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Histalog 刺戟에 依한 消化性 潰瘍의 胃液所見에 關한 硏究
兪宣穆,高侊道 우석대학교 의과대학 1971 우석의대잡지 Vol.8 No.1
Among the conventional methods for the study of secretory function of the stomach, the histamine test has been widely used for study of gastric response. Although it is a very useful test, it has some such drawbacks as side action and short acting duration as compared with response to Histalog. Recently Histalog(betazole, Lilly) has been used as a substitute for histamine to produce a gastric response. The author has studied the subjects with peptic ulcer between 1967 and 1968. Peptic ulcers were classified by location in the stomach as follows: lesser curvature(incisura angularis), pyloric region, antrum region and duodenum. Subjects and procedure:- there were 46 subjects(33 men and 13 women): 9 has lesser curvature(incisura angularis), 8 had pylorus, 5 had antrum and 24 were duodenal ulcer. After an over night fast, the stomach was intubated, the residual content was removed, continuous suction was applied manually with a 50㏄ syringe, and secretion collected for three 15 minute periods(basal secretion). Histalog was injected intra-musculary, a dose of 0.5㎎. per kilogram of body weight, and continuous aspirations were made for four additional 15 minute periods. The results obtained were as follows: 1) In patients with gastric ulcer, the mean rate of secretion of free hydrochloric acid varies with the location of the ulcer in the stomach. Ulcers of the lesser curvature of the stomach are observed about twice the normal levels of secretion after the injection of Histalog stimulant(Basal: 13.2±7.02 mEq/45 minut. after the injection of Histalog: 24.13±5.87 mEq/60 minut.), whereas ulcers of the duodenum are observed about three times the normal levels after the injection of Histalog stimulant(Basal: 12.96±6.33 mEq/45 minut., after the injection of Histalog: 36.77±18.63 mEq/60 minut.). But the others were not significantly different. Peptic ulcers were not seen in subjects who did not secrete free acid. 2) The secretory rate of free hydrochloric acid was measured as higher during one hour of secretory response. 3) In patients with gastric ulcer, the mean rate of secretion of pepsin varies with the location of the ulcer in the stomach. Ulcers of the lesser curvature of the stomach are observed about 1.5 times the normal levels of secretion after the injection of Histalog stimulant(Basal 4.17±1.21 P.KU./45 minut. after the injection of Histalog: 5.03±1.45 P.KU./60 minut.) whereas ulcer of the duodenum are observed about twice the normal levels after the injection of Histalog stimulant (Basal: 5.24±2.14 P.KU./45 minut. after the injection of Histalog: 6.24±2.11 P.KU./60 minut.). But the others were not significantly different. 4) The secretory rate of pepsin was measured as higher during one hour of secretory response. The peak of the responses to Histalog was marked significantly between 30 to 75 minutes. 5) Levels of sodium, chloride, and potassium were not significantly different. However, the response of sodium to Histalog was low significantly between 60 and 90 minutes. But the response peaks of chloride and potassium to Histalog were observed significantly between 30 and 75 minutes.
유선목 ( S. M. Yoo ),이진희 ( J. H. Lee ) 대한내과학회 1969 대한내과학회지 Vol.12 No.2
A case of dye (Rhodamine B) intoxication was reported in this paper, A 28 year old woman had been admitted to this hospital because of whole reddish skin at around 30 minutes after intake Rhodamine B. The dosage was half a teaspoon. The Rhodamine B. is a d
유선목 ( S. M. Yoo ),민수홍 ( S. H. Min ),김승진 ( S. J. Kim ) 대한내과학회 1969 대한내과학회지 Vol.12 No.10
In this report, a case of malignant lymphoma is reported. A 41 year old man has complained of epigastric discomfort, anorexia and weight loss for about 14 months, On the physical examination, there were epigastric tenderness, palpable liver of 1 finger bre
유선목 ( S. M. Yoo ),이진희 ( J. H. Lee ),민수홍 ( S. H. Min ),박경남 ( K. N. Park ) 대한내과학회 1968 대한내과학회지 Vol.11 No.5
In this report, a cases of bronchobiliary fistula is reported. A 15 year-old girl has complanined of productive cough and expectorated bile for about four months. On the physical examination, there were epigastric tenderness, palpable liver of 3 finger bre
유선목 ( S. M. Yoo ),정충수 ( C. S. Chung ),김승진 ( S. J. Kim ) 대한내과학회 1970 대한내과학회지 Vol.13 No.1
In this report, a case of neurilemmoma is reported. A 58 years old man has complained of melena and pain in left upper quadrant for one week before admission. On the physical examination, there were anemic conjunctiva and tenderness in left upper quadrant