Anti-acne Properties of Artemisia annua Extract In Vitro

유지영,노경백,오세영,정용택,박덕훈,정은선,You, Jiyoung,Roh, Kyung-Baeg,Oh, Se-young,Jung, Yong-Taek,Park, Deokhoon,Jung, Eunsun Society of Cosmetic Scientists of Korea 2021 대한화장품학회지 Vol.47 No.3

여드름은 털피지샘단위(pilosebaceous unit)와 관련된 만성 염증 피부 질환으로, 여드름 병변에서는 피지 과다분비(hyperseborrhea)나 이상분비(dysseborrhea), 염증반응, 그리고 다른 피부상재균들에 비해 증가된 Cutibacterium acnes (C. acnes)로 인한 피부 미생물 균총의 불균형이 관찰된다. 이 연구는 개똥쑥 추출물(Artemisia annua extract: AAE)의 항여드름 효과를 확인한 것으로, 피부 미생물 균총의 균형유지와 관련된 항균효과와 염증반응의 억제, 과도한 피지 분비의 감소 측면에서 실험을 진행하였다. C. acnes와 Staphylococcus epidermidis(S. epidermidis)를 AAE와 공동배양 하였을 때, S. epidermidis의 성장률은 저해되지 않았지만 C. acnes의 성장률은 저해된 것을 확인하였다. 또한 AAE를 처리하여 배양한 C. acnes 배양배지를 세포에 처리하였을 때, 인터루킨-1β(IL-1β), 종양괴사인자-α(TNF-α)와 인터루킨-6(IL-6) 같은 사이토카인 분비의 감소와 TLR2 활성 억제도 확인하였다. 마지막으로 피지세포에 AAE를 처리한 결과, 팔미트산에 의해 유도된 피지형성을 감소시키는 것을 확인하였다. 이 결과들은 AAE가 다양한 타깃을 지닌 천연추출물로써 여드름의 주요 원인들인 C. acnes의 선택적 성장저해와 C. acnes로부터 유도되는 염증반응을 억제할 수 있으며, 과도한 피지형성을 감소시켜 결과적으로 여드름을 완화시키는 물질로 사용될 수 있다는 것을 제시한다. Acne vulgaris is a chronic inflammatory skin disease related to pilosebaceous unit. In acne lesions, hyperseborrhea, dysseborrhea, inflammatory event, and an imbalance in skin microflora, particularly an increase in Cutibacterium acnes (C. acnes) colonization comparing to other bacteria, have been observed. The objective of this study was to evaluate anti-acne effects of Artemisia annua extract (AAE) on antibacterial activity related to preservation of the balance in skin microbiome, inhibition of inflammation, and reduction of excessive sebum production. When C. acnes and Staphylococcus epidermidis (S. epidermidis) were co-cultured in the presence of AAE, the reduction of C. acnes growth by AAE was greater than that of S. epidermidis. In addition, when C. acnes was cultured in a medium containing AAE (C. acnes AAE), levels of cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and IL-6 and toll-like receptors-2 activity were decreased in comparison with C. acnes cultured in a medium without AAE (C. acnes CM). Moreover, AAE significantly inhibited excessive sebum production induced by palmitic acid. These results suggest that AAE, as a natural extract with various targets, can inhibit selective growth of C. acnes and inflammatory reactions derived from C. acnes, which are the main causes of acne, and consequently can be used as a substance to alleviate acne by reducing excessive sebum formation.

여성 우울증 입원 환자에서 폐경 여부에 따른 인지기능의 차이

유지영,민정아,전양환,한상익,박이진,You, Ji-Young,Min, Jung-Ah,Jeon, Yang-Whan,Han, Sang-Ick,Park, E-Jin 대한생물정신의학회 2016 생물정신의학 Vol.23 No.4

Objectives Although forgetfulness is a common complaint among menopausal depressed women, there is still a debate about the relationship between memory impairment and menopause. The aim of this study is to examine whether menopause is related to cognitive decline among women with depressive disorders. We hypothesized that postmenopausal depressed women show generally poorer performance than premenopausal depressed women on various cognitive function tests. Methods With a retrospective chart review, we identified a total of 87 female patients (45 premenopausal patients and 42 postmenopausal patients) who were hospitalized with depressive disorders from 2000 to 2016. Demographic and clinical variables and cognitive test results were compared between two groups. Results Education year is longer in premenopausal group than postmenopausal group whereas clinical characteristics (illness duration, recurrence, and symptom severity) and mean Intelligence Quotient (IQ) were similar between two groups. The postmenopausal group took longer time for Bender-Gestalt Test (BGT) recall, Trail Making Test (TMT)-A, and TMT-B than the premenopausal group. After controlling for age and education, significant difference was remained for BGT recall (p = 0.029). Conclusions Postmenopausal state may be related with decline of visuospatial memory function, in particular, among depressed female patients. Other areas of cognitive function including complex attention, verbal memory, auditory memory, and working memory might be interpreted while considering age and education level.

조선시대 임명관련 교지의 문서형식

유지영 ( Ji Young You ) 한국고문서학회 2007 古文書硏究 Vol.30 No.-

T1-2 림프절 음성 삼중음성유방암의 예후인자

유지영 ( Ji Young You ),이혜윤 ( Hye Yoon Lee ),이은숙 ( Eun Sook Lee ),배정원 ( Jeoung Won Bae ),우상욱 ( Sang Uk Woo ),박경화 ( Kyong Hwa Park ) 대한임상종양학회 2011 Korean Journal of Clinical Oncology Vol.7 No.2

배경: 삼중음성유방암은 비삼중음성유방암군에 비해 조기라 해도 더 나쁜 예후를 보이는 걸로 알려져 있다. 따라서 삼중음성유방암의 초기 치료를 위해서 정확한 예후인자를 찾는 것이 중요하다. 본 연구에서는, T1-2 림프절 음성인 삼중음성유방암의 나쁜 예후와 관련된 예후인자를 찾아 보고자 하였다. 방법: 1995년부터 2006년까지 고려대학교 의료원 안암병원에서 유방암으로 근치절제술을 시행받은 환자 중 림프절 전이나 원격전이가 없는 환자를 대상으로 하였다. 이 중에서 호르몬 수용체 및 HER2 수용체 여부에 대한 기록이 있는 환자들만을 포함시켰다. 의무기록의 후향적 분석을 통해 삼중음성유방암 및 비삼중음성유방암 환자들의 임상병리적 특징이 분석되었다. 결과: 79명 (22.9%) 의 환자들이 삼중음성유방암군으로 분류되었다. 삼중음성유방암군에서 p53 양성 환자군에서 p53 음성 환자군보다 더 낮은 무병생존율을 보였다 (p=0.028). 다변량 회귀분석에서는 35세 이하의 낮은 연령이 삼중음성유방암과 관련된 독립적인 예후인자로 나타났으며, Ki-67은 단변량 회귀분석에서 삼중음성유방암과 통계적으로 유의하게 관련성을 보였다. 결론: 본 연구에서, T1-2 림프절 음성인 삼중음성유방암에서 연령은 독립적인 예후인자이고 어릴수록 나쁜 예후와 연관됨을 알 수 있었고, Ki-67 은 통계적으로 증명되지는 않았지만, 삼중음성유방암의 예후인자가 될 수 있을 것으로 생각된다. Purpose Triple-negative breast cancer typically results in poorer prognoses compared to non-triple negative breast cancer, even in early stages. The initial management of triple negative breast cancer patients and detection of clear prognostic factors are therefore of great importance. We aimed to identify specific prognostic factors associated with unfavorable outcomes of triple negative breast cancer in T1-2 node-negative breast cancer. Materials and Methods We analyzed breast cancer patients without lymph node metastasis or distant metastasis who underwent curative surgery at the Anam Hospital of the Korea University Medical Center between 1995 and 2006. Among them, patients were eligible for analysis, only if the reports about hormone receptor and human epidermal growth factor receptor-2 status were available. Clinico-pathological features were reviewed by retrospective examination and comparison of medical records of triple negative breast cancer and non-triple negative breast cancer patients. Results Seventy-nine patients (22.9%) were categorized to the triple negative breast cancer group. The disease-free survival rate of TNBC p53-positive patients was significantly lower than that of p53-negative patients (p =0.028). In multivariate analysis, young age was an independent prognostic factor for disease-free survival of the triple negative breast cancer group. High Ki-67 expression was a significant prognostic factor in univariate analysis in triple negative breast cancer, but it was not significant in multivariate analysis. Conclusion We suggest that age is an independent prognostic factor of triple negative breast cancer in T1-2 and node-negative patients and that Ki-67 could also be a prognostic factor in these patients.

조선후기 手本의 한 연구 : 慶州 驪州李氏 癡菴宗宅 소장 고문서를 중심으로

유지영(You Ji-young) 한국학중앙연구원 2005 장서각 Vol.0 No.14

In this thesis, I reviewed the document called 'Su-bon(手本)' which has never been introduced. There are many kinds of Su-bon, meanwhile we have known them as official document. But I would try to give another type of Su-bon a term of 'Sojihyung Su-bon (所志型 手本)' that have similar shapes of 'Soji(所志)' which had been submitted a petition to a local government. And looking into Su-bon, I studied what it had forms, contents, writings, processes of disposition. After through out all these analysis, I could reach the several conclusions below. First. Writers of Su-bon were peoples, servants, officials of the smallest unit of the administrative organization(ex. 風?, 上任, 洞任 etc.) When they submitted Su-bon, there were not in the name of an individual but a joint signature at least four persons. Second. Forms of Su-bon were similar to a kinds of 'So-ji' which had been submitted a petition to a local government. Besides a 'So-ji' of the most similar to 'Deong-jang(等狀, a petition which had been submitted to official government in many people's signatures), nothing but just replace Su-bon with So-ji. Third. The measuring organization of Su-bon were the competent authorities (本官) and Royal secret inspector(暗行御史). In spite of a same content of petition, submitted to the provincial authorities(監司), not written as Su-bon but Ui-song(議送, a petition which had been submitted to the provincial authorities) Forth. The contents of Su-bon were not concerned with personal dispute but a tax . Especially that was something to do with the tax which have relation to a local society's interests. Fifth. Based on forth, the matter was concerned with official affairs. So in the process of handling the matter, the government office should have intervened in it eagerly. According to the conclusion above, we can know another side of Su-bon which have a different style except for the side of Su-bon as 'a public report'. Generally there were many kinds of written petition, just like a group of So-ji (所志類), for instance So-ji(所志), Bal-gwal(白活, this is pronounced natively in Korea), Dan-ja(單子), Sang-seo(上書) and exceptionally in addition to another document, called 'Su-bon' that have never ever been known to.

학령전기 소아외상 환자의 연령별 비교 연구

유지영 ( Ji Young You ),이재일 ( Jae Il Lee ),유지영 ( Ji Yeong Ryu ) 대한외상학회 2004 大韓外傷學會誌 Vol.17 No.2

Background: Trauma is a leading cause of morbidity and mortality for children. This study was conducted to describe the characteristics of pediatric trauma and to compare the differences of two groups based on age. Methods: We performed a retrospective analysis of pediatric patients under 7 years of age admitted to our emergency department after a trauma from January 2003 through June 2003. The patients were divided into two groups based on age: group A (infant/toddlers, 0~3 years) and group B (preschool children, 4~6 years). Results: The most common cause of trauma was slip down in both groups. Fall down and burn were more frequent in group A, automobile and bicycle accident were more frequent in group B(p=0.000). The most common place of trauma was house in both groups, but other places were more frequent in group B(p=0.000). The most common trauma related device was furniture/electronics in group A, sporting goods in group B(p=0.002). Conclusions: From this study, we found statistically significant differences between the groups. Knowledge of age-related characteristics could result in improved diagnosis, treatment, and prevention of these injuries.

ADHD 아동의 문제행동 감소 및 사회성 기술 향상을 위한 음악과 미술치료프로그램의 효과성 비교연구

유지영 ( Jee Young You ),전은주 ( Eun Ju Jeon ),김춘경 ( Chon Kyung Kim ) 한국정서ㆍ행동장애아교육학회 2009 정서ㆍ행동장애연구 Vol.25 No.3

자기효능감과 자아탄력성이 초등학생의 학습된 무기력에 미치는 영향

유지영 ( Jee Young You ),김춘경 ( Choon Kyung Kim ) 한국정서·행동장애아교육학회(구 한국정서학습장애아교육학회) 2014 정서ㆍ행동장애연구 Vol.30 No.1

본 연구는 초등학생의 자기효능감과 자아탄력성이 학습된 무기력에 미치는 영향을 밝히고자 하였다. 연구대상은 초등학교 4, 5, 6학년 809명이었고 학습된 무기력, 자기효능감, 자아탄력성 설문지를 실시하였다. 자료분석은 SPSS 14 통계처리프로그램으로 연구대상의 일반적 특성을 확인하였고, 학습된 무기력, 자기효능감, 자아탄력성 간의 Pearson 상관계수, 학습된 무기력, 자기효능감, 자아탄력성 간의 중다회귀분석을 실시하였다. 자기효능감과 자아탄력성이 초등학생의 학습된 무기력에 미치는 영향을 분석한 결과, 첫째, 자기효능감과 자아탄력성은 학습된 무기력과 부적 상관이 있는 것으로 나타났다. 둘째, 자기효능감의 하위변인인 자신감과 자기조절 효능감은 초등학생의 학습된 무기력에 영향을 미치는 것으로 나타났다. 셋째, 자아탄력성의 하위변인인 친구관계, 활력성, 감정통제는 초등학생의 학습된 무기력에 영향을 미치는 것으로 나타났다. 넷째, 학습된 무기력의 하위변인에 대한 자기효능감과 자아탄력성의 하위변인의 영향력을 분석한 결과, 자기효능감의 하위변인인 자신감과 자아탄력성의 하위변인인 활력성, 친구관계가 학습된 무기력의 하위변인에 많은 영향을 미치는 것으로 나타났다. 이러한 연구결과가 학습된 무기력 수준이 높아서 다양한 정서, 행동적 문제를 가진 초등학생들을 지도하는 교사나 상담사에게 주는 시사점을 논의하였으며, 후속연구를 위한 제언을 하였다. The purpose of this study was to analyse the effects of self-efficacy, self-resilience on learned-helplessness of Elementary school students. The Participants were 809 4th~6th elementary school students and learned-helplessness, self-efficacy, self-resilience were measured with questionnaire based on several studies. The data analyzed by using frequence, percentage, Pearson correlation, multiple regression. The research findings were as follows. First, There were negative correlations between learned-helplessness with self-efficacy and self-resilience. Second, Subordinate concept, confidence and efficacy of self-adjustment of self-efficacy have effects on learned-helplessness of elementary school students. Third, Subordinate concept, relationship of friend, vitality, emotion-control of self-resilience have effects on learned-helplessness of elementary school students. Forth, Subordinate concept, confidence of self-efficacy and vitality, relationship of friend of self-resilience have effects on subordinate concept of learned-helplessness. The results of the study showed that learned-helplessness of elementary school students is decreased by increasing self-efficacy, self-resilience to theaters and therapists. Finally, implications for future studies and the limitations of this study were descussed.

메틸렌 블루

유지영 ( Ji Young You ) 대한임상독성학회 2010 대한임상독성학회지 Vol.8 No.1

Methylene blue is a very effective reducer of drug-induced methemoglobinemia. It has dose-dependent oxidation or reduction properties. In most cases, a dose of 1 to 2 mg/kg IV given over 5 minutes and immediately followed by a 15- to 30-mL fluid flush to minimize the local pain is both effective and relatively safe. The onset of action is quite rapid, and the effects are usually seen within 30 minutes. The dose may be repeated after 30 to 60 minutes and then every 2 to 4 hours as needed. The total dose should not exceed 7 mg/kg as a single dose or 15 mg/kg within 24 hours. Repeated treatment may be needed for treating compounds that have prolonged elimination or those compounds that undergo enterohepatic recirculation (e.g., dapsone). Methylene blue can cause dose-related toxicity. At high doses, methylene blue can also induce an acute hemolytic anemia and rebound methemoglobinemia. The reasons for treatment failure with methylene blue include ineffective GI decontamination, the existence of other forms of hemoglobin (e.g., sulfhemoglobin), a low or high dose of methylene blue and the toxicokinetics of some agents, such as aniline, benzocaine or dapsone.

추어를 첨가한 떡갈비의 개발 및 품질특성

유지영 ( Ji Young You ),김현진 ( Hyun Jin Kim ),임종준 ( Jong Jun Lim ),백서준 ( Seo Jun Baek ),이성실 ( Sung Sil Lee ),최준호 ( Joon Ho Choi ) 한국산업식품공학회 2021 산업 식품공학 Vol.25 No.3

This study was performed to improve awareness of mudfish and develop tteokgalbi supplemented with mudfish suitable for young ages. Tteokgalbi was produced with flour·starch (control), rice paste was replaced with wheat flour·starch, and mudfish paste was substituted with 5, 10, and 15% of meat and tallow. No differences were found in the moisture content, pH, and Brix of all samples supplemented with rice and mudfish paste. The samples supplemented with rice and mudfish pastes had reduced cooking loss rates compared to the control. The samples supplemented with rice and mudfish pastes increased in both a and b values but decreased in L values compared to the control. The hardness and adhesiveness of the control were higher than in other samples. The adhesiveness of the samples was reduced with an increase in quantities of mudfish pastes. The overall acceptability of samples supplemented with rice and mudfish pastes was better than that of the control, and the proper quantity for substituting mudfish paste appears to be 10%. The unique flavor and taste of mudfish did not affect the sensory evaluation and did not distinguish even in the principal component analysis using an electronic nose. Finally, the mudfish paste was confirmed as a good ingredient for enhancing consumer acceptability in manufacturing tteokgalbi.