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현대문학 : 이청준의 「매잡이」연구 -랜서의 시점이론을 중심으로
이성희 ( Sung Hee Lee ) 문창어문학회 1999 문창어문논집 Vol.36 No.-
The purpose of this subject is to prove Lee tried to describe that the point of view concerns not only how to express, based on Lancer`s theory, but also how the author illustrates his theme. Lancer`s theory explains that the point of view, although it is a matter of expression, is influenced by author`s ideology. In 「Hawker」, the hero Tae-joon Min incarnates Lee`s ideology, formulating the main stream. Lee`s intention to stay away from readers is ultimately premised on his own authorization. This is why I selected 「Hawker」 to clarify Lee`s authorization and the conclusion is as follows. Lancer`s theory implies the structure of narrative, point of view and the authorization are on the same boat. I studied how the implication reflects the authorization through the structure-point analysis.
이성희,고영배,이종원,정해철,박재현,이옥성,Lee, Sung-Hee,Ko, Young-Bae,Lee, Jong-Won,Jung, Hae-Chul,Park, Jae-Hyun,Lee, Ok-Sung 한국금형공학회 2012 한국금형공학회지 Vol.6 No.2
A multi-cavity injection mold system of protein chip for point-of-care with cavity temperature and pressure sensors was proposed in this work. In advance of manufacturing for the multi-cavity injection mold system, a single cavity injection mold system to mold protein chip was considered. Injection molding analysis for the presented system was performed to optimize the process of the molding and suggest guides to design. On the basis of the results for the single cavity system, a multi-cavity injection mold system for protein chip was analyzed, designed and manufactured with cavity temperature and pressure sensors. Results of balanced filling for protein chip models were obtained from the presented mold system.
소아의 단순성 비만증에 의한 지방간의 진단: ALT치와 복부 전산화단층촬영 및 간생검 소견간의 상관관계
이성희,김화중,오재철,한혜정,김희섭,차한,박호진,신미경,이민진,이상천,Lee, Seong-Hee,Kim, Hwa-Jung,Oh, Jae-Cheol,Han, Hae-Jeong,Kim, Hee-Sup,Tchah, Hann,Park, Ho-Jin,Shin, Mi-Keong,Lee, Min-Jin,Lee, Sang-Chun 대한소아소화기영양학회 1999 Pediatric gastroenterology, hepatology & nutrition Vol.2 No.2
목 적: 소아비만의 중요한 합병증 중 하나인 지방간을 진단함에 있어 ALT치와 CT 및 간생검 소견간의 상관관계를 살펴봄으로써, 선별검사로서 ALT치의 유용성과 확진검사로서 CT 및 간생검의 필요성을 알아보고자 한다. 대상 및 방법: 1990년 3월부터 1997년 12월까지 서울적십자병원 소아과에 내원하여 단순비만으로 진단 받은 78명 중 지방간 진단을 위해 CT를 실시한 26명을 대상으로 하였으며, 생화학검사 중 지방간의 선별검사로서 보다 특이성이 높은 ALT치가 지나치게 높거나 비만도가 심한 비만아들 중 15례에서 간생검을 실시하였다. 이들을 ALT치에 따라 3개 군으로 분류하고 각 군별로 신체계측지수, CT 및 간생검상 지방침착도 간의 상관관계를 비교 분석하였다. 결 과: 1) ALT치와 신체계측지수간의 상관관계: 대상 비만아 26례 중 ALT치는 17례(63.4%)에서 이상 상승(>30 IU/L)되었으나, ALT치의 상승과 신체계측지수들(비만도, RI, BMI, 체지방률) 간에는 유의한 상관관계가 없었다(p>0.05) 2) CT상 지방침착도와 ALT치 및 신체계측지수 간의 상관관계: 26례 중 13례(50%)에서 CT상 정상이었고, 나머지 13례는 정도의 차이는 있으나 모두 간음영이 증가된 지방간 소견을 보였다. CT상 지방간의 정도와 ALT치의 상승간에는 유의한 상관관계가 있었으나(p=0.01), 신체계측지수와는 유의한 상관관계가 없었다(p>0.05). 3) 간 생검상 지방간의 정도와 비만도, ALT치와의 상관관계: 26례 중 15례에서 간 생검을 실시한 결과, 1례에서 정상이었고 나머지 14례에서 모두 지방간 소견을 보였다. 그러나 간 생검상 정상인 1례는 고도비만이었으나 ALT치는 정상치였고, 중등도의 지방간 소견 보인 3례 중 1례는 고도비만이었음에도 ALT치는 정상이었으며 2례는 ALT치가 정상이거나 약간 증가하였으며, 심한 지방간 소견 보인 9례 중 1례는 경한 비만이었으나 ALT는 158 IU/L로 심한 상승을 보였다. 간 생검상 지방간인 14례를 지방침착도에 따라 3개 군으로 분류하여 비만도와 ALT치를 비교분석한 결과 비만도와 간 생검 소견간에는 유의한 차이가 없었으나(p>0.05), ALT치와 간 생검상 지방간의 정도간에는 유의한 차이가 있었다(p=0.01). 4) CT와 간 생검 소견간의 상관관계: 26례 중 15례에서 CT와 간 생검 모두를 시행한 결과, CT상 6례는 정상이었고, CT상 지방간 소견 보인 9례에서는 간의 지방침착도에 따른 음영의 변화를 기준으로 한 CT소견과 간 생검상 지방침착도간에 유의한 상관관계를 보였다(r=0.6094). 결 론: 최근 소아비만이 급증 추세에 있고 그에 따른 여러 가지 합병증들은 물론 성인비만으로 이행될 수 있으므로 학교보건 등을 통해 경각심을 높이도록 해야 하며, 특히 비만에 따른 지방간을 진단하기 위한 선별검사인 ALT치 등 생화학적인 간 기능 검사로는 간 손상 정도를 평가할 수 없기 때문에 보다 저비용이며 비침습적인 초음파검사를 적극 활용토록 하고 선별검사 등으로 선정된 고위험군에 대해서는 간 생검을 통해 간 손상 정도를 정확히 평가하고 지속적으로 추적 관리해야 할 것이다. Purpose: The purpose of our study is to provide useful information for diagnostic methods of fatty liver by childhood simple obesity and to provide correlation between serum alanine aminotransferase (ALT) for screening test and abdominal computerized tomography (CT) and liver biopsy for confirmative diagnostic methods of fatty liver. Methods: Among 78 obese childrens who visited our hospital, CT was carried out in 26 childrens. Of these, liver biopsy was carried out in 15 childrens who had high obesity index or severe elevated ALT. Based on the level of serum ALT, 26 cases were classified into 3 groups, and compared with physical measurements and degree of fatty infiltration on CT and liver biopsy. Results: 1) Correlation between ALT and physical measurements: Of 26 obese children, ALT was abnormally elevated (>30 IU/L) in 17 cases (67.4%) but there was no significant correlation between ALT and physical measurements (p>0.05). 2) Correlation between degree of fatty infiltration on CT and ALT: Of 26 cases, 13 cases (50%) revealed fatty liver on CT. The degree of fatty liver on CT had significant correlation with elevation of ALT (p<0.05). 3) Correlation between the degree of fatty infiltration on liver biopsy and ALT: Liver biopsy was performed in 15 cases of which 14 cases revealed fatty liver. But one case had normal hepatic histology with severe obesity and normal ALT. Fourteen fatty liver cases on liver biopsy were classified into 3 groups by the degree of fatty infiltration and analysed with obesity index and ALT. The histologic hepatic steatosis had no significant correlation with obesity index (p>0.05), but significant correlation with ALT (p<0.05). 4) Correlation between CT and liver biopsy finding: Both CT and liver biopsy were performed in 15 cases of which 6 cases revealed normal finding on CT and 9 cases manifested fatty liver. There was significant correlation between CT and liver biopsy findings (r=0.6094). Conclusion: The results of our study suggest that abdominal CT and liver biopsy are useful and accurate methods of estimating fatty liver in the childhood obesity. But biochemical abnormalities of routine liver function tests dot not correlate well with severity of the fatty liver and liver injury.
이성희,고영배,이종원,김성규,양진석,허영무,Lee, Sung-Hee,Ko, Young-Bae,Lee, Jong-Won,Kim, Sung-Kyu,Yang, Jin-Suk,Heo, Young-Moo 한국금형공학회 2008 한국금형공학회지 Vol.2 No.5
A micro-injection mold for ultra-thin-walled plate was considered in this work. The proposed mold system is for the fabrication of ultra-thin walled plastic plate with micro features by injection molding. As the injection molding of thin-walled plastic, which has the thickness under $400{\mu}m$, itself is not easy, the injection molding of the micro-features in the thin-walled structure is more complicated and difficult. To investigate the basic phenomenon of the ultra-thin walled part during the injection molding process, design of the part and mold system were performed in the present study. The injection molding and structural analysis of the suggested part and mold system were also performed. Consequently, injection molding system for ultra-thin walled plate with micro features were manufactured and presented.
세 명의 대한민국 제 V형 당원축적근육병(McArdle 병) 환자들의 유전학적 및 임상적 특성 보고
이성희,강은구,김윤명,이범희,김구환,유한욱,Lee, Sunghee,Kang, Eungu,Kim, Yoonmyung,Lee, Beom Hee,Kim, Gu Hwan,Yoo, Han Wook 대한유전성대사질환학회 2016 대한유전성대사질환학회지 Vol.16 No.2
목적: McArdle 병은 당원분해의 주요 속도 조절 단계인 당원인산화의 장애로 운동 초기에 적절한 에너지 공급이 이루어지지 않아 운동내성 및 근력약화가 발생하는 상염색체 열성 근육병으로, 저자의 관점 하에 현재까지 보고된 대한민국 McArdle 병은 4례로, 본 논문은 대한민국 McArdle 병 환자를 추가 보고하고 이들의 임상증상 및 유전학적 변이를 밝히고자 한다. 방법: 2006년부터 2011년까지 임상증상과 일반 혈액 및 생화학 검사, 그리고 PYGM 유전자 검사로 확진된 총 3명의 McArdle 병 환자의 전자 차트를 후향적으로 검토하여, 검사 소견, 시행된 운동요법과 약물치료, 그리고 예후를 확인하였다. 돌연변이 분석은 말초 혈액에서 분리한 DNA에서 genomic DNA를 분리하고, primer를이용해PYGM의 20개 exon과 intronic flanking 배열을 증폭한 후 전기영동으로 DNA 염기서열을 분석하였다. 결과: 세 증례의 증상 발생 평균 연령은 $10.33{\pm}4.73$ 세로, 공통적으로 심한 근육통, 근육부종을 동반한 잦은 횡문근융해증, 높은 기저 혈청 크레아틴키나아제과 마이오글로빈 농도, 뚜렷하지 않은 second wind phenomenon을 보였다. 근육생검 결과, 증례 1은 정상소견을 보였으나, 증례 2는 subsarcolemmal 공간 내 당원침착과 적색열의 퇴행 및 괴사, 증례 3은 periodic acid Schiff stain에 염색되는 물질을 갖는 공포와 내핵을 포함한 근섬유 소견을 보여 당원축적증에 합당한 양상을 보였다. 결론: PYGM 염기서열 분석 결과에서는 증례 1에서 $p.Arg50^*$;p.Trp798Arg, 증례 2에서 $p.Arg50^*$;p.Glu779 del, 증례 3에서 $p.Asp511Thrfs^*28$;p.Phe710 del 복합 이형 접합자 돌연변이를 보였다. Purpose: McArdle disease, glycogen storage disease type V (GSD V), is one of the most common adolescent-onset glycogen storage diseases. It is caused by recessive mutations in PYGM encoding myophosphorylase, which is critical to glycogen metabolism. Since only a few korean patients have been reported, we will observe the clinical and genetic features of three korean patients with McArdle disease. Methods: We retrospectively reviewed the medical records of three patients with genetically confirmed McArdle disease, including the results of forearm ischemic exercise test, electromyogram, nerve conduction velocity, muscle biopsy, and PYGM analysis in peripheral leukocytes. Results: All three cases were males and their age of symptom onset was 12, 5, 14 years old, respectively. A high basal level of serum creatine kinase was noted in all three patients. They experienced the recurrent episodes of rhabdomyolysis, but second wind phenomenon was not definite. In muscle biopsy, subsarcolemmal space vacuoles including periodic acid schiff stained materials were found in two patients, while no evidence of glycogen storage disease was found in the other. A total of five different mutations, $p.Arg50^*$, p.Trp798Arg, $p.Arg50^*$, p.Glu779del, $p.Asp511Thrfs^*28$ and p.Phe710del, were found in three patients. Avoidance of isometric exercise, aerobic exercise and glucose intake before each exercise were recommended for all patients. Conclusion: The three Korean patients with McArdle disease showed the typical manifestations of the condition. The most mutations were private. Therefore, identification of more cases with long-term follow-up will be required to understand the clinical and genetic features of this disease among Korean population.
ARB법에 의해 강소성가공된 Al/SiC<sub>p</sub> 입자분산복합재료의 미세조직 및 기계적 특성
이성희,김형욱,Lee Seong-Hee,Kim Hyoung-Wook 한국분말야금학회 2006 한국분말재료학회지 (KPMI) Vol.13 No.1
The $Al/SiC_p$ particle reinforced composite fabricated by a powder-in sheath rolling (PSR) method was severely. deformed by the accumulative roll-bonding (ARB) process. The ARB process was performed up to 8 cycles at ambient temperature without lubricant. The ARBed composite exhibited an ulbricant. grained structure similar to the other ARBed bulky materials. Tensile strength of the composite increased gradually with the number of ARB cycles, but from the 6th cycle it rather decreased slightly. These characteristics of the composite were somewhat different from those of Al powder compact fabricated by the same procedures. The difference in microstructure and mechanical properties between Al powder compact and the composite was discussed.
반복겹침접합 압연공정에 의해 제조한 초미세립 AA1050/AA5052 복합알루미늄합금판재의 어닐링 특성
이성희,이광진,Lee, Seong-Hee,Lee, Gwang-Jin 한국재료학회 2011 한국재료학회지 Vol.21 No.12
An ultrafine grained complex aluminum alloy was fabricated by an accumulative roll-bonding (ARB) process using dissimilar aluminum alloys of AA1050 and AA5052 and subsequently annealed. A two-layer stack ARB process was performed up to six cycles without lubricant at an ambient temperature. In the ARB process, the dissimilar aluminum alloys, AA1050 and AA5052, with the same dimensions were stacked on each other after surface treatment, rolled to the thickness reduction of 50%, and then cut in half length by a shearing machine. The same procedure was repeated up to six cycles. A sound complex aluminum alloy sheet was fabricated by the ARB process, and then subsequently annealed for 0.5h at various temperatures ranging from 100 to $350^{\circ}C$. The tensile strength decreased largely with an increasing annealing temperature, especially at temperatures of 150 to $250^{\circ}C$. However, above $250^{\circ}C$ it hardly decreased even when the annealing temperature was increased. On the other hand, the total elongation increased greatly above $250^{\circ}C$. The hardness exhibited inhomogeneous distribution in the thickness direction of the specimens annealed at relatively low temperatures, however it had a homogeneous distribution in specimens annealed at high temperatures.