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正常 大腸粘膜과 大腸癌의 癌性胎兒性抗原, 分泌成分 및 分泌型 IgA의 出現에 관한 免疫組織化學的 硏究
柳建一,崔宗相,金世民 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.1
The predominant immunoglobulin in external secretions of humans and various other mainmals is a special form of IgA known as secretory IgA, a molecule composed of a dimer of serum-type IgA plus a J chain :and a distinctive polypeptide chain known as secretory component (SC). Histological localization of SC and a chain of IgA in normal mucosa has been studied by immunchistological methods and identified in the cytoplasm of epithelial cells in mucous membranes, spaces between these cells, and secretion. On the other hand. carcinoembryonic antigen is a fetal glycoprotein which may reappear during malignant transformation of entodermal epithelial cell. The purpose of this study is ito compare distribution of SC in normal and malignant epithelial cell to understand local immunological defense mechanism, especially along the luminal surface replaced by tumor mass. Each 5 cases of formalin fixed and paraffin embedded well, moderately and poorly differentiated adenocarcinoma of colon were selected and immunoperoxidase staining of Avidin-Biotin-Complex method mere performed using anti-CEA, SC, and IgA antiserum and compared distribution of each antigen between normal mucosa and carcinoma. The result obtained are as follows : 1. Carcmoma of the colon revealed strong CEA positive reaction along the luminal surface of the gland structure or in the cytoplasm while normal Lieberkuhn epithelial cell showed negative reaction. 2. Normal Lieberkuhn epithelial cells showed SC positive reaction in the cytoplasm while carcinoma cells of the colon disclosed no SC in the cytoplasm, regardless of degree of differentiation of the tumor cell. 3. IgA positive plasma cells were noted mainly along the lamina propria and epithelial cells lining Lieberkuhn's crypt also revealed positive reaction while neither tumor cell not interstitium revealed any evidence IgA. Above findings suggests that mucosa of colon which is replaced by carcinoma is devoid of local immunological defense mechanism as far as SC and IgA are concerned. And disappearance of SC in colonic carcinoma cell seems to be a useful indicator in the field of histologic differential diagnosis of metastatic carcinoma.
유건선 한라대학교 2009 論文集 Vol.12 No.-
This paper is concerned with the bulking factor for dredged marine clay to be reclaimed by a pump dredger Marine clay is deposited naturally with several ten percent of water content however once it is dredged by pump dredger its water content increases upto a few thousand percent rapidly After it is transported to confinement area and undergoes sedimetation and self-weight consolidation process its water content is reduced but still higher than before dredging This means the volume of marine clay increases than before In this study the empirical method and numerical analysis method are used to calculate and compare the bulking factors of marine clay by dredging The calculated results show the bulking factor of numerical analysis method is lesser than that of the empirical method
유건선,유남재,이종호 江原大學校 産業技術硏究所 1996 産業技術硏究 Vol.16 No.-
This research is the experimental and umerical study of investigating the characteristics of consolidation due to selfweight of soft marine clay. Column tests and centrifuge tests were carried out to selfweight of soft marine clay. Column tests and centrifuge tests were carried out to simulate the selfweight consolidations in field. Tests were conducted with changing drain boundary conditions and initial void ratios corresponding to four and five times of liquid limits. The RI meter was used to meaure void ratio during consolidation of sample in column tests. Test results were analyzed by using the Terzaghi's infinitesimal strain theory and the finite strain theory.