아동기 과체중 위험 인자로서의 TV시청시간, 사회계층요인, 부모의 과체중 및 부모의 활동수준

윤군애 대한지역사회영양학회 2002 대한지역사회영양학회지 Vol.7 No.2

This study was done to determine the factors associated with childhood overweight in 721 sixth grade elementary school students, in Busan. The students' heights, weights, waist circumferences and triceps-skinfold thicknesses were measured using standard techniques. Other data were collected using a questionnaire that included information about physical activity, television watching, and the amount of exorcise taken during leisure times, family history of diseases related to obesity: social data including family income, parents'education and occupations, eating behaviors; parental weights and heights; and parental activity levels. Childhood overweight was defined as a body mass index at or above the 85th percentile for age and sex. The prevalence of overweight revealed no significant difference between sexes, (24.2% in boys and 22.03% in girls). The risk of childhood overweight was significantly greater if either the mother or the father were overweight. The odds ratio for childhood overweight associated with maternal overweight was 5.045 (94% CI : 3.262-7.801), and 2.727 (95% CI : 1.764-4.218) was the case for parental overweight. Children having a history of hear diseases had higher odds ratios than those who did not. The odds ratios for overweight associated with income were not different. However, a higher odds ratio for overweight was observed in children whose fathers had only an elementary or middle school education than those whore fathers had a high school or college education. Children whose fathers' occupations were service workers or shopkeepers (OR : 3.314, 95% C = 1.851-5.934) or had no occupation (OR = 3.756, 95% CI : 1.898-7.430) had a treater risk of overweight than those whose fathers'were professionals or once workers. The risk of overweight increased in children having more irregular meal times and faster eating times, rather than those having an intake pattern of high energy and sugar containing floods. The amount of exercise taken during leisure times, and daily physical activity showed no difference between overweight and non-overweight children. However, television watching time, especially on weekends, was greater in overweight children than in non-overweight children. Television watching time was positively correlated with BMI, triceps-skin(31d thickness, waist circumference and waist/height ratio. Therefore, television watching was found to be a useful predictor of overweight in children. Television watching in children was negatively related to paternal activity levels, and positively related to parental television watching time. In fact, fathers whose children were overweight were physically less active than fathers whose children were non-overweight. Parents appeared to be a strong influence on their children's physical activity levels. In conclusion, a low family social class, defined on the basis of the father's occupation or education, parental overweight, increased television watching, and unhealthy physical activity levels in parents were all considered risk factors for childhood overweight. Among these, television watching time and lack of physical activity were considered to be the most important risk factors that could be easily modified for the prevention of and intervention in, overweight in children.

과체중 대학생에서 저열량식이 또는 저열량식이와 운동병합에 의한 체중 감량 효과

윤군애,안현호,박보혜,유단비,박선민 한국영양학회 2012 Journal of Nutrition and Health Vol.45 No.4

Korean undergraduate students attempt to lose weight but often fail due to utilizing ineffective weight loss strategies. Some diet programs have succeeded, yet, they have not provided adequate skills for long-term weight maintenance. The aim of the study was to determine the effect of a low calorie diet and exercise with nutritional education on weight loss, serum lipid profiles, nutrient intakes, and dietary behavior modification in overweight and obese undergraduate students. The subjects in the low calorie diet group (LCD n = 12) and the low calorie diet plus exercise group (LCDE n = 13) had the same goal of losing 4 kg during a 12 week program. Nutrient intakes were assessed by the 24 hour recall method. Also, food habits and dietary behaviors were investigated by self-administered questionnaires before and after the weight control program and one month after completing the program. LCD and LCDE groups lowered body weight by 2 kg and 1 kg, respectively, although they decreased calorie intake by 355 and 287 kcal per day compared to intakes prior to the study. Body fat mass decreased in both the LCD and LCDE groups; however, the decrease was greater in the LCDE group. In addition, only the LCDE group increased muscle mass. The LCD group had a slightly better effect in reducing body weight, body fat, and waist circumference than the LCDE group. However, their decrease was reversed after the mid-study check in the LCD group; the reduction was better maintained and decreased more in the LCDE group. However, serum lipid profiles were already in borderline prior to the study; moreover, they were not modified after losing weight. The dietary behavior program helped students to develop better dietary habits. In conclusion, the combination of a low calorie diet and exercise is necessary in order to maintain longer weight loss by increasing muscle mass and decreasing body fat.

자귀나무(Albizzia julibrissin)의 물 추출물과 Doxorubicin 혼용의 마우스 Sarcoma에 대한 항암상승효과

윤군애,채선영,김광현 대한암예방학회 2012 Journal of cancer prevention Vol.17 No.3

To confirm synergistic anticancer activity against mouse sarcoma, combination of water extract (HaWD80) of Albizzia julibrissin and doxorubicin was applied in vivo and in vitro. In sarcoma cells treated with HaWD80 or doxorubicin alone, IC50 of HaWD80 and doxorubicin was 12.5μg/ml and 0.25μg/ ml, respectively. In sarcoma cells treated with mixture of HaWD80 and doxorubicin, however, IC50 of HaBD80 and doxorubicin against the cells was 1.6μg/ml and 0.13μg/ml, respectively. Therefore mixture of HaWD80 and doxorubicin appeared synergistic anticancer activity against the sarcoma cells in vitro, because ΣFIC was 0.648μg/ml. Tumor Inhibition Ratio (TIR) of the mouse bearing the sarcoma treated doxorubicin (2.5 mg/kg) or HaWD80 (50 mg/kg) alone was 25.66% and 4.61%, respectively. However, TIR of the mouse bearing the sarcoma treated simultaneously doxorubicin (2.5 mg/kg) and HaWD80 (50 mg/kg) was 29.28%. Consequently mixture of HaWD80 and doxorubicin appeared synergistic anticancer activity against mouse sarcoma in vitro and in vivo.

청소년들의 식생활습관과 영양이 피곤 자각도에 미치는 영향

윤군애 대한지역사회영양학회 2000 대한지역사회영양학회지 Vol.5 No.4

Linolenic Acid/linoleic Acid 비율이 다른 식이가 연령이 다른 흰쥐의 뇌구조지방 조성과 acetylcholinesterase 활성에 미치는 영향

윤군애 동의대학교 생활과학연구소 1997 生活科學論集 Vol.1 No.-

This study was undertaken to investigate the influence of age and dietary linolenic acid content and the linolenic acid/linoleic acid(LNA/LA) ratio on the brain lipid composition and membrane-bound enzyme, acetylcholinesterase(AchE) activities. AchE was selected as a test case for the relationship between cell lipid composition and cell membrane function. The male rats were fed diets with 0.2, 0.4, 0.6 of LNA/LA ratio within 8% LNA(H-LNA) or 4% LNA(L-LNA) of total fatty acid content for different feeding period (1, 4, 12 month). The fats used as source were sesame oil, perilla oil, soybean oil and beef tallow. The AchE activity of brain crude synaptosomal fraction was reduced with advancing age, showing 20-30% reduction in 12 M compared with 1 M, and the P/C ratio was reduced in old rats. In 1 and 4 monthed rats, AchE activities was higher in H-LNA-0.2 and L-LNA-0.2 and 0.4 group. In accordance with rising of AchE activities, the PC/PE ratio increased in those groups. Particularly in L-LNA, the PC/PE ratio increased as the AchE activities were high within each age. These data indicate the reduction of AchE activity was responsible for decline of membrane fluidity with increasing cholesterol and decreasing P/C ratio when rats were old. Also, AchE activity increased with increasing PC/PE ratio which depended on the dietary LNA/LA ratio within each LNA content. Therefore, it is concluded that the lipid composition of cell membrane influenced the AchE activities, which was mediated by aging and the modification of dietary LNA/LA ratio.

성인 여성의 비만위험도와 TV 시청시간 및 신체활동 수준과의 관계

윤군애(Yoon Gun-Ae) 韓國營養學會 2003 Journal of Nutrition and Health Vol.36 No.7

부산지역 일부 청소년의 체중상태와 신체활동량과의 관계

윤군애(Yoon Gun-Ae) 韓國營養學會 2001 Journal of Nutrition and Health Vol.34 No.1

성인 남성의 교육수준 및 생활습관에 따른 비만위험도

윤군애(Yoon Gun-Ae) 韓國營養學會 2004 Journal of Nutrition and Health Vol.37 No.5

식이단백질과 칼슘 수준이 흰쥐의 칼슘대사에 미치는 영향

윤군애(Gun Ae Yoon),황혜진(Hye Jin Hwang) 한국식품영양과학회 2005 한국식품영양과학회지 Vol.34 No.2

흰쥐를 대상으로 하여 식이 단백질 수준에 따라 칼슘 수준을 달리하여 식이를 공급하여 칼슘 식이효율, 칼슘대사와 관련된 호르몬, 대퇴골의 무게 및 칼슘 함유량, 골밀도를 측정하였다. 실험식이의 구성은 ① HPNC군-고단백 적정칼슘 군(protein: 400 g/㎏ diet, calcuim: 0.5%) ② HPLC군-고단백 저칼슘군(protein: 400 g/㎏ diet, calcium: 0.1%) ③ NPNC군-적정 단백 적정 칼슘군 protein: 200 g/㎏ diet, calcium: 0.5%) ④ NPLC군-적정단백 저칼슘군(protein: 200 g/㎏ diet, calcium: 0.1%)으로 구별하였다. 실험 종료까지의 체중은 NPLC군에서 가장 많이 증가하였으나, 실험군간의 차이를 나타내지 않았고, 식이 섭취량도 실험군간에 차이를 보이지 않았다. 뇨 칼슘배설량은 고단백군이 적정단백군보다 높은 경향을 나타내었고, HPLC군에서 유의적으로 높은 값을 보였으며 체내 칼슘보유량과 흡수율은 실험군에 따른 차이가 없었다. 뼈형성의 biomarker인 ALP의 활성은 저칼슘 식이군인 NPLC군에서 유의하게 높았고, 고단백 적정칼슘을 섭취한 HPNC군에서 유의적으로 낮았다. 혈액의 PTH 농도는 HPLC군에서 가장 낮게 나타났으며, 소변의 DPD농도는 저칼슘 식이군인 HPLC군과 NPLC군에서 높은 수치로 관찰되었고, HPNC군에서는 유의적으로 낮아졌다. 대퇴골의 건조 전의 습윤무게는 중 100 g당의 무게로 환산했을 때 NPLC군에서 가장 낮았으며 건조 후의 대퇴골의 무게 역시 다른 군에 비해 NPLC군에서 가장 낮았다. 대퇴골의 회분 함량은 실험군간의 큰 차이를 나타내지 않았고, 칼슘 함량은 NPLC군과 HPLC군에서 유의하게 낮았다. 대퇴골의 골밀도는 NPNC군에서 가장 높게 나타났으며, NPLC군은 가장 낮게 나타났다. 본 연구결과 고단백 저칼슘 식이 섭취시 요중 칼슘 배설량이 가장 많았고, DPD 농도가 다른 군에 비하여 유의적으로 높았으며, 골밀도도 가장 낮게 조사되어 고단백식이 섭취시 칼슘섭취 부족은 칼슘대사에 좋지 못한 결과를 나타냄을 알 수 있었다. 이로 볼 때 적절한 단백질과 칼슘 섭취가 골격의 건강을 유지하고 노령화에 따른 골격질환을 예방할 수 있고, 특히 고단백 섭취시에는 칼슘영양이 부족할 경우 골격대사를 저해할 수 있으므로 충분한 칼슘 섭취가 무엇보다도 중요하다고 본다. This study was conducted to examine effect dietary protein and calcium levels on calcium metabolism of the rat. Weaned 6-week old male rats were divided into 4 groups and were fed experimental diets for six weeks. Experimental groups were HPNC group-high protein normal calcium (protein: 400 g/㎏ diet, calcium: 0.5%), HPLC group-high protein low calcium (protein: 400 g/㎏ diet, calcium: 0.1%), NPNC group-normal protein normal calcium (protein: 200 g/diet, calcium: 0.5%), NPLC group-normal protein low calcium (protein: 200 g/diet, calcium: 0.1%). The calcium excretion in urine was higher in high protein group than in normal protein group, and it was highest in HPLC group. The activation of alkaline phophatase had a tendency to low in normal calcium group, and the concentration of parathyroid hormone (PTH) was the lowest in HPLC group. The deoxypyridinoline (DPD) concentration of urine was investigated as the highest in HPLC group and it was significantly lower in HPNC group that consumed normal calcium. The bone density of the femur was the highest in NPNC group and the lowest in NPLC group. As the results of this study, calcium excretion in urine and DPD density were the highest and the bone density was the lowest in HPLC group. It may suggest that the deficiency of calcium causes adversely effect in calcium metabolism upon consuming high protein diet. Therefore, it should be emphasized to consume enough calcium to prevent the hindrance of skeletal metabolism caused by deficiency of calcium upon consuming high protein diet.

흡연이 혈장의 비타민 C 함량과 지질과산화 및 지질의 농도 변화에 미치는 영향

윤군애(Yoon Gun-Ae) 한국영양학회 1997 Journal of Nutrition and Health Vol.30 No.10