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신경릉 기원세포의 피부종양에서 S-100단백의 면역조직화학적 연구
윤영곤,신동식,정병수,최규철 朝鮮大學校 附設 醫學硏究所 1989 The Medical Journal of Chosun University Vol.14 No.1
By permitting of cell-specific antigens, immunohistochemistry adds a new dimension to the identification of cells not recognizable by morphologic features alone, It also has the advantage of being applicable to routine paraffin-embedded histologic sections. We examined the presence of S100 Protein in 33 cases of skin tumors derived from cells of neural crest origin, by immunohistochemical technique (ABC method). The results obtained are as follows : 1. Of 33 cases of skin tumors derived from cells of neural crest origin, 30 were positively stained for S100 Protein. 2. S100 Protein was found in most of tumora derived from Schwann cell and melanocyte but blue nevi and Ota nevi contained little or no S100 protein. 3. In pigmerited nevi, compound nevi and intradermal nevi were more strongly stain for S100 protein than junctional nevi. 4. The intensity of S100 protein immunostaining was far less in neurofibroma than in neurilemmoma and was strongest in malignant melanoma. 5. Our results suggest that S100 protein is widely distributed among pigmented nevi and melanotic tumors and is also a very useful diagnostic indicator for skin tumors derived from cells of neural crest origin.
윤영곤,최규철 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.2
Giant cell tumor of the tendon sheath (GCTTS) is the second most common tumor of the fingers and hands but has been described rarely in the dermatologic literatures because of its clinical and pathological confusions with other lesions. Although its pathogenesis has been debated, it is probably a type of fibrous histiocytoma. This tumor is always benign but may locally invade the overlying dermis and be confused with malignant neoplasma. It often extends to the synovium of the adjacent joint space and necessitates total excision to prevent local recurrence. We report a case of GCTTS who showed a slowly growing tumor over the distal phalanx of right ring finger in 44-years-old woman. Skin biopsy from the lesion showed the well-capsulated tumor mass in the dermis. It consisted of a mixture of abundant histiocyte-like, foam, and multinucleated giant cells of the osteoclast type.
윤영곤,윤경주,Yoon, Joseph YoungKon,Yoon, Kyungjoo DAEHAN Society of Industrial Management 2017 산업융합연구 Vol.15 No.2
본 논문은 알고리즘을 활용한 최적화를 바탕으로 한 시스템 다이내믹스 피드백 모델을 통해 고용 시뮬레이션의 특징을 제시하는 목적을 가지고 있고 직위, 근무기간, 계급 등의 요소를 중심으로 적정한 고용 인원을 제시하는 3차원 논리적 판단구조를 제공한다. 호주 육군의 고용정책에 대해 보다 신축적인 고용시스템을 제시할 목적으로 시스템 다이내믹스 모델을 통해 국방부의 변화가 심한 정책에 대한 안정적 고용 적정선을 파악한다. 특히 생산성을 최대로 발휘할 수 있는 필요한 고용 패턴 및 외부 인력의 고용, 내부인력의 타 조직으로 이동 등 다양한 가능성을 분석한다. This paper illustrates key features of an enterprise employment simulation which integrates a system dynamic feedback model with a cost-effectiveness optimisation capability utilising genetic algorithms. Its core is a 3-dimensional array structure tracking staff numbers by rank, by time-in-rank, by years-of-service. The resultant model, which could readily be adapted to non-Defence use, can identify, given user specification of any mix of employment rules, the likely patterns of employment behaviour including: resultant time-in-rank and years-of-service profiles; ability of a Unit to fill all positions to target strength; ability to fill promotional positions within normal rules for substantive promotion; need to fill promotional positions using rules for temporary promotion or transfer from outside; necessary recruitment pattern to sustain target strength.
최규철,윤영곤 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.1
One case of metastatic skin tumor from carcinoma of the ovary was reported with literature re-view. A 20-year-old woman had an episode of total hysterectomy and bilateral salpigo-ophorectomy under the diagnoisis of mucinous cystadenocarcinoma about one year ago. About 2 months ago, a nodule developed on the site of operation wound of the abdomen. Thereafter, multiple nodules developed succeedingly on the abdomen, back and scalp. The nodules were considered to be originated from carcinoma of the ovary in the view of histopathological, immunohistochemical and electron-microscopic finding.
강인경,윤영곤 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.1
Dermatofibrosarcoma protuberans(DFSP) is an uncommon tumor that arises in the dermis. It is characterized by slow invasive growth, frequent local recurrence after excision and infrequent metastasis. We report a case of DFSP who presented with an erythematous, firm nodule with satellite lesion on the left quadrant of the abdomen in a 52-year-old female. Histopathologically, this tumor showed a uniform cellular proliferation of fibroblast in a storiform or cartwheel pattern in the dermis and subcutis. The peripheral portions of the tumor may have a deceptively bland appearance, approaching that of normal collagen.