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관류 기니픽 심장에서 melatonin에 의한 Mg<sup>2+</sup> 유리 조절
장효진,육지혜,김진상,Chang, Hyo-jin,Youk, Ji-hea,Kim, Jin-shang 대한수의학회 2001 大韓獸醫學會誌 Vol.41 No.3
Several recent studies demonstrate that cAMP accumulation evokes marked changes in magnesium ($Mg^{2+}$) homeostasis. The goal of this study was to investigate the effect of melatonin, the principal hormone of the vertebral pineal gland, on $Mg^{2+}$ regulation in perfused guinea pig hearts. We hypothesized that melationin would regulate $Mg^{2+}$ efflux induced by adrenergic drugs and cAMP analogues because melatonin inhibites adneylate cyclase (AC) and phospholipase C(PLC) in the hearts. The $Mg^{2+}$ content in the perfusate was significantly higher in the presence than in the absence of melatonin. The addition of forskolin, isoproterenol or dimaprit to perfused hearts induced a marked $Mg^{2+}$ efflux. These effluxes were not inhibited by melatonin. The $Mg^{2+}$ efflux could also be induced by phenylephrine, a ${\alpha}_1$-adrenoceptor agonist. This phenylephrine-induced $Mg^{2+}$ efflux was inhibited by melatonin. In addition, the phenylephrine-induced $Mg^{2+}$ efflux was potentiated by PMA, a protein kinase C(PKC) activator. This $Mg^{2+}$ efflux was inhibited by melatonin. In conclusion, these data suggest that melatonin regulates $Mg^{2+}$ homeostasis and the inhibitory effect of melatonin on ${\alpha}_1$-adrenoceptor-stimulated $Mg^{2+}$ efflux may occur through an inhibition of PLC pathway in perfused guinea pig hearts.
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박준조 ( Jun Jo Bark ),육지혜 ( Ji Hea Youk ),김휴경 ( Hu Kyoung Kim ),박혜원 ( Hye Won Park ),김인경 ( In Kyung Kim ),이우성 ( Woo Seong Lee ) 한국가축위생학회 2007 韓國家畜衛生學會誌 Vol.30 No.3
This study was conducted two kinds of aims: 1) to modify the analytical methods(conditions) by high performance liquid chromatography-fluorescence detector for the detection of residual ivermectin in raw milk, 2) to provide basic information for the evaluation of standard of the residual ivermectin in raw milk. It could be considerable that negative ion spectra can be better method in the LC/MS analysis for the detection of residues. Characteristic daughter ions were observed in negative ion spectra, however, linear line was not formed in positive ion one. Three Holstein cows (500±10kg) were applied to commercial ointment of ivermectin just one time at the first day of test, and residues in raw milk were examined for 20day after administration. The limit of detection(LOD) was 0.65ng(n=5) by HPLC/FLD, and recovery rates were 87.85%~99.47%. The peak was observed at the 4th day, and residues lasted to the end. Thus ivermectin was prohibited when lactating.
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