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황칠나무의 용매 분획별 추출물의 항산화 활성 및Acetyl-cholinesterase 저해 활성비교
유지민,문형인 한국자원식물학회 2018 한국자원식물학회지 Vol.31 No.1
The leaves and stems of Dendropanax morbiferus were separated from organic solvents with methanol. The organic solvent fractions were fractionated with dichloromethane, ethyl acetate and butanol according to the systematic fractionation method. Oxidation in the body induces aging, and antioxidant activity has attracted the attention of many people as a preventive component to suppress negative reactions in the body. To investigate the antioxidant activity of Dendropanax morbiferus were subjected to DPPH free radical assay. In addition, acetyl cholinesterase inhibitions were performed for Alzheimer’s disease as an aging neurological disease. As a result, it was confirmed that the antioxidant effect of DPPH was generally good in the antioxidant test. The ethyl acetate fractions of Dendropanax morbiferus stems and leaves were IC50=30 ㎍/㎖. Acetyl cholinesterase inhibition experiments were carried out at a concentration of 250 ㎍/㎖. Dendropanax morbiferus stems fractions showed dichloromethane fraction of 57.68%, which significantly inhibited the activity of acetyl cholinesterase. Key words - Acetylcholinesterase inhibitory activity, Dendropanax morbiferus, Free radical scavenging 황칠나무 잎과 줄기를 분리하여 각각 methanol 추출하여, 계통분획상법에 따라 dichloromethane, ethyl acetate, butanol 로 분획하였다. 분획물로 실시한 TLC에서 알칼로이드 성분으로 분리되는 성분을 확인할 수 있었다. 잎과 줄기 모두 ethyl acetate분획물은 IC50 30 ㎍/㎖으로 높게 측정 되었으며, ethyl acetate, dichloromethane, butanol분획물 순으로 저해 활성이 높게 나타났다. Acetyl cholinesterase inhibition assay를 실시한결과 황칠나무 잎과 줄기 모두 dichloromethane, ethyl acetate, butanol 분획물 순으로 저해 활성이 높은 것으로 나타났으며, 가장 높은 활성을 보인 황칠나무 줄기와 잎의 dichloromethane 분획물의 알칼로이드 함량이 상대적으로 높은 것으로 보아 알칼로이드 성분에 의한 것으로 유추 할 수 있으므로, 알칼로이드 성분의 동정 및 성분구조의 규명을 통하여 AChE저해 활성을 이용한 신경관련 질환에 도움을 줄 수 있는 천연물의 개발이 가능할것으로 사료된다.
유지민,이태일,Mrinmoy Misra 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.66 No.-
CuS/Au/ZnO core-sell nanorods (NRs) have been synthesized by a novel and facile chemical method in an aqueous medium. The CuS/Au/ZnO NRs showed higher catalytic activity as compared to the ZnO NRs, Au/ZnO NRs, and CuS/ZnO NRs. The wavelength-dependent photocatalytic activity of the CuS/Au/ZnO NRs confirmed that the Au NPs act as the surface plasmon generated photocatalytic activity boosters and that CuS performs as a co-catalyst. The photocurrent generation and photo-electrochemical study further exhibited higher photocurrent generation and reduction of charge transfer resistance due to the synergistic impact of the Au NPs and CuS coating on the ZnO NRs.
노년기 주관적 기억력 감퇴의 예측인자 : 한국인의 건강과 노화에 관한 종적 연구 결과
유지민,김기웅,박준혁,이석범,최은애,최진영,정지운,도연자,노현아,박영선,이동영,우종인 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6
Objectives : We investigated the predictors of subjective memory complaints in the community-dwelling normal elderly. Methods : This study was conducted as a part of Korean Longitudinal Study on Health and Aging (KLoSHA). 747 non-demented community-dwelling elderly aged 65 years or older were recruited. All participants underwent clinical evaluation for dementia and psychiatric disorder conformed to the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K.) Clinical Assessment Battery and Korean version of Mini-Intemational Neuropsychiatric Interview, res-pectively. Word list recall test, frontal assessment battery, Mini Mental Status Examination (MMSE-KC) and Korean version of Geriatric depression scale (GDS-K) were administered to evaluate episodic memory, frontal function, global cognition and depression, respectively. Subjective memory complaint was defmed in two different ways: worse than one's past (SMC-P) and worse than others of one's age (SMC-O). Results : In highly educated elderly, minor depressive disorder (0R=7.23, 95% C.I.= 2.29-22.86) and frontal dysfunction (0R=2.48, 95% C.I.= 1.29-4.77) significantly increased the risk of SMC-O. However, they did not influence the risk of SMC-P. In low educated elderly, both the minor depressive disorder and frontal dysfunction did not influence the risk of SMC-0 as well as that of SMC-P. Conclusion : SMC-O can be a sensitive subjective recognition of mild depression and/or frontal dysfunction in highly edu-cated normal elderly.