정상성인에서 ALDH-I의 변이가 알콜의 정신운동성 수행과 주관적 평가에 미치는 영향

윤보현,윤진상,Yoon, Bo Hyun,Yoon, Jin Sang 대한생물정신의학회 1996 생물정신의학 Vol.3 No.2

The purpose of this study was to evaluate the effects of alcohol on the psychomotor performance and subjective assessment in healthy Korean adults with acetaldehyde dehydrogenase I(ALDH-I) isozyme variance. A total of 20 male subjects, half with active ALDH-I and the other half with inactive ALDH-I, were selected through both a self-reporting questionnaire examining alcohol sensitivity and the Higuchi's ethanol patch test detecting ALDH-I deficiency. In a doule-blind, placebo-controlled cross-over design, each subject consumed four doses of alcohol(0.25, 0.5, 0.75, 1.0g/kg) and placebo on five separate occasions at weekly intervals, Treatment order was fully balanced using a $5{\times}5$ Latin square, Psychomotor performance tests[coritical flicker fusion threshold(CFF) and choice reaction time(CRT)] and self-estimate questionnaires were conducted at baseline and at time points of 20, 40, 60, 90, 120, 150, 180 minutes after consuming the test drug for 20 minutes, Blood alcohol concentrations(BACs) using breath analyzer were measured at baseline and at time points of 10, 20, 30, 40, 50, 60, 75, 90, 105, 120, 150, 180 minutes after drinking, The BACs and the mean changes in the psychomotor performances and subjective assessments from pre-alcohol baseline, were compared between the two groups. The findings were summarized as follows : 1) BACs were tended to be higher in the inactive group than the active in all of the four alcohol doses. However significant group differences were only after the 0.5g/kg dose of alcohol. 2) The inactive group showed significant impairment in CFFT at most time points alter 0.75 and 1.0g/kg doses of alcohol. 3) In CRT, total reaction time(TRT) significantly prolonged in the inactive group than the active group at 20 minutes after 0.25 and 1.0g/kg doses of alcohol and at 40, 60, 90 minutes alter 0.75g/kg dose of alcohol. In the inactive group, recognition time component significantly increased at 20, 60, 90 minutes after 1.0g/kg dose of alcohol, while movement time component significantly increased at 40, 60 minutes after 0.75g/kg dose of alcohol. 4) Subjective evaluation of the effect of alcohol revealed that physical and mental conditions as well as a self-estimate of the effects of alcohol on performance were significantly worse in the inactive group than the active at some time points alter all of the lour alcohol doses, wihch were more pronounced after 0.75 and 1.0g/kg doses of alcohol. 5) Most of the group differences mentioned above, still remained statistically significant after BAC was entered as a covariate, These findings demonstrated that the alcohol sensitivity is higher in individuals with inactive ALDH-I than those with active ALDH-I both on the subjective assessments and the objective psychomotor performances. Furthermore, these results suggest thai the alcohol sensitivity may be determined by acetaldehyde concentration rather than BAC per se. In future studies, after more accurate genotyping for ALDH-I, the relationships between BAC, acetaldehyde concentration and alcohol sensitivities should be clearly defined. ALDH-I 활성군과 비활성군에서 음주후 정신운동성 수행 및 주관적 평가에 미치는 영향을 비교하였다. 사교적 음주에 상응하는 4종류의 알콜(0.25, 0.5, 0.75, 1.0g/kg)을 투여한 결과 비활성군이 활성군에 비해 보다 부정적인 평가를 하였다. 이는 특히 고용량의 알콜(0.75 및 1.0g/kg)을 투여시 분명하였다. 이러한 결과는 비활성군이 활성군에 비해 알콜에 대한 민감성이 주관적인 판단과 객관적인 수행에서 모두 더 높다는 사실을 반영한다.

벤처기업 경영자 특성이 경영성과에 미치는 영향에 관한 연구;대덕연구개발특구를 중심으로

윤보현,박준병,Yoon, Bo-Hyun,Park, Joon-Byoung 한국벤처창업학회 2007 벤처창업연구 Vol.2 No.3

Current researches have been proceed on CEO's Characteristics of venture business because the CEO has considered as one of the important factors for the success of venture business. But prior research on the performance of venture business has produced inconsistently in terms of CEO's characteristics. The purpose of this study is to develop a comprehensive model for the relation between the performance and a type of CEO's characteristics by a growth process of venture business, which is the main subject of analysis in venture business. Also, this study analyzes various CEO's characteristics and the effects for performance of venture business which are in the Daedeok valley. To achieve the purpose of this research, an empirical study by using research model and hypotheses including the general characteristics of venture business and CEO's demographic characteristics has been presented as a research method for relation analysis. The principal findings of the research and its significance are summarized as follows: First, it was found that there is a significant different in the performance of CEO's behavioral characteristics by the scale, type and growing step of organization for venture business. Second, it was found that there is not a significant between an academic career, management experience, foundation experience for business and related working experience of venture CEO and the performance, but there os a partially significant difference in CEO's behavioral characteristics. Third, it was found that there is a partially significant difference between CEO's behavioral characteristics of venture business and the performance by the general characteristics of organization for venture business and demographic characteristics. In conclusion, in spite of the insufficient research for venture business in Daedeok, the implications of theses findings and contributions made by this research is to confirm the characteristics factor of CEO for venture business and general characteristics of organization for venture business by multidisciplinary side. In addition, the findings provide the basis for the analyzing of managerial strong point and weak point referred to supporting system for venture business. Finally, the findings of this study suggest that the results should be a useful data for groping a solution for upbringing plans in terms of a long-term point of view.

한국 주식시장에서의 대안 인덱스투자전략 연구

윤보현 ( Bo Hyun Yoon ),최영민 ( Young Min Choi ) 한국파생상품학회(구 한국선물학회) 2014 선물연구 Vol.22 No.2

본 연구는 주식시장의 시가총액 비중 시장 인덱스의 위험 대비 수익률 관점의 비효율을 지적하며 등장한 다양한 대안적인 인덱스 투자전략을 한국 주식시장에 적용하여 실증 분석한다. 대안 인덱스 투자전략이란 인덱스를 구성하는 종목의 비중 계산을 시가총액 비중이 아닌 재무제표를 이용하거나, 평균-분산 최적화 결과를 이용하는 등의 방법을 이용하는 것으로 한국 주식시장에서 포트폴리오를 구성하여 수익률을 측정한 결과, 시장 인덱스보다 위험 대비 수익률의 효율성이 증대함을 확인하였다. 또한 대안인덱스의 초과수익률은 Fama-French의 3요인 분석 결과 시장요인 및 기업규모요인 그리고 가치요인의 세 가지 요인으로 설명이 가능한 것으로 나타났다. 하지만, 이 사실이 대안 인덱스의 유용성을 해친다고 할 수는 없다. Fama-French의 기업규모요인이나 가치요인은 매수/매도 포지션으로 이루어져있고, 포트폴리오 재구성 시 높은 수준의 시장충격이 발생할 가능성이 높기 때문이다. 본 연구는 이러한 측면에서 대안 인덱스가 100% 매수 포지션으로만 이루어져 있고 회전율도 높지 않기 때문에 기업규모요인이나 가치요인을 실질적으로 투자가능하게 만들어주는 순기능이 존재할 수 있음을 제시하였다. There have been several studies of alternative equity index strategies which suggest better investment opportunities with higher risk adjusted return pointing out empirical evidence of inefficient risk-return trade-off implied in the market-cap weighted index. Commercial products based on these strategies, regarded as passive equity strategies, become more popular in the U.S. and European stock markets. We investigates whether these strategies are also valid in Korean stock market and our empirical results add support to their efficacy. From Fama-French 3-factor analysis, we find that the excess return of alternative equity index is attributed to market, size and value factors and it does not show a significantly positive alpha. Even without positive alpha, however, these strategies are valuable to investors in the sense that they offer opportunities to fully exploit size and value premium with long-only portfolios. The advantage of these strategies is more straightforward recalling the fact that rebalancing of Fama-French factor portfolios involves short-sale and high turnover.

만삭전 조기양막파수 산모에서 양수내 백혈구수 측정의 진단 및 예후적 가치

윤보현(Bo Hyun Yoon),김미하(Mi Ha Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.1

N/A Objective : The aim of this study was 1) to determine the diagnostic performance of amniotic fluid white blood cell (WBC) count for the antenatal detection of intrauterine infection and 2) to identify the value in prediction of preterm birth and significant neonatal morbidity in patients with preterm premature rupture of membranes. Methods : Transabdominal amniocentesis was done in 255 singleton pregnancies with preterm premature rupture of membranes before 36 weeks of gestational age. Amniotic fluid was cultured for aerobic and anaerobic bacteria and mycoplasmas. Receiver-operator characteristic curve, survival analysis and logistic regression were used for statistical analysis. Results : 1) Prevalence of positive amniotic fluid culture was 19.6% (50/255). Amniotic fluid WBC count was higher in the patients with positive amniotic fluid culture than those with negative amniotic fluid culture (median 269 [0-19764] cells/mm3 vs median 2 [0-7956] cells/mm3, p<0.001). 2) As a diagnostic and prognostic means, the increased amniotic fluid WBC (≥20 cells/mm3) had sensitivity of 74%, specificity of 74%, positive predictive value of 41% and negative predictive value of 92% for the positive result of amniotic fluid culture. 3) An increased amiotic fluid WBC was strongly associated with shorter amniocentesis-to-delivery interval even after adjustment of gestational age at amniocentesis(hazard ratio 3.2736, p<0.0001). 4) Amniotic fluid WBC count was higher in patients with significant neonatal morbidity or congenital neonatal infectious morbidity than those without these (p<0.001 and p<0.005 respectively). 5) Patients with increased amniotic fluid WBC count had higher incidence of significant neonatal morbidity and congenital neonatal infectious morbidity than those with low amniotic fluid WBC count and the association between amniotic fluid WBC and significant neonatal morbidity was statistically significant after adjustment of gestational age at amniocentesis (OR 3.3649, p<0.0001). Conclusion : Amniotic fluid WBC count is of value in antenatal diagnosis of intrauterine infection and prediction of maternal and neonatal outcomes in patients with preterm premature rupture of membranes.

조기양막파수 산모에서 중합효소 연쇄반응 기법을 이용한 양수내 Ureaplasma urealyticum 의 검출과 양수내 염증성 반응 및 주산기 예후와의 연관성

윤보현(Bo Hyun Yoon),이희선(Hee Sun Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.6

연구 목적 : 만삭전 조기양막파수 산모의 양수에서 중합효소 연쇄반응 (polymerase chain reaction, PCR) 기법을 이용하여 Ureaplasma urealyticum이 검출된 산모의 혈액 및 양수내 염증성 반응과 주산기 예후를 알아보고자 하였다. 연구 대상 및 방법 : 임신 36주 이전에 분만진통을 동반하지 않는 조기양막파수로 진단되어 양수천자술이 시행된 단태임신 산모 131명을 대상으로 하였다. 양수의 일반 미생물 및 mycoplasma 배양검사와 U urealyticum에 대한 시발체 (primer)를 이용한 PCR을 시행하였다. 양수배양 검사 및 U urealyticum에 대한 PCR 결과에 따라 산모를 양수배양 음성이며 U urealyticum에 대한 PCR결과는 음성인 군 (제 1군, n=84), 양수배양은 음성이나 U urealyticum PCR결과는 양성군 (제 2군, n=12), PCR결과에 관계없이 양수배양이 양성인 군 (제 3군, n=35)으로 분류하였다. 산모와 양수내 염증성 반응을 알아보기 위해 산모 혈액내 C 반응성 단백 농도와 산모 혈액 및 양수내 백혈구 수를 측정하였다. 결과 : 1) 양수배양에서 세균이 검출된 경우는 26.7% (35/131)였으며, U urealyticum은 18.3% (24/131)에서 검출되었다. U urealyticum에 대한 PCR은 26.7% (35/131)에서 양성이었다. 2) 양수내 백혈구 수는 배양음성 PCR 양성군 (제 2군)에서 배양음성 PCR음성군 (제 1군)에 비해 유의하게 증가되어 있었으며, 배양양성군 (제 3군)과는 유의한 차이가 없었다 (median 169 [1-2,295] cells/㎣ vs median 1 [0-7,956] cells/㎣, p<0.001; median 169 [1-2,295] cells/㎣ vs median 270 [0-13,248] cells/㎣). 3) 산모 혈액내 백혈구 수 및 C 반응성 단백의 농도는 배양음성 PCR음성군 (제 1군)과 배양음성 PCR양성군 (제 2군)간에 유의한 차이가 없었다 (백혈구 수: median 8,500 [1,300-19,500] cells/㎣ vs median 10,600 [4,000-21,400] cells/㎣; C 반응성 단백: median 0.2 [0-10.0] ㎎/㎗ vs median 0.4 [0-5.0] ㎎/㎗). 4) 제대염의 빈도는 배양음성 PCR양성군 (제 2군)에서 배양음성 PCR음성군 (제 1군)에 비해 유의하게 높았으나 (24.6%[15/61] vs 71.4%[5/7], p=0.02), 배양양성군 (제 3군)과는 유의한 차이가 없었다. 5) 신생아 패혈증과 폐렴을 합한 선천성 감염성 이환률 및 기관지폐 이형성증의 발생빈도가 배양음성 PCR양성군 (제 2군)에서 배양음성 PCR음성군 (제 1군)에 비해 유의하게 높았다 (선천성 감염성 이환: 11.4% [9/79] vs 36.4% [4/11]; 기관지폐 이형성증: 2.5% [2/79] vs 27.3% [3/11], p<0.05). 결론 : PCR을 이용하여 양수 내에서 U urealyticum이 검출된 만삭전 조기양막파수 산모에서 양수내 염증성 반응이 증가되고 불량한 주산기 예후를 보임을 확인하였다. Objective : The aim of this study was 1) to determine the clinical significance of isolation of Ureaplasma urealyticum (U urealyticum) by polymerase chain reaction (PCR) in amniotic fluid and 2) to identify the association of positive result of PCR for U urealyticum with maternal and intraamniotic inflammatory response in patients with preterm premature rupture of membrane (PROM). Methods : Amniocentesis was done in 131 patients with preterm PROM during the period from January, 1994 to January, 1998. Amniotic fluid was cultured for bacteria and mycoplasmas. PCR with primer for U urealyticum was performed. Patients were divided three groups according to the results of amniotic fluid culture and PCR for U urealyticum: those with a negative amniotic fluid culture and negative PCR (group 1, n=84), those with a negative amniotic fluid culture but positive PCR (group 2, n=12) and those with a positive amniotic fluid culture (group 3, n=35). Results : 1) U urealyticum was isolated in 18.3% (24/131) by conventional culture method and in 26.7% (35/131) by PCR. 2) Patients with a negative amniotic fluid culture but positive PCR for U urealyticum (group 2) had significantly higher amniotic fluid white blood cell (WBC) count and higher rate of funisitis than those with a negative amniotic fluid culture and negative PCR (group 1) (amniotic fluid WBC: median 169 [1-2,295] cells/㎣ vs median 1 [0-7,956] cells/㎣ p<.001; funisitis: 71.4%[5/7] vs 24.6%[15/61], p=0.02). 3) Patients with a negative culture but positive PCR for U urealyticum (group 2) had higher rate of congenital infectious morbidity and bronchopulmonary dysplasia in their babies than those with a negative culture and negative PCR (group 1) (congenital infectious morbidity: 36.4% [4/11] vs 11.4% [9/79]; bronchopulmonary dysplasia: 27.3% [3/11] vs 2.5%[2/79], p<0.05 for each). 4) No significant differences in perinatal outcome were observed between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture (group 3). Conclusion : Isolation of U urealyticum by PCR in amniotic fluid is associated with an intense intraamniotic inflammatory response and adverse perinatal outcomes in patients with preterm premature rupture of membranes.

발육지연태아를 분만한 임산부의 산전 자궁동맥 혈류속도파형의 양상

윤보현 ( Bo Hyun Yoon ),강영제 ( Yeong Je Kang ),이필량 ( Pyl Ryang Lee ),송현진 ( Hyun Jin Song ),신희철 ( Hee Chul Syn ),김승욱 ( Syng Wook Kim ) 대한주산의학회 1991 Perinatology Vol.2 No.2

한국인 산모에서 임신중기 양수내 alpha-fetoprotein치의 정상 범위

윤보현(Bo Hyun Yoon),김미하(Mi Ha Kim),신희철(Hee Chul Syn),문정빈(Jeong Bin Moon),전종관(Jong Kwan Jun),임준희(June Hee Lim),오수영(Soo Young Oh),이용희(Yong Hee Lee),박중신(Joong Shin Park) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.6

목적 : 본 논문의 목적은 정상아 분만이 확인된 한국인 산모에서 임신중기의 양수내 alpha-fetoprotein(AFP)의 정상범위를 구하고자 하는 것이다. 연구방법 : 1992년 5월부터 1999년 7월까지 서울대학교병원에서 양수검사의 다양한 적응증에 해당되는 임신중기의 산모에서 방사면역법에 의해 양수내 AFP를 측정하여 정상아 분만이 확인된 640례의 단태아 임신에서 정상범위를 구하였다. 결과 : 한국 임신부의 임신주수별 알파태아단백의 중앙값은 15주에 13,250ng/mL, 16주에 12,900ng/mL, 17주에 11,150ng/mL, 18주에 9,430ng/mL, 19주에 8,019ng/mL, 20주에 6,800ng/mL, 21주에 5,850ng/mL, 22주에 5,750ng/mL, 23주에 5,210ng/mL, 24주에 3,420ng/mL이었다. 결론 : 본 연구에서 한국인 임신부의 임신주수별 양수내 AFP의 정상범위는 기존의 보고와 유사한 결과를 보였으며, 이 결과는 신경관 결손증과 같은 다양한 질환의 산전 진단에 참고값으로 이용될 수 있을 것이다. Objective: Our purpose was to determine normal amniotic fluid α-fetoprotein level in midtrimester Korean pregnant women whose neonatal outcomes were normal. Methods: Amniotic fluid α-fetoprotein(AFAFP) levels were measured by specific radioimmunoassay (RIA) in midtrimester pregnant women for various indications of amniocentesis from May 1992 to July 1999 at Seoul National University Hospital. Normal ranges were obtained from 640 singleton pregnancies in which neonatal outcomes were normal.Results: Median values of AFAFP in Korean pregnant women were 13,250ng/mL, 12,900ng/mL, 11,150ng/mL, 9,430ng/mL, 8,019ng/mL, 6,800ng/mL, 5,850ng/mL, 5,750ng/mL, 5,210ng/mL, 3,420ng/mL at 15 week, 16 week, 17 week, 18 week, 19 week, 20 week, 21 week, 22 week, 23 week, 24 week, respectively.Conclusion: This determination of the median values and the normal range of AFAFP level by each gestational week in uncomplicated Korean women could be used reference values for prenatal diagnosis of various disorders like open neural tube defect.

정상 성인에서 ALDH2 유전형에 따른 알코올 민감성, 음주행태 및 알코올 효과에 대한 기대의 비교

윤보현(Bo-Hyun Yoon),윤진상(Jin-Sang Yoon),최태석(Tae-Suk Choi),송제헌(Je-Heon Song) 한국중독정신의학회 1999 중독정신의학 Vol.3 No.2

To investigate the interrelations of ALDH2 genotype (biological factor) and alcohol expectancy (psychosocial factor) as the predictors of alcohol use and alcohol-related problems, we compared the alcohol sensitivity, alcohol habits and alcohol expectancy in normal adults with ALDH2 variations. A total of 20 healthy male subjects (the half with ALDH2*1/*1, the other with ALDH2*1/*2) was selected through screening tests and genotyping by amplification created restriction site. The questionnaires for alcohol sensitivity, drinking history and habits, and the modified version of Alcohol Expectancy Questionnaire (AEQ) were administered to the subjects. Data were compared between two groups of ALDH2 genotype. ALDH2*1/*2 subjects reported more negative physiological responses than ALDH2*1/*1 subjects. ALDH2*1/*1 subjects had more frequent histories of alcohol-induced blackouts and consumed more alcohol in terms of frequency and quantity than ALDH2 *1/*2 subjects. ALDH2*1/*1 group showed significantly high scores on negative expectancy, socializing expectancy and tension reduction expectancy scales among 5 subsets of AEQ. This study suggests that the ALDH2 genotype not only clearly affect the alcohol-induced biological responses, but also have the effects on psychosocial dimensions that are related with alcohol use and abuse.

Doppler초음파를 이용한 발육지연태아의 흉부하강대동맥 혈류속도파형의 양상

윤보현 ( Bo Hyun Yoon ),이필량 ( Pyl Ryang Lee ),김승협 ( Seung Hyup Kim ),신희철 ( Hee Chul Shin ),김승욱 ( Syng Wook Kim ) 대한주산의학회 1990 大韓周産醫學會雜誌 Vol.1 No.1

A real time sector scanner with a pulsed Doppler transducer was used to study and compare the blood flow velocity wavefroms of fetal descending thoracic aorta in 97 normal pregnancies and 50 cases of fetal growth retardation with 170 and 67 examinations, respectively. All pregnancies were in the third trimester. In both groups, A / B ratio, resistance index, and pulsatility index remained unchanged with increasing gestational age. In growth reatarded pregnancies, there were singnificant increases in A / B ratio, pulsatility index, and resistance index, and significant decrease in end diastolic velocity compared to those in normal pregnancies(p<0.05), reflecting increased peripheral vascular resistance. In the 8 distressed fetuses, Doppler findings were more pathological than those in the fetuses without distress. This method may be of value in the evaluation of fetal well-being in risk pregnancies by giving an early sign of hemodynamic changes in developing hypoxia.

배플을 적용한 Cargo용 연료탱크 내부의 슬로싱 저감 연구

윤보현(Bo-Hyun Yoon),윤준규(Jun-Kyu Yoon),임종한(Jong-Han Lim) 한국마린엔지니어링학회 2010 한국마린엔지니어링학회지 Vol.34 No.8