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이근수,장홍준,서연림,안규중,김종민,이종주 ( Geun Soo Lee,Hong Zoon Jang,Yeon Lim Suh,Kyu Joong Ahn,Jong Min Kim,Chong Ju Lee ) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.5
A Case of Hypomelanosis of lto Geun Soo Lee, M.D., Hong Zoon Jang, M.D., Yeon Lim Suh*, M.D., Kyu Joong Ahn, M.Dl., Jong Min Kim, M.D., Chong Ju Lee, M.D. Departments of Dermatology and Pathology*, Clooege of Medicine, Hallym University Seoul, Korea We report a case of hypomelansis of Ito developed in a 6-year-old male patient. He had numberous bizarre, hypopigmented streaky macules on the left side of the chest, and upper arm. The histopathologi findings demonstrated that hypopigmented areas contained slightly decreased basal pigmentation with decreased content of intracellualr melanin in keratinocytes and melanocytes and revealed neither inflammatory changes nor dropping of melanin granule into the dermis. The electron microscopic finding showed decreased number of melanosomes, incomplete melaniztion, and cytoplasmic vacuoles in keratinocytes and melanocytes. Extra-cutaneous alterations were not found.
Correlation between Upper Extremity Strength and the Oral Health of Stroke Patients
이근수,Ji Sun Lee,Eun Young Kang 대한예방치과학회 2021 International Journal of Clinical Preventive Denti Vol.17 No.3
Objective: The objectives of this study were to evaluate the correlation between upper extremity strength and oral health in stroke patients, as well as to determine the need for improvement in oral health measures, including rehabilitation to enhance upper extremity strength, and education and training for patients and their guardians related to oral hygiene. Methods: To evaluate the oral health of stroke patients, we performed an examination of oral health and survey of oral hygiene behavior. Using the Oral Health Assessment Tool, an examiner evaluated oral health using a dental mirror. The upper extremity muscle strength was also assessed using the Manual Muscle Testing (MMT) grading system. Results: Patients with higher-grade upper extremity muscle strength had better oral health. Patients with higher MMT grades were more likely to brush their teeth independently, and more often, compared to those with lower grades. Conclusion: The MMT grade of patients with chronic stroke was significantly related to the oral health. Therefore, to improve oral health, patients should receive oral hygiene education and rehabilitation to increase their MMT grade. Combined efforts by rehabilitation and dental departments are required to improve the oral health of chronic stroke patients.
새로운 노화 방지 성분으로서 글루쿠로닉 애씨드의 기능과 화장품 응용
이근수 ( Geun-soo Lee ),김진화 ( Jin-wha Kim ),이천일 ( Chun-il Lee ),표형배 ( Hyeong-bae Pyo ),이공주 ( Kong-joo Lee ) 대한화장품학회 2004 대한화장품학회지 Vol.30 No.4
피부 세포는 외부의 유해 요소 즉, 스트레스 환경에 노출되었을 때 세포 자신을 보호하기 위하여 다양한 방어 및 복구 체계를 가지고 있는데 그 중 하나가 보호단백질인 열충격단백질 70 kDa의 발현이다 Glucuronic acid를 피부세포에 다양한 농도로 전처리한 다음 유해자극(열, 활성산소)을 주었을 경우, western blottting을 통해 0.12% 농도에서 세포 내 열충격단백질이 발현됨을 알 수 있었다 그리고 confocal microscopy 및 세포생존율 실험을 이용하여 열 및 활성 산소에 대한 우수한 세포보호 효과를 확인하였다. 또한 마우스 피부를 이용하여 glucuronic acid 및 수중유(O/W)형 에멀젼에 적용하였을 때 경피 흡수 양상을 비교한 결과, glucuronic acid는 빠른 경피흡수거동을 보였다(투과속도 0.83114 mg/㎠/h, 지연시간 1.2 h, 분배계수 0.114). 에멀젼에서는 투과속도는 0.04153 ㎍/㎠}/h, 누적투과량은 1456.25 ㎍/㎠로 감소하였지만 지연시간은 2.48 h으로 증가하였고 지속적인 경피흡수(서방성)를 보였다. Exposure to elevated temperatures, chemical (active oxigen), or physical stress (UV light) induces immediate physiological response, the expression of heat shock proteins in cells. Thus, cells with elevated Heat Shock Protein levels become more tolerant to stress conditions that are otherwise lethal. First, we studied on the new function of glucuronic acid (GA) as preventive material of skin aging. The application of the GA shows significant induction of Heat Shock Protein 70 kDa (HSP 70 kDa) in contrast to cells without it. GA at the concentration which can induce HSP 70 kDa, protects the cell death induced by second stress (heat shock and hydrogen peroxide) in NIH3T3 cells. Second, we studied on in vitro transdermal permeation characteristic of GA through the excised mouse skin. In this study, we compared the skin permeability of GA in water with O/W emulsion. As a result, skin permeation parameters of GA shows lag time 1.2 h, partition coefficient 0.114, permeation flult rate 0.83114 mg/㎠/h. In case of lag time, O/W emulsion containing GA increase 2.48 h. Also, the total accumulation permeation content decreased in contrast to GA solution after 24 h. But it has long-term permeability of glucuronic acid. These results suggest that glucuronic acid could be a good cosmetic active ingredient.
새로운 주름개선 소재: 3,9-diferuloyl-6-oxopterocarpen (Tensolin-F<sup>®</sup>)의 개발과 화장품 응용
이범천 ( Bum-chun Lee ),이정재 ( Jeong-jae Lee ),박성민 ( Sung-min Park ),김철배 ( Chul-bae Kim ),심관섭 ( Gwan-sub Sim ),김진화 ( Jin-hwa Kim ),이근수 ( Geun-soo Lee ),이천일 ( Chun-il Lee ),표형배 ( Hyeong-bae Pyo ) 대한화장품학회 2004 대한화장품학회지 Vol.30 No.1
3,9-Dihydro-6-oxopterocarpen과 ferulic acid의 에스테르 반응을 통해 페룰산 유도체인 3,9-diferuloyl-6-oxopterocarpen (Tensolin-F<sup>®</sup>)를 합성하여 이를 함유한 주름개선 화장품을 개발하였다. Tensolin-F<sup>®</sup>는 농도 의존적으로 DPPH와 superoxide radical에 대한 소거효과를 나타냈으며, 각각 0.8 mM에서 78%, 0.053 mM에서 92.9%로 DPPH와 superoxide radical을 소거하여 우수한 항산화 효과를 나타내었다. MMP-1 효소 활성 저해 효과도 0.16 mM에서 74%를 저해하였다. HDF에서 UVA에 의해 발현이 증가되는 MMP-1의 발현 저해 효과는 Tensolin-F<sup>®</sup> 0.8 uM에서 85.5%로 단백질 수준에서 모두 농도 의존적으로 발현 저해효과가 나타났다. Tensolin-F<sup>®</sup>를 함유한 제품의 피부 주름개선 효과 평가 결과, Tensolin-F<sup>®</sup>를 함유한 화장품을 약 8주 간 도포한 경우 유의한 주름개선 효과가 있음을 확인 할 수 있었다. 본 연구를 통하여 Tensolin-F<sup>®</sup>는 항산화 효과와 MMP-1활성 저해 효과 및 UVA에 의한 MMP-1의 발현을 저해하는 효과가 나타났으며 새로운 주름개선 기능성 화장품으로 이용될 수 있을 것이다. As a novel anti-wrinkle agent, 3,9-diferuloyl-6-oxopterocarpen (Tensolin-F<sup>®</sup>) has been synthesized and its anti-aging effects have been investigated. In the present study, to investigate the relationship between aging and Tensolin-F<sup>®</sup>, we examined its effect on scavenging activities of radicals and reactive oxygen species (ROS), in vitro inhibition activity of matrix-metalloproteinase (MMP) and expression of UVA-induced MMPs in human dermal fibroblasts (HDF). Tensolin-F<sup>®</sup> was found to show activities of scavenging radicals and ROS with the IC<sub>50</sub> values of 0.2 mM and 0.95 mM against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and superoxide radicals, respectively, in the xanthine/xanthine oxidase system. Fluorometric assays for the proteolytic activities of MMP-l (collagenase) were performed using fluorescent collagen substrates. Tensolin-F<sup>®</sup> inhibited the activities of MMP-l in a dose-dependent manner and the IC<sub>50</sub> values calculated from semi-log plots were 0.025 mM. Also, UVA induced MMP-1 expression was reduced 85% by treatment with Tensolin-F<sup>®</sup> at 0.8 uM, which was reduced dose-dependent manner. The results of clinical study showed that 4.8 mM Tensolin-F<sup>®</sup> treated group reduced wrinkle significantly compared with placebo treated group (P<0.05). Taken together, these result suggest that Tensolin-F<sup>®</sup> act as an anti-wrinkle agent by taking effects to antioxidation and reducing UVA-induced MMP-l production.-l production.
3차원 전기비저항 탐사를 이용한 친환경수처리 부지 내부상태 평가
이근수 ( Lee Keun-soo ),임은상 ( Im Eun Sang ),김남룡 ( Kim Nam-ryong ),조현철 ( Cho Hyeun Cheol ),김홍석 ( Kim Hongsuck ) 한국구조물진단유지관리공학회 2023 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.27 No.1
최근 이상기후 및 산업화에 따른 하천수의 오염은 사회적인 문제로 대두되고 있으며, 친환경적인 수질 개선 필요성이 부각되고 있다. 이에 따라 K-water에서는 친환경수처리 가늠터(T/B)를 구축하여 수질개선 효율에 대한 연구가 진행중이며, 그 결과, 우수한 처리효율을 보이는 것으로 보고되고 있다. 그러나, 친환경수처리 부지의 경우 유체흐름은 육안으로 확인이 어려운 내부에서 진행되므로 편흐름 등 문제 발생 여부 및 원인을 진단하기 어렵다는 단점이 있다. 이 연구에서는 비파괴 조사법인 3차원 전기비저항 탐사를 수처리부지 내에 적용하여 전기비저항 변화로부터 유체흐름 및 내부상태에 대해 진단하고자 하였다. 그 결과, 일부 영역에서의 문제점 및 원인 파악이 가능하였다.