항암치료 후 발생하는 구강 점막염의 병태생리

윤정훈,최종훈,Yoon, Jung-Hoon,Choj, Jong-Hoon 대한안면통증구강내과학회 2000 Journal of Oral Medicine and Pain Vol.25 No.4

Oral mucositis or stomatitis produced by stomatotoxic chemotherapy and/or radiation therapy are painful, restrict oral intake and, importantly, act as sites of secondary infection and potals of entry for the endogenous oral microflora often leading to bacteremias or sepsis. A number of clinical observations and studies of animal model suggests a pathophysiological complexity in the development of mucositis. The condition appears to represent a sequential interaction of the oral mucosal cells and tissues, pro-inflammatory cytokines, and local environmental factors in the mouth. This article discussed and reviewed biological process of the mucositis and, the role of cytokines as initiators and amplifiers of the process. The recognition that the pathophysiology of mucositis is a multifactorial process has presented opportunities for intervention based upon biological attenuation.

만성 박리성 치은염

윤정훈,최성호,Yoon, Jung-Hoon,Choi, Seong-Ho 대한치주과학회 2000 Journal of Periodontal & Implant Science Vol.30 No.3

Desquamative gingivitis is characterized by a diffuse erythema of the free and attached gingiva associated with areas of vesiculation, erosion, and desquamation. Desquamative gingivitis is not a distinct disease entity but represents a reaction pattern of the gingiva to various stimuli. Pemphigus vulgaris, cicatricial pemphigoid, and lichen planus may presents as desquamative gingivitis. We observed 3 patients whose disease was limited to the gingiva, and studied them by light and direct immunofluorescence microscope. We classified them according to clinical, histologic, and immunopathologic observations. Identification of the underlying causes of desquamative gingivitis is of utmost importance and is dependent upon clinical, histologic, and immunologic criteria.

하악골에 발생한 근섬유종

윤정훈,김수관,이상호,Yoon, Jung-Hoon,Kim, Su-Gwan,Lee, Sang-Ho 대한소아치과학회 2003 大韓小兒齒科學會誌 Vol.30 No.1

근유종은 소아에 주로 발생하는 다발성 종양으로 처음에 기술되었지만, 단독으로 발생하는 경우가 더 많고, 어느 연령층에서나 발생한다. 성인과 소아형 모두 비슷한 임상적 특성과 병리조직학적 특징을 갖는다. 이 증례는 9세 남아의 하악에 경계가 명확한 단방성의 방사선 투과성 병소로, 병리조직학적으로 방추형 세포들이 다발을 이루며 증식하며, 일부에는 혈관주피종과 유사한 부위가 관찰되었다. 면역조직화학적으로 종양세포는 vimentin과 smooth muscle actin에 양성, S-100, desmin, cytokeratin AE1/3에 음성이었다. 이 증례에서와 같이 소아에서 단방성 방사선 투과상의 고형성 종괴로 나타나는 경우 근섬유종을 감별진단에 포함시켜야 한다고 생각된다. 환자는 수술 1년이 경과한 현재까지 재발의 소견은 없지만 재발한 경우도 보고되어 있어 철저한 추적 관찰이 필요하며, 현재 #43, 44 치아의 맹출을 유도하는 중에 있다. Myofibroma is a rare spindle cell neoplasm that consists of myofibroblsasts. Although it was originally described as a multicentric tumor process affecting infants and young children, it is now recognized that most cases of the tumor are soliatary and that it can occur at any age. This case is a myofibroma involving the right mandibular body in a 9-year-old boy. Radiographic examination revealed a relatively well-demarcated radiolucent lesion surrounding the impacted right mandibular canine and first premolar crown. The histologic sections composed of interlacing bundles of spindle cells with tapered or blunt-ended nuclei admixed with a foci of hemangiopericytoma-like appearance. Immunohistochemical staining demonstrated a positive reaction to vimentin and smooth muscle actin, but they are negative for desmin and S-100. The presence of well circumscribed radiolucent solid lesion in children as observed in this case, differential diagnosis of myofibroma must be included. In this case, there was no recurrence 6 months after enucleation and eruption guide of the impacted tooth is ongoing now.

상악골 절제술을 시행한 완전 무치악 환자에서 폐쇄장치를 이용한 보철 수복 증례

윤정훈,김종진,백진,차현석,이주희,Yoon, Jung-Hoon,Kim, Jong-Jin,Baik, Jin,Cha, Hyun-Suk,Lee, Joo-Hee 대한치과보철학회 2017 대한치과보철학회지 Vol.55 No.1

수술로 인한 상악골 결손 환자는 저작, 발음, 연하의 기능적 손상과 안모 변형으로 인한 어려움을 겪게 된다. 보철 치료의 목적은 폐쇄 장치를 통해 가능한 한 정상적인 기능과 안모를 회복하는 것이다. 이러한 목표는 재건에 대한 보철과 의사와 외과 의사의 술 전 의사소통을 통해 성취할 수 있다. 본 증례에서는 우측 상악동에 편평상피암 진단을 받은 환자에서 수술 전 치과 검진을 통해 보철적 재건에 대한 계획을 수립하였다. 상악골 절제술 4개월 후 수술용 폐쇄장치, 이행 폐쇄장치를 거쳐 최종 폐쇄장치를 제작하였다. 이를 통해 환자는 저작, 발음, 연하, 안모의 만족스러운 개선을 얻었기에 보고하고자 한다. Most patients with acquired maxillary surgical defects have difficulties such as functional impairments of mastication, speech, and deglutition as well as various degrees of facial deformity. The purpose of a prosthetic approach is to restore function and appearance with an obturator as normal as possible. This goal can be achieved when there is thoughful preoperative communication between a prosthodontist and a surgeon regarding a rehabilitation. In this case report, prosthetic rehabilitation was planned before the surgery for the patient diagnosed with squamous cell carcinoma in the right maxillary sinus with careful oral examination. Four months after maxillectomy, a definitive obturator was fabricated following the surgical and interim obturation phase. The objective of this case report is to describe the satisfactory results of the patient with improved rehabilitation of mastication, speech, deglutition, and appearance.

치아종과 동반한 석회화 치성낭

윤정훈,김수관,이창섭,이상호,Yoon, Jung-Hoon,Kim, Su-Gwan,Lee, Chang-Seop,Lee, Sang-Ho 대한소아치과학회 2002 大韓小兒齒科學會誌 Vol.29 No.3

석회화 치성낭은 하나의 독립된 유형의 치성 병소로 인정하고 있지만, 조직학적 소견이 다양하고 분류 체계도 학자들마다 다르다. 또한 석회화 치성낭의 피복상피는 인접한 결합조직에 치성조직을 유도할 수 있는 능력을 갖고 있어 다른 치성 종양과 흔히 동반하여 발생한다. 이 증례는 5세 여아의 상악 전치부에 발생한 치아종을 동반한 석회화 치성낭으로, 매복된 상악 좌측 중절치 및 측절치 치관 주위로 경계가 잘 된 방사선 투과성 병소와 다발성의 방사성 불투과성 석회화 물질이 혼재된 병소였다. 병리조직학적으로 피복상피는 법랑모세포와 유사하였고 상피 내에 유령세포의 군집이 관찰되었다. 석회화된 종괴는 일부 잔존한 범랑기질이 상아질로 둘러싸여 있었고, 퇴축 법랑상피 및 유령세포의 군집이 관찰되어 복잡 치아종이 동반된 석회화 치성낭으로 진단하였다. 이 증례에서와 같이 소아에서도 매복치와 동반하여 방사선 투과 및 불투과상의 혼합 병소가 관찰되면 석회화 치성낭의 가능성을 항상 염두에 두어야 할 필요가 있다. 환자는 수술 1년이 경과한 현재까지 재발의 소견은 없었고, 현재 혼합치열기의 간격조절을 시행 받고 있는 중이다. The calcifying odontogenic cyst(COC) showed diverse terminology or classification, clinicopathologic features as well as in its biologic behavior, although it was recognized as a distinct clinicopathologic entity. The epithelial lining of a COC appears to have the ability to induce the formation of dental tissues in the adjacent connective tissue wall, and that other odontogenic tumors may sometimes be associated with it. This case is a COC associated with a complex odontoma involving an impacted left maxillary lateral incisor in a 5-year-old female child. Radiographic examination revealed a well-demarcated radiolucent lesion partially occupied by a radiopaque mass, involving the left lateral incisor crown. The histologic sections showed a cystic cavity lined with ameloblastic epithelium containing ghost cell masses with admixed with complex odontoma components. The presence of mixed radiolucent-radiopaque lesion in children as observed in this case, the possibility of COC must be considered. In this case, there was no recurrence 1 year after enucleation and the space control is ongoing now.

지속적인 치통으로 나타난 상악동 악성 림프종 1예

윤정훈(Jung Hoon Yoon),육종인(Jong In Yook),김진(Jin Kim) 대한치과의사협회 2000 대한치과의사협회지 Vol.38 No.6

고압산소 치료에 대한 일개 권역 응급센터의 최근 10년 경험 및 제언

윤정훈 ( Jung Hoon Yoon ),김기운 ( Gi Woon Kim ),정윤석 ( Yoon Seok Jung ),한철수 ( Cheol Soo Han ),민영기 ( Young Gi Min ),조준필 ( Joon Pil Cho ),최상천 ( Sang Cheon Choi ) 대한임상독성학회 2013 대한임상독성학회지 Vol.11 No.2

Purpose: The aim of this study is to investigate current status, indications, and complications of hyperbaric oxygen therapy. Methods: A retrospective investigation of patients who underwent hyperbaric oxygen therapy at a university medical center from September 2004 to August 2013 was conducted based on patients’ medical records and results of an email survey for 99 emergency centers. Results: During the study period, a total of 233 patients underwent hyperbaric oxygen therapy. Indications for hyperbaric oxygen treatment of illness or injury were as follows: 1) 151 cases of acute carbon monoxide poisoning( 65.4%), 2) flap wound management, including 42 cases(18.2%), 3) skin care transplanted, including 23 cases(10.4%), 4) Burger’s disease, including 5 five cases(2.1%), respectively. Total application time* frequency was 1,088 and total time was 1,239 hours. Among 233 patients who underwent hyperbaric oxygen therapy, 32 patients(13.7%) had complications: 1) otalgia in 21 cases(9.0%), 2) mastoiditis?in six cases(2.6%), 3) hemotympanum in five cases(2.1%), respectively. There were only 8 emergency centers that currently had an operational hyperbaric oxygen chamber in 77 emergency centers(10.4%). Conclusion: Indications identified through this study showed difference from current indications worldwide. It seems necessary that physicians’ perception regarding application of hyperbaric oxygen therapy for more indications be changed and improved. A hyperbaric chamber capable of providing respiratory assistance and intensive care is also needed. A good network for sharing treatment experiences and a specialized team for administration of hyperbaric oxygen therapy is also required.

새로운 룩업테이블 방법을 이용한 컴퓨터 형성 동영상 홀로그램의 고속 생성

윤정훈(Jung-Hoon Yoon),김승철(Seung-Cheol Kim),김은수(Eun-Soo Kim) 한국통신학회 2008 한국통신학회 학술대회논문집 Vol.2008 No.7

3D 동영상에 대한 컴퓨터 형생 홀로그램의 효과적인 생성

윤정훈(Jung-Hoon Yoon),김승철(Seung-Cheol Kim),김은수(Eun-Soo Kim) 한국통신학회 2007 한국통신학회 학술대회논문집 Vol.2007 No.7

구강점막의 유두상 병소

윤정훈(Jung-Hoon Yoon) 대한치과의사협회 2012 대한치과의사협회지 Vol.50 No.12

Oral mucosal lesions with a papillary or verrucous surface are a heterogenous group of conditions with widely varying clinical behaviour. The etiology is variable and includes infective, traumatic or neoplastic processes. The majority of these lesions are precanceous lesion. Therefore, a biopsy is required to establish a diagnosis and the microscopic examination must be coordinated with the clinical findings. This paper reviews the clinical features and significance of papillary or verrucous lesions.