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RISS 인기검색어
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- 저자 : 유현선 ( Hyun Seon You ) (검색결과 1 건)
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원발성 비팽대부 십이지장선암: 단일기관에서의 15년간의 경험
유현선 ( Hyun Seon You ),홍정우 ( Jeong Woo Hong ),윤은영 ( Eun Young Yun ),김진주 ( Jin Joo Kim ),이재민 ( Jae Min Lee ),이상수 ( Sang Soo Lee ),김홍준 ( Hong Jun Kim ),하창윤 ( Chang Yoon Ha ),김현진 ( Hyun Jin Kim ),김태효 ( Ta 대한소화기학회 2015 대한소화기학회지 Vol.66 No.4
Background/Aims: Primary non-ampullary duodenal adenocarcinomas (PNADAs) comprise <0.3% of gastrointestinal malignancies. The rarity of PNADA and poorly defined natural history often leads to a delayed correct diagnosis. This study was conducted to evaluate the clinical characteristics of PNADA and to identify its prognostic factors. Methods: Data were collected by retrospectively reviewing the medical records of patients with PNADA managed at Gyeongsang National University Hospital from January 2000 to December 2014. Demographic, clinical, endoscopic, and pathological variables were investigated, and factors related to survival were analyzed. Results: Twenty-seven patients with PNADA were identified, and their median age was 64.9±13.6 years with 16 (59.3%) being male. The majority of patients (25/27, 92.6%) were initially diagnosed during upper endoscopy with biopsies. The tumor was located on the 1st or 2nd portion of duodenum in 92.6% (25/27) of patients. At the time of diagnosis, 85.2% (23/27) had advanced diseases (stage III or IV), 48.2% (13/27) had distant metastasis. Median survival time was 12 months (1-93 months). One and 3-year survival rates were 48.1% and 33.3%, respectively. On multivariable analysis, total bilirubin ≥2 mg/dL (OR, 85.28, 95% CI, 3.77-1,938.79, p=0.005) and distant metastasis (OR, 26.74, 95% CI, 3.13-2,328.14, p=0.003) at the time of diagnosis were independent poor prognostic factors. Conclusions: The majority of patients were diagnosed at an advanced stage. Presence of distant metastasis was independent prognostic factor of PNADA together with elevated total bilirubin. (Korean J Gastroenterol 2015,66:194-201)
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