열, 살균소독제, 항생제에 의한 분리 Cronobacter spp. (Enterobacter sakazakii) 제어

이은진,박종현,Lee, Eun-Jin,Park, Jong-Hyun 한국축산식품학회 2010 한국축산식품학회지 Vol.30 No.3

Tolerance against heat, sanitizers, and antibiotics of 112 Cronobacter isolates classified by desiccation was determined to permit effective biocontrol in powdered foods. The isolates were classified into three groups: dry-tolerant (n=37), dry-sensitive (n=7), and dry-intermediate (n=68). The strains that were highly tolerant to drying also showed high heat tolerance that they seemed to have high tolerance to heat after dry stress in powdered foods like infant formula. Sodium hypochlorite and benzalkonium chloride concentrations necessary to achieve a 5-log reduction in viable counts (CFU/mL) were 15-25 ppm and 5-15 ppm, respectively. However, there was little difference of the efficacy of these sanitizers between dry-sensitive and -tolerant strains for planktonic cells suspended in 3% albumin. The minimal inhibition concentration (MIC) of $\beta$-lactam ampicillin was 64-128 ppm for 90% of the strains. The isolates were consistently sensitive to kanamycin and naldixic acid (MIC=4 ppm). Dry-tolerant strains displayed more antibiotic resistance than dry-sensitive strains. The results indicate that dry-tolerant Cronobacter isolates often possess heat and antibiotic resistance, indicated the need for potent sterilization treatments of powdered foods.

고 안정성 전구체를 사용한 InP/ZnS 반도체 나노입자 합성 및 발광 특성 향상

이은진,문종우,김양도,신평우,김영국,Lee, Eun-Jin,Moon, Jong-Woo,Kim, Yang-Do,Shin, Pyung-Woo,Kim, Young-Kuk 한국분말야금학회 2015 한국분말재료학회지 (KPMI) Vol.22 No.6

We report a synthesis of non-toxic InP nanocrystals using non-pyrolytic precursors instead of pyrolytic and unstable tris(trimethylsilyl)phosphine, a popular precursor for synthesis of InP nanocrystals. In this study, InP nanocrystals are successfully synthesized using hexaethyl phosphorous triamide (HPT) and the synthesized InP nanocrystals showed a broad and weak photoluminescence (PL) spectrum. As synthesized InP nanocrystals are subjected to further surface modification process to enhance their stability and photoluminescence. Surface modification of InP nanocrystals is done at $230^{\circ}C$ using 1-dodecanethiol, zinc acetate and fatty acid as sources of ZnS shell. After surface modification, the synthesized InP/ZnS nanocrystals show intense PL spectra centered at the emission wavelength 612 nm through 633 nm. The synthesized InP/ZnS core/shell structure is confirmed with X-ray diffraction (XRD) and Inductively Coupled Plasma - Atomic Emission Spectrometer (ICP-AES). After surface modification, InP/ZnS nanocrystals having narrow particle size distribution are observed by Field Emission Transmission Electron Microscope (FE-TEM). In contrast to uncapped InP nanocrystals, InP/ZnS nanocrystals treated with a newly developed surface modified procedure show highly enhanced PL spectra with quantum yield of 47%.

L - 아르기닌이 오메프라졸의 안정성에 미치는 효과

이은진,한경두,신희종,김정우,김종국 ( Eun Jin Lee,Kyung Doo Han,Hee Jong Shin,Jung Woo Kim,Chong Kook Kim ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.1

N/A To investigate the effect of L-arginine as stabilizing agent for omeprazole, the degradation rate constant of omeprazole in aqueous solution was determined at 30, 40 and 50℃ with various ratios of L-arginine to omeprazole. The pH of omeprazole solutions was also determined. As the amount of L-arginine increased, the pH of omeprazole solution also increased, and the solution appeared to be more stable. The omeprazole in aqueous solution could be stabilized by more than 15:1 molar ratio of L-arginine to omeprazole. The stability of omeprazole in commercial products using L-arginine or sodium phosphate dibasic as stabilizing agent was investigated. Among the commercial products, the omeprazole product prepared with L-arginine (molar ratio of L-arginine to omeprazole, 20:1) was most stable.

자존 없는 경쟁

이은진,Lee, Eun-Jin 한국대학교육협의회 1995 大學敎育 Vol.78 No.-

미국 군수산업의 구조전환

이은진,Lee, Eun-Jin 한국방위산업진흥회 1996 國防과 技術 Vol.- No.205

두경부 편평상피세포암의 p53단백과 PCNA 및 Ki-67의 발현양상

이은진,이상한,손윤경,Lee, Eun-Jin,Lee, Sang-Han,Sohn, Yoon-Kyung 대한구강악안면외과학회 2001 대한구강악안면외과학회지 Vol.27 No.2

To investigate the correlation between the clinical features and the expression of p53, PCNA, and Ki-67 of the head neck squamous cell carcinoma, immunohistochemicalstaining of p53, PCNA, and Ki-67 on the paraffin embedded tissue blocks of 116 surgically removed specimens were done. The staining intensity was divided as grade 1 to grade 3 and the results were statistically analysed. 1. The positive reation rates of cell proliferation markers (PCNA and Ki-67) were higher than that of p53. There was significant correlations of the PCNA and Ki-67 expression but there was no significant correlations between p53 and PCNA or p53 and Ki-67. 2. There were no significant correlation between the expression of p53, PCNA and Ki-67 and tumor site or tumor size. 3. There was no significant differences in the positive response according to the nodal status. The node metastasis groups revealed that higher proportion of grade 3 staining of PCNA and Ki-67 than node negative group. From the above results it is concluded that p53 and cell proliferation markers PCNA and Ki-67 might have their unique mechanism involving in the growing and progression of tumor. Overexpression of p53 does not appear to represent an independent prognostic marker in head neck squamous cell carcinoma.

Clinical Characteristics of Patients with Taste Disorders

이은진,박원규,남진우,윤종일,고홍섭,Lee, Eun-Jin,Park, Won-Kyu,Nam, Jin-Woo,Yun, Jong-Il,Kho, Hong-Seop Korean Academy of Orofacial Pain and Oral Medicine 2009 Journal of Oral Medicine and Pain Vol.34 No.4

There is tremendous variability in the ways patients present with taste problems. Because of complex and multifactorial etiological background, it is not simple to evaluate patients with taste disorders. Accurate assessment of patients' status by prudent, thorough history taking and symptom analysis is the most essential for exact diagnosis of taste disorders. The aim of this study was to investigate the clinical characteristics of patients with taste problems as a primary complaint. Consecutive series of 50 patients (12 males and 38 females, mean age $53.6\;{\pm}\;14.7$ years) were included for the present study. All subjects were requested to complete a comprehensive questionnaire. Clinical evaluation procedures included oral examination, interview, questionnaire analysis, panoramic radiography, blood test and measurement of salivary flow rate. The obtained results were as follows: 1. Among the patients, 36 patients (72%) complained of oral mucosal pain or burning sensation. Of these patients, 18 patients (36%) were diagnosed as burning mouth syndrome. 2. Nineteen patients (38%) complained of subjective oral dryness. The flow rate of unstimulated whole saliva was less than 0.1 mL/min in 14 patients (28%) and 17 (34%) had a stimulated whole salivary flow rate of less than 0.5 mL/min. 3. Among the types of taste disorders, hypogeusia, the most frequently reported, was found in 25 patients (50%), dysgeusia in 18 patients (36%), phantogeusia in 15 patients (30%), hypergeusia in 10 patients (20%), and ageusia in 5 patients (10%). Nineteen patients (38%) reported more than one type of taste disorder and the most frequent combination was dysgeusia + hypogeusia (n=6, 12%). 4. Based on data from the medical and dental histories and examinations, the patients were assigned to 12 probable causal categories. Taste disorders due to oral mucosal diseases and idiopathic taste disorder were the most frequent (n=9; 18%, each), followed by psychogenic taste disorder (n=8; 16%), drug-induced taste disorder (n=7; 14%), and taste disorder due to dry mouth (n=6; 12%). These 5 categories of taste disorder accounted for 78% of all cases in this study.

소아에 발생한 삼일열 말라리아의 임상적 특성

이은진,이종국,조종래,Lee, Eun Jin,Lee, Chong Guk,Cho, Chong Rae 대한소아감염학회 2003 Pediatric Infection and Vaccine Vol.10 No.2

목 적 : 말라리아는 국내에서 1970년대 말에 소멸된 것으로 알려져 있었으나, 1993년 비무장지대에 근무하던 군인에서 첫 환자가 발생한 이후, 지속적으로 증가되어 2000년에는 4,142명, 2001년에는 2,556명, 2002년에는 1,797명의 말라리아 환자가 보고되었다. 1999년부터는 민간인의 비율이 점차 증가되고 있고, 토착형 말라리아 환자가 늘어남에 따라 국내에 존재하는 매개숙주(중국 얼룩날개 모기)에 의해 주민간에 전파될 가능성도 높아진다. 저자들은 말초혈액 도말 검사 및 말라리아 항체 검사에서 말라리아로 확진된 소아 환자 13명을 조사하여 역학적 분석 및 임상적 특성을 알아보고자 하였다. 방 법 : 2000년 1월부터 2003년 8월까지 일산백병원에 내원한 소아 환자 중 말초혈액 도말 검사 및 말라리아 항체 검사로 확진된 15세 이하의 소아 환자 13명에 대하여 의무기록을 후향적으로 조사하였다. 결 과 : 13례 모두 토착형 말라리아 감염이었고, 원인 원충은 삼일열 말라리아(Plasmodium vivax)였다. 13례 중 남아와 여아의 비율은 9 : 4이었고, 발병 당시 평균 연령은 $9.5{\pm}3.6$세였다. 지역별로는 13례 중 9례가 일산 시내였으며, 11례의 발병 시기가 6~8월로 여름에 주로 발생했다. 13례 중 2례만이 3일 주기의 발작적인 발열을 보였고 나머지 11례는 지속적인 발열 및 불규칙한 발열 양상을 보였다. 혈소판 감소증은 가장 두드러진 소견으로 13례 중 12례에서 동반되었으며, 3례에서는 범혈구 감소증을 보였다. 신생아를 제외한 12례에서 hydroxychloroquine과 primaquine을 투약했고, 이후 시행한 혈액 도말 검사상 더 이상의 원충은 발견되지 않았고 혈액학적 이상 소견 역시 호전되었다. 결 론 : 저자들이 경험한 소아 말라리아 환아는 모두 Plasmodium vivax에 의해 발병되고 일부 환아는 유행외 지역에서 발병된 것으로 보아 이 원충에 의한 토착화의 확산을 추정할 수 있었다. 또한 전형적 삼일열 말라리아의 발열 양상이 없다하여도 혈소판 감소증 소견이 동반된 발열 환아에서 이 질환을 의심하여야 하며 말라리아 항체 검사가 선별 검사로 유용한 것으로 추정된다. Purpose : Malaria is known to have been eradicated for a few decades through persistent national health program in South Korea. However, malaria caused by Plasmodium vivax has started to reappear incidiously among military personnel near to DMZ since 1993. After then, the number of malarial cases have been increased abruptly year by year. We analyzed the children of indigenous malaria who were diagnosed by peripheral blood smear and malarial antibody test with regards to epidemiologic and clinical manifestations. Methods : The study 13 cases below 15 years of age, who were confirmed as vivax malaria during from January 2000 to August 2003. We retrospectively analyzed epidemiologic data, clinical manifestations, laboratory findings and therapeutic responses. Results : All of 13 cases were indigenous and tested positive for Plasmodium vivax. Of 13 patients, 9 were male and 4 were female. Mean age of onset was $9.5{\pm}3.6$ years old. Ilsan(n=9) was the most prevalent area, the most patients(n=11) were presented in summer (from June to August). A characteristic feature of periodic 3 day fever in patients with P.vivax infection was reported in only 2 among 13 cases. Thrombocytopenia was most prominent findings, which was accompanied by 12 of 13 patients and pancytopenia was appeared in 3 patients on this study. The therapeutic responses of hydroxycholoquine were very good in all cases, and abnormal laboratory findings were recovered and no relapse during follow-up period. Conclusion : Vivax malaria is indigenous in Korea near to DMZ, but recently endemic area seemed to be extended southward. Plasmodium vivax is the cause of indigenous malaria of children. As for children with high fever accompanying thrombocytopenia in endemic area of Korea, malaria must be included in differential diagnosis whether the type of fewer is periodic 3 day fever or not. Malaria antibody test is helpful as a screening test for malaria.

쟁점으로 읽는 '97년의 지성사-사회학

이은진,Lee, Eun-Jin 대한출판문화협회 1997 출판저널 Vol.226 No.-

현실문제에 고민하는 이들은 사회학이 현실을 이해하는 데 도움을 주길 원한다. 이런 고민은 정보사회에 대한 낙관적 흐름과 생태학적 위험, 경제적 위기에 대한 비관적 흐름에 관심을 갖게 한다.

21세기에도 빛날 20세기 고전(3)-한국 사회과학편

이은진,Lee, Eun-Jin 대한출판문화협회 1999 출판저널 Vol.253 No.-

한국 사회과학이 근대적 학문으로 정립된 역사는 일천하다. 여기서 일천하다는 것은 그 역사가 짧다는 뜻이 아니라 학문이 발전될 수 있는 사회적 조건이 덜 성숙돼 있었다는 의미다. 지식인 사회가 서구 중심의 시각으로 무장하고 있는 상황, 한국의 경험적인 연구를 가능케 하는 자료의 부족, 한국인의 주체적인 문제의식의 방황(지식인 사회에서의 자기 문제에 대한 평가 부족), 연구방법에서 지나친 서구 의존은 바로 사회과학이 발전하기 어려운 상황을 증명한다. 그럼에도 불구하고 지식인 100명이, 한국인이 저술하고 한국을 연구대상으로 삼은 책을 8권 선정한 것은 이러한 사회적 조건 아래에서도 문제의식.자료.연구방법의 측면에서 높은 수준을 보여줬다는 점을 평가했을 것으로 추측된다.