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이수혁,장재혁,전형택,Jisu Lee,유승민,박진성,이명신 한국미생물학회 2016 The journal of microbiology Vol.54 No.11
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the major etiologic agent of Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. Recent studies have indicated that KSHV can be detected at high frequency in patient-derived bladder cancer tissue and might be associated with the pathogenesis of bladder cancer. Bladder cancer is the second most common cancer of the genitourinary tract, and it has a high rate of recurrence. Because drug resistance is closely related to chemotherapy failure and cancer recurrence, we investigated whether KSHV infection is associated with drug resistance of bladder cancer cells. Some KSHV-infected bladder cancer cell lines showed resistance to an anti-cancer drug, cisplatin, possibly as a result of downregulation of reactive oxygen species. Additionally, drug resistance acquired from KSHV infection could partly be overcome by HDAC1 inhibitors. Taken together, the data suggest the possible role of KSHV in chemo-resistant bladder cancer, and indicate the therapeutic potential of HDAC1 inhibitors in drug-resistant bladder cancers associated with KSHV infection.
이수혁(Soo-Hyuk Lee),허성모(Sung-Mo Heo),조혜민(Hye-Min Cho),손현성(Hyunsung Son),정성민(Seong-Min Jeong),박준영(Junyoung Park) 한국기계가공학회 2010 한국기계가공학회지 Vol.9 No.3
In the engineering field, sloshing in rolling vessel is a hot issue because of the counection with ship stability problem. The sloshing phenomena also can be utilized in the field of structure or facility vibration damper. This paper explores the possibility which sloshing of multi-particles can be used to dissipate energy in a rolling container. This energy dissipation can be utilized to the application of rotating damper. Some of the parameters expected to dissipates energy, such as vessel size, particle size, mass fraction and ramp height, have been experimentally and theoretically studied.
배기 소음 저감을 위한 반사형 저정압 경량 소음기 개발
이수혁(Soo Hyuk Lee),이장현(Jang hyun Lee),김학선(Hak Sum Kim),오진우(Jin Woo Oh) 한국소음진동공학회 2016 한국소음진동공학회 학술대회논문집 Vol.2016 No.4
Recently many companies make an effort to reduce noise for a civil complaint because a civil affairs is important to image of company. Coating factory of K plant is being constructed with the soundproofing measures to solve a civil complaint. In this study practical exhaust noise is measured and analyzed. The silencer is developed to satisfy on field condition. The silencer is required to have low pressure drop, lightweight and excellence reduction at 160Hz band of 1/3Octave. Types of the silencer are resonator and expansion. The result of insertion loss is 22dB at 160Hz band on KS I ISO7235 standard and 10dB overall noise level on field.
회전하는 원통형 용기에서의 분체 슬로싱 현상에 의한 에너지 소실
이수혁(Soo-Hyuk Lee),조혜민(Hye-Min Cho),허성모(Sung-Mo Heo),박준영(Junyoung Park) 한국기계가공학회 2009 한국기계가공학회 춘추계학술대회 논문집 Vol.2009 No.6월
In the engineering field, sloshing in rolling vessel is a hot issue because of the connection with ship stability problem. The sloshing phenomena also can be utilized in the field of structure or facility vibration damper. This paper explores the possibility which sloshing of multi-particles can be used to dissipate energy in a rolling container. Some of the parameters expected to dissipates energy, such as vessel size, particle size, mass fraction and ramp height, have been experimentally and theoretically studied.