약학대학생들의 입학전형요소와 학업성취도의 상관관계에 관한 연구

원권연,주상훈 대한약학회 2014 약학회지 Vol.58 No.4

Background: A new admission procedure was introduced to Korea when Doctor of Pharmacy (Pharm. D.) pro- gram was first established in 2011. In the new procedure, applicants are reviewed based on quantitative ualifications, which include Pharmacy Education Eligibility Test (PEET) scores, Test of English for International Communication (TOEIC) scores, and grade point average (GPA), as well as qualitative qualifications such as essay writing, urricular activities including volunteer experiences. Purpose: This study aimed to find relationships between entrance qualifications and aca-demic performance of pharmacy students. Method: Entrance qualifications and academic performance of 164 first-year stu-dents were analyzed from 2011 to 2013 at Catholic University of Daegu. Other characteristics such as age and gender were also considered in the study. Results: Only GPA and TOEIC scores showed positive Pearson correlation with academic per-formance, while PEET scores did not. Conclusion: GPA and TOEIC scores could potentially have predictive validity for aca-demic performance in pharmacy school. PEET scores, however, should simply be considered as pre-entrance qualifications, without predictive validity for academic performance.

유럽연합의 의약품 허가·심사 체계 분석

원권연,임화경,송윤경 한국에프디시규제과학회(구 한국에프디시법제학회) 2021 FDC법제연구 Vol.16 No.1

경희 동서약학연구소 업적 초록집 ( 1984 ~ 1993 ) - 제 6 권 경희동서약학연구소보로 명칭 변경 ( 1989 ) / 원보 : 의약품의 용출에 관한 연구 ( 제 24 보 ) - Diclofenac Sodium 의 용출에 미치는 HPMC 의 영향 -

원권연(Kwon Yeon Weon),김수억(Soo Uck Kim),서성훈(Seong Hoon Seo) 경희대학교 동서약학연구소 1994 경희동서약학연구소보 Vol.11 No.-

Diclofenac Sodium 의 용출에 미치는 Hydroxypropyl Methylcellulose 의 영향

원권연(K . Y . Weon),서성훈(S . H . Seo),김수억(S . U . Kim) 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.4

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메트포르민의 서방출을 위한 팽윤성 위체류 약물전달시스템 설계

원권연(Kwon Yeon Weon),김세기(Se Gie Kim) 한국산학기술학회 2020 한국산학기술학회논문지 Vol.21 No.3

메트포르민은 제2형 당뇨병의 1차 치료제로 사용되는 약물로 다른 당뇨병 치료제에 비해 투여 용량이 크고 용해도는 높으나 위장관 투과도가 낮은 특성을 갖고 있으며 주로 위장관 상부에서만 흡수되는 이유로 생체이용률이 40~60%로 낮은 편이다. 따라서 본 연구를 통해 위체류 약물전달시스템을 적용하여 제제가 위에 머무르는 시간을 증가시키고 제제로부터 방출된 약물을 서서히 소장으로 이동시킨다면 생체이용률을 증가시킬 수 있을 것으로 기대된다. 팽윤성 시스템은 다른 위체류 약물전달시스템에 비해 안정성이 높아 개발목표기술로 선정하였고, 팽윤성 기제로는 기존의 연구와 다르게 카라기난과 히프로멜로오스를 병용하여 차별성을 확보하였다. 카라기난과 히프로멜로오스 병용 시스템은 각각의 함량이 15/110 질량분율일 때 가장 높은 팽윤성과 적절한 서방성 용출패턴을 나타내었다. 또한 각각의 함량이 15 %와 14 %가 되도록 제조한 메트포르민 정제를 시판 정제와 비교 시 더 우수한 팽윤성이 나타남을 확인하였다. 결론적으로 본 연구 결과에 의해 메트포르민의 서방출을 위한 새로운 팽윤성 위체류 약물전달시스템이 개발되었으며 다양한 주성분에 대한 추가적인 연구가 수행되면 의약품, 화장품, 건강기능식품 등의 분야에서 효과적인 약물전달시스템으로 응용될 수 있을 것으로 기대된다. Metformin is a recommended first-line therapy drug for type 2 diabetes patients. However, compared to other oral antidiabetic drugs (OAD), metformin has a large unit dosage, with bioavailability of 40-60%. This limiting bioavailability is because metformin is absorbed only in the upper gastrointestinal tract as a BCS class 3 drug. Hence, we propose that applying the Gastroretentive Drug Delivery System (GRDDS) and extending drug release time in the stomach will result in improved bioavailability. We selected the swelling type delivery system, as it is considered the most stable gastroretention technology compared to other GRDDSs. We modified the swelling excipient by using a natural swelling excipient to form a swelling tablet made of carrageenan and hydroxypropyl methylcellulose (HPMC). Our results indicate that the swelling complex tablet made of carrageenan and HPMC has a good swelling ability and shows required sustained release in a dissolution pattern. In addition, the carrageenan complex has a better swelling ability than the marketed metformin tablet, as determined by the ratio, (swelling ability)/(excipient weight). Taken together, our results indicate that the carrageenan complex can be developed as a good swelling excipient. Further optimizations are required for the commercialization of the carrageenan complex.

Pharmaceutical application and development of fixed-dose combination: dosage form review

김동욱,원권연 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.5

Background Fixed dose combination (FDC) products are common in the treatment of various disease such as hypertension, diabetes, HIV and HCV, Pain, Respiratory disease for improving therapeutic efficacy and tolerability. They make it possible to combine more than two drug molecules with optimal doses, dosage form and optimize the treatment. Area covered This review provides discussions of the FDC application in variety of disease. various formulation technologies such as bilayer system, active film coating, co-crystal, multi-particulate system, Hot-melt co-extrusion, hot fusion method, spray drying and 3D-printing that consider characteristics of each active pharmaceutical ingredient (API) in FDC to maximize the benefits and overcome the challenges of developing FDC products. Expert opinion FDC has utilized as a promising dosage form to increase the oral absorption of drugs. From beneficial perspective, they offer efficacy and safety improvement, product exclusivity, patient compliance, medicinal cost reduction. while disadvantage perspectives such as a lack of dose flexibility, drug interaction, difference dosage regimen, dose difference and difference of physicochemical properties should be considered for the use of FDC, differences in individual drug characteristics, drug release profiles, therapeutic dose, and solubility should be considered for FDCs design and formulation.

이탈리아의 의약품 허가심사 체계 분석

권세웅,김희윤,송윤경,원권연 한국에프디시규제과학회(구 한국에프디시법제학회) 2021 FDC법제연구 Vol.16 No.2

식물성 연질캡슐의 겔 조성물 안정성 개선 연구

이연희(Yeon Hui Lee),원권연(Kwon Yeon Weon) 한국산학기술학회 2016 한국산학기술학회논문지 Vol.17 No.5

본 연구의 목적은 식물성 연질캡슐의 원활한 대량생산을 위하여 피막형성용 겔 조성물(gel mass)의 유동학적 특성 및 안정성에 영향을 미치는 요인을 파악하고 겔 조성물의 적절한 점도 및 안정성을 확보하는 것이다. 실험방법으로는 겔 조성물의 각 구성성분이 점도에 미치는 영향을 안정성 확보 목표시간인 6시간 동안 확인하였고 또한, 카라기난에 강알칼리 또는 전해질을 첨가하여 황산기를 중화함으로써 얻어지는 겔 조성물의 특성도 평가하였다. 결과로 강알칼리 및 강전해질을 첨가 시 상대적으로 적은 양의 카라기난이 사용되어도 겔 조성물의 점도가 증가함은 물론 안정성도 향상되는 효과를 확인 할 수 있었다. 특히 이오타 카라기난 3.0%에 황산기를 중화 시킬 수 있는 당량농도와 첨가용액 중 3.6 M KCl을 첨가했던 조성에서 최고의 점도 증가율 및 안정성을 확보할 수 있었다. 이상의 결과를 산업분야에 적용시 의약품 뿐 아니라 건강식품 등 다양한 분야에서 식물성 연질캡슐 생산의 응용을 확대할 수 있을 것으로 사료된다. The objective of this study is to determine the physical characteristics of the gel mass of vegetable soft capsules and to maintain their rheological stability for improving manufacturability. The effect of each capsule shell component on the viscosity of the gel mass was studied for 6 hours, and the effects of adding an alkalizer or electrolytes to neutralize the sulfate groups on the carrageenan molecule were also investigated. Carrageenan was identified as a major component that affects the viscosity of the gel mass, and it showed unstable properties with age. The viscosity and stability of the gel mass were remarkably improved when an alkalizer or electrolytes were added at 3.0% relative to the carrageenan. 3.6 M KCl showed the highest effect on increasing the viscosity. A stable gel mass composition for vegetable soft capsules was successfully developed, which can be considered to increase the application of the capsules in the pharmaceutical and food industries.

연질캡슐 피막물질로서 식물성 성분 원료와 젤라틴의 대한 품질특성 비교

김동욱(Dong Wook Kim),원권연(Kwon Yeon Weon) 대한약학회 2015 약학회지 Vol.59 No.2

A Softgel is an oral dosage form for medicine similar to capsules and softgel dosage form offers several advantages over other oral dosage forms, such as delivering a liquid matrix designed to solubilize and improve the oral bioavailability of a poorly soluble compound as a unit dose solid dosage form, delivering low and ultra-low doses of a compound. This study aimed to qualify a proprietary vegetable soft capsule which contains modified starch and carrageenan as capsule shell components compare to the conventional gelatin softgel. Four kinds of samples were prepared with vegetable and gelatin capsule shell, respectively. Morphology of capsule shell, mechanical strength of capsule, and hygroscopic properties were studied for comparing the quality attributes of softgel. Short-term stability against heat and moisture was also investigated in this study. Vegetable capsule shell showed better mechanical strength, physical stability and disintegration time for temperature and humidity than those of conventional gelatin capsule shell with four different filling materials used frequently as soft capsule form. Conclusively, this vegetable capsule shell polymer system can replace easily gelatin-shell systems and additionally allows encapsulation of lipid fills at high temperatures that are semisolid or solid-like at room temperature.

Development of Novel Mucoadhesive Pellets of Metformin Hydrochloride

Jingshu Piao,이지은,원권연,김동욱,이정석,James D. S. Park,김진석,Yuichi Nishiyama,Ikuo Fukui 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.3

Mucoadhesive polymer-coated pellets containing metformin hydrochloride were prepared by the powder-layering technique using a centrifugal fluidizing (CF)-granulator. Four high-viscosity polymers were applied to make the pellets: 1) hydroxymethylcellulose (HPMC), 2) sodium alginate (Na-Alg), 3) HPMC/Carbopol, and 4) sodium carboxylmethylcellulose (Na-CMC). The physical crushing test, mucoadhesive test, zeta-potential test, in vitro release study and observation of gastroretention state of the dosage form were performed to investigate the pellets. The strong adhesive interaction between the Na-CMC-coated pellets and the mucin disc was obtained by mucoadhesive test. Na-Alg was most effective among the polymers used in changing the value of zeta potential of the mucin solution by the interaction between a polymer and a mucin particle. Results from drug dissolution study showed that over 95% of the drug from all the four pellets was released before 2 h, while Na-CMC- and Na-Alg-coated pellets showed a moderate sustained-release in SGF (simulated gastric fluid) and SIF (simulated intestine fluid), respectively. In conclusion, Na-CMC and Na-Alg seem to be promising candidates for mucoadhesive formulation and further studies to improve the sustained-release property are underway for achieving the ultimate goal of once-a-day formulation of metformin hydrochloride.