(A)study on the fluctuation and elasticity of network polymers : constrained Gaussian chain model

이윤석 Pohang Institute of Science and Technology 1995 국내석사

복합운동 형태에 따른 비만 여대생의 신체둘레 변화와 대사호르몬에 미치는 영향

이윤석 강원대학교 교육대학원 2008 국내석사

The purpose of this study was to find out the effects of different combinations of exercises on changes in body circumference and leptin levels by testing 13 obese female college students with over 30% of body fat rate for 8 weeks. The 13 experimental subjects were divided into two groups, A(40 minutes of aerobic exercise and 20 minutes of anaerobic exercise) and B(20 minutes of aerobic exercise and 40 minutes of anaerobic exercise), each consisting of 6 and 7 subjects, respectively. The aerobic exercise was specified by walking on the treadmill with the HRmax intensity of 70%, while the anaerobic exercise was conducted by nine types of resistive exercises each repeated 15~20 times with a 1RM intensity of 60~65%. As a result, subjects in group A showed decrease in circumferences of chest, arm, waist, and hip but not a statistically significant difference. The thigh circumference, however showed a decrease of 8.60% and was significantly different (p<.001). In the case of group B, the decrease in all parts of the body with the exception of chest circumference was significantly different: there was a 7.52% decrease in arm circumference (p<.01), 3.37% decrease in waist (p<.01), 1.75% decrease in hip (p<.05), and 10.51% decrease in thigh circumference (p<.001). Also, the 9.95% reduction of the subcutaneous fat in the sub scapula showed a statistically significant difference (p<.05). However, the difference in the change of body size between the two groups failed to show statistically significant difference. In the other hand, the difference in the change of leptin levels between the two groups was shown a statistically significant difference due to a 49.96% decrease in group B (p<.05). 본 연구는 체지방률 30%이상인 비만 여대생 13명을 대상으로 A그룹 6명(유산소운동 40분, 무산소운동 20분), B그룹 7명(유산소운동 20분, 무산소운동 40분)으로 분류하여 8주 동안 복합운동 형태를 다르게 실시함으로 나타나는 신체둘레의 변화와 leptin농도에 어떠한 영향을 미치는지 알아보고자 하는데 목적을 두었다. 유산소운동은 트레드밀에서 HRmax70%의 강도로 걷기를 실시하였으며, 무산소운동은 근저항운동으로 1RM의 60~65%강도와 15~20회 반복횟수를 적용하여 9종목을 실시하였다. 그 결과 A그룹의 경우 가슴둘레, 팔 둘레, 허리둘레, 엉덩이둘레에서 둘레의 감소는 보였지만 유의한 차이가 나타나지 않았고 다리둘레에서 8.60% 감소하여 유의한(p<0.01) 차이를 보였다. B그룹의 경우 가슴둘레를 제외한 팔 둘레 7.52%(p<.01), 허리둘레 3.37%(p<01), 엉덩이둘레 1.75%(p<.05), 다리둘레 10.51%(p<.001), 또한 피하지방에서 견갑하골 9.95%(p<.05)감소하여 통계적으로 유의한 차이가 나타났다. 두 집단 간에는 통계적으로 유의한 차이가 나타나지 않았다. leptin의 경우 B그룹에서 49.96%(p<.05)감소하여 통계적으로 유의한 차이가 나타났다.

전자상거래 특성을 고려한 웹서버 제작에 관한 연구

이윤석 홍익대학교 1999 국내석사

유비쿼터스 센서 네트워크기반 조명로봇 제어

이윤석 한양대학교 대학원 2010 국내석사

Most lamp units at ceilings, walls, and streets are static and no automatic motion capabilities are available at all to adjust lamp tilting angles and its zooming position. This paper proposes a new robotic lamp that creates three degrees of freedom (DOF) motion by using a spherical-type parallel mechanism with a unique forward kinematic position. In the robotic lamp, three motors are located. at the base frame to control its two tilting angles and its one-DOF zoom in-and-out motion for a localized light. And ubiquitous sensors installed at environment are used to detect the location of the human body. The kinematic model of this device is derived and the prototype has been developed. A test room equipped with nine PIR sensors, a Zigbee, and one robotic lamp has beed developed. The performance of this device was verified through experiments.

林慶業傳 硏究

이윤석 연세대학교 대학원 1978 국내석사

아데노신 A3 수용체 작용물질인 새로운 핵산 유도체의 개발

이윤석 포항공과대학교 대학원 2010 국내박사

Nucleosides are very active and important biomolecules. Most people think that the main role of nucleosides is ‘saving’ genetic information in our DNA, but this is only on side of nucleosides function. Especially adenosine has a lot of other functions. Adenosine plays important roles as a neurotransmitter, signal transmitter (cAMP is second messenger), and energy transfer agent (ATP) during cell regulation. The first seven HIV drugs were modified nucleosides discovered at university or research institutes and not in a big pharmaceutical company. In our body there are over 2000 enzymes related to nucleosides. Therefore modified nucleosides are an important drug class and the chance to find a lead-compound is better than pure chemically synthesized compounds. One of the first anticancer drug-class and antiviral drug-class were modified nucleosides. Since that time many other class of anticancer and antiviral drugs are developed (for example protein kinase inhibitor as anticancer drug and protease inhibitor as antiviral drugs). For university and research institutes with limited budget is the focus on modified nucleosides a good method to develop novel drugs. 1.1. Synthesis of 5-Isoxazol-5-yl-2´-deoxyuridines Exhibiting Antiviral Activity Against HSV and Several RNA Viruses We describe a simple method for synthesizing a small library of 5-isoxazol-5-yl-2´-deoxyuridines from 5-iodo-2´-deoxyuridine. Nitrile oxides were generated in situ from oximes using a commercial bleaching agent; their cycloaddition with 5-ethynyl-2´-deoxyuridine yielded isoxazoles possessing activity against herpes simplex viruses 1 and 2, Encephalomyocarditis virus, Coxsackie B3, and vesicular stomatitis virus; these isoxazoles were, however, inactive against corona virus, influenza virus, and HIV. 1.2. C5-Modified Nucleosides Exhibiting Anticancer Activity We describe (i) a simple method for the synthesis of C5-modified nucleosides from 5-iodo-2´-deoxyuridine and (ii) their activity against six types of human cancer cell lines (HCT15, MM231, NCI-H23, NUGC-3, PC-3, ACHN). We generated nitrile oxides in situ from oximes using a commercial bleaching agent; their cycloadditions with 5-ethynyl-2´-deoxyuridine yielded isoxazole derivatives possessing activity against the cancer cell lines. We synthesized several azides from benzylic bromides and their click reactions with 5-ethynyl-2´-deoxyuridine provided triazole derivatives. 1.3. C5-azide-2’-deoxyuridine A novel method was carried out to reduce the 5 steps literature synthesis scheme for C5-azide-2’-deoxyuridine to one step reaction. 2.1 Novel adenosine scaffolds displaying in vitro and in vivo anticancer activities We have prepared novel N6-modified adenosines exhibiting in vitro and in vivo anticancer activities. Based on the concept that we could increase the anticancer activity by reducing of the flexibility of the benzyl ring, we synthesized 23 nucleosides through mild PyBOP-mediated couplings using inosine as the starting material and then tested these modified adenosines against six different human cancer cell lines (HCT15, MM231, NCI-H23, NUGC-3, PC-3, ACHN). We performed an in vivo tumor xenocraft study of the compound displaying best activity in the cancer cell assay. Our tetrahydrothienopyridine-containing nucleoside 24 reduced the value of tumor growth inhibition after 11 days by 35.0%; the toxicity of our compound is lower than that of the cancer drug Nexavar. Nexavar treated mice lost 8.1% weight in average, but our compound treated mice lost only 2.0% weight in average. 2.2 N6-Propargyl modified adenosine scaffolds showing in anticancer and rheumatoid arthritis activities We have prepared novel N6-modified adenosines contain an acetylene moiety as A2a and A3 Adenosine Receptor agonists. However the compound with good in vitro anticancer activity showed no activity in vivo experiment. Compounds from same scaffold showed very good anti rheumatoid activity in vivo experiment.

한우 6번 염색체 QTL영역에서 경제형질 연관 후보유전자 규명과 haplotype 분석에 관한 연구

이윤석 嶺南大學校 2009 국내박사

광선추적법에 의한 자동 광검사 장비용 조명 광학계의 분석 및 최적 설계

이윤석 인하대학교 대학원 2010 국내석사

본 연구에서는 자동 광 검사장비에서 사용되는 정밀검사 조명 광학계의 특성 분석 및 최적 설계를 위한 프로그램을 개발하였으며, 개발한 프로그램을 이용하여 목적에 맞는 조명을 설계할 수 있었다. 개발된 프로그램은 광선 추적법을 기반으로 작성된 것으로, 자동 광 검사장비용 조명 광학계의 모든 구성 요소를 정의 할 수 있으며, 설계된 조명 광학계로부터 방출되는 조명광의 밝기 분포와 조명각 분포를 분석하여 조명 광학계를 평가할 수 있다. 끝으로 최적의 조명 광학계를 설계하는 방법론을 제안하고, 그 절차에 준하여, 조명 광학계의 구성, 평가, 수정, 보완하는 과정을 진행하였으며, 그 결과로 요구된 조건을 만족하는 최적의 조명 광학계를 설계할 수 있었다. 이 연구를 통해 개발된 프로그램과 설계법은 향후 자동 광 검사용 조명 광학계의 설계 및 최적화에 많은 도움이 될 것이다.

복강경으로 확진된 결핵성 복막염의 임상적 고찰

이윤석 고려대학교 1988 국내석사

나노 식각공정의 신뢰성 향상을 위한 두께 진단 센서

이윤석 대전대학교 일반대학원 2023 국내석사

With the development of the industry, the miniaturization and high integration of semiconductor devices are rapidly progressing. In particular, with the rapid increase in demand in various fields, yield is emerging as a very important issue in semiconductor device fabrication. In order to maximize semiconductor productivity, it is necessary to measure the semiconductor process in real time and use the result to stabilize and improve the process. However, various unexpected variables that occur during the process and errors in judgment on them sometimes lead to large losses for companies. For that reason, the development of a reliable system is also important, but a sensor technology that can compensate for this and accurately monitor the thickness is also very important. In this study, a basic study was conducted for the concept of a thickness diagnosis sensor through the change of physical quantity of thin film according to etching. A significant change in physical quantity was observed according to the thickness change using a resistivity meter of the thin film. In addition, to measure the reliability, the change in physical quantity according to the thickness was measured several times and quantified.