엔젤만 증후군의 특징적인 뇌파 패턴

윤중수,송운흥,최화식 대한임상검사과학회 2010 대한임상검사과학회지(KJCLS) Vol.42 No.2

The two new female cases of Angelman syndrome (AS) were described, which diagnosed on the basis of clinical features (dysmorphic facial features, severe mental retardation with absent speech, peculiar jerky movements, ataxic gait and paroxysms of inappropriate laughter) and neurophysiological findings. Failure to detect the deletion of the long arm of chromosome 15 or the absence of epileptic seizure were not considered sufficient to exclude a diagnosis of AS. Feeding problems, developmental delay and early signs of ataxia, especially tremor on handling objects and unstable posture when seated, proved effective as the clinical markers for early diagnosis of AS. Most of the authors agreed about the existence of three main EEG patterns in AS which may appear in isolation or in various combinations in the same patient. The most frequently observed pattern in children has prolonged runs of high amplitude rhythmic 2-3 Hz activity predominantly over the frontal region with superimposed interictal epileptiform discharges. High amplitude rhythmic 4–6 Hz activity, prominent in the occipital regions, with spikes, which can be facilitated by eye closure, is often seen in children under the age of 12 years. The EEG findings are characteristic of AS when seen in the appropriate clinical context and can be helpful to identify AS patients at an early age when genetic counselling may be particularly important. .

우리나라 小兒 死亡原因의 特性 變遷에 關한 硏究

尹重洙,李時伯 서울大學校保健大學院 1995 國民保健硏究所硏究論叢 Vol.5 No.2

Recently, the National Health Insurance Scheme has been improved. The fertility rate has been slowed down while life expectancy is constantly increasing. It is significant to study on children mortality which is improtant for the development of the national and provied the basis of policy establishment. This study is intended to analyze the causes of children mortality on the basis of Mortality Report Data from 1982 through 1993. The major findings of the study are as follows: Under one year old group: The congenital abnormality and perinatal diseases increase whild infection and parasistic diseases, respiratory diseases, cardiovascular disease, digestive diseases and unknown symptoms and diagnosis decreases. Age group of 1-4: The congenital abnormality, injury and poisoning and neoplasm increases and the decreasing trend is similar to that of under one year old group. Age group of 5-14: increasing and decreasing trend are similar to those of 1-4 age group. The neoplasm of 0-4 and 5-14 age group is increasing faster than other diseases. The ten major death causes of children are found to be follows: 1) accidents, 2) congenital abnormality, 3) neoplasm, 4) pneumonia & bronchitis, 5) perinatal diseases, 6) cerebral palsy and paralysistic diseases, 7) heart diseases, 8) meningitis, 9) homicide, and 10) cerobrovascular diseases.

석탄폐기물을 이용한 강화플라스틱 소재개발(III)

윤중수 ( Joong-soo Yoon ),이상우 ( Sang-woo Lee ),최종문 ( Jong-moon Choi ) 한국환경분석학회 2018 환경분석과 독성보건 Vol.21 No.3

Reinforced plastics containing waste polypropylene, waste coal, and fly ash were manufactured, and the usefulness of reinforcing agents such as waste coal and fly ash was investigated from the physical properties of the manufactured reinforced plastics. The physical properties (tensile strength, tensile elongation, flexural strength, impact strength, and hardness) of the manufactured reinforced plastic using waste coal or fly ash as the reinforcing agent were superior to those of general particle-reinforced plastics but inferior to those of fiberreinforced plastics. When increasing amounts of reinforcing agents were added, the physical properties of the reinforced plastic increased proportionally. In general, the efficiency of fly ash as a reinforcing agent is better than that of coal waste. Using a combination of the two reinforcing agents, improved the physical properties of reinforced plastic compared to those of the individual agents because of the homogeneity of the mixture. Because coal waste and fly ash may contain various harmful ingredients, their elution will be of concern in long term. However, harmful components such as cadmium, chromium, mercury, lead, and organic bromine were not detected in these wastes. The manufactured reinforced plastics investigated in this work may be used to replace the concrete rain storage systems, which have a high construction cost, weak shock-resistance, and are difficult to manage. Moreover environmental problems due to waste coal and fly ash can be minimized if they are reused as reinforcing agents.

APR+의 농축폐액 처리방안 고찰

이상섭,윤중수,김성환 한국방사성폐기물학회 2009 한국방사성폐기물학회 학술논문요약집 Vol.7 No.2

APR+ 신형원전 개발현황

김대헌,윤중수,박영섭 한국에너지학회 2013 한국에너지공학회 학술발표회 Vol.2013 No.5

Saccharomycopsis fibuligera 발효 생강나무 꽃 추출물의 항산화 및 항염효과

박상남,윤중수,이옥희 중소기업융합학회 2021 융합정보논문지 Vol.11 No.11

본 연구에서는 생강나무 꽃 발효 추출물의 항산화능 및 항염능을 확인하였다. 항산화능 측정을 위해 DPPH 실험, ABTS 실험을 실시하였다. 동시에 폴리페놀 농도 측정, 플라보노이드 농도 측정을 통해 항산화 물질 의 정량을 실시하였다. 플라보노이드, DPPH, ABTS에서는 발효 후의 항산화능이 증가한 것을 확인하였다. 이 때 플라보노이드 농도는 5.0%, DPPH 실험에서는 33.27%, ABTS 실험에서는 29.82%의 항산화능 개선 효과가 나타 났다. 항염능 실험에서는 세포 독성 실험과 LPS로 유도된 염증에 대한 항염능을 알아보기 위한 NO 생성 억제능 실험을 실시하였다. 세포독성의 경우 대조군과 발효군 모두 낮은 세포독성을 보였지만 발효군에서 더 낮은 세포독 성을 보였다. NO 생성 억제능의 경우 발효군이 대조군에 비해 50% 이상의 항염능 증가를 보여 발효 생강나무 꽃이 기존 생강나무 꽃에 비해 더 개선된 화장품 원료로서 사용가능함을 보였다. In this study, the antioxidant activity and anti-inflammatory activity of Lindera obtusiloba flower fermentation extracts were identified. To evulate antioxidant activity and antioxidant concentration, polyphenol concentration measurements, flavonoid concentrations measurements, DPPH experiments, and ABTS experiments were conducted. In Flavonoids, DPPH and ABTS assay, antioxidant activity were increased after fermentation. At this time, the flavonoid concentration was 5.0%, the DPPH experiment showed 33.27% and the ABTS experiment showed 29.82% antioxidant increase. In the anti-inflammatory experiment, we conducted a cytotoxicity experiment and an anti-inflammatory experiment for LPS-induced inflammation. Cytotoxicity showed low cytotoxicity in both control and fermentation groups, but lower cytotoxicity in fermentation groups. In the case of NO production inhibition, fermented Lindera obtusiloba flowers showed an increase in anti-inflammatory activity by more than 50% compared to the control group, showing that they can be used as a cosmetic ingredient with anti-inflammatory function.

임상병리사의 직무만족도와 이직의도 관련 요인분석

김정현,윤중수,조민호 한국의료정보교육협회 2022 보건의료생명과학논문지 Vol.10 No.1

본 연구는 임상병리사들의 성별, 연령, 경력, 병원 형태, 근무 형태에 대한 직무만족도, 근무환경, 대인관계, 교육수준, 소속, 여가, 이직 의도, 총 만족도 등의 차이를 알아보고, 특히 직무만족도와 이직 의도 간에 미치는 영양을 확인하고 향후 임상병리사들의 업무 효율성을 높이는데 기초자료로 활용 하고자 시도하였다. 연구결과 임상병리사의 총 만족도는 3.33±0.52점으로 나타났다. 요인 별로는 대인관계 만족도 3.83±0.52점으로 가장 높았고, 직무 만족도, 교육 만족도, 소속 만족도, 근무환경 만족도, 여가 만족도, 이직 의도 순으로 나타났다. 임상병리사의 직무 만족도는 나이와 경력이 많아질수록, 정규직일수록 만족도가 높았다. 임상병리사의 직무 만족도를 높이고 이직 의도를 감소시키기 위해서는 직무만족도가 가장 낮고, 이직 의도가 가장 높은 20대, 경력 1-3년차의 정규직, 비정규직 모두에서 복지, 임금, 근무환경 등의 실질적인 변화를 고려해야 할 필요가 있으며, 이러한 요인 분석을 토대로 이직 의도를 파악하고 효율적인 인사정책을 수립하는데 초점을 맞춰야 할 것으로 사료된다.

기체크로마토그래피에 의한 캡사이신, 디하이드로캡사이신 및 노니바마이드(PAVA)의 정량

김상수,윤중수 한국의료정보교육협회 2021 보건의료생명과학논문지 Vol.9 No.1

Determination of capsaicin, dihydrocapsaicin and nonivamide in pungent liquids of self-defense spray were studied. The nonivamide having almost same spicy taste with capsaicin have been containing a few amounts in natural products, it had called as synthetic capsaicin or PAVA, have used to flavorings for foodstuffs and incapacitating agents of riot controls. Nowadays, it has been occasionally found that the quality controls of a self-defense sprays were not properly due to flood of illegal self-defense sprays. Thus, the simple analytical method with gas chromatography is developed, it is identified whether the products which have contained synthetic capsaicin were marked like natural materials as well as the pungent ingredients in it obeyed with permissible concentration to human or not was investigated. Finally, the pungent components and amounts in some kinds of self-defense spray were investigated. 호신용 스프레이의 자극성 액체에 포함된 capsaicin, dihydrocapsaicin 및 nonivamide의 함량을 기체크로마토그래피로 정량하는 방법에 대해 연구하였다. Capsaicin과 거의 동등한 수준의 매운맛을 내는 nonivamide는 천연물 내에도 극히 소량 존재하므로 합성된 nonvamide를 합성 캡사이신(Synthetic capsaicinoid) 또는 PAVA(Pelargonic Acid Vanillyl Amide)라고 부르며 식품 향미 재료나 폭동진압용 무능화 작용제로 이용되어왔다. 호신용품이 난립하는 요즘 각종 불법 호신용 스프레이의 품질관리가 제대로 이행되지 않는 사례가 종종 발견되고 있다. 따라서 기체크로마토그래피로 합성 캡사이신이 포함된 제품이 천연 유래인 것처럼 도용되거나 허용농도를 준수하는 지를 판별할 수 있는 간단한 분석방법을 개발하고자 하였다. 마지막으로 분석방법이 확립되면 시판되는 호신용 스프레이 내에 존재하는 자극성 액체의 성분과 함량 조사에 응용하여 보았다.

APR+ 원전 후쿠시마 원전사고 초기사건 분석

김대헌,윤중수 한국에너지학회 2015 한국에너지공학회 학술발표회 Vol.2015 No.11

검사건수에 따른 임상병리사의 인원편성에 관한 설문조사 분석

김정현,김대은,윤중수,이정수,박태화 대한임상검사과학회 2019 대한임상검사과학회지(KJCLS) Vol.51 No.1

본 연구는 국내의 진단검사의학과의 검사현황 및 인력배치현황과 검사 건수를 파악하기 위함이다. 지역별, 규모별 임상병리사를 대상으로 설문조사를 실시하여 최종 441부를 분석 자료로 사용하였다. 자료의 분석은 STATA (version 12.0)를 이용하여 Descriptive statistics analysis, Chi-square test, ANOVA test를 실시하였다. 병원 규모별 임상병리사 분포는 의원급 5.8 명, 병원급 14.9명, 종합병원 25.8명, 대학병원 45.4명으로 나타났다. 부서별검사건수, 1인 1일 검사건수는 의원, 병원, 종합병원, 대학병원간의 유의한 차이가 있었다. 임상병리사의 1일검사건수와 1일 적정 검사건수의 차이는 상급병원으로 갈수록감소하는 것으로 나타났다. 정도관리는 상급병원의 부서별 정도관리 평균 시간은 2시간 이내로 나타났다. 급여만족도, 근무환경만족도, 검사성취도, 복지제도측면에서 의원, 병원급에서불만족도 다수 차지하는 것으로 나타났다. 이는 선진국형 의료수준에 맞는 신뢰성 있는 검사의 데이터를 제공하기 위해 임상병리사의 근무환경에 따른 근무의 만족도와 임상검사의 정확도를 높이기 위해서라도 임상병리사의 처우개선에 초점을 맞추어야 할 것으로 사료된다. This study examined the relationship between the number of medical technologists and the medical test count. Data was obtained from 441 medical technologists in a hospital through a self-reported questionnaire. The Pearson correlation test, student’s t-test, ANOVA or descriptive statistics were performed for data analysis. The distribution of medical technologist according to the size of hospitals was small 5.8, medium 14.9, large 25.8, and super 45.4. The analysis demonstrated a relationship between the number of medical technologists and the number of medical tests in the field, number of clinical tests per MT, and number of optimal medical test per MT according to the hospital size (P<0.001). The average time for quality control by the department at a higher hospital was less than two hours. In terms of the satisfaction of salary, work environment, test accomplishment, and welfare service, the dissatisfaction of medical technologists in small and medium hospitals was higher than those in large and super hospitals. Overall, a focus on intensifying systemic supplementation and improving the condition of medical technologists is needed to provide reliable data for medical examinations in medical areas.