초기 족관절 골관절염 환자에서의 히알루론산 관절강 내 주사 요법

이두형,김태훈,한승환,Lee, Doo-Hyung,Kim, Tae-Hun,Han, Seung-Hwan 대한족부족관절학회 2011 대한족부족관절학회지 Vol.15 No.1

Purpose: This study evaluated the efficacy of an intra-articular injection of sodium hyaluronate in the treatment of early stage osteoarthritis of the ankle. Materials and Methods: Early stage ankle osteoarthritis (Takakura stage I and II) patients who received hyaluronic acid injection therapy were retrospectively reviewed. Patients underwent intra-articular injections of 2 mL of sodium hyaluronate for 3 consecutive weeks. Clinical evaluation and Visual Analogue Scale (VAS) scoring were performed at every three months after treatment. Results: Total 27 patients were involved and mean age was 55 year old (range 33 to 77 years). There were 13 male and 14 female patients. Mean follow up duration was 13 month and. Pre-intra-articular VAS score was $8.9{\pm}0.7$ and three month follow up score was $3.8{\pm}2.8$. VAS score of last follow up was $3.2{\pm}3.4$. The effect of hyaluronic acid continued about one year when analyzed the VAS score change of the patients followed for more than one year. Patients' satisfaction was "very satisfied" in nine, "satisfied" in 12, "fair" in one, and "not satisfied" in five patients. Overall satisfaction rate was 82%. There were no ankle osteoarthritis stage changes in serial follow up radiograph. Conclusion: Symptomatic relief of signs and symptoms of osteoarthritis of the ankle was achieved by injection of an intra-articular hyaluronate injection. Efficacy of Hyaluronate acid injection persisted more than 1 year in our study. Intra-articular hyaluronate injection to ankle osteoarthritis is safe and effective as knee joint and should be considered as a valid conservative treatment for ankle osteoarthritis.

FTIR 가스분석에 의한 고분자재료의 연소가스독성 평가

이두형,공영건,Lee. Doo-Hyung,Kong. Young-Kun 한국방재학회 2005 한국방재학회논문집 Vol.5 No.4

건축물, 운송수단에 많이 사용되는 고분자재료는 화재에 노출되면 다량의 열 및 연소가스를 발생시켜 피해를 야기시키는데 특히 유독성 연소가스는 인명피해의 주된 원인이 된다. 본 연구에서는 화재시 발생되는 다양한 종류의 연소가스를 동시에 연속적으로 분석할 수 있는 새로운 분석방법인 FTIR(Fourier Transform Infrared) 분석방법을 이용하여 ASTM E 1678 실험장치에서 발생시킨 PVC, FRP, SMC 및 Ureathane foam 4종의 고분자재료 연소가스를 분석하였고, 분석된 연소가스 데이터를 NIST에서 개발한 FED 독성 모델에 적용하여 연소가스 유해성을 정량적으로 제시하였다. 또한 현재 우리나라에서 사용되고 있는 마우스를 사용한 KS F 2271 가스유해성 실험결과와 비교분석을 하였으며, FTIR 연소가스 분석방법을 이용하면 동물을 사용하지 않고서도 연소가스 유해성을 정량적이고 정확하게 평가할 수 있음을 알 수 있었다. When polymeric materials are exposed to fire condition, a lot of heat and toxic gases evolved and cause damage to property and human being. Especially toxic gases are major hazard to life safety. This study FTIR(Fourier Transform Infrared) spectrometer analysis was performaed to etermine the gas analysis and the concentration of gases evolved from PVC, FRP, SMC and Ureathane foam using ASTM E 1678 fire model. And FED toxicity index calculated from FTIR data also presented. By the comparison of animal test adopted in KS F 2271 and FTIR gas analysis method, FTIR gas analysis method can replace current animal toxicity test and produce precise and quantitative combustion gas data.

당뇨병성 족부 감염 환자의 초기 선택 항생제 효율성

이두형,한승환,박민정,Lee, Doo-Hyung,Han, Seung-Hwan,Park, Min-Jung 대한족부족관절학회 2009 대한족부족관절학회지 Vol.13 No.2

Purpose: Foot infections are common complications in patients with diabetes. The patients are usually immune-compromised; therefore the pathogens could be resistant to narrow spectrum antibiotics. Those drugs, however, are categorized as specially managed antibiotics, and access are difficult without confirming of the pathogens. Our aim was to analyze the common pathogens in diabetic foot infection and figure out the proper antibiotics. Materials and Methods: We studied 68 patients treated with diabetic foot infection. The pathogens which caused the infection and their sensitivity to initial antibiotics were analyzed. We also investigated the change of the antibiotics after the confirming of the culture result and average time to get the result. Results: Among the 68 patients, 56 (82%) received cephalosporin and beta-lactam antibiotics. Only 12 (18%) who were confirmed the drug resistant pathogens from previous culture, were treated with broad spectrum antibiotics such as vancomycin and tazoperan. Average culture study time was 6 days. Methicillin-resistant staphylococcus aureus (MRSA) was cultured in 19 patients (28%), Methicillin-resistant coagulase negative staphylococcus (MRCNS) in 11 patietns (17%), pseudomonas in 11 patients (17%). Total 44 (65%) including 3 of other antibiotics resistant pathogen needed broad spectrum antibiotics. Thirty two patients (47%) were resistant to initial antibiotics.irt follow up culture, 2 MRSA and 2 MRCNS were found. The antibiotics resistant pathogens were confirmed in 48 (71%) patients at last. Conclusion: Diabetic patients with foot infection need proper antibiotics from initial treatment. The proper broad spectrum antibiotics should assigned to the patients from the first time without the confirming of the culture results.

사지에 발생한 편평세포 상피암의 치료

이두형,신규호,이수현,한수봉,Lee, Doo-Hyung,Shin, Kyoo-Ho,Lee, Soo-Hyun,Hahn, Soo-Bong 대한근골격종양학회 2005 대한골관절종양학회지 Vol.11 No.2

목적: 화상흔, 만성골수염 등의 고위험인자를 동반하는 경우가 많으며 예후가 서구에 비해 나쁜 것으로 알려진 우리나라의 사지에 발생한 편평세포 상피암의 치료 결과를 알아보고자 하였다. 대상 및 방법: 1993년 8월부터 2002년 9월 사이에 본원에 내원당시 원격전이가 없었고, 치료 후 36개월 이상 외래추적 관찰이 가능하였던 20예를 대상으로 광범위 절제술 및 절제연을 얻기 힘든 사지 말단부나 신경, 혈관계를 침범한 경우에는 절단술을 시행하였다. 평균 연령은 57.2세였고, 남자와 여자는 각각 16명과 4명이었다. 병기는 TMN Stage를 이용하여 분류하였고, 절제한 병변의 조직학적 분화도를 측정하였다. 결과: 평균 48.3개월(36~84개월)간의 외래 추적 결과 총 6예(30%)에서 전이가 있었다. 근접 림프절로의 전이가 3예, 원격전이가 3예였으며 원격 전이 장소로는 폐가 3예, 흉추가 1예였다. 최종 추시 상 생존은 18예였고 5년 생존률은 50%였다. 국소재발이 3예에서 있었으며 재발된 평균 시간은 11개월(4~18개월)이었다. 합병증으로 광범위 절제술 시행 후 이식 피부의 부분적인 착상 실패가 2예가 있었다. 광범위 절제술을 시행한 군은 평균 1.9번의 수술을 받았고, 절단술을 시행한 군은 평균 1.3번의 수술을 받았다. 결론: 우리나라에 상대적으로 흔한 사지에 생긴 화상 반흔이나 만성 골수염에 속발한 편평 세포 상피암은 높은 전이율을 보였으며, 광범위한 절제연을 확보할 수 있는 경우 절단술과 비슷한 예후를 보이는 것으로 사료된다. Purpose: to know the treatment result of squamous cell carcinoma in extremity had poor prognosis with risk factor including burn scar and chronic osteomyelitis. Material and Methods: Between Octorber 1993 and September 2002, 20 patients with squamous cell carcinoma in extremity had no distant metastasis was got operation and followed over 36 months. Amputation was done when it was hard to get enough wide margin or neurovascular structure was involved instead of wide excision. Mean age of patients was 57.2 years old and male to female was 16 to 4. TMN staging and histologic grading were performed. Results: There were 6 metastasis (30%) in 20 cases for mean 48.3 months (36-84 months). 3 metastasis to local lymph node and 3 distant metastasis were happened at lung (in 3 cases) and thorasic vertebra (in 1 case). Survival was 18 cases at last look. 5-year survival rate was 50%. 3 local recurrence was developed at average 11 months (4-18 months). Complication was focal skin defect after wide excision and skin graft in 2 cases. The patients by wide excision got average 1.9 time operation and by amputation got average 1.3 time. Conclusion: Squamous cell carcinoma at extremity in Korea had high metastasis rate due to burn scar and chronic osteomyelitis, and it showed equal treatment result which treated by wide excision compared with amputation.

개인별 권장사용 치솔의 외형 규격에 관한 임상적 연구

이두형,신승철 ( Doo Hyung Lee,Seung Chul Shin ) 대한예방치과·구강보건학회 1993 大韓口腔保健學會誌 Vol.17 No.1

메타분석 시 연구결과들의 동질성에 관한 연구: 수중운동

이두형(Doo Hyung Lee),김진서(Jin Seo Kim),조영석(Young Seuk Cho) 한국데이터정보과학회 2021 한국데이터정보과학회지 Vol.32 No.1

메타분석이란 같은 주제의 연구 결과들을 객관적이고 체계적인 방법을 통해 하나의 결과로 나타내는 분석 방법이다. 본 연구의 목적은 수중운동에 대한 메타분석에서 연구결과들의 사전집단 특성을 고려한 것과 고려하지 않은 것의 결과를 비교하는 데 있다. 분석에 사용된 자료는 14편의 연구로 선정하였으며 수중운동 프로그램의 체중감량효과에 대한 평균효과크기를 살펴보았다. 그 결과, 사전집단의 특성을 고려하지 않은 메타분석 방법에서 평균효과크기는 -0.3747 (p-value=0.0696)이고, 사전집단 특성을 고려한 총 11편의 연구에 대해 실시한 메타분석 방법에서는 평균효과크기가 -0.5126 (p-value=0.0406)으로 나타났다. 즉, 사전집단의 특성을 고려한 경우와 그렇지 않은 경우의 통계적 유의성에 차이가 있음을 알 수 있었다. Meta-analysis is the method of analyzing the results of studies on the same subject as one result through objective and systematic methods. The purpose of this study is to compare the results that have not been done with the consideration of the characteristics of the results in the meta-analysis of underwater exercise. The data used in the analysis were selected by 14 studies and the mean effect size of the weight-loss of the underwater exercise program was examined. The results showed that the mean effect size was - 0.3747 (p-value=0.0696) for the meta-analysis method that did not take into account the characteristics of the pre-group, and that the mean effect size was -0.5126 (p-value= 0.0406) for the 11 studies that considered the pre-group characteristics. The results showed that there was a difference in statistical significance.

회전근개 질환 환자에서 초음파 상 견봉하관절낭염 소견과 견봉하 코르티코 스테로이드 주사 효과와의 관계: 전향적 비교 연구

이두형(Doo-Hyung Lee),윤승현(Seung-Hyun Yoon),홍기용(Kee Yong Hong) 대한견주관절의학회 2018 대한견주관절학회 학술대회논문집 Vol.2018 No.3

골다공증의 병인론

이두형 ( Doo Hyung Lee ),원예연 ( Ye Yeon Won ) 대한고관절학회 2007 Hip and Pelvis Vol.19 No.3

알츠하이머병 환자에서 정신증적 증상과 연관된 좌측 판개부 및좌측 외측 후두회의 피질 두께 변화

이두형(Doo Hyoung Lee),김경미(Gyung Mee Kim),박선철(Seon-Cheol Park),김태형(Tae Hyung Kim),최승은(Seung Eun Cho),정태영(Tae-Yeong Jeong),이봉주(Bong Ju Lee),문치웅(Chi Woong Mun),이정구 (Jung Goo Lee),김영훈(Young Hoon Kim) 대한노인정신의학회 2017 노인정신의학 Vol.21 No.2

Objective:The aims of this study was to present an association between the presence of psychotic symptoms and cortical thicknesses/subcortical volumes in patients with Alzheimer’s disease (AD). Methods:Fourteen AD patients with psychotic symptoms and 41 without psychotic symptoms underwent 3T MRI scanning. After adjusting the effects of confounding variables, the cortical thicknesses were compared between the AD patients with and without psychotic symptoms in multiple regions, across the continuous cortical surface. In addition, the subcortical volumes were compared with a structure-by-structure manner. Results:AD patients with psychotic symptoms were characterized by significant smaller cortical thickness of left pars opercularis (F=4.67, p=0.02) and left lateral occipital gyrus (F=6.05, p=0.04) rather than those without psychotic symptoms, after adjusting the effects of age and scores on the Stroop test, non-psychotic items of Neuropsychiatry Inventory and Clinical Dementia Rating, triglyceride level and total intracranial volume. However, there were no significant differences in the subcortical volume between the two groups. Conclusion:These results suggest that AD psychosis may reflect more severe deterioration of neuropathologic change in specific brain region.

유무선 혼합 네트워크 환경에서 TCP 스킴의 성취도측정 평가

이두형 ( Doo-hyung Lee ),배상태 ( Sangtae Bae ),구자환 ( Jahwan Koo ),정진욱 ( Jinwook Chung ) 한국인터넷정보학회 2009 인터넷정보학회논문지 Vol.10 No.2

본 논문에서는 유무선 혼합 네트워크상에서 TCP 스킴을 평가하기 위해 굿풋, 굿풋 인덱스, 정규화된 굿풋 인덱스 등을 정의하였다. 이러한 메트릭스들은 주로 TCP 스킴을 측정하기 위해 사용된 성능 메트릭스와는 달리 주어진 네트워크 상황에서 목적을 달성할 수 있는 능력인 성취도 개념을 포함하고 있다. In this paper, we define Achieved Goodput(AG), Achieved Goodput Index(AGI) and Normalized Achieved Goodput Index(NAGI) in order to evaluate TCP schemes over heterogeneous wireless networks. These metrics contain a concept of achievement, the ability of accomplishing an objective in a given network situation unlike performance metrics commonly used to evaluate TCP schemes.