체외수정 과배란 유도에서 hCG 주사 당일의 혈청 Progesterone과 Estradiol 농도가 수정율 및 임신율에 미치는 영향에 관한 연구

이은숙,이상훈,배도환,Lee, Eun-Sook,Lee, Sang-Hoon,Bae, Do-Hwan 대한생식의학회 1996 Clinical and Experimental Reproductive Medicine Vol.23 No.1

체외수정 시술을 위해 중앙대학교부속병원 산부인과학 교실 불임크리닉을 방문한 환자중 1993년 3월부터 1994년 8월까지 난관폐쇄로 인하여 불임이 된 환자 113명(119주기)을 대상으로 GnRH-a 병합요법 중 Short protocol 방법으로 과배란시 임신된 45명(47주기)과 임신이 되지 않은 68명(72주기)에서 hCG 투여 당일 혈청내 E2 및 P4 수치를 측정하여 임신의 결과를 비교하였다. 1. 환자의 평균 연령 및 불임기간은 임신군에서 $33.2{\pm}14.8$세 및 $4.2{\pm}3.4$년이었으며 비 임신군에서는 $34.5{\pm}21.7$세 및 $3.9{\pm}2.8$년으로 연령 및 불임기간의 차이는 없었다. 2. hGC 투여 당일 측정한 혈중 E2치는 임신군에서는 $1643{\pm}987.9$ pg/ml, 비임신군에서는 $1367{\pm}875.8$ pg/ml로 임신군에서 유의하게 높았다(P<0.01). 또한 혈중 LH치는 인신군 에서는 $16.7{\pm}10.4$ ng/ml, 비임신군에서는 $18.3{\pm}8.3$ ng/ml로 임신군에서 유의하게 낮았다 (P<0.01). 혈중 P4치는 임신군에서는 $1.0{\pm}0.7$ ng/ml이었고 비임신군에 서는 $2.1{\pm}1.4$ ng/ml로서 임신군에서 유의하게 낮았다(P<0.001). 3. hCG 투여당일 E2/P4 비는 임신군에서 $1865.6{\pm}318.1$, 비임신군에서는 $1324{\pm}377.7$ 로서 유의한 차이가 있었다(P<0.01)(Table 3). 4. 주기당 수정율은 임신군에서 $61.3{\pm}21.3%$, 비임신군에서는 $41.1{\pm}20.3%$로 임신군에서 의미있게 높았고(P<0.01) 이식된 배아의 수는 임신군 47주기에서 $4.2{\pm}2.2$개, 비임신군 72주기에서는 $2.3{\pm}1.2$개로 두 군간의 차이는 없었다(Table 4). 이상에서 임신이 된 군은 임신이 안된 군보다 혈중 progesterone 치가 의미있게 낮았고 혈중 estradiol 치는 의미있게 높았음을 알 수 있었다. 혈중 progesterone 및 estradiol치는 과배란 유도 후 체외수정시술에 있어서 수정율 및 임신율에 영향을 줄 수 있다고 생각되며 이는 체외수정시술시 과배란후 임신의 예후판정에 효용성이 있을것으로 사료된다. Controlled Ovarian hyperstimulation(COH) is generally used to obtain synchronous high quality oocytes in in vitro fertilization-embryo transfer(IVF-ET). Many investigators have studied the relationship between serum hormone levels and outcomes of IVF-ET because there is no accurate estimation method of oocyte quality. Early premature luteinization of follicles before oocyte retrieval is the most troublesome problem in COH for IVF-ET. Gonadotropin-releasing hormone agonists(GnRH-a) are used as adjuncts with gonadotropins for COH in patients undergoing in IVF. The possible benefits of GnRH-a pretreatment include improving oocyte quality, allowing a more synchronous cohort of follicles to be recruited, and preventing premature lueinization hormone surges. In COH of IVF cycles, we investigated whether an elevated progesterone(P4) level on the day of human chorionic gonadotropin(hCG) administration indicates premature luteinization and is associated with a lower fertilization rate. Many investigators have studied that the lower fertilization rates seen in patients with elevated P4 levels might result from an adverse effect of P4 on the oocytes. We hypothesizes that serum P4 levels around the day of hCG may be helpful prediction of out come in IVF-ET cycles. Success rates after COH of IVF-ET cycles are dependent upon many variable factors. Follicular factors including the number of follicles, follicular diameters and especially serum estradiol(E2) levels as an indirect measurement of follicular function and guality have been thought to influence the outcomes of IVF-ET. To assess whether serum P4 and E2 levels affect the fertilization and pregnancy rate, we reviewed the stimulation cycles of 113 patients (119 cycles) undergoing IVF-ET with short protocol with GnRH-a, from March 1993 to August 1994 retrospectively. The serum P4 and E2 levels were compared on the day of hCG in the pregnant group, 45 patients(47 cycles) and in the non-pregnant group, 68 patients (72 cycles) respectively. The serum E2 level in non-pregnant group was $1367{\pm}875.8$ pg/ml which was significantly lower than that of pregnant group, $1643{\pm}987.9$ pg/ml( p< 0.01 ). And the serum P4 level in non-pregnant group was $2.1{\pm}1.4$ ng/ml which was significantly higher than that of pregnant group, $1.0{\pm}0.7$ ng/ml( p< 0.001 ). The fertilization rate was $61.3{\pm}21.3%$ in pregnant group which was higher than that of non-pregnant group, $41.1{\pm}20.2%$ (p< 0.01). We suggest that the serum levels of P4 and E2 on the day of hCG administration are additional parameters that predict the outcomes of IVF-ET cycles.

국민학생의 현존 치아우식 및 구강 환경상태와 Snyder검사 결과간의 상관관계에 관한 연구

이은숙,이백현,신승철 ( Eun Sook Lee,Baik Hyun Lee,Seung Chul Shin ) 대한예방치과·구강보건학회 1992 大韓口腔保健學會誌 Vol.16 No.2

학교보건의 발전을 바람

이은숙,Lee, Eun-Suk 한국학교보건협회 1978 학교보건 Vol.6 No.-

일도시 기혼 직장여성의 피로도 및 역할에 관한 조사

이은숙,Lee, Eun-Suk 한국지역사회간호학회 1990 지역사회간호학회지 Vol.2 No.1

간호대학생의 셀프리더십, 학업적 자기효능감 및 교수-학생 상호작용이 자기주도학습에 미치는 영향

이은숙,봉은주,Lee, Eun Sook,Bong, Eun Ju 경희대학교 동서간호학연구소 2017 동서간호학연구지 Vol.23 No.2

Purpose: The purpose of this study is to investigate the influencing factors of self-leadership, academic self-efficacy and instructor-student interaction on self-directed learning in nursing college students. Methods: This study used a descriptive survey design. Participants were 190 nursing college students at three universities in Jeollanam-do and Gyeongsangnam-do. Data were collected from May 10 to June 12, 2016 using self-report questionnaires. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson correlation coefficient, and multiple regression with SPSS 19.0. Results: The results showed that the self-leadership of the nursing students was 3.49, academic self-efficacy, 3.17, instructor-student interaction, 3.71, and self-directed learning, 3.43, respectively. Self-directed learning of nursing college students was positively associated with self-leadership(r=.65, p<.001), academic self-efficacy(r=.61, p<.001) and instructor-student interaction (r=.36, p<.001). 001). Self-leadership, academic self - efficacy, major satisfaction, GPA 4.0 or above explained 65% of the total variance in self-directed learning among nursing college students. Conclusions: The findings of this study indicated that nursing interventions for increasing self-leadership, academic self-efficacy and major satisfaction should be developed to improve self-directed learning of nursing students. Additional studies for changes in the overall teaching and learning environment to promote the self-directed learning environment in nursing education should be conducted.

도시재정비 촉진 특별법이 주택시장에 미치는 영향

이은숙,Lee, Eun-Suk 한국주택협회 2006 주택과 사람들 Vol.190 No.-

지난 2월 21일, 파크하얏트에서 경원대학교 도시계획학과 박환용 교수의 특강이 있었다. 이날 특강은 오는 7월 시행을 앞두고 있는 도시재정 비촉진특별법에 대한 주요 내용과 이 법과 관련해 미리 숙지해두어야 할 점 등을 짚어보는 시간이었다.

논문편 : 소비자의 자아조정 수준에 따른 상황별 의복행동 연구

이은숙,박재옥 ( Eun Sook Lee,Jae Ok Park ) 대한가정학회 1997 Family and Environment Research Vol.35 No.6

냉해동 처리에 따른 오미자 담금주의 추출 특성

이은숙,지윤정,이승은,김형돈,최재훈,강민혜,김금숙,최수지,장귀영,Lee, Eun Suk,Jee, Yun-jeong,Lee, Seung Eun,Kim, Hyung Don,Choi, Jehun,Kang, Min Hye,Kim, Geum Soog,Choi, Su Ji,Jang, Gwi Yeong 한국식품영양학회 2021 韓國食品營養學會誌 Vol.34 No.3

Fresh Omija (Schisandra chinensis) has good marketability, but its quality is difficult to maintain during storage and distribution. Freezing and freeze-thawing treatments can be utilized for the quality maintenance and processing of cold press juice. In this study, the color, antioxidant properties, and the major components of soaked liquor from Omija with freeze-thawing treatment were analyzed during the extraction periods. Each of the frozen and freeze-thawed Omija samples was soaked in 35% ethanol, extracted for 15 days, and used for analysis. The frozen and freeze-thawed samples showed a tendency toward better color and higher antioxidant activity and major component levels than the controls, and freeze-thawing was the best. The results of this study showed that freeze-thawing treatment improved the color, antioxidant properties, and level of the major components of Omija soaked liquor, and freeze storage is suitable for making soaked liquor.

상악동 병변의 인지시 파노라마 방사선사진의 유용성

이은숙,박창서,Lee Eun-Sook,Park Chang-Seo 대한영상치의학회 1999 Imaging Science in Dentistry Vol.29 No.1

Purpose: to evaluate the usefulness of the panoramic radiography, generally used in dental clinic, for the detection of the maxillary sinus pathosis due to the inflammation and tumor, through the comparison with CT findings as the absolute standard. Materials & Methods: 150 maxillary sinuses of 75 patients with or without particular signs and symptoms and showing soft tissue lesions or destruction of maxillary sinus walls in at least one sinus in CT, were selected as subject samples, and the panoramic radiography of the same patients were interpretated by 3 dental radiologists and 3 non dental radiologist given no previous informations. Using the CT findings as the absolute standard, the diagnostic ability of panoraimc radiography in the mucosal thickening, maxillary sinus haziness, inferior wall destruction, medial wall destruction, posterolateral wall destruction and the superior wall destruction was evaluated using the ROC curve and the difference between dental radiologist group and non dental radiologist group was also evaluated. Results: 1. When dental radiologist group interpretated the destruction of inferior wall and posterolateral wall, the kappa value which shows interobserver's coincidence was above 0.75. 2. The diagnostic ability according to site of interpretation was the highest when the inferior wall was interpretated in both observer groups and there was a statistically significant difference between the dental radiologist group and non dental radiologist group in interpretating the mucosal thickening, haziness, destruction of the inferior and medial wall(p<0.05). 3. The diagnostic ability in detecting the destruction of the sinus walls was better than in soft tissue lesions in both groups and between the groups there was a statistically significant difference(p<0.05). Conclusion: When detecting the destruction of inferior and posterolateral wall of the maxillary sinus there was coincident with that of CT findings, and so it is considered that diagnostic ability of panoramic radiography is high in this point. But in interpretating the destruction of medial wall and soft tissue lesions, diagnostic ability of the panoramic radiography was relatively low and there was a significant difference between the dental radiologist group and non dental radiologist group. Therefore CT or other auxiliary diagnostic method will be necessary when evaluating thorough pathosis of maxillary sinus objectively.

기묘한 매력이 있는 나라, 터키

이은숙,Lee, Eun-Suk 한국주택협회 2006 주택과 사람들 Vol.193 No.-

터키의 매력은 소소한 일상이 드러나는 도시의 뒷골목에 있다. 나라 전체가 하나의 역사 박물관이라고 해도 손색없는 터키. 거리 곳곳에 숨어 있는 기독교 문화유산과 이슬람 문화유산을 번갈아 바라보면 저절로 묘한 매력에 빠지게 된다.