간호사의 야간교대근무로 인한 혈압의 일중 변동 양상

이안생,이상재,김남호 한국직업건강간호학회 2009 한국직업건강간호학회지 Vol.18 No.1

사회적 지지와 자아탄력성이 병원간호사의 간호업무 성과에 미치는 영향

이안생,윤치근,박진규 한국직업건강간호학회 2012 한국직업건강간호학회지 Vol.21 No.3

병원간호사의 자아탄력성과 사회적 지지가 우울감에 미치는 영향

이안생,윤치근,이정미 한국직업건강간호학회 2012 한국직업건강간호학회지 Vol.21 No.1

노인전문병원 입원환자의 낙상 위험 요인분석 - 낙상 보고서를 중심으로 -

이안생,윤치근 한국자료분석학회 2010 Journal of the Korean Data Analysis Society Vol.12 No.5

This study is to analyze the risk factors of falling of the elderly in hospital. About 60.7% of the subjects were women while men took 39.3%. The experience of re-hurt within one year accounted for 29.1%(34 people). According to age and risk factors for falls in the form of reasons for the fall, 'trip'(51.3%) and falls type 'of walking'(35.9%) experienced the largest falls, the place 'room'(47.9%) showed a statistically significant difference(p<.05). The most common charge for the falling risk was 'gait disturbance' (63.7%), 'sleep disturbance'(45.1%), and 'systemic breakdown'(40.7%). Fall injury of the elderly patients taking the drug can have a major impact on patients and caregivers. It is necessary to inform the special care needs in order to prevent fall injury. In order to give fall prevention intervention, it is essential to provide fall prevention education including fall prevention activities, prevention performance and customized fall prevention education. 본 연구는 노인전문병원에서 의사, 간호사가 작성한 낙상 보고서를 이용하여 노인 입원환자의 낙상에 대한 인식을 파악하고, 낙상에 미치는 위험요인을 분석하는데 목적이 있다. 자료분석은SPSS 12.0 프로그램을 이용하였으며 연구결과는 다음과 같다. 낙상 경험자는 여자가 60.7%로 남자 39.3%보다 많았고, 낙상 경험 후 1년 이내 재 낙상을 경험한 노인은 29.1%였다. 연령에 따른 낙상의 형태와 위험요인에 있어 낙상유형은 '보행 중'(35.9%) 낙상이 가장 많았고, 장소는 '병실'(47.9%)로 통계적으로 유의한 차이를 보였다(p<.05). 신체상태 및 약물복용과 낙상위험과의 관계에 있어서는 '보행장애'(63.7%), '수면장애'(45.1%), '전신 쇠약'(40.7%)이 가장 많았고, 약물복용은 노인환자에서 낙상 발생과 관련이 있을 수 있어 환자 및 보호자에게도 교육하는 등 특별한 낙상 예방 간호가 필요함을 의미한다. 입원 시 낙상 위험요인에 대한 낙상 예방 중재는 고 위험군 환자에게 낙상 예방활동을 적극적으로 시행하고, 환자 개개인에게 적합한 맞춤식 낙상 예방 교육이 수행되어야 할 것이다.

병원에서 환자안전에 대한 간호사의 인식 조사 연구

이안생 ( An Saeng Lee ),윤치근 ( Chi Keun Yoon ) 대한보건협회 2010 대한보건연구 Vol.36 No.2

Study objects: This study is to investigate nurses` perception to the patient safety in hospital, in order to provide the patient with the more safe medical care services. Methods: This study method used the Hospital Survey on Patient Safety Culture developed by AHRQ(2004) to investigate nurses` perception to the of patient safety in hospital. This survey was conducted to the 359 nurses in university hospital. Result: The result of this study are as follows. First, nurses` perception to the patient safety culture in hospital shows generally on the average score(3.16±.29). Among three categories, Patient Safety in Ward(Work Area/Unit), patient safety within hospital and reporting procedures on error related to the patient safety, patient safety within hospital was the highest score(3.37). Second, the correlation between patient safety in ward(work arealunit), patient safety within hospital and safety perception, safe and reporting system showed positive relationship. The relationship between safety perception, reporting completeness and openness on communication within hospital was most positive relation. Third, nurses` recognition to the patient safety Is very different by respondent`s characteristics. Conclusion In order to improve the patient safety in hospital, the active measures were developed in efficient communications within hospital.

파골세포 분화와 골 흡수에 myricetin의 효과

이안생(An-Saeng Lee),장성조(Sung Jo Jang) 한의병리학회 2010 동의생리병리학회지 Vol.24 No.1

간호사의 직무 스트레스와 과민성 장 증후군에 관한 연구

윤치근,이안생 한국직업건강간호학회 2009 한국직업건강간호학회지 Vol.18 No.2

경구당 부하 후 혈당의 상승이 관상동맥 혈류 예비력에 미치는 영향

송미진,김남호,이안생,최준호,김용철,김승환,박은미,이상재,윤경호,이은미,유남진,오석규,정진원 대한심장학회 2008 Korean Circulation Journal Vol.38 No.4

Background and Objectives: Patients with chronic diabetes mellitus (DM) have an increased risk of cardiac dysfunction and mortality. There is some evidence that suggests acute hyperglycemia may cause vascular dysfunction. However, it is unknown whether acute, short-term hyperglycemia affects coronary microcirculation function in healthy subjects. The present study was undertaken to explore this issue. Subjects and Methods: We evaluated 20 healthy males who had no history of DM or impaired glucose tolerance, ranging in age from 23 to 36 years (25.9±3.3 years). We checked blood sugar, 12-lead electrocardiography, pulse wave velocity, and coronary flow reserve using echocardiography during fasting, and 30, 60, 90, and 120 minutes after ingestion of 75 g of glucose orally. Results: Non-significant prolongation of the QTc dispersion was observed after the 75 g glucose loading. No significant difference in the pulse wave velocity of the carotid-to-femoral artery, carotid-to-radial artery, or femoral-to-dorsalis pedis artery was observed after the 75 g glucose loading. There was a significant reduction in the coronary flow reserve at 60 (4.06±0.75 vs. 3.54±0.82, p=0.021) and 90 minutes (4.06±0.75 vs. 3.59±0.63, p=0.021) after the 75 g glucose loading compared to that on fasting. Conclusion: The results of this study suggest that acute exposure to high circulating glucose levels does not affect heterogeneity of the ventricular repolarization or arterial stiffness, but it does reduce the coronary flow reserve in healthy young men. Background and Objectives: Patients with chronic diabetes mellitus (DM) have an increased risk of cardiac dysfunction and mortality. There is some evidence that suggests acute hyperglycemia may cause vascular dysfunction. However, it is unknown whether acute, short-term hyperglycemia affects coronary microcirculation function in healthy subjects. The present study was undertaken to explore this issue. Subjects and Methods: We evaluated 20 healthy males who had no history of DM or impaired glucose tolerance, ranging in age from 23 to 36 years (25.9±3.3 years). We checked blood sugar, 12-lead electrocardiography, pulse wave velocity, and coronary flow reserve using echocardiography during fasting, and 30, 60, 90, and 120 minutes after ingestion of 75 g of glucose orally. Results: Non-significant prolongation of the QTc dispersion was observed after the 75 g glucose loading. No significant difference in the pulse wave velocity of the carotid-to-femoral artery, carotid-to-radial artery, or femoral-to-dorsalis pedis artery was observed after the 75 g glucose loading. There was a significant reduction in the coronary flow reserve at 60 (4.06±0.75 vs. 3.54±0.82, p=0.021) and 90 minutes (4.06±0.75 vs. 3.59±0.63, p=0.021) after the 75 g glucose loading compared to that on fasting. Conclusion: The results of this study suggest that acute exposure to high circulating glucose levels does not affect heterogeneity of the ventricular repolarization or arterial stiffness, but it does reduce the coronary flow reserve in healthy young men.

젊고 건강한 비흡연 남자에서 고용량 비타민 C가 관상동맥 혈류 속도와 혈류 예비력에 미치는 단기 효과

박무림,정진원,이안생,윤경호,유남진,신성희,이은미,오석규,김남호,박옥규 한국심초음파학회 2004 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.12 No.2

Background and Objectives:Vitamin C, water-soluble antioxidant, has been reported to restore coronary microcirculatory responsiveness and impaired coronary flow reserve in smokers. However, the effect of high dose of vitamin C on coronary circulation is unclear in nonsmokers. Methods:We used transthoracic echocardiography to measure the coronary flow reserve, an integrated measure of coronary flow in 20 male healthy nonsmokers (26±3 years) before and after administration of the high dose of vitamin C. Results:The coronary peak diastolic velocity was increased by 14.8% after administration of antioxidant vitamin C, whereas the coronary flow reserve did not changed. Conclusion:High dose of vitamin C acutely increases the coronary flow velocity without restoration of coronary flow reserve in male healthy nonsmokers. 연구목적: 비타민 C는 강력한 수용성 항산화제로 작용한다. 이러한 항산화제인 비타민 C가 흡연자에서 고용량으로 투여하였을 때 관상동맥의 혈류 예비력을 개선시킨다는 보고가 있다. 하지만, 산화물질에 많이 노출되어 있지 않은 비흡연자인 건강한 성인에서도 이와 같은 효과를 기대할 수 있을지는 명확하지 않다. 그래서 본 연구는 흡연의 기왕력이 없는 건강한 성인 남자를 대상으로 하여 고용량 비타민 C가 관상동맥 혈류 속도와 혈류 예비력에 미치는 영향을 관찰하고자 하였다. 대상 및 방법: 20명의 비흡연자인 건강한 성인 남자(평균 연령 26±3세)를 대상으로 하였다. 첫째날 기저상태의 관상동맥 이완기 혈류 최고 속도(PDV) 및 혈류 예비력(CFR)을 측정하고, 30분에 걸쳐서 생리 식염수 투여 후 재차 PDV, CFR을 측정하였다. 둘째날 똑같은 시간에 PDV, CFR 측정후 30분에 걸쳐서 10 g 비타민 C를 정맥으로 투여 후 PDV, CFR을 측정하였다. 결 과: 고용량 비타민 C 투여시에 PDV는 23.0±3.3 cm/sec에서 26.4±4.8 cm/sec로 14.8% 의의있게 증가하였으나, CFR은 생리식염수 투여시 3.80±0.90에서 3.78±0.86, 고용량 비타민 C 투여시 3.43±0.72에서 3.24±0.69로 의의있는 변화는 없었다. 결 론: 젊고 건강한 비흡연 남자에서 고용량의 비타민 C는 즉시 관상동맥 혈류를 증가시키나 혈류 예비력의 개선 효과는 없었다.

급성 심근경색증 환자에서 순환 내피전구세포에 대한 조기 스타틴 치료의 효과

최준호,오석규,윤경호,신익상,김승환,이안생,박은미,이상재,유남진,이은미,김남호,정진원 대한심장학회 2008 Korean Circulation Journal Vol.38 No.8

Background and Objectives: The mobilization of circulating endothelial progenitor cells (EPCs) might represent a useful strategy for the clinical therapy of ischemic heart disease. We examined the effect of early statin therapy before reperfusion therapy on the circulating EPCs during the acute phase in patients with acute myocardial infarction (AMI). Subjects and Methods: A total of 84 consecutive AMI patients undergoing primary percutaneous coronary intervention (PCI) within 24 hours of pain onset were included in this study. We randomly divided the patients into 3 groups according to rosuvastatin therapy before PCI: the control group (n:27, 19 males and 8 females, 58±2 years of age), the rosuvastatin 10 mg group (n: 28, 21 males and 7 females, 58±3 years of age) and the 40 mg group (n: 29, 23 males and 6 females, 59±2 years of age). The circulating EPCs and high sensitivity C-reactive protein (hs-CRP) levels were analyzed on admission and at 1, 3, 5, 7 and 30 days after PCI. The circulating EPCs were measured by flow cytometry as the CD45lowCD34+VEGFR2+ cells. Results: The circulating EPCs peaked on day 3 after PCI, whereas the increment of circulating EPCs was significantly suppressed in the rosuvastatin 10 mg and 40 mg groups compared with the control group on day 3 (control vs rosuvastatin 10 mg vs rosuvastatin 40 mg: 0.072% vs 0.067% vs 0.061%, respectively, p=0.002) and day 5 (0.068% vs 0.060% vs 0.058%, respectively, p=0.029). The level of hs-CRP markedly increased from day 1 and this peaked on day 3 after PCI. Early statin therapy significantly suppressed the elevation of hs-CRP compared with the control group on day 1 (24.36 mg/L vs 17.88 mg/L vs 13.08 mg/L, respectively, p=0.035) and on day 3 (30.15 mg/L vs 22.78 mg/L vs 17.16 mg/L, respectively, p=0.034). There was a statistically significant correlation between the circulating EPCs and the hs-CRP (r=0.349, p=0.007). Conclusion: In the AMI patients, the early stain therapy before reperfusion therapy didn’t increase the mobilization of circulating EPCs, but it suppressed the elevation of hs-CRP. This data suggests that the mobilization of circulating EPCs may be related to systemic inflammation during the acute phase in patients with AMI. Background and Objectives: The mobilization of circulating endothelial progenitor cells (EPCs) might represent a useful strategy for the clinical therapy of ischemic heart disease. We examined the effect of early statin therapy before reperfusion therapy on the circulating EPCs during the acute phase in patients with acute myocardial infarction (AMI). Subjects and Methods: A total of 84 consecutive AMI patients undergoing primary percutaneous coronary intervention (PCI) within 24 hours of pain onset were included in this study. We randomly divided the patients into 3 groups according to rosuvastatin therapy before PCI: the control group (n:27, 19 males and 8 females, 58±2 years of age), the rosuvastatin 10 mg group (n: 28, 21 males and 7 females, 58±3 years of age) and the 40 mg group (n: 29, 23 males and 6 females, 59±2 years of age). The circulating EPCs and high sensitivity C-reactive protein (hs-CRP) levels were analyzed on admission and at 1, 3, 5, 7 and 30 days after PCI. The circulating EPCs were measured by flow cytometry as the CD45lowCD34+VEGFR2+ cells. Results: The circulating EPCs peaked on day 3 after PCI, whereas the increment of circulating EPCs was significantly suppressed in the rosuvastatin 10 mg and 40 mg groups compared with the control group on day 3 (control vs rosuvastatin 10 mg vs rosuvastatin 40 mg: 0.072% vs 0.067% vs 0.061%, respectively, p=0.002) and day 5 (0.068% vs 0.060% vs 0.058%, respectively, p=0.029). The level of hs-CRP markedly increased from day 1 and this peaked on day 3 after PCI. Early statin therapy significantly suppressed the elevation of hs-CRP compared with the control group on day 1 (24.36 mg/L vs 17.88 mg/L vs 13.08 mg/L, respectively, p=0.035) and on day 3 (30.15 mg/L vs 22.78 mg/L vs 17.16 mg/L, respectively, p=0.034). There was a statistically significant correlation between the circulating EPCs and the hs-CRP (r=0.349, p=0.007). Conclusion: In the AMI patients, the early stain therapy before reperfusion therapy didn’t increase the mobilization of circulating EPCs, but it suppressed the elevation of hs-CRP. This data suggests that the mobilization of circulating EPCs may be related to systemic inflammation during the acute phase in patients with AMI.