양측성 외전신경 마비 환자 치험 1례

이동혁,이영은,이보윤,두경희,김수경,조승연,박성욱,박정미,고창남,Lee, Dong Hyuk,Lee, Young Eun,Lee, Bo Yun,Doo, Kyung Hee,Kim, Soo Kyung,Cho, Seung Yeon,Park, Seong Uk,Park, Jung Mi,Ko, Chang Nam 대한중풍순환신경학회 2014 대한중풍.순환신경학회지 Vol.15 No.1

■ Objectives The purpose of this case report is to show an effect of korean medicine for patient with bilateral abducens nerve palsy. ■ Methods This patient was 58 year-old man who was diagnosed with bilateral abducens nerve palsy. The patient had Diabetes Mellitus, hypertension, benign prostatic hyperplasia and dyslipidemia as underlying diseases. The patient had symptoms of limited eye movement to lateral, diplopia, dizziness and mild headache. He was treated by korean medicine, containing electroacupuncture, pharmacoacupuncture, moxibustion and herb medicines during 13 days of hospitalization and following outpatient department. His eye movement was evaluated by the method of Scott and kraft and discomfort from his symptoms was scored by the Numerous Rating Scale. And other general conditions were measured. ■ Results After that period, patient's abduction deficit was improved and subjective discomfort from his symptoms was getting better. His other conditions were also better, compared with his admission. ■ Conclusion This study suggests that Korean medicine could have a therapeutic effect for bilateral abducens nerve palsy. So, It could help to relieve patient's symptoms and make general conditions better.

兩義供辰丹을 倂用한 한방치료가 重症度의 통증 환자에 미치는 진통 효과 : 후향적 연구

이동혁,이영은,이보윤,김연진,조승연,박성욱,정우상,문상관,고창남,조기호,박정미,Lee, Dong-hyuk,Lee, Young-eun,Lee, Bo-yun,Kim, Yeon-jin,Cho, Seung-yeon,Park, Seong-uk,Jung, Woo-sang,Moon, Sang-kwan,Ko, Chang-nam,Cho, Ki-ho,Park, Jung-mi 대한한방내과학회 2015 大韓韓方內科學會誌 Vol.36 No.3

Objectives: The aim of this study was to investigate the analgesic effect of Yang Eui Gongjin-dan (YEGJD), a traditional Korean medicine, on severe pain or numbness, including acute and chronic non-cancer pain. Methods: Records of patients visiting the Department of Traditional Korean Internal Medicine, Stroke and Neurological Disorders Center, from March 2011 to January 2015, were searched. Their chief complaint was severe numbness or pain (NRS≥7). We compared the NRS of pain pre- and post-YEGJD treatment in 34 patients; and analyzed changes in pain severity pre- and post-YEGJD treatment in 17 chronic non-cancer pain patients. We also investigated other accompanying symptoms, such as insomnia, anorexia, dyspepsia, fatigue, coldness, and excessive sweating, related to the deficiency state (虛症) in traditional Korean medicine. Results: The average pain NRS for the 34 patients significantly decreased from 8.04±1.08 to 3.75±2.54 after YEGJD treatment. The average pain NRS score in chronic non-cancer pain patients also significantly declined from 7.91±0.97 to 3.29±2.29. Conclusions: The traditional Korean medicine Yang Eui Gongjin-dan has an analgesic effect and is useful for treating severe pain or numbness. We recommend a randomized controlled trial using objective assessment scales and a large patient sample to further test the effects of Yang Eui Gongjin-dan.

Bovine Herpesvirus Type 1 정량 검출을 위한 Real-Time PCR

이동혁,정효선,이정희,김태은,이정숙,김인섭,Lee, Dong-Hyuck,Jeong, Hyo-Sun,Lee, Jung-Hee,Kim, Tae-Eun,Lee, Jung-Suk,Kim, In-Seop 한국미생물학회 2008 미생물학회지 Vol.44 No.1

소의 혈액, 세포, 조직, 기관 등은 생물의약품과 조직공학제제, 세포치료제의 원료로 널리 사용되고 있다. 소유래 물질을 원료로 사용한 제제의 경우 소유래 원료 물질에 다양한 바이러스가 오염된 사례가 있기 때문에 바이러스 안전성 검증이 필수적이다. Bovine herpesvirus type 1 (BHV-1)은 소에게 가장 흔하게 감염되는 바이러스중의 하나이다. 소유래 물질을 원료로 하는 생물의약품, 조직공학제제, 세포치료제 등에서 BHV-1안전성을 확보하기 위해, 원료물질, 제조공정, 완제품에서 BHV-1을 정량적으로 검출하고, 제조공정에서 BHV-1 제거 검증을 위한 시험법으로 활용이 가능한 BHV-1 real-time PCR 시험법을 확립하였다. BHV-1에 특이적인 primer를 선별하였으며, 형광염료 SYBR Green I을 사용하여 BHV-1 DNA 정량 검출 시험법을 최적화하였다. 세포배양법에 의한 감염역가와 비교한 결과 real-time PCR 민감도는 $2\;TCID_{50}/ml$이었다. 확립된 시험법의 신뢰성(reliability)을 보증하기 위해 시험법 검증을 실시한 결과 특이성(specificity)과 재현성(reproducibility)이 우수함을 확인하였다. 확립된 real-time PCR을 생물의약품 제조공정 검증에 적용할 수 있는지 확인하기 위하여 인위적으로 BHV-1을 오염시킨 Chinese hamster ovary (CHO) 세포주와 소유래 콜라겐에서 BHV-1 검출 시험을 실시하였다. BHV-1을 감염시킨 CHO 세포에서 세포변병효과를 관찰할 수 없었지만, 세포와 세포배양 상청액에서 BHV-1을 정량적으로 검출할 수 있었다. 소유래 콜라겐에서도 $10\;TCID_{50}/ml$까지 정량적으로 검출할 수 있었다. 위와 같은 결과에서 확립된 BHV-1 real-time PCR 시험법은 생물의약품 안전성 보증을 위한 세포주 검증, 생물의약품생산공정 검증, 바이러스 제거 공정 검증 등에서 감염역가 시험법과 같은 생물학적 시험법을 대신할 수 있는 신속하고, 특이성과 민감성이 우수한 시험법임을 확인하였다. Bovine blood, cell, tissue, and organ are used as raw materials for manufacturing biopharmaceuticals, tissue engineered products, and cell therapy. Manufacturing processes for the biologicals using bovine materials have the risk of viral contamination. Therefore viral validation is, essential in ensuring the safety of the products. Bovine herpesvirus type 1 (BHV-1) is the most common bovine pathogen found in bovine blood, cell, tissue, and organ. In order to establish the validation system for the BHV-1 safety of the products, a real-time PCR method was developed for quantitative detection of BHV-1 in raw materials, manufacturing processes, and final products as well as BHV-1 clearance validation. Specific primers for amplification of BHV-1 DNA was selected, and BHV-1 DNA was quantified by use of SYBR Green I. The sensitivity of the assay was calculated to be $2\;TCID_{50}/ml$. The real-time PCR method was validated to be reproducible and very specific to BHV-1. The established real-time PCR assay was successfully applied to the validation of Chinese hamster ovary (CHO) cell artificially infected with BHV-1. BHV-1 DNA could be quantified in CHO cell as well as culture supernatant. Also the real-time PCR assay could detect $10\;TCID_{50}/ml$ of BHV-1 artificially contaminated in bovine collagen. The overall results indicated that this rapid, specific, sensitive, and robust assay can be reliably used for quantitative detection of BHV-1 contamination during the manufacture of biologics.

$^{99m}Tc$ 표지화합물을 사용한 심근 관류 SPECT 검사에서 심장과 타 장기와의 중첩 방지를 위한 자세 변화의 유용성

이동혁,오신현,정석,조석원,남궁혁,김재삼,이창호,Lee, Dong-Hyuk,Oh, Shin-Hyun,Jeong, Seok,Jo, Seok-Won,NamKoong, Hyuk,Kim, Jae-Sam,Lee, Chang-Ho 대한핵의학기술학회 2012 핵의학 기술 Vol.16 No.1

게이트 심근 관류 SPECT는 심근관류를 평가하고 관상동맥질환을 진단하는 비침습적인 방법으로 매우 가치가 있는 검사이다. $^{99m}Tc$를 이용한 표지화합물들은 특성상 간과 담낭에 많이 농축이 되며 장으로 배설이 된다. 본 연구에서는 소화기관을 통해 배출되는 방사성의약품의 일부가 장기 내에 남아 심장의 음영을 침범하는 경우 자세의 변화를 통해 영상의 획득 방법을 변형하여 효과적으로 분리 관찰할 수 있도록 하는데 그 목적을 두었다. 2011년 1월부터 8월 사이에 심장과 심혈관계 질환이 의심되거나 이에 따른 시술 및 수술을 받은 20명의 환자들을 대상으로 시행하였다. 대상 군에 대하여 $^{99m}Tc$-sestamibi 또는 $^{99m}Tc$-tetrofosmin 370 MBq (10 mCi)을 정맥 주사하였다. 주사 30분 후에 지방식을 하도록 하였으며, 약 1시간 후에 검사를 시행하였다. 기본적인 검사는 앙와위 자세에서 양팔을 머리 위로 거상한 자세로 하였다. 휴식기 검사가 종료되면 약 3~4시간 후에 아데노신에 의한 약물부하를 시행하였다. 부하는 6분간 실시 하였으며, 아데노신이 주입되기 시작한지 4분째에 다시 한번 방사성의약품을 주사하였다. 부하기 때의 방사성 의약품은 1,110 MBq (30 mCi)을 주사 하였으며, 지방식 및 검사 시간은 휴식기 때와 동일하게 하였다. 휴식기와 부하기 검사에서 심장과 장기의 중첩이 발생한 경우에는 곧바로 앙와위 자세에서 고정 용구를 사용하여 상체를 거상시켜 환자 자세를 변화시키고 그 이외의 다른 조건들은 동일하게 하여 영상을 다시 한번 획득하였다. 기존의 앙와위 자세에서는 횡격막 이하 장기의 일부가 심장과 중첩이 일어났으나 고정 용구를 사용한 환자 자세의 변화로 심장과 중첩되었던 타 장기들의 대부분이 신체의 아래쪽으로 내려가 심장과 충분히 분리되는 모습을 육안적으로 관찰할 수 있었다. 장기의 일부가 심장에 중첩된 경우에 비해 분리된 경우의 재구성 영상에서 각각 전체 평균의 차이는 확장기말 용적이 2.75 mL 증가, 수축기말 용적은 3.16 mL 감소, 심박출 계수는 3.58% 증가하였고, 결손 부위의 면적은 부하기에서 $3.58cm^2$ 감소, 휴식기에서 $3.92cm^2$ 감소하였다. 또한 각각의 수치들을 토대로 시행한 대응표본 $t$-검정에서는 $p$>0.05로 유의한 차이는 없었다. 본 연구에서는 심근 관류 SPECT에서 심장과 타 장기와의 중첩된 부분을 고정 용구를 사용함으로써 효과적으로 분리시켜 영상화할 수 있었다. 이와 같이 지연 검사가 필요한 경우 적절한 고정 용구를 사용하게 된다면 보다 더 효율적인 검사가 이루어질 수 있을 것이라 사료된다. Purpose: The present study has an objective of effectively separating and making observations on a portion of radiopharmaceutical excreted via digestive organ to remain in the organ and invade a heart shadow. Materials and methods: When heart shadow is blocked by the organ in tests during a resting phase and a loaded phase, additional images were obtained using immobilization device. The immobilization devices were used to tilt the upper body forward from supine position. Results: In the reconstructed image for the separated case, as compared with the case where a part of organ is overlapped with heart, in terms of an overall mean value for each parameter, the end-diastolic volume increased by 2.75 mL, the end-systolic volume decreased by 3.16 mL, the left ventricle cardiac coefficient increased by 3.58%, and the area of defect region decreased by 3.58 and 3.92 cm for loading and resting phase, respectively. Conclusions: In the present study with myocardial perfusion SPECT, overlapped areas of heart and other organs could be effectively separated and visualization by the use of an immobilization device.

치매(痴呆)에 대한 임상 한의학 연구 경향 분석 : 지난 10년간의 국내 논문을 중심으로

이동혁,Lee, Dong Hyuk 대한예방한의학회 2020 대한예방한의학회지 Vol.24 No.1

Objective : In this article, we overviewed clinical Korean Medicine studies on dementia by analyzing papers published in Korea from 2010 to 2019. Methods : We explored research articles on dementia from 5 Korean research databases using the keyword 'dementia' and 'Korean Medicine'. We included original articles and reviews of clinical Korean Medicine and excluded single case study and experiment article of animal model. Then we analyzed them according to the published year, journal type, and research topics. Results & Conclusions : Research topics were classified into 'research trend', 'treatment', 'prevention', 'evaluation', 'medical expenses', 'collaborative practice' and 'others'. The largest number of articles were published in 2011(24.4%). 'Journal of Oriental Neuropsychiatry' was the journal with the most published articles(46.3%). In research topics, the analyses of research trend accounted for the largest portion(39.0%) and the articles about treatment for dementia or evaluation index in Korean medicine had the second largest proportion(14.6%). We hope that various researches for therapeutic effects, mechanisms and preventive effects of Korean Medicine in dementia would be conducted for future study.

경량합성벽체의 전단성능 및 압축내력 평가

이동혁,이상섭,배규웅,문태섭,Lee, Dong Hyuck,Lee, Sang Sup,Bae, Kyu Woong,Moon, Tae Sup 한국강구조학회 2005 韓國鋼構造學會 論文集 Vol.17 No.1

본 논문은 스틸스터드로 구성된 골조에 경량기포모르터를 타설 양생하여 제작한 경량합성벽체의 반복가력 전단실험에 의한 에너지 소산능력과 압축내력 실험을 통한 압축성능의 평가에 대한 연구이다. 경량기포모르터의 유무, 경량기포모르터의 비중(0.6, 0.8, 1.0, 1.2), 마감재(경량기포모르터, OSB, 석고보드) 및 브레이스의 유무, 벽체의 단위(1단위-$900mm{\times}2,400mm$, 2단위-$1,800mm{\times}2,400mm$)를 변수로 하여 실시하였던 경량합성벽체의 전단내력 평가 실험 가운데 반복 실험 결과를 동일 조건의 단조 실험과 비교하였다. 또한 기존 스틸하우스벽체와 경량합성벽체의 압축내력도 실험을 통해 조사하였다. 반복가력 실험결과, 단조가력 실험체의 거동과 약간의 차이를 보이고 있으며 이는 벽체에 채운 경량기포모르터의 비중에 따른 차이라고 생각된다. 압축내력 실험결과, 기존형 실험체에 비하여 경량기포모르터를 타설한 실험체의 최대내력은 2~2.5배, 초기강성은 2~3배 정도 증가하였다. This paper presents the test results and evaluations for the energy dissipation capacity and compressive performance of light-weight hybrid panels. A total of 26 full-scale specimens of light-weight hybrid panels were tested. The parameters include the presence of light-weight foamed mortar, the specific gravity of light-weight foamed mortar (0.6, 0.8, 1.0, 1.2), the finishing materials (light-weight foamed mortar, OSB [Oriented Strand Board], gypsum board), the shape of bracing (x, ~), and the size of panels (1P-900 mm 2,400 mm, 2P-1,800 mm 2,400 mm). The results of the cyclic tests are somewhat different from those of monotonic tests, due to the different specific gravity of light-weight foamed mortar. It was found from the compressive tests that the ultimate strength and initial stiffness are increased by means of light-weight foamed mortar (2~2.5 times in ultimate strength and 2~3 times in initial stiffness).

디지털프린팅법을 이용한 미세 배선 기술의 특허 동향

이동혁,홍태환,Lee, Dong-Hyouk,Hong, Tae-Whan 대한용접접합학회 2008 대한용접·접합학회지 Vol.26 No.2

직렬 연결된 두 코일과 YBCO Coated Conductor로 구성된 초전도 전류제한기의 권선방향과 권선 비에 따른 전류제한 특성 분석

이동혁,두호익,김용진,한병성,한상철,이정필,Lee, Dong-Hyeok,Du, Ho-Ik,Kim, Yong-Jin,Han, Byoung-Sung,Han, Sang-Chul,Lee, Jeong-Phil 한국전기전자재료학회 2011 전기전자재료학회논문지 Vol.24 No.1

The ongoing Superconducting Fault Current Limiter(SFCL) development mainly has focused on the application of commercializaton and power system through combining with normal-conducting device, moving away from current-limiting method, which is solely dependant on the existing superconductor. Compared to the structural development above, on the other hand, the research on applying superconducting current-limiting element to SFCL, the heart of SFCL, still has a lot left to do, apart form traditional resistive type SFCL. In this study, we looked into the current limiting characteristic of SFCL using core and coil. YBCO coated conductor with stainless steel stabilizer layer was verified by the excellent of current-limiting element of the resistive type SFCL that has a high Jc and index as well as being superior in mechanical property. Also, we study temperature characteristics and resistance characteristics, max voltage, response time and current-limiting ability that can be an indicator as current-limiting element while applying to superconducting current-limiting element caused by variation of winding direction, winding ratio of SFCL using core and coil.

소각로의 연소 공기 유동 해석

이동혁,Lee, Dong-Hyuk 한국금형공학회 2022 한국금형공학회지 Vol.16 No.2

It is known that the fluidized bed incinerator, which is the subject of analysis, shows excellent performance in heat and mass transfer due to excellent mixing and contact performance between fluidized sand and fuel, and also shows relatively good combustion characteristics thanks to good mixing and long residence time for low-grade fuels. have. In this study, air flow analysis is performed to understand the characteristics of co-firing of sludge, waste oil and solid waste in the fluidized bed incinerator, flow characteristics of flue gas, and discharge characteristics of pollutants.The fluidized bed incinerator subject to analysis is a facility that incinerates factory waste and general household waste together with sludge, with a processing capacity of 32 tons/day. to be. In addition, the operation method was designed for continuous operation for 24 hours. As a result, it can be seen that the lower combustion air and the introduced secondary air are changed to a strong turbulence and swirl flow form and exit through the outlet while rotating inside the freeboard layer. The homogeneous one-way flow form before reaching the secondary air nozzle has very high diffusivity with the high-speed jet flow of the nozzle.

하이브리드 태양광 LED 가로등 시스템 연구

이동혁,Lee, Dong-Hyuk 한국금형공학회 2022 한국금형공학회지 Vol.16 No.2

In line with the rapid economic growth of many countries, fossil fuel energy sources are also rapidly depleting. Therefore, the price is also rising rapidly, so it is necessary to develop new and renewable energy sources such as hydropower, geothermal power, nuclear power, wind power and solar energy to replace fossil fuel energy in the future. In this study, development of rotating concentrator module system, development of rotating module control control system, development of lamp and charge control controller, configuration and prototype production of rotating concentrating solar LED street light system, efficiency of rotating concentrating solar LED street light, and power production. The research was conducted in the order of evaluation of comprehensive performance tests such as consumption and consumption. As a result, the developed high-efficiency rotation-concentrating hybrid solar LED street light module system has a 50% higher light-gathering efficiency than existing products by tracing sunlight by self-developing a rotation-collecting module on existing solar LED street lamps according to the characteristics of Korea's topography. and the power generation was improved by more than 40%.