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人體 胃癌 및 胃炎에서의 CEA의 表現에 對한 免疫酵素 組織學的 硏究
元南熙,李大一,白承龍 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.3
Carcinoembryonic antigen (CEA) isolated from adenocarcinomata of human digestive system and fetal or embryonic gut tissue is one of tumor associated antigens. In recent years, extensive studies to detect CEA in the blood as well as in the tissue of various conditions have been reported. However, characterization of CEA in the tissue of stomach cancer, common malignant tumor in Korea, has rarely been investigated. The author performed peroxidase-antiperoxidase immunohistologic study with anti-CEA antibody to determine the presence of CEA in 51 cases of gastric adenocarcinoma and 18 cases of chronic gastritis. All tissues examined were obtained with endoscopic biopsy, fixed in 10% formalin and embedded in paraffin. The findings were analysed and results obtained are as following. 1. CEA positive reaction to anti-CEA antibody was noted in 45 of the 51 cases with gastric cancer (88.2%). 2. Patterns of positive reaction to anti-CEA antibody of 45 CEA positive adenocarcinomas were focal in 9 cases (20.0%), moderate in 10 cases (22.2%) and diffuse in 26 cases (57.8%). 3. Comparing the pattern of CEA positive reaction with histologic differentiation of cancer cell, the differentiated type showed diffuse linear pattern along membrane the surface and undifferentiated type revealed focal positive pattern in the cytoplasm. 4. Of 18 cases with chronic gastritis, 8 cases of non-specific gastritis and 10 cases of intestinal metaplasia, CEA poistive reaction to anti-CEA antibody was noted in 4 cases at the lesion of intestinal metaplasia. The results obtained above suggest that presence of CEA in gastric cancer is detected 88% of cases, variable in pattern, partly depending on morphologic differentiation, and even exhibit in goblet cells in some intestinal metaplasia which is believed to be a precancerous condition of stomach cancer.
조원용(Won Yong Cho),김인옥(In Ok Kim),정동국(Dong Guk Chung),김형규(Hyoung Kyu Kim),원남희(Nam Hee Won),박희봉(Hee Bong Park) 대한내과학회 1987 대한내과학회지 Vol.33 No.5
N/A To assess the clinical significance of immune doposits in the clinical course of minimal change nephrotic syndrome, we have studied 27 patients with minimal change nephrotic syndrome, aged from 13 to 51 years. The clinical course of 13 patients with mesangial immune deposits was compared with those of 14 patients without mesangial immune deposits. The results obtained in this study were as follows 1) In IF positive group, serum abumin level was 1.57±0.25 gm/dl and 24 hour urine protein 9.50±4.45 gm/day. In IF negative group, serum albumin level was 1.40±0.34 gm/dl and 24 hour urine protein 11.44±8.67 gm/day. There were no significant differences between two groups. 2) The presenting symptoms such as hypertension, hematuria, and azotemia were appeared in variable ratio, but no significant difference in two groups were noted. 3) In IF positive group, all cases had IgM deposits in mesangium, and two cases had IgA deposits in mesangium. There were no significant differences in symptoms, signs and responses to therapy according to varieties of immunoglobulin or complement deposits. 4) In the clinical course along the steroid therapy, there were no significant differences in the two groups, namely, in IF positive group, complete remission occurred in 46%, and in IF negative group complete remission occurred in 61.5%, somewhat higher ratio, but had no significant difference. There were no difference in any particular clinical onset, histologic pattern on light microscopy, therapy response or clinical course in two groups in our relatively short follow up period. So we concluded that immune deposits is not a marker for response to therapy in patients with idiopathic nephrotic syndrome and that to define new disease entity, IgM nephropathy, further study and follow up were required.
조원용(Won Yong Cho),이은주(Eun Joo Lee),김용섭(Yong Sup Kim),권현민(Hyun Min Kim),권영주(Young Joo Kwon),김형규(Hyung Kyu Kim),원남희(Nam Hee Won) 대한내과학회 1991 대한내과학회지 Vol.40 No.5
N/A To evaluate the relationship between derangement of renal function and the pathological findings in hemorrhagic fever with renal syndrome (HFRS), renal biopsy and functional studies were performed in 23 cases of HFRS. To correlate the pathologic findings with renal funtion, serum creatinine, creatinine clearance, and proteinurea were measured, and also an immunohisto-chemical study in kidney tissue was performed. The results were as follows: 1) The study population included 9 oliguric HFRS cases and 14 nonoliguric HFRS cases. Clinical manifestations at admission were more severe in oliguric cases. 2) Serum creatinine in oliguric cases at admission were 12.5±4.5 mg/dl, higher than the nonoliguric cases, 8.4±3.9 mg/dl (p<0.05). 3) There were no significant differences in the pathologic findings between oliguric and nonliguric HFRS. Pathologic findings were focal infiltration of inflammatory cells and edema of interstitium and destructive changes of tubular structure. 4) The infiltrating inflammatory cells were mostly T-lymphocytes. From the above findings, we can conclude that renal functional changes in HFRS are not related with the severity of the pathologic lesion. It is also sugsseted that infiltrating T-lymphocytes in the interstitium may be related with renal functional derangement ant the pathogenesis of proteinuria.