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크롬 取扱勤勞者의 血中 및 尿中 크롬 含量에 關한 硏究
李相澤,金光鍾 고려대학교 의과대학 1980 고려대 의대 잡지 Vol.17 No.1
It is well known that chromium and its compounds (esp. hexavalent) produce reverse effect for homeostasis if persons are exposed for long period. Outstanding damages in case of chronic chromium poisoning are perforation of nasal septum, dermatitis and bronchogenic carinoma. It is easy to presume that some of workers in the industries dealing with chromium in the process would suffer from chromium poisoning, because so many workers in this country have been involved in chromium handling since the industrialization of Korea. However, only a few researches have been concerned with chromium concentration in blood and urine of chromium workers in this country. In view of the above reasons, the author selected 47 workers who have worked in a chromium producing factory and collected both the blood and urine from the workers to measure the concentration in relation to their working environment using atomic absorption spectrophotometer. The results were as follows: 1. Average chromium concentrations in blood and urine were 0.066±0.033 and 0.019±0.014㎍/㎖ respectively. A majority of 45.5% of workers revealed 0.04-0.069㎍/㎖ of chromium content in their blood, and of 48.9% of workers revealed 0.011-0.015㎍/㎖ in their urine samples. 2. A null hypothesis that the concentration of chromium in blood and urine would increase as the age of the workers increase was rejected statistically. 3. Linear correlations were found between the duration of occupational exposure and chromium concentration in blood and urine respectively showing following equations; y=0.000726x+0.0484, with r=0.33(P<0.05) in blood. y=0.000269x+0.1047, with r=0.35(P<0.05) in urine. where y indicates concentration in blood or urine and x indicates duration (month) of exposure. 4. There was no significant correlation between chromium concentrations in air of working environment and in blood or urine. 5. It was found to be very clear that concentration of chromium in urine of workers serving in hazardous environment, higher concentration of chromium, decreased in a few months after transfer from hazardous to safe places.