BCG가 Ehrlich 암세포를 이식한 생쥐의 막창자꼬리점막 흡수세포의 미세구조에 미치는 영향

이운우,박경호,박대균,고정식 대한체질인류학회 2007 대한체질인류학회 학술대회 연제 초록 Vol.50 No.-

고객만족에 영향을 미치는 물류시스템요인에 관한 연구

이운우,김정대 啓明專門大學 産業開發硏究所 1999 啓明硏究論叢 Vol.17 No.1

본 연구의 목적은 기업의 판매와 시장 점유율에 영향을 미치는 고객만족에 대한 물류시스템요인의 전략적 중요성을 분석하고자 한다. 기업의 고객만족요인은 전통적인 마케팅믹스요인과 고객서비스요인으로 이루어져 있으며, 물류시스템은 물적공급요인과 물적유통요인, 그리고 이들을 연결 통합하는 연결과정요인으로 구성되어있다. 이들의 관계를 분석하기 위한 연구모형을 제시하고자 하며, 향후 수집된 자료는 LISREL을 이용하여 통계처리 될 것이다. The purpose of the study is to analyze strategic importance of the logistics system factors in customer satisfaction affecting firm's sales and market share. Firm's factors to satisfy customers may be considered as a function of two constructs : traditional marketing mix, and customer service, and also logistics systems may be considered as a function of the three constructs : physical supply factor, physical distribution factor, and logistical spanning process factor integrating or linking each of these constructs. We are going to propose a research model for analyzing each relationships of these constructs and the collected data will be analyzed by LISREL statistical package in future.

BCG가 Ehrlich 암세포를 이식한 생쥐의 막창자꼬리점막 흡수세포의 미세구조에 미치는 영향

이운우,박경호,김명수,박대균,고정식,Lee, Woon-Woo,Park, Kyung-Ho,Kim, Myeong-Soo,Park, Dae-Kyoon,Ko, Jeong-Sik 한국현미경학회 2007 Applied microscopy Vol.37 No.3

Ehrlich 암세포를 샅부위에 이식한 후 BCG를 투여하였을 때 생쥐 막창자꼬리점막 흡수세포의 미세구조적 변화를 관찰하였다. 실험동물로는 체중 25 gm내외의 성숙한 생쥐 (ICR계통)를 정상대조군, 암세포이식대조군, BCG투여군으로 구분하였다. 암세포이식대조군과 BCG투여군 동물들은 샅부위 피부밑조직에 각각$1{\times}10^7$의 Ehrlich 암세포를 주사하여 이식하였다. 암세포이식대조군은 암세포이식 후에 약제 대신 0.5mL의 생리식염수를, BCG 투여군은 일정량(0.5 mL/25 gm B.W.: $0.03{\times}10^8{\sim}0.32{\times}10^8CFU$)의 BCG를 하루건너 한 번씩 7번 피부밑조직에 주사하였다. 절취된 막창자꼬리조직은 통상적인 방법으로 고정 및 탈수과정을 거쳐 araldite 혼합액에 포매하여 절편을 만든 다음 JEM 100CX-II(JEOL, Japan)전자현미경으로 비교 관찰하였다. 정상군 막창자꼬리점막의 흡수세포는 미세융모, 골지복합체, 과립세포질세망 및 자유면쪽의 미세소포 등, 미세구조가 전형적인 소화관 흡수세포의 것과 유사하였다. 암세포이식대조군의 흡수세포는 자유면쪽에 미세융모가 매우 조밀하게 형성되고 작은 소포들이 다수 관찰되고, 다수의 사립체, 잘 발달된 골지복합체, 과립세포질세망 및 용해소체를 포함하고 있는 모습이 정상대조군의 모습과 유사하였다. BCG투여군의 흡수세포는 세포소기관의 미세구조를 비롯한 전체적인 모습이 정상대조군의 모습과 유사하였으나 세포질 내에 말이집구조를 포함하고 있는 세포들이 자주 관찰되었으며, 사립체에 전자밀도가 높은 과립모양의 구조를 포함하고 있는 세포들이 비교적 자주 관찰되었다. 이상의 결과를 종합하여 보면 BCG를 반복 투여하면 막창자꼬리점막의 흡수세포는 미세구조에 다소 손상을 받아 흡수기능이 다소 억제되나 그 정도가 매우 경미하였으므로 BCG는 막창자꼬리점막 흡수세포의 기능에 큰 손상을 주지 않는다고 생각된다. This experiment was performed to evaluate the ultrastructural responses of the absorptive cells in the appendix of the mouse, inoculated with Ehrlich carcinoma cells in the inguinal area, following administration of BCG (Bacillus Calmette-Guerin). Healthy adult ICR mice weighing 25 gm each were divided into normal and experimental groups (experimental control group and BCG treated group). In the experimental groups, each mouse was inoculated with $1{\time}10^7$ Ehrlich carcinoma cells subcutaneously in the inguinal area. From next day after inoculations, 0.5mL of saline or BCG (0.5 mL/25gm B.W.: $0.03{\times}10^8{\sim}0.32{\times}10^8CFU$) were injected subcutaneously to the animals every other day. The day following the last injection, each mouse was sacrificed. Pieces of the tissue were taken from the appendix, prefixed with 2.5% glutaraldehyde-1.5% paraformaldehyde solution, followed by post-fixation with 1% osmium tetroxide solution. The ultrathin sections were stained with uranyl acetate and lead citrate. In the normal control, experimental control and BCG treated mice, general morphology of the absorptive cells of appendix were similar. But myelin figures and intramitochondrial dense granules were more frequently observed in the absorptive cells of BCG treated mice than normal control ones. Above results show that BCG did show slight ultrastructural alterations in the absorptive cell of the appendix. These results that BCG may slightly suppress function of the absorptive cells of the appendix.

포스타발표 : 담도암환자에서 간흡충감염의 빈도

이운우,황재석,강영우,허정욱,안성훈,박승국 대한소화기학회 1994 대한소화기학회지 Vol.26 No.2

生産企業의 效果的 硏究 開發戰略 : 新製品開發을 中心으로

李雲雨 啓明大學校 産業經營硏究所 1980 經營經濟 Vol.13 No.1

The research and development program of manufacturing enterprise beings with basic understanding and support of top mangement. The frst - stage is to grasp the necessary technology. The activities of our enterprise in research and development is considered to be very poor comparing to that of advanced industrial nations. But for the existance and growth of enterprises, research and development, technology innovation, new product development are the essential factors. Furthermore, the success of new product in the market is to accomplish goal as profit and its success can contribute to group of enterprise interest. The new product to be successful in the market, the originality of its product, such product factors as, adoptability of consumer's desire, adoptabtability on enterprise's goal and situation, etc. should be in correspondence with such industrial factors as relationship between product factors and enterprise organization, marketing activities and other environmental factors. As strategy to satisfy these above mentioned factors, the necessity on technology and technological are the important ones. In terms of the systematic side, the establishment and management of statistcal research & development organization is essential . In marking side, the contemplating in the market keeping the leading technology is desirable in case of self-developed technological products. On the other hand the comtemplating to the market is considered to be desirable in case of outside-development technology with the low-price and diversified in products. Finally, research development operation of enterprise should be supported and encouresed in the ways of establishing special research institutes in University and colleges and an active support is necessary as a mather of policy level by government.

만성 부비동염 환자에서 2(α-thenaylthio)-propionylglycine Na (thenothiola Na, Ronpect^(�))의 임상적 효과

이운우,윤병문,백석인,박동준 최신의학사 1995 最新醫學 Vol.38 No.7

운동장애성 소회불량 환자에서 Dual - Head Gamma Camera 를 이용한 고형식의 위배출 연구

이운우(Woon Woo Lee),황재석(Jae Seok Hwang),강영우(Young Woo Kang) 대한내과학회 1995 대한내과학회지 Vol.49 No.6

N/A Objectives : The present study was performed to evaluate gastric emptying delay of solids using a dual-head gamma camera in patient with dysmotility-like functional dyspepsia. Methods: 75 patients with dysmotility-like functional dyspepsia and 30 healthy volunteers were studied gastric emptying of solids using a ADAC dual-head gamma camera. Results: The mean gastric emptying time (Tl/ 2) was 74.6±17.6 min in normal controls. Delayed gastric emptying defined as the time above 92.2 minutes, when it was defined as the value above mean+lSD of normal controls. There was no significant difference in gastric emptying time between dysmotility-like functional dyspepsia (66.9±19.6min) and normal cotrols(74.6±17.6min)(p>0,05), A gastric emptying delay was observed in 9% (7 cases) of 75 patients with dysmotility-like functional dyspepsia. Conclusion: The present study revealed a few incidence of delayed gastric emptying in patients with dysmotility-like functional dyspepsia, which resulted from a wide range of normal controls, and the need for study of gastrointestinal dysmotility and dysperception besides a gastric emptying delay.

고실 사구종 1례

윤병문,이운우,박동준,봉정표 대한이비인후과학회 1995 대한이비인후과학회지 두경부외과학 Vol.38 No.11

전형적인 신증후군을 동반한 유전문증 1 예

주일,이운우,권진경,박성배,김현철,박관규 대한신장학회 1994 학술대회및초록집 Vol.13 No.2

기관협착증에서 3차원적 영상 진단의 의의

정동학,봉정표,이운우,노정래,성기준 대한기관식도과학회 1995 大韓氣管食道科學會誌 Vol.1 No.1

Three-dimensional reconstruction of computed tomographic image(3D CT) is a well-established imaging modality which has been investigated in various clinical settings. It is commonly performed in case of congenital or developmental abnormalities, and traumatic fracture of skull and face that requires reconstruction of osseous structure. However reporting the 3D CT in laryngeal or tracheal stenosis is rare and its results are obscure. The authors performed 3D CT in six cases of tracheal stenosis and found diagnostic value of 3D CT. A Comparision of diagnostic information obtained from plain X-ray, 2D CT and 3D CT has performed in total six cases of tracheal stenosis. Surgical treatment of the tracheal stenosis was following in these cases : tracheal end to end anastomosis In 1 case, laryngotracheal end to end anastomosis in 2 cases. 3D CT information was compared with operative finding. In two of six cases, satisfactory information was not obtained from 3D CT in evaluating an exact stenosis of trachea. Future, it will be helped in evaluating of tracheal stenosis by 3D CT.