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The aim of this study is to investigate the effects of jangdan (traditional Korean rhythmic percussion) storytelling activities on children’s expressive musical capabilities, expressive language abilities, and playfulness. The participants in this study were 40 3-year-old children attending 'S' kindergarten in Seoul. The experimental group engaged in jangdan storytelling activities 24 times over 8 weeks. During the same period, the comparison group engaged in similar activities involving Korean vocal melodies an equal number of times. For measurement, Kim, Kwang-Ja's musical expression ability test, Jang, Young-Ae's language expressive ability test, and Kim, Young-hi's playfulness test were used. T-verification of the independent sample was done to observe changes in the experiment and comparison groups. The results revealed that the jangdan storytelling activities had positive effects on musical expressive capabilities including singing, playing instruments, body language, and musical composition. Additionally, the activities had positive effects on language expressive abilities such as number of words and sentences, content matching, linking ideas, and creative expression. Finally, the activities had positive effects on playfulness such as increased physical spontaneity, social spontaneity, cognitive spontaneity, expression of pleasure, and sense of humor were observed. 본 연구는 스토리텔링을 통한 장단놀이 활동이 만 3세 유아의 음악표현력, 언어표현력 및 놀이성에 미치는 효과를 알아보는데 그 목적이 있다. 연구의 대상은 서울시에 소재한 S유치원에 다니는 만 3세반 유아 40명이었다. 실험집단에는 8주 동안 총 24회에 걸쳐 스토리텔링을 통한 장단놀이 활동을 적용하였고, 비교집단에는 같은 기간 동안 구음을 통한 장단놀이 활동을 적용하였다. 측정도구는 김광자(2004)가 사용한 음악표현력 검사도구와 장영애(1981)가 개발한 언어표현력 검사도구, Barnett(1991)이 제작한 아동의 놀이성 척도 CPS(Children's Playfulness Scale)를 김영희(1995)가 수정・보완한 놀이성 검사도구를 사용하였다. 비교집단과 실험집단의 변화를 살펴보기 위해 독립표본 t검증을 실시하였으며, 연구결과 첫째, 스토리텔링을 통한 장단놀이 활동은 노래부르기, 악기연주, 신체표현, 음악 만들기 등 유아의 음악표현력 향상에 효과적이었다. 둘째, 스토리텔링을 통한 장단놀이 활동은 단어 수, 문장 수, 내용의 일치, 내용의 연계, 창의적 표현 능력 등 유아의 언어표현력 향상에 효과적이었다. 마지막으로, 스토리텔링을 통한 장단놀이 활동은 신체적, 사회적, 인지적 자발성, 즐거움의 표현, 유머감각 등 유아의 놀이성 향상에 효과적이었다.
Purpose: Recent advancements in molecular techniques have greatly contributed to the discovery of genetic causes of unexplained developmental delay. Here, we describe the results of array comparative genomic hybridization (CGH) and the clinical features of 27 patients with global developmental delay. Methods: We included 27 children who fulfilled the following criteria: Korean children under 6 years with global developmental delay; children who had at least one or more physical or neurological problem other than global developmental delay; and patients in whom both array CGH and G-banded karyotyping tests were performed. Results: Fifteen male and 12 female patients with a mean age of 29.3±17.6 months were included. The most common physical and neurological abnormalities were facial dysmorphism (n=16), epilepsy (n=7), and hypotonia (n=7). Pathogenic copy number variation results were observed in 4 patients (14.8%): 18.73 Mb dup(2)(p24.2p25.3) and 1.62 Mb del(20p13) (patient 1); 22.31 Mb dup(2)(p22.3p25.1) and 4.01 Mb dup(2)(p21p22.1) (patient 2); 12.08 Mb del(4)(q22.1q24) (patient 3); and 1.19 Mb del(1)(q21.1) (patient 4). One patient (3.7%) displayed a variant of uncertain significance. Four patients (14.8%) displayed discordance between G-banded karyotyping and array CGH results. Among patients with normal array CGH results, 4 (16%) revealed brain anomalies such as schizencephaly and hydranencephaly. One patient was diagnosed with Rett syndrome and one with Möbius syndrome. Conclusion: As chromosomal microarray can elucidate the cause of previously unexplained developmental delay, it should be considered as a first-tier cytogenetic diagnostic test for children with unexplained developmental delay.
Tuberculous involvement of the tracheobronchial tree usually coexists with active pulmonary parenchymal or intrathoracic lymph node infection and very rarely has veen showed normal chest roentgenogram. This paper described 30 cases of endobronchial tuberculosis confirmed by bronchoscopy and biopsy in correlation to broncbographic finding on the patients from jan 1983 to Nov 1986 in Department of Radiology National Medical Center. The results were as follows; 1. Sex distribution of endobronchial tuberculosis showed 8 cases (26.7%) in male 22 cases (73.3%) in female and the higheset incidence in the third decade. 2. The radiologic findings of initial plain chest showed lobar or segmental collapse 16 cases (53.3%) minimal pulmonary tuberculosis 7 cases (23.3%) moderately advanced pulmonary tuberculosis 4 cases (13,3%) far advanced pulmonary tuberculosis 2 cases (6.7%) and normal finding 1 case (3.3%) 3. 25 cases of 28 bronchogram showed bronchial obstruction The left side was affected slightly more than the right (14:11) 4. The obstruction site of bronchus showed complete obstruction in11 cases among them sharp cut off in 2 rat tail narrowing in 1 symmetrical V-shaped narrowing in 8 and incomplete obstruction in 14 cases among them thumbprinting indentation in 2 circumferential symmetrical narrowing in 12. 5. 10 cases of 25 obstruction showed an associated bronchiectatic change of distal or adjacent to the lesion sote among them tubular in 3 saccular in 2 cystic in 5 cases
이경연,최용석,이유진,배현숙,김흥중,조광희,장현선,박주철,Lee, Kyoung Yeon,Choi, Yong-Seok,Lee, You-Jin,Bae, Hyun-Sook,Kim, Heung-Jeong,Cho, Kwang-Hee,Jang, Hyun-Seon,Park, Joo-Cheol 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.1
Periodontal ligament (PDL) is the connective tissue located between the tooth root and alveolar bone. In a previous study, PDLs22 was isolated as a PDL-specific gene by using subtractive hybrid-ization between cultured PDL fibroblasts and gingival fibroblasts. It was also suggested that PDLs22 plays important roles in the development, differentiation and maintenance of periodontal tissues. However, little is known about functional study of PDLs22 using recombinant protein in PDL fibroblast differentiation and periodontium formation. In this study, in order to produce the PDLs22 recombinat protein, PDLs22 expression vector were constructed and expressed its protein in various host cell and temperature conditions. The results were as follows: 1. PDLs22 protein was not strongly expressed In the induction system using pRSET-PDLs22 construct. 2. When the BL21(DE3) pLysS was used as a expression host, PDLS22 protein was strongly ex-pressed in the induction system using pHCEIIBNd-PDLs22 construct. 3. The PDLs22 protein was recognized at a molecular weight of 28 kDa in western blots. 4. Almost of the expressed PDLs22 protein was not soluble and observed like as inclusion body. 5. The protein solubility was not improved after modification of induction time and temperature during PDLs22 protein production. In this study, the system for the PDLs22 protein production was connstructed. However, the re-results suggest that further studies will be needed to produce the considerable amount of PDLs22 re-combinat protein, which can use for the periodontal regeneration.
한국 재래닭에서 성장에 따른 유전자들의 발현 변화를 알아보고 성장 촉진, 대사 및 면역 관련 유전자를 발굴하기 위하여 주령별로 닭의 간에서 RNA를 추출하였으며 10개의 arbitrary ACPs를 이용하여 차등 발현되는 유전자를 조사하였다. 발현량에 현저한 차이를 보이는 5개의 유전자들이 선별되었으며, 이 중 3개의 유전자들은 BLAST search 결과 이미 기능이 알려진 FTH1, SAA와 HSP90B1으로 밝혀졌다. 그러나 2개의 유전자들은 닭의 genome sequence가 끝났음에도 불구하고 기능이 밝혀져 있지 않아 앞으로 이 유전자들의 기능에 대한 연구가 지속되어야 함을 의미한다. 본 연구에서 닭의 간에서 성장 단계별로 발현 차이를 보이는 유전자들은 앞으로 다른 유전자와 단백질들과의 관계를 통하여 닭의 성장 및 지방 대사를 이해하는데 도움을 줄 것으로 사료된다. The chicken liver has been involved in various biological functions including detoxification, glycogen storage and plasma protein synthesis. The aim of this study was to investigate differentially expressed genes in chicken liver in four different growing stages. Using 10 arbitrary Annealing Control Primers (ACPs), five differentially expressed genes have been identified. Based on the Basic Local Alignment Search Tool (BLAST) search results, three of them were matched with previously known genes, and the other two were matched with unknown EST sequence and a hypothetical protein, respectively. In order to confirm the expression results, quantitative real-time PCR was also performed. The high similarities between the expression data using arbitrary ACPs and quantitative real-time PCR indicate that the identified genes are the real differentially expressed genes in different growing stages. The genes identified in this study can be used as valuable biomarkers in chicken with further investigation of the functions.
In the present study, experiments were designed to see whether there was a relationship between the development of narcotic tolerance and the qualitative change in opiate receptor in vitro. Studies were conducted in the coaxially stimulated vas deferens isolated from naive or chronically morphine-treated rat. The results were as follows; 1. In naive and chronically morphine-treated groups, the inhibitory action of morphine was decreased by naloxone. 2. The ID_50 of morphine in naive group was 0.39±0.03 μM and the value was increased in chronically morphine-treated group(1.07±0.13μM ). 3. The PA₂ value in naive group was 8.41 and the value was significantly decreased in chronically morphine-treated group(7.60). From the above results, it is suggested that the decrease in inhibitory action of morphine by chronic morphine treatment is closely related to affinity changes in opiate receptor.
A Case of X-Linked Agammaglobulinemia Associated withSevere Neutropenia Kyoung Yeon Lee, M.D., Dong Kyu Lee, M.D., Jun Eun Park, M.D.,Jae Ho Lee, M.D.* and Myung Ik Lee, M.D. 저자들은 폐렴치료 중 1개월 이상 심한 호중구 감소증이 지속되었던, 유전자 분석으로 확진된 XLA 환아를 경험하였기에 문헌고찰과 함께 보고하며, 만성 혹은 반복되는 감염의 증상과 함께 호중구 감소증이 나타날 때 XLA를 포함한 면역결핍질환을 의심하는 것이 필요하다고 사료된다.