베타3-아드레날린성 수용체 유전자 변이와 체지방 분포

윤태승,김용득,김혜순,김미정,서영성,권중혁,최진수,김정국,하승우,김보완,원규장,이형우,손호상,이지현,윤현대,김원호,윤영길,이인규 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

연구배경: 비만의 발생 원인은 크게 유전적인 요인과 환경적인 요인으로 나눌 수 있으며, 치근 비만과 관련된 유전자 연구가 활발히 진행되고 있다 지금 까지 알려진 비만 관련 유전자로는 Leptin, UCP, PPAR-r, β3-AR 유전자 등이 있으며, 이 중에서 β3-AR 유전자는 내장 지방에 주로 존재하면서 G 단백질과 결합하여, 아드레날린성 신호에 의해 c-AMP 증가로 지방 분해와 열 발생을 일으킨다. 이 유전자의 64번째 아미노산인 trpytophan이 arginine으로 치환된 변이에서 기초대사율 감소와 체중 증가가 있다는 보고가 있으나, 비만과 무관하다는 보고도 있어, 본 연구는 좀 더 많은 수를 대상으로 β3-AR 유전자 변이에 따른 비만과의 연관성을 확인 위해 시행되었다. 방법: 연구 대상자는 정상군 97명 비만군 101명으로 하여, β3-AR 유전자 변이에 따른 체질량지수, 허리둘레, 엉덩이둘레, 허리엉덩이둘레비, 복부 내장지방면적, 피하지방면적, 내장지방/피하지방면적비율을 비교하고, 총 콜레스테롤, 중성 지방, 고밀도 지단백, 저밀도 지단백 등을 비교하였다. 결과: β3-AR유전자의 다형성이 비만군에 있어 이형접합체변이 (Trp/Arg)와 동형접합체 변이 (Arg/Arg)비율이 43%, 5%로 정상인 36%, 1% 비해 높았으나 통계학적 유의성은 없었다. 복부 피하지방면적 비교에 있어 정상군(Trp/T게)에서는 213.9± 109.6 ㎠인 반면에 동형 접합체변이 (Trp/Arg)와 이형접합체변이 (Arg/Arg)군에서 각각, 244.0±127.7 ㎠, 323.9±189.8 ㎠로 통계학적 유의성이 있었으며, 그 외에 허리 둘레,엉덩이 둘레, 허리 엉덩이 둘레비, 내장지방면적, 내장지빈피하지방면적비 등은 유전자 변이군에서 전반적인 증가는 있었지만 통계학적 유의성은 없었다. 결론: 3-AR 유전자 변이와 비만과의 관련에 대한 본 연구에 의하면, β3-AR 유전자 변이에 따른 비만 연관성은 복부 피하지방면적 증가에 있어서 통계학적으로 유의하게 증가 소견 보였으며, 그 외 다른 비만 관련 인자들에 있어 통계학적 의의는 없으나 전반적인 증가 소견을 보여, 한국인에 있어 β3-AR 유전자 변이는 비만과 연관성이 있을 것이라는 결론을 얻을 수 있었다. Background: Reasons for obesity include environmental facotrs and, more largely so, genetic factors. There have been many studies on these genetic factors. So far, genes related to obesity such as Leptin, Uncoupling Protein(UCP), Peroxisome proliferator activated receptor-gamma (PPAR-γ), and Beta3-adrener-gic receptor(β3-AR) gene have been discovered. Among these, β3-AR is expressed in visceral adipose tissue and is thought to contribute to the regulation of resting metabolic rate and lipolysis. The missense mutation of β3-AR gene, resulting in replacement of tryptophan by arginine at position 64 (Trp64Arg), is associated with decreased resting metabolic rate and weight gain. We performed this study to determine if Trp64Arg polymorphism of β3-AR gene is associated with obesity in Koreans. Method: We investigated the relationship between the (33-AR gene mutation and body mass index (BMI), waist circumference, hip circumference, waist to hip ratio (WHR), area of subcutaneous fat, area of visceral fat, visceral to subcutaneous fat ratio (VSR), and lipid profile. 198 subjects were included in this study of which 97 were of normal weight and 101 were obese. Anthropometric data was obtained from physical examination and medical records. Result: In the cases of (33-AR gene mutation of the obese group, the ratio of Trp/Arg and Arg/Arg are 43% and 5%, respectively, which were higher than the normal group(36%, l%), although a statistical significant was not found. There was significant difference in the are of subcutaneous fat. Normal group (Trp/Trp) measured at 213.9k109.6 ㎠ versus 244.0k127.7 ㎠ (Trp/Arg) and 323.9k189.9 ㎠ (Arg/Arg) for the mutation groups. Circumference of waist, circumference of hip, WHR, area of visceral fat, and VSR were higher in the mutation groups than in normal subject, but not significantly different. Conclusion: These results suggest that a genetic mutation in the (33-AR gene can affect body fat composition, and is associated with obesity in Korean adults (J Kor SOC Endocrinol 18:184-192, 2003).

알파-리포산이 HepG2 간세포에서 SREBP-1c 발현에 미치는 효과

윤태승,민애경,김남경,김미경,조호찬,김혜순,황재석,류성열,박근규,이인규 대한내분비학회 2008 Endocrinology and metabolism Vol.23 No.1

Background: Non-alcoholic fatty liver disease is common in patients with insulin resistance. Sterol regulatory element binding protein-1c (SREBP-1c) is a member of a family of transcription factors that have been recognized as key regulators for lipid accumulation in the liver that activate enzymes involved in the fatty acid biosynthetic pathway. This study was designed to evaluate whether alpha-lipoic acid (ALA) inhibits insulin-stimulated SREBP-1c expression.Methods: We investigated the effects of ALA on insulin-stimulated SREBP-1c expression in a human hepatoma cell line (HepG2 cells) using Northern and Western blot analysis. We also examined the effect of ALA on the promoter activity of the SREBP-1c gene to examine whether ALA can affect SREBP-1c expression at the transcriptional level. To discern the mechanism by which ALA inhibits SREBP-1c expression, we examined the role of AMP-activated protein kinase (AMPK). Results: Insulin increased the expression of SREBP-1c mRNA and protein in HepG2 cells in a dose depended manner. Co-treatment with ALA inhibited the insulin increased SREBP-1c expression in a dose-dependent manner. ALA also inhibited insulin-stimulated activation of the SREBP-1c promoter activity, indicating that ALA inhibited SREBP-1c expression at the transcriptional level. ALA increased phosphorylation of AMPK in HepG2 cells. Inhibition of the AMPK activity by compound C markedly reversed the inhibitory effects of ALA for insulin-stimulated SREBP-1c expression. These results suggest that ALA-induced suppression of SREBP-1c expression is at least in part mediated via AMPK activation.Conclusion: The present study suggests that ALA has an inhibitory effect on insulin-stimulated SREBP-1c expression. Therefore, further studies on the effects of ALA on hepatic steatosis in an animal model need to be performed. (J Kor Endocr Soc 23:27~34, 2008)

중소벤처기업을 위한 특허풀 구성 및 공동대응방안 모색의 중요성

윤태승,Yun, Tae-Seung 한국전자정보통신산업진흥회 2006 電子振興 Vol.26 No.4

C2DPCA & R2DLDA for Face Recognition

윤태승(Tae-Sung Yun),송영준(Young-Jun Song),김동우(Dong-Woo Kim),안재형(Jae-Hyeong Ahn) 한국콘텐츠학회 2010 한국콘텐츠학회논문지 Vol.10 No.8

본 논문에서는 열방향 2차원 PCA(Column-directional 2 Dimensional PCA, C2DPCA) 와 행방향 2차원 LDA(Row-directional 2 Dimensional LDA, R2DLDA)를 사용하여 얻은 각각의 투영 행렬을 동시에 사용하는 방법을 제안하였다. 제안 방법은 얼굴의 가로 특징과 세로 특징을 모두 포함한 저 차원의 특징 행렬을 얻음으로써, 훈련 영상의 수에 관계없이 안정적이고 높은 인식률을 얻을 수 있다. 또한, 같은 알고리즘으로 가로 방향과 세로 방향에 PCA와 LDA를 각각 달리 적용한 실험(C2DPCA & R2DLDA, C2DLDA & R2DPCA)에서 가로 방향의 특징에 2차원 LDA를 적용한 시스템(C2DPCA & R2DLDA)이 그 반대의 경우보다 저차원으로 높은 인식률을 얻을 수 있음을 확인할 수 있었다. 실험 결과 제안한 방법이 2DPCA와 2DLDA 등 의 기존 방법보다 인식율이 높은 99.4%를 얻었다. 또한 제안 방법의 인식 처리 속도도 기존의 2DPCA와 2DLDA 방법보다 3배 이상 빠름을 확인하였다. The study has proposed a method that simultaneously takes advantage of each projection matrix acquired by using column-directional two-dimensional PCA(C2DPCA) and row-directional two-dimensional LDA(R2DLDA). The proposed method can acquire a great secure recognition rate, with no relation to the number of training images, with acquired low-dimensional feature matrixes including both the horizontal and the vertical features of a face. Besides, in the alternate experiment of PCA and LDA to row-direction and column-direction respectively(C2DPCA & R2DLDA, C2DLDA & R2DPCA), we could make sure the system of 2 dimensional LDA with row-directional feature(C2DPCA & R2DLDA) obtain higher recognition rate with low dimension than opposite case. As a result of experimenting that, the proposed method has showed a greater recognition rate of 99.4% than the existing methods such as 2DPCA and 2DLDA, etc. Also, it was proved that its recognition processing is over three times as fast as that of 2DPCA or 2DLDA.

리니어 압축기를 적용한 냉장고 사이클의 냉동 부하변동에 따른 운전특성에 관한 연구

윤태승(Tae-Seung Yoon),송상진(Sang-Jin Song),민병채(Byung-Chae Min),김건우(Geon-woo Kim),나상경(Sang-kyung Na),최경민(Gyung-Min Choi) 대한설비공학회 2016 대한설비공학회 학술발표대회논문집 Vol.2016 No.6

An experimental investigation on effects of variation of ambient temperature and compressor stroke in a refrigerator was conducted with a linear compressor. The refrigerant of 115g was charged from the results of comparing the power consumption and on-time ratio with different refrigerant charge amount. The cooling capacity of a linear compressor was increased with the ambient temperature increase due to ability of self-modulation of the compressor. The power consumption and cooling time were compared with variation of the cooling capacity of a linear compressor from 60% to 100%. As a result, the power consumption of a linear compressor was reduced by 22.4% with the compressor capacity increase. However, on-time ratio was increased by 11.3%.

하악과두골절에서 근육과 인대를 통한 기능적인 정복술

장환용,윤태승,김현준,이학기,장현석,임재석,이의석 대한통합치과학회 2015 대한통합치과학회지 Vol.4 No.2

Introduction: Practitioner used 2 different plate fixation after reduction of mandibular condyle fracture. This study was to compare sliding plate between conventional 4 hole plate after condyle fracture reduction. Method and materials: A total of 30 patients were operated for condyle fracture. Group was separated two. Control group operated and fixated 4 hole conventional plate (n=13). Experimental group operated and fixated sliding plate (n=17). Approximately 3~6 month later followed up through panorama & reverse townes view X-ray. In these X-ray, we compared angle of non-fracture opposite side condyle between fracture site condyle. Statistical analyzed with Mann-whitney analysis (P<0.05). Results: Observing through Panoramic X-ray fracture site condyle angle and non-fracture site condyle angle’s difference were 2.1 degree at sliding plate and 7.12 degree at 4 hole conventional plate. In reverse towens view X-ray, fracture site condyle angle and non-fracture site condyle angle’s difference is 13.5 degree at sliding plate and 16.5 degree at 4 hole conventional plate. Conclusion: We suggest using sliding plate to reduce condyle fracture. No significant difference measured changing condyle angle after operation between sliding plate and 4 hole conventional plate in panoramic & reverse townes view.

블록 내 움직임 정보를 이용한 다단계 움직임 예측 알고리즘

곽내정,윤태승,한재혁,안재형 충북대학교 컴퓨터정보통신 연구소 2001 컴퓨터정보통신연구 Vol.9 No.2

본 논문에서는 불록 내의 움직임 정도에 따라 다단계의 볼록레벨을 설정하고, 그 블록레벨에 따라 각기 다른 다단계의 움직임 예측을 수행하는 다단계 움직임 예측 알고리즘을 제안한다. 제안방법은 3단계의 블륵 레벨을 설정하고. 각 불록 레벨에는 서로 다른 크기의 고정 블록을 설정한다 또한 각 블록 레벨에서 수행되는 움직임 예측에는 탐색 단계와 탐색 범위를 차등적으로 적용하였다. 이는 움직임이 없거나 적은 영역에서의 잉여 탐색 과정을 제거하여 계산적 효율성을 중대하고, 움직임 정도가 큰 영역에 대해서는 움직임 예측 과정을 심화시켜 예측의 정확성을 향상시킨다 실험 결과 프레임당 적은 수의 블록으로 고정된 크기의 볼록을 가진 전역 탐색 블록 정합 알고리즘보다 적은 예측 에러를 발생시켜 MSE를 20% 정도 감소시키며, 연산량을 95% 정도 절감하는 효과를 얻을 수 있었다. In this Paper. we Propose a multi-level block matching algorithm using motion information in blocks. In the Proposed algorithm, the block-level of a block is decided by the motion degree in the block before motion searching Procedure, and then adequate motion searching performs according to the block-level. The number of block-level is 3 step and different fixed-block sixte is assigned to each block-level. Also. in motion estimation of each block-level is differential applied search step and search area. Which imProves computational efficiency by eliminating an unnecessary searching Process in no motion or low motion regions. and brings more accurate estimation results by deepening motion searching process in high motien legions. Simulation results shew that the proposed algorithm brings the lower estimation error about 20% MSE(mean squared error) reduction with the fewer blocks per frame and the lower computational loading about 98% operational amount reduction than full search block matching algorithm with constant block size.

움직임 예측을 위한 비트패턴을 이용한 고속 워핑 예측

강봉구,윤태승,곽내정,안재형 충북대학교 컴퓨터정보통신 연구소 2002 컴퓨터정보통신연구 Vol.10 No.2

본 논문에서는 비트패턴을 이용한 고속 워핑 예측을 제안한다. 워핑 예측은 이웃한 노드들의 움직임 벡터에서 움직임 정보를 가져오는 공간적인 의존성 때문에 최적의 움직임을 찾기 위해서는 반복적인 탐색을 요구한다. 반복적인 탐색에 의해 발생하는 연산량의 증가는 워핑 예측의 사용을 저해하는 큰 이유 중의 하나이다. 본 논문에서 제안한 방법은 비트패턴을 이용해서 움직임 여부를 판단한다. 움직임이 없는 영역에서의 의미 없는 움직임 예측을 제거하고, 움직임이 있는 영역에서만 워핑 예측을 수행함으로써 빠른 움직임 예측이 가능하게 된다. 제안된 방법으로 실험한 결과 기존의 워핑 예측을 수행했을 때보다 성능은 근접하면서도 연산량이 75% 이상 감소하였다. In this paper, we propose a fast warping prediction using bit-pattern. Because of the spatial dependency between motion vectors of neighboring node points carrying motion information, the optimization of motion search requires an iterative process. The computational load stemming from the iterative search is one of the major obstacles for practical usage of warping prediction. The motion estimation in the proposed algorithm measures whether the motion content of the area is or not, using bit-pattern. Warping prediction using the motion content of the area make the procedure of motion estimation efficient by eliminating an unnecessary searching process. Experimental results show that the proposed algorithm can reduce about 75% of iterative search while maintaining performance as close as the conventional warping prediction.

하악 과두에서 발생한 골연골종의 수술적 치료: 증례 보고 및 문헌 고찰

이학기,김규태,김민수,김현준,윤태승,임호경,장현석,이의석 대한구강악안면병리학회 2016 대한구강악안면병리학회지 Vol.40 No.3

Osteochondroma is one of the most common benign tumors of the bone. Although osteochondroma is rarely seen in the facial region, it was reported that the cases occured in the mandibular region, especially around the condyle. Patients complain about malocclusion, temporomandibular disorders and facial asymmetry. The treatments of these cases include total condylectomy or local resection of the lesion. A 48-year-old man visited our hospital. His chief complaints were pain in the left temporomandibular joint (TMJ) and deviation of mandible during mouth opening. Panoramic radiograph showed an enlarged left condyle. A bony proliferation with benign sign was also observed in the computed tomography. Surgical treatment was done by removing the bony mass. Histologically, biopsy result was an osteochondroma. After surgery, there was reduced pain and normal mouth opening. Deviation of the mandible was also observed. We report a case of osteochondroma on the mandibular condyle and a review of literature about the surgical treatment.

전신성 홍반성 루프스에 동반된 횡단성 척수염 1례

서창균,김상현,이승현,윤태승,박재호,임정근 啓明大學校 醫科大學 2002 계명의대학술지 Vol.21 No.1

Systemic lupus erythematosus (SLE) is an autoimmune disease associated with variable symptoms in many organs. Involvement of central nervous system in SLE is a relatively common complication. However, transverse myelitis is a rare and late complication of SLE and its prognosis is very poor, resulting in death or severe neurologic sequelae. We report a case of transverse myelitis who was diagnosed as SLE before the onset of neurologic symptoms. Transverse myelitis was diagnosed, based on the clinical presentation and MRI findings. This patient indicated that transverse myelitis could be a relatively early manifestation of SLE. We treated the patient with pulse methyprednisolone followed by cyclophosphamide. However, the treatment did not improve clinical condition of the patient.