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재발한 이개혈종에서 연골막의 조직학적 변화에 대한 연구
이법영,한규철 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.3
Otohematoma is a fairly comon disease in otolaryngologic clinics. Many physicans have been chalanged with various method most of these treatments are recurrent problems and eventually become the cauliflower ear. A treatment involves a total excision of the newly formed fibroneocartilaginous layer. If hematoma persists, perichondrium becomes irregular by thickned fibroneoca-rtilage formation. We treated 11 patients with otoplasty to remove fibroneocartilage under local anesthesia. We found that the pe-richondrium formed severe fibroneocarilage and organization after 2 weeks. We studied the sequence of pathological changes that occurs after injury. (Korean J Otolaryngol 2003 ;46 :198-201)
부비동 수술시 상악동 개구부에 대한 Mitomycin C의 효과
김선태,이법영,고상현,정유삼,조창현,박정수,차흥억 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.6
Background and Objective:Adhesion and stenosis are important in causing poor results of sinus surgery. Mitomycin C (MMC) is an antibiotic-antineoplastic agent that decreases fibroblast proliferation and scar formation. This study was designed rate after an endoscopic sinus surgery. Materials and Methods:A total 20 patients diagnosed with chronic sinusitis with nasal polyp were used. After midle meatal antrostomy, a piece of merocel soaked with 0.04 mg/mL MMC 1.5 mL was ap-lied on right antrostomy site for 5 minutes. Left antrostomy site was used as control without applying MMC. The antrost-omy size was measured by using gauze instrument under endoscopy at operation, 1, 3 and 6 months after surgery. Mucocilliary clearance rate was assessed by saccharine time test after 2 weks, 1, 3 and 6 month. Results:The MC group has showed lower incidence of stenosis, granulation and adhesion than the control group. At 1 month, the percentage of remaining an-trostomy size was 61.6± 31.6% in MMC group, whereas that of the control group was 46.9± 23.3% . There was a significant difference in the antrostomy size betwen the two groups at 1 month, but there was no significant difference at 3 and 6 month. The saccharine time test between the two groups showed no significant diference after operation. Conclusion:The use of MMC will improve the success rate of sinus surgery if it is used as adjuvant therapy after antrostomy. Further study will be needed on the duration of application time, concentration of MMC and method. (Korean J Otolaryngol 2002;45:585-8)