dose fluence was tested. All the comparison studies have shown good agreements. In this study, the MatriXX was evaluated as a reliable dosimeter, and it could be used as a simplistic and convenient tool for radiotherapy qualify assurance.

메타카올린 및 실리카퓸 첨가율에 따른 구조용 PVA 섬유와 시멘트 복합재료의 부착특성

이정우,박찬기,Lee, Jung-Woo,Park, Chan-Gi 한국농공학회 2012 한국농공학회논문집 Vol.54 No.5

In this study, the effect of metakaoline and silica fume on the bond performances of structural polyvinyl alcohol (PVA) fiber in cement mortar, including bond strength, interface toughness, and microstructure analysis are presented. Metakaoline and silica fume contents ranging from 0 % to 15 % are used in the mix proportions. Pullout tests are conducted to measure the bond performance of PVA fiber from cement mortar. Test results showed the incorporation of metakaoline and silica fume can effectively enhance the PVA fiber-cement mortar interfacial properties. Bond strength and interface toughness increased with metakaoline and silica fume content up to 10 % in cement mortar and decreased when the metakaoline and silica fume content reached 15 %. The microstructural observation confirms the findings on the interface bond mechanism drawn from the fiber pullout test results.

Effects of Cranial Electrotherapy Stimulation on Electrocephalogram

이정우,Hyejein Lee,박웅식 국제물리치료연구학회 2019 Journal of International Academy of Physical Ther Vol.10 No.1

Background: Although cranial electrotherapy stimulation (CES) is reported to have positive effects on mental functions such as depression and sleep improvement, detailed studies regarding awakening, attention and concentration among brain waves reflecting brain activity are lacking. Objective: To examine the effects of cranial electrotherapy stimulation (CES) on various electroencephalograms (EEGs) reflecting brain activities. Design: Randomized controlled clinical trial (single blind) Methods: This study selected 30 healthy adult women in their 20s who volunteered for this experiment. A total of 30 subjects were randomly assigned to three groups (Sham group, 0.5 Hz CES group, and 100 Hz CES group). EEGs were measured before and after the single CES, and the results were compared and analyzed. Results: The relative theta, alpha, and gamma waves indicated no significant differences in the interaction effects between time and group. The relative fast alpha wave only showed significant differences in the interaction effects between time and group in P4. The relative slow beta wave only indicated statistically significant differences in the interaction effects between time and group in T3 and T4. The relative mid and fast beta waves showed statistically significant differences in the interaction effects between time and group in all areas. Conclusions: These results suggest that a CES of 0.5 Hz awakens consciousness and has a positive influence on brain activity, while a CES of 100 Hz has a positive influence on thinking activity accompanying mental load during concentrating on one subject. Key words: Cranial electrotherapy stimulation

소아에서 수술 후 발생한 장폐색에 대한 복강경 유착박리술의 초기 경험

이정우,정은영,박우현,최순옥,Lee, Jeongwoo,Jung, Eunyoung,Park, Woo-Hyun,Choi, Soon-Ok 대한소아외과학회 2013 소아외과 Vol.19 No.1

The purpose of this study is to analyze the early experience of the laparoscopic adhesiolysis for the intestinal obstruction due to postoperative adhesion. Seven patients were included in this study. The median age of those patients was 13, and there were 3 males and 4 females. Previous diagnosis and surgical procedure were various in seven cases, including small bowel resection with tapering enteroplasty, Boix-Ochoa fundoplication, Ladd's procedure with appendectomy, mesenteric tumor resection with small bowel anastomosis, ileocecal resection and anastomosis, primary gastric repair, and both high ligation. A successful laparoscopic adhesiolysis was performed in one who had high ligation for inguinal hernia and had a single band adhesion. Six out of 7 (86%) cases needed to convert open surgery due to multiple and dense type of adhesion. In conclusion, laparoscopic approach with postoperative small bowel adhesion seems safe. However, it might be prudently considered because of high rates of conversion in children.