간암에서 색전술의 효과를 평가하는데 있어서 99mTc-MAA SPECT 를 이용한 간동맥 혈류 검사의 의의

이병희,유형식,이종두,정진일,박창윤,이종태 ( Byung Hee Lee,Hyung Sik Yoo,Jong Doo Lee,Jin Ill Chung,Chang Yun Park,Jong Tae Lee ) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.1

섬유주절제술에서 결막편에 따른 여과포 형태 비교

이병희,최원석,이종욱,이규원,Byeong Hee Lee,Won Suk Choi,Jong Wook Lee,Kyoo Won Lee 대한안과학회 2011 대한안과학회지 Vol.52 No.12

Purpose: To compare the bleb morphology and surgical outcomes of a limbus-based group with those of a fornix-based group who underwent trabeculectomy with mitomycin C (MMC). Methods: Sixty-five eyes of 59 patients who had undergone trabeculectomy with MMC and who were observed for one year or more were included in the present study. A limbus-based conjunctival flap was used for 34 eyes of 31 patients and a fornix-based conjunctival flap for the other 31 eyes of 28 patients. The bleb morphologies were classified and compared after one year or more postoperatively according to the Moorfield Bleb Grading System, and intraocular pressure and success rates were evaluated. Results: The central bleb vascularity of the limbus-based group was statistically significantly lower than that of the fornix- based group (1.79 ± 0.64; 2.16 ± 0.73, p = 0.042). The risk of cystic bleb formation was higher in the limbus-based group (38.2%; 16.5%, p = 0.047). There were no differences in the IOP or success rate between the two groups. Conclusions: There were no differences between the two groups with regard to the IOP or cumulative success rate. However, in the fornix-based group, the central bleb vascularity was lower and the risk of avascular cystic bleb formation was higher than those in the limbus-based group. J Korean Ophthalmol Soc 2011;52(12):1461-1469

양쪽머리 군날개의 수술적 치료에 대한 임상연구

이병희,이광자,박영정,이규원.Byeong Hee Lee. MD. Gwang Ja Lee. MD. Young Jeung Park. MD. Kyoo Won Lee. MD 대한안과학회 2010 대한안과학회지 Vol.51 No.5

Purpose: To evaluate two surgical methods-amniotic membrane transplantation (AMT) and split-conjunctival grafts (SCG)-for double-head pterygium, with regard to the postoperative outcome and recurrence rate. Methods: In a total of 16 eyes (14 patients), 7 eyes (6 patients) receiving amniotic membrane transplantation and 9 eyes (8 patients) receiving split-conjunctival grafts were compared to evaluate recurrence and complications. Results: Within the amniotic membrane transplantation group, two eyes (29%) had corneal recurrence, and 3 eyes (43%) had conjunctival recurrence. The mean follow-up period was 21.9±3.5 months, and all recurrences were on the nasal side. The average period preceding the corneal recurrences was 7.2±1.8 months. Within the split-conjunctival grafts group, the mean follow- up was 13.6±2.1 months, and neither the corneal nor conjunctival recurrences were observed. In addition, the eyes of this group were more aesthetically stable, with only one eye exhibiting pseudo-pterygium at the donor site. Conclusions: In cases of double-head pterygium without contraindication of conjunctival autograft, the split-conjunctival grafts produced fewer recurrences and showed enhanced cosmetic results, as compared to the amniotic membrane transplantation, indicating that the split-conjunctival grafts is the superior choice over amniotic membrane transplantation. J Korean Ophthalmol Soc 2010;51(5):642-650

40 프리즘디옵터 이상의 외사시에서 수술 전 예측한 수술 후 사시각의 정확성

이병희,이종욱,이정호,오동렬,이규원,권정윤,Byeong Hee Lee,MD,Jong Wook Lee,MD,Jung Ho Lee,MD,Dong Ryeul Oh,MD,Kyoo Won Lee,MD,Jung Yoon Kwon,MD 대한안과학회 2010 대한안과학회지 Vol.51 No.12

Purpose: To assess the accuracy of estimating postoperative deviation in large-angle exotropia over 40 prism diopters (PD). Methods: A retrospective analysis was performed on 61 exotropia patients with over 40 PD exotropia who had undergone 2-muscle surgery by two surgeons and with at least 6 months follow-up. The accuracy was assessed by analyzing the discrepancy between preoperatively predicted residual deviation and deviation at postoperative 6weeks. Successful surgery was defined as deviation within ± 10 PD at the last postoperative visit. Results: More accurate residual deviation was predicted in exotropia with prism diopters between 40 and 59 (97.8%) than in exotropia with 60 PD or more (62.5%). And there was no significant difference between two surgeons. Surgical success rates at six months and one year after surgery were 96.8%, 94.7% in exotropia with 40 to 49 PD, 71.4%, 60.0%, 50 to 59 PD, 50.0%, 45.5%, 60 PD or more, respectively. There were four patients of whom the postoperative deviation angle exceeded more than 10 PD of the estimated deviation. Conclusions: The accuracy of estimating residual deviation prior to surgery was higher and more successful surgery was achieved in exotropia ranging in 40 to 59 PD than in exotropia with 60 PD or more. Therefore, 2- muscle surgery will be suitable for large-angle exotropia with less than 60 PD. J Korean Ophthalmol Soc 2010;51(12):1614-1619

Evaluation of Embolization Effect of Hepatocellular Carcinoma by Hepatic Arterial Flow Study with $^{99m}Tc$-MAA SPECT

이병희,유형식,이종두,정진일,박창윤,이종태,Lee, Byung-Hee,Yoo, Hyung-Sik,Lee, Jong-Doo,Chung, Jin-Ill,Park, Chang-Yun,Lee, Jong-Tae The Korea Society of Nuclear Medicine 1994 핵의학 분자영상 Vol.28 No.1

This study was aimed to compare the density of the functional microcirculation of hepatocellular carcinoma (HCC) with normal liver and to investigate the effect of hepatic-arterial oily chemoembolization (HAE) by radionuclide examination. Methods : Eight patients with HCC proven by biopsy in five, and clinically and radiologically in three were included. The mixture of 2 cc normal saline with three to four mCi of $^{99m}Tc$-MAA was infused through a hepatic-arterial catheter for a minute. Dynamic images were obtained at a rate of 4 sec per frame for a minute, and static images and SPECT were followed. Results : In three patients who underwent hepatic arterial angiography (HAA) alone, radioactivity was markedly increased in tumors compared to the adjacent liver immediately after infusion of $^{99m}Tc$-MAA. The ratios of tumoral and extratumoral up-take (T/E ratio) were above 6.5 (range; $6.5{\sim}l9$, mean; 12.5). In four of the five patients who under-went superselective HAE, T/E ratio were remark-ably decreased ($0.5{\sim}1.3$). The areas of embolization were better delineated in radionuclide study than in postembolization HAA. In the other one who was considered to be embolized completely on HAA, strong radiouptake in the tumor was disclosed (T/E ratio; 7.0). Conclusions : Therefore hepatic-arterial flow study with radionuclide imaging using $^{99m}Tc$-MAA can be a valuable method to assess the accurate embolization effect in HCC. 본 저자들은 $^{99m}Tc$-MAA를 이용하여 정상 간조직에 대한 간암의 상대적인 미세 혈류량을 조사하고 간암 환자에서 간동맥 색전술을 시행 후 상대적인 혈류량의 변화를 검사함으로써 간동맥 색전술의 효과를 알아보고자 하였다. 여덟명의 간암 환자들을 대상으로 하였는데, 이 중 다섯 명은 조직 생검으로, 그리고 나머지 세 명은 임상적, 그리고 방사선학적으로 진단되었다. 3내지 4mCi의 $^{99m}Tc$-MAA를 2cc의 생리식염수에 혼합하여 간동맥내에 위치된 카테터(catheter)를 통하여 1분간에 걸쳐 서서히 주입한 후 바로 동적영상을 4초 간격으로 1분 동안 얻었으며, 이어서 정적 영상과 SPECT를 시행하였다. 간동맥 혈관 조영술만을 시행한 세명의 환자에서 $^{99m}Tc$-MAA를 주입하자마자 주변 간 조직에서 비해 간암내에 강한 방사능 섭취를 보였으며, 주변 간조직에 대한 간암의 방사능 섭취율은 6.5 이상이었고, 그 범위는 6.5에서 19였으며 평균은 12.5였다. 간동맥 색전술을 시행한 5명 중 4명에서 주변 간조직에 대한 간암의 방사능 섭취율이 심하게 감소하였다($0.5{\sim}1.3$). 또한 색전된 부위는 색전술 후 시행한 추적 간동맥 혈관 촬영상에서 보다 동위원소 검사에서 잘 관찰되었다. 간동맥혈관 촬영상에서 완전히 색전된 것으로 생각된 한 환자에서 동위원소 검사상 간암에 강한 방사능 섭취를 보였다(주변 간조직에 대한 간암의 방사능 섭취율 7.0). 따라서 본 저자들은 $^{99m}Tc$-MAA를 이용한 간 동맥 혈류 검사는 간암에서 색전술의 효과를 정확히 평가할 수 있는 유용한 검사법으로 이용될 수 있으리라 생각한다.

민간비영리 조직을 통한 보건의료 R&D 방향 설정

이병희,비케이 안,유기봉,김태현,김봉신,박현춘,이예진,노진원,이승훈,Lee, Byeonghui,Ahn, Bekay,Yoo, Ki-Bong,Kim, Tae Hyun,Kim, Bongshin,Park, Hyunchun,Lee, Yejin,Noh, Jin-Won,Lee, Seung Hoon 한국병원경영학회 2017 병원경영학회지 Vol.22 No.3

Purposes: The purpose is to establish the direction of healthcare R&D through private nonprofit organization. Methodology: The data is divided into two groups: 12 physicians and pharmacists, and 16 persons including professors related to university donation, non-profit foundation executives. Each group was subjected to two Delphi surveys. To analyze the validity of the opinion, the content validity ratio and the consensus of experts were verified. Findings: Funding should be invested in 'development research' and 'application research'. The factors that hinder the donation culture are 'donation prevention system such as tax imposition system and rebate double penalty system', 'insufficient motivation of fund raising person', and 'lack of fund specializing specialist'. The fund raising strategy should be centered on a small number of large donors or a balance between large and small donors. The fund raising target should be effective to raise funds for corporate and individual donors. It is necessary to clarify the purpose of the social problem to be solved by the campaign strategy for promoting donation, to announce the validity of the trust and transparency of the institution, and to emphasize the social investment by the private sector. Practical Implications: It is necessary to present directions through private nonprofit organizations for the future development of healthcare R&D. The legal and institutional deficiencies of the domestic nonprofit organization fundraising infrastructure should be improved. In order to create a social investment climate, it is necessary to improve the awareness of donations and develop various donation programs for the private sector.

알기쉬운 과학용어

이병희,Lee, Byeong-Hui 한국과학기술정보연구원 2006 지식정보인프라 Vol.23 No.-

오프라인 인쇄체 문장부호, 일본 문자, 영문자, 한자 인식에서의 오인식 문자 교 정에 관한 연구

이병희,김태균,Lee, Byeong-Hui,Kim, Tae-Gyun 한국정보처리학회 1997 정보처리학회논문지 Vol.5 No.1

최근 상용 오프라인 문자 인식시스템들이 계속 발표되고 있다. 본 눈문에서는 적 은 메모리와 빠른 시간내에 검색이 가능한 자기조직화 구조를 가진 단어 사전을 구축 하고 검색하는 알고리즘을 제시하며 오프라인 문자 인식 시스템을 이용하여 오인식 교정의 측면에서 문장부호, 영문자, 한자를 인식한 후에 나온 오인식된 문자들을 수 집하여 오인식 형태를 제분류하였다. 영문자에 대해서는 영문자의 오인식 형태와 오 인식의 예들을 조사하고 오인식이 자주 일어나는 글자에 대해 오인식 혼동 테이블을 작성하였으며 25,145개의 영어 단어가 입력된 자기조직화된 영어 단어 사전을 가지고 교정을 행하여 0.5%의 인식률 향상을 가져왔다. 한자에 대해서도 영문자와 마찬가지 로 오인식 행태를 조사하고 혼동 테이블을 작성하였으며 34,593개의 단어가 입력된 자기조직화된 한자 단어 사전을 이용하여 교정을 행하여 인식률을 6.1% 향상시켰다. In the recent years number of commercial off-line character recognition systems have been appeared in the Korean market. This paper describes a "self -organizing" data structure for representing a large dictionary which can be searched in real time and uses a practical amount of memory, and presents a study on the character correction for off-line printed sentence marks, Japanese, English, and Chinese character recognition. Self-organizing algorithm can be recommenced as particularly appropriate when we have reasons to suspect that the accessing probabilities for individual words will change with time and theme. The wrongly recognized characters generated by OCR systems are collected and analyzed Error types of English characters are reclassified and 0.5% errors are corrected using an English character confusion table with a self-organizing dictionary containing 25,145 English words. And also error types of Chinese characters are classified and 6.1% errors are corrected using a Chinese character confusion table with a self-organizing dictionary carrying 34,593 Chinese words.ese words.

전세포 β- galactosidase 의 캡슐 고정화

이병희,정긍식,하태욱,박중곤 ( Byung Hee Lee,Geung Sik Jeong,Tae Wook Ha,Joong Kon Park ) 한국화학공학회 1995 화학공학의이론과응용 Vol.1 No.1

알기쉬운 과학용어

이병희,Lee, Byeong-Hui 한국과학기술정보연구원 2006 지식정보인프라 Vol.22 No.-