신성빈혈에 관한 연구 : 급성신성빈혈의 실험적 고찰 Experimental Study in Acute Renal Anemia

윤조은 대한핵의학회 1969 핵의학 분자영상 Vol.3 No.2

신성빈혈의 발생기전을 관찰하기 위하여 선택적으로 신세뇨관과 계구체에 병변을 일으키는 potassium perchlomate와 Canthalidin액을 가토에 주입하여 실험적으로 신에 변화를 일으킨 후 각종 혈액 및 뇨변화를 관찰하는 동시에 (59)^Fe와 (51)^Cr 동시 표식법을 사용하여 철대사 및 적혈구수명을 측정하여 다음과 같은 성적을 얻었다. 1) 적혈군 hematocrit 및 혈색소치는 pot. perchlomate 투여군에서는 약간 감소하였고 canthalidin 투여군에선 현저한 감소를 보였으며 강상구는 pot. perchlomate 투여군에서는 불변이었으나 canthalidin 투여군에서는 증가를 보였다. 2) 혈청철치는 양군에서 불변이었고 혈청 Mg치는 pot. perchlomate 투여군에서 약간 증가하고 canthalidin 투여군에서 불변이었다. 3) 혈중잔여실소와 creatinine치는 canthalidin 투역군에서 약간 증가하고 pot. perchlomate 투여군에서 불변이었다. 4) 뇨소견을 보면 양군에서 모두 단백뇨를 보았고 pot. perchlomate 투여군에선 잠혈이 거의 없었고 canthalidin 투여군에선 현저한 잠혈을 보았다. 5) 혈장량은 양군에서 불변이었고 적혈구량과 전혈량은 pot. perchlomate 투여군에서 약간 감소하고 canthalidin 투여군에서 현저한 감소를 보였다. 6) Ferrokinetics의 성적을 보면 다음과 같다. ⅰ) 혈장철소실속도는 양군에서 연장되었으며 혈장군교대율, 적혈구철이용률, 적혈구철교대율등은 양실험군에서 모두 감소, 1일적혈구철신생율은 양실험군에서 증가, 순환적혈구철은 canthalidin 투여군에서 현저히 증가하고 pot. perchlomate 투여군에서 불변이었으며 적혈구철농도는 양실험군에서 불변이었다. ⅱ) P.I.T.R.-R.C.I.T.치는 양실험군에서 증가하였으나 canthalidin 투여군에서 약간 더 증가하였다. 강상구지수, 적혈구철교대율지수, 혈장철교대율지수 및 유효조혈지수등은 양실험군에서 모두 감소하였다. 상술한 제성적을 종합하면 pot. perchlomate 내지 canthalidin 투여로 야기된 실험적신염이 조혈능에 미치는 영향은 거의 같으며 병리조직학적 ferrokinetics상으로 무효조혈의 상대적항진을 인지할 수 있었으며 이것은 잔여실소보다 오히려 조혈촉진인자 및 기외의 불명한 원인에 의한 수내용혈의 항진이 신성빈혈의 성인기전이 된다고 생각된다. The double tracer study on erythrokinetics was carried out experimentally with radioactive iron((59)^Fe) and chromium ((51)^Cr) in rabbits. The 0.1% canthalidin solution and 1% pot. perchlomate solution was given subcutaneously to 20 rabbits respectively. 3 and 6 days after injection, the blood chemistry, urine examination, ferrokinetics and apparent half survival time of RBC were ((51)^Cr T½) determined. Following were the results: 1) Red blood cell hematocrit and hemoglobin values were moderately reduced and B.U.N. and serum creatinine values were slightly increased in the canthalidin group, while B.U.N. and serum creatinine values were within normal limits in the pot. perchlomate group. Reticulocyte values were slightly increased in the canthalidin group, while was normal range in the pot. perchlomate group. 2) Blood chemistry finding was not significant statistically in both experimental groups, but serum iron value was moderately reduced in both group. 3) Plasma volume was unchanged in both grop, but red cell volme and whole blood volume were slightly reduced in both groups. 4) Results of ferrokinetics were as follows: ⅰ) The plasma iron disappearance rate was delayed in both groups. Plasma iron turnover rate, red cell iron utilization and red cell iron turnover rate were decreased in both groups, and then red cell iron turnover rate was more decreased than plasma iron turnover rate in both groups. Circulating red cell iron was slightly increased in canthalidin group and red cell iron concentration was within normal range in both groups. ⅱ) P.I.T.R.-R.C.I.T. value moderately increased in the canthalidin group and slightly increased in the pot. perchlomate group. Reticulocyte index, red cell iron turnover index, plasma iron turnover index and effective erythropoiesis index were wholely reduced in both groups. ⅲ) The red cell life span was slightly shortened in the canthalidin group while was within normal range in pot. perchlomate group. The pathologic finding of renal biopsy of the canthalidin group shows a selectidamage in glomerulus, while shows almost normal range or slight damage in tubules. And that of the pot. perchlomate group shows a selective damage in tubules with slight damage of glomerulus. $quot;

The Effects of Twin Text Instruction with Different Readability Levels on EFL Children’s Reading Comprehension

윤조은(Yoon, Jo-an),이문복(Lee, Moon-bok) 융합영어영문학회 2021 융합영어영문학(구.English Reading and Teaching) Vol.6 No.2

In the present study, the i-1 method is applied to young EFL learners who have a low level of English proficiency as well as reading motivation. The experiment of twin-text instruction was conducted in a community English library center, AJU Good Dream Center, in Seoul, Korea. The participants of the experiment were 13 elementary school students who enrolled in an English reading program during the winter vacation. There were 9 female students and 4 male students, and their grades ranged from 1st to 6th. The whole experiment was conducted for fourteen sessions, where each session consisted of one pretest, twelve teaching sessions with 12 pairs of text sets about the same topic in the order of ‘i-1’ level non-fiction texts to ‘i+1’ level of fiction texts, and one posttest. The findings are as follows. First, the twin-text reading instruction had positive effects on young Korean EFL learners, especially when the i-1 method was applied to expository text to pair with narrative text. Statistical analyses demonstrated that the posttest scores are higher than the pretest scores after the twin-text instruction, and the positive effects were greater for those with a lower level reading comprehension ability. Also, the students agreed that the twin-text instruction is helpful for improving their reading comprehension ability, and those with a lower level of reading comprehension ability had a more positive evaluation of the twin-text instruction. These results suggest that the i-1 method in twin-text instruction can be a good solution to reduce inequality in English education.

The Effects of Twin Text Instruction with Different Readability Levels on EFL Children’s Reading Comprehension

윤조은(Yoon, Jo-an),이문복(Lee, Moon-bok) 한국영어독서교육학회 2021 ENGLISH READING AND TEACHING Vol.6 No.2

In the present study, the i-1 method is applied to young EFL learners who have a low level of English proficiency as well as reading motivation. The experiment of twin-text instruction was conducted in a community English library center, AJU Good Dream Center, in Seoul, Korea. The participants of the experiment were 13 elementary school students who enrolled in an English reading program during the winter vacation. There were 9 female students and 4 male students, and their grades ranged from 1st to 6th. The whole experiment was conducted for fourteen sessions, where each session consisted of one pretest, twelve teaching sessions with 12 pairs of text sets about the same topic in the order of ‘i-1’ level non-fiction texts to ‘i+1’ level of fiction texts, and one posttest. The findings are as follows. First, the twin-text reading instruction had positive effects on young Korean EFL learners, especially when the i-1 method was applied to expository text to pair with narrative text. Statistical analyses demonstrated that the posttest scores are higher than the pretest scores after the twin-text instruction, and the positive effects were greater for those with a lower level reading comprehension ability. Also, the students agreed that the twin-text instruction is helpful for improving their reading comprehension ability, and those with a lower level of reading comprehension ability had a more positive evaluation of the twin-text instruction. These results suggest that the i-1 method in twin-text instruction can be a good solution to reduce inequality in English education.

유착성 견관절염 환자에서 하이알루론산과 스테로이드 병용요법의 효과

김철,윤조은,김덕유,박용범 대한재활의학회 2010 Annals of Rehabilitation Medicine Vol.34 No.3

Objective: To investigate the effects of sono-guided intraarticular steroid injection followed by sodium hyaluronate injection weekly for 2 weeks on adhesive capsulitis of the shoulder Method: In this prospective randomized controlled trial, 16 patients (group A) were treated with intraarticular injection with a mixture of 0.5% lidocaine 9 ml and triamcinolone 40 mg once a week for 3 weeks, and 13 patients (group B) were treated with intraarticular injection with a mixture of 0.5% lidocaine 9 ml and triamcinolone 40 mg for the first week, and subsequently a mixture of 0.5% lidocaine 8 ml and sodium hyaluronate 2 ml once a week for the next 3 weeks. A self exercise program was instructed for all subjects. The effects were assessed using visual numeric scale (VNS), shoulder pain and disability index (SPADI), and range of shoulder motion (flexion, abduction, internal rotation. external rotation, and extension) at study entry, every week until 2 weeks have passed after the last injection. Results: The VNS, SPADI, and range of shoulder motion improved 1 week after 1st injection and continued to improve until 2 weeks after last injection in both two groups. There were no difference in changes of VNS and SPADI between these two groups, but range of shoulder motion especially in passive and active internal rotation of patients in group A improved more than those in group B. Conclusion: Steroid injection combined with hyaluronic acid injection has comparable effects with triamcinolone for treatment of adhesive capsulitis of the shoulder. Sono-guided intraarticular injection of steroid combined with hyaluronic acid can substitute for intraarticular injection of triamcinolone and be useful especially for patients susceptible to adverse effects of steroid injection. (J Korean Acad Rehab Med 2010; 34: 310-315)

ST파 상승 심근경색 및 ST파 비상승 심근경색에서의 심장재활 효과

김철,박윤경,윤조은 대한재활의학회 2009 Annals of Rehabilitation Medicine Vol.33 No.3

Objective: To compare the effects of cardiac rehabilitation between patients with ST elevation myocardial infarction (STEMI) and non-ST elevation myocardial infarction (NSTEMI). Method: Thirty three patients with STEMI or NSTEMI who underwent percutaneous transluminal coronary angioplasty were recruited. All patients participated in cardiac rehabilitation program including ECG monitoring exercise for 6 weeks. Several parameters such as exercise duration, oxygen consumption, heart rate, blood pressure and rate pressure product were evaluated through graded exercise test before and 6 months after initiation of cardiac rehabilitation program. Results: After cardiac rehabilitation program, the STEMI group showed significant changes in exercise time, maximum oxygen consumption, resting heart rate and submaximal rate pressure product. The NSTEMI group also showed significant improvement of exercise time, maximum oxygen consumption and submaximal rate pressure product. There was no significant difference in the changing rate between two groups. Conclusion: Both the STEMI and the NSTEMI groups showed similar improvement of cardiopulmonary exercise capacity 6 months after cardiac rehabilitation program. Objective: To compare the effects of cardiac rehabilitation between patients with ST elevation myocardial infarction (STEMI) and non-ST elevation myocardial infarction (NSTEMI). Method: Thirty three patients with STEMI or NSTEMI who underwent percutaneous transluminal coronary angioplasty were recruited. All patients participated in cardiac rehabilitation program including ECG monitoring exercise for 6 weeks. Several parameters such as exercise duration, oxygen consumption, heart rate, blood pressure and rate pressure product were evaluated through graded exercise test before and 6 months after initiation of cardiac rehabilitation program. Results: After cardiac rehabilitation program, the STEMI group showed significant changes in exercise time, maximum oxygen consumption, resting heart rate and submaximal rate pressure product. The NSTEMI group also showed significant improvement of exercise time, maximum oxygen consumption and submaximal rate pressure product. There was no significant difference in the changing rate between two groups. Conclusion: Both the STEMI and the NSTEMI groups showed similar improvement of cardiopulmonary exercise capacity 6 months after cardiac rehabilitation program.

관상동맥질환에서의 Ankle Brachial Index

김철(Chul Kim),박용범(Yong-Bum Park),윤조은(Jo-Eun Yun),유현우(Hyun-Woo Rue) 대한임상노인의학회 2007 대한임상노인의학회지 Vol.8 No.2

연구배경: 관상동맥질환을 갖고 있는 환자는 말초동맥질환을 함께 갖고 있을 가능성이 더 높은 것으로 알려져 있다. 국내에서는 아직 말초동맥질환에 대한 관심이 부족한 탓에 이에 대한 연구가 미흡한 실정이다. 이에 본 연구에서는 Ankle Brachial Index를 이용하여 관상동맥질환 환자가 대조 군에 비하여 말초동맥질환의 위험도에 차이가 있는지 조사하였고 당뇨병 및 흡연자와 정상 대조군 간의 차이를 알아보았다. 방법: 관상동맥질환으로 입원한 환자 20명을 실험 군으로 하고, 과거 뇌졸중이나 관상동맥 질환의 병력이 없는 60명(정상인 20명, 흡연자 20명, 당뇨병 환자 20명)을 대조군으로 하였다. 실험군에 속한 20명은 급성 관상동맥질환으로 입원하여 관상동맥조영검사 상 관상동맥협착증이 확인된 환자로 국한하였다. 소형 도플러와 혈압기로 대상자들의 상지 및 하지에서 혈압을 측정하였고 이를 이용하여 ABI를 구하였다. 이상의 결과들에 대한 관상동맥질환 군, 당뇨 군, 흡연자 군, 정상 군 간의 차이를 비교하였다. 또한 관상동맥조영검사에서 50% 이상의 협착을 보인 혈관의 개수로 관상동맥협착의 중증도를 판단하였고 ABI결과와의 연관성을 알아보았다. 결과: 관상동맥질환 군과 정상인의 ABI는 각각 0.92와 0.94였으며 관상동맥질환 군과 당뇨 군의 ABI는 각각 0.92와 0.90이었고 관상동맥질환 군과 흡연자 군의 ABI는 0.92와 0.91로 모두 통계적 유의성은 없었다. 당뇨 군과 정상인의 ABI는 0.90과 0.94였으며 흡연자 군과 비흡연 정상인 군의 ABI는 0.91과 0.94로 통계적 유의성은 없었다. 그러나, 50% 이상 협착을 보인 관상동맥의 개수와 ABI의 중증도간의 연관성은 있었다(P<0.05). 결론: 관상동맥질환 군 중 심근경색증 군에서는 ABI 값이 유의하게 낮았으며, 관상동맥협착의 정도와 ABI값의 중증도 간에도 유의한 상관관계가 있었다. 그러나 관상동맥질환의 위험인자를 갖고 있을 때 말초동맥질환의 이환율이 더 높다는 외국 문헌의 결과와 달리 본 연구에서는 정상 대조군, 흡연자, 당뇨환자 간의 ABI 값에 차이가 없었다. 이러한 결과가 우리나라 환자의 일반적인 특성인지에 대해서는 더 많은 연구가 이루어져야 할 것이다. Background: To determine the concomitant presence of PAD in patients with CAD, usingthe ankle brachial index (ABI). a new noninvasive method to find PAD. Methods: ABI was measured in 20 patients with CAD and 60 controls without medical history of any atherosclerotic disease such as CAD, PAD, and cerebrovascular accident (CVA). 60 controls included 20 diabetes group, 20 smoking group, and 20 normal control group. We compared the value of ABI among those groups. Results: There was no significant difference in the value of ABI among CAD group and three control groups, but ABI in subgroup of myocardial infarction (MI) was significantly lower than three control groups (P<0.05). And the value of ABI was significantly correlated with the degree of coronary stenosis in CAD (P<0.05). Conclusion: A strong relationship between the degreeof stenosis in CAD and PAD was demonstrated quantitatively by ABI measurement. A decrease in ABI in CAD may be a risk factor for PAD.

각종 환자에 있어서의 혈청 아연량의 변동에 관한 연구

강신일 ( Shin Ihl Kang ),이정상 ( Jung Sang Lee ),구인서 ( In Suh Koo ),장석주 ( Suck Joo Chang ),윤조은 ( Zo Eun Youn ) 대한내과학회 1969 대한내과학회지 Vol.12 No.3

The purpose of this study is to investigate the changes of the serum zinc concentration in various diseases and thyroid disorders including hyperthyroidism, hypothyroidism, and euthyroidism. Serum zinc concentration was determined by using dithizone method