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이병찬 ( Lee Byeong Chan ),이재규 ( Lee Jae Gyu ),이강창 ( Lee Gang Chang ),정종길 ( Jeong Jong Gil ),이건목 ( Lee Geon Mog ),신민교 ( Sin Min Gyo ),송호준 ( Song Ho Jun ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.3
N/A Objectives : It is well known that oxidative stress of reactive oxygen species is involved in neuronal disease. The purpose of this study was to examine the cytotoxicity of glucose oxidase(GO) and protective effect of Ramulus et Uncus Uncariae(REUU) on GO- induced cytotoxicity in the cultured cerebral neurons of mouse. Methods : Neurototoxicity of GO and protective effect of REUU were done by MTT assay, after cerebral neurons were cultured in the media containing 1-40 mU/ml CO for 4 hours. Results : GO decreased cell viability in dose-and time-dependent mannner, and REUU increased cell viability decreased by C d induced cytotoxicity in these cultures. Conclusion : From these results. Go showed neurotoxicity, and REUU is very effective in preventing GO-mediated cytotoxicity in cultured mouse cerebral neurons.