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Frontotemporal Lobar Degeneration(FTLD)의 임상적, 병리적 특징과 타우 단백질의 분자 유전학
우성일,Woo, Sung-Il 대한생물정신의학회 2003 생물정신의학 Vol.10 No.2
Criticisms about amyloid cascade hypothesis of Alzheimer's disease(AD) are based on the findings, first, that the degree of dementia does not correlate with the number of plaques, and second, that the neurofibrillary tangle formation seems to predate plaque formation. In addition, neurofibrillary tangle counts correlate well with the degree of cognitive impairment. These findings suggest the independent importance of tau abnormality in AD research which is involved in the neurofibrillary tangle formation. Recently, tau pathology without amyloid deposits and mutations in tau protein gene were reported to be the major pathogenic mechanism in Pick's disease, progressive supranuclear palsy, corticobasal degeneration and FTDP-17(frontotemporal dementia and parkinsonism linked with chromosome 17). These data suggest that understanding the causes and consequences of tau dysfunction might give new clinical and therapeutic solutions to many known tauopathies.
한국인 정신분열병 환자의 지연성 운동장애와 $CYP2D6^*4$ 및 $CYP2D6^*10$ 다형성들의 연합에 대한 고찰
우성일,강동우,서한길,김봉조,이인상,정근화,박소영,정치영,이환철,정경천,손진욱,Woo, Sung-Il,Kang, Dong-Woo,Seo, Han-Gil,Kim, Bong-Jo,Lee, In-Sang,Jeong, Geun-Hoa,Park, So-Young,Jung, Chi-Yeong,Lee, Hwan-Cheol,Jeong, Kyeong-Cheon,Sohn, 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2
P450 CYP2D6 enzyme(=debrisoquine hydroxylase) is known to metabolize many neuroleptics and some genetic polymorphisms in the CYP2D6 gene were reported to be associated with tardive dyskinesia(TD). We investigeted the association of two genetic polymorphisms in the CYP2D6 gene, $CYP2D6^*4$ and $CYP2D6^*10$, with TD in Korean schizophrenic subjects. Subjects consisted of 71 Korean schizophrenics and TD was evaluated using the Abnormal Involuntary Movement Scale (AIMS). There were no statistically significant differences in the demographic variables of age, male to female percentage and the current antipsychotic(CPZ equivalent) dose between the group with TD and the group without TD. But the duration of antipsychotic drug exposure was significantly higher in the group without TD(p=0.000, by independent t-test). The mean AIMS score in the group with TD was $11.2{\pm}6.6$(S.D.). Genotypings for the presence of $CYP2D6^*4$ and $CYP2D6^*10$ were done using PCR amplifications and endonuclease digestions. There were no statistically significant genotypic and alleleic associations between TD and $CYP2D6^*4$(by chisquare tests), and between TD and $CYP2D6^*10$(by chi-square tests). These results indicate that the $CYP2D6^*4$ and $CYP2D6^*10$ polymorphisms have no significant roles in the causation of TD.
우성일,Woo, Sung-Il 대한생물정신의학회 1999 생물정신의학 Vol.6 No.2
Transgenic mice models of Alzheimer's disease were produced by overexpressing APP(amyloid precursor protein) mutant and presenilin mutant genes using the promotors that induced neuronal expression. The neuropathologies, electrophysiological changes and behavioral changes that were demonstrated in these transgenic mice models were amyloid changes, gliotic changes, A-beta increases, deficit in LTP(long-term potentiation) and behavioral changes. Some or all of the above changes were found in each transgenic mice model. These models generally showed amyloid neuropathology but they usually lacked the neurofibrillary tangles. So, they can be regarded as partial models of Alzheimer's disease. The development of them is undoubtedly the great progress toward future research.
선천성 낭선종성 기형이 의심되었던 환아에서 진단된 흉막폐모세포종 1례
우성일 ( Sung Il Woo ),김효빈 ( Hyo Bin Kim ),송준섭 ( Joon Sup Song ),구현령 ( Hyun Lyoung Koo ),임호준 ( Ho Jun Lim ),홍수종 ( Soo Jong Hong ) 대한소아알레르기호흡기학회 2006 소아알레르기 및 호흡기학회지 Vol.16 No.2
Congenital cystic adenomatoid malformation(CCAM) is one of the most common congenital lung lesions. Clinical manifestations that show are neonatal respiratory distress, recurrent respiratory infection, pneumothorax, and hemothorax. But, there are patients who are asymptomatic until mid-childhood. The treatment of asymptomatic CCAM is controversial. There is a possibility to resolve it spontaneously, but late complications such as recurrent pulmonary infection, pneumothorax, hemothorax, and cancer, which includes bronchoalveolar carcinoma and rhabdomyocarcinoma, pleuropulmonary blastoma still remain. Some investigators advocate routine surgery for all cases of CCAM that are apparent at birth. A previously healthy 16-months-old girl who had suffered from a cough for 2 weeks was transferred to Asan Medical Center with CCAM. Due to a chest CT and fever, we first thought that she had CCAM with infection. After we treated her with antibiotics for one week, we performed surgery to confirm the diagnosis and to prevent further complication. But by surgical wedge resection, a pleuropulmonary blastoma was found. There were no evidence of metastasis and adjacent involvement. She started her chemotherapy with vincristine, actinomycin D and cyclophosphamide, and is now continuing maintenance chemotherapy with etoposide, vincristine, and Ifosfamide. We report pleuropulmonary blastoma that presented as CCAM. So we recommend surgical resection in asymptomatic CCAM to confirm the diagnosis and to prevent its malignant transformation, even not accompanied by symptoms. [Pediatr Allergy Respir Dis(Korea) 2006;16:177-182]
소아 아토피 천식 환자에서 실내 흡입 알레르겐 특이 IgE 농도와 총 IgE 농도 및 기도 과민성 사이의 연관성
우성일 ( Sung Il Woo ),임정숙 ( Jeong Sook Lim ),한윤수 ( Youn Soo Hahn ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2009 소아알레르기 및 호흡기학회지 Vol.19 No.1
목적: 아토피 천식 소아에서 실내 흡입 알레르겐에 대한 특이 IgE의 농도의 총 IgE 농도에 대한 기여도를 분석하고, 특이 IgE 농도와 기도 과민성 및 폐기능 사이의 관계를 알아보고자 하였다. 방법: 청주 지역에 거주하는 5-16세의 아토피 천식 소아 232명을 대상으로 하였다. 주요 실내 알레르겐인 Dermatophagoides pteronyssinus (Der p), Dermatophagoides farinae (Der f), Alternaria, 바퀴, 개 상피항원, 고양이 상피항원에 대한 혈청 특이 IgE 농도와 총 IgE 농도를 측정하였다. 집먼지진드기에 감작된 180명의 소아에서 %FEV1과 메타콜린 PC20을 측정하였다. 결과: 혈청 특이 IgE 양성률은 Der p (90.0%)와 Der f (92.7%)를 포함한 집먼지진드기에 대해 가장 높았으며, Alternaria에 대한 양성률(21.6%)은 두 번째로 높았다. Der p와 Der f 특이 IgE 농도가 총 IgE 농도에서 차지하는 비율은 다른 흡입 알레르겐에 비해 월등히 높았으며,(P<0.001) Der f가 Der p보다 높은 비율을 차지하였다.(P<0.001) 특이 IgE 농도와 총 IgE 농도 사이에서 Der p (r=0.677, P<0.001), Der f (r=0.657, P<0.001)로 유의한 상관관계를 보였다. Der f에 대한 특이 IgE의 농도가 높을수록 기도 과민성이 높은 비율로 관찰되었고 FEV1은 감소하였다. 결론: 청주 지역 소아 아토피 천식 환자의 대다수에서 관찰된 총 IgE의 상승은 집먼지진드기에 대한 IgE 반응에 의하였으며 집먼지진드기 특이 IgE 농도는 기도 과민성과 폐기능 감소와 유의한 관련성을 나타내었다. Purpose: We assessed the relationship of indoor aeroallergen specific IgE levels with total IgE level, airway hyperresponsiveness (AHR) and lung function in children with atopic asthma. Methods: Two hundred twenty-eight children with atopic asthma in Cheongju area were studied. Sera were assayed for total IgE and specific IgE antibodies to important indoor allergens including Dermatophagoides pteronyssinus (Der p), Dermatophagoides farinae (Der f), Alternaria, cats, dogs, and cockroaches. One hundred eighty children sensitized to house dust mites (HDMs) were evaluated for %FEV1 and methacholine PC20. Results: Serum specific IgE to HDMs presented the highest prevalence (90.0% for Der p and 92.7% for Der f), followed by specific IgE to Alternaria (21.6%). A contribution of >10% of the total was only common for IgE antibody to Der p or Der f. The level of specific IgE to Der p (r=0.677, P<0.001) or Der f (r=0.657, P<0.001) was significantly correlated with total IgE level. Higher level of Der f-specific IgE was associated with higher incidence of AHR and FEV1 decline. Conclusion: Concentration of specific IgE antibody produced to HDMs provides an explanation for the higher total IgE levels found in a major portion of children with atopic asthma and has a close relationship with AHR and lung function. [Pediatr Allergy Respir Dis (Korea) 2009;19:47-56]
주요우울장애 환자에서 자살사고 동반 여부에 따른 부적격 짝맞추기 음성파의 비교
이민지,이연정,황재욱,우성일,김민재,강병주,김영근,한상우,Lee, Minji,Lee, Yeon Jung,Hwang, Jaeuk,Woo, Sung-il,Kim, Min Jae,Kang, Byungjoo,Kim, Younggeun,Hahn, Sang-Woo 대한불안의학회 2021 대한불안의학회지 Vol.17 No.2
Objective : Mismatch negativity (MMN) is known to reflect several abnormalities of cognitive functioning. This study is aimed to investigate the differences in MMN among major depressive disorder (MDD) patients with or without suicidal ideation. Methods : Sixty-seven patients with MDD were recruited into this study. MMN was measured by a 64-channel electroencephalography (EEG) using oddball paradigm over the front-central area. Clinical characteristics were assessed using the Beck Anxiety Inventory (BAI), the Beck Depression Inventory-II (BDI-II), and the Beck Scale for Suicide ideation (SSI-BECK). Patients were divided into two groups, no suicidal ideation (N=12) and suicidal ideation (N=55), depending on the presence of suicide ideation in SSI-BECK questionnaires. Results : The MMN latencies were significantly longer in the MDD patients with suicidal ideation than in the MDD patents without suicidal ideation (p<0.05). The MMN amplitudes were not significantly different between the two groups. Conclusion : Suicidal ideation may be associated with longer MMN latencies, and it suggests that MMN may play a potential role in assessing the suicidal risk among MDD patients.
지연성 운동장애와 5-$HT_{2A}$ 수용체 유전자 T103C 다형성과의 관계
한상우,신정원,최태윤,우성일,정한용,정희연,한선호,Hahn, Sang Woo,Shin, Jeong Won,Choi, Tae Youn,Woo, Sung Il,Jung, Han Yong,Jung, Hee Yeoun,Han, Sun Ho 대한생물정신의학회 2003 생물정신의학 Vol.10 No.2
Objective:Some candidate gene polymorphisms were reported to be associated with tardive dyskinesia (TD). The aim of this study was to investigate the association of the 5-$HT_{2A}$ receptor gene polymorphisms with TD in Korean schizophrenic subjects. Method:Subjects were of 59 schizophrenic patients with TD and 60 schizophrenic patients without TD for studying of 5-$HT_{2A}$ receptor gene polymorphisms. TD was evaluated using the Abnormal Involuntary Movement Scale(AIMS). Genomic DNA was amplified by PCR and digestion with MspI and BsmI. Result:There were no statistically significant differences in the demographic variables, such as age, male to female percentage, duration of illnesses and duration of antipsychotic drug exposure between the TD group and control group. 1) T102C polymorphisms and TD Comparing the TD group and control group, the 102T/C allele was associated with a significantly increased risk for TD (${\chi}^2$=5.560, df=1, p=0.018). 2) Three AIMS categories of TD and T102C genotype. There were statistically significant differences in the three AIMS categories(${\chi}^2$=6.835, df=2, p=0.033). Conclusion:These result suggest 102T/C genotypes of the 5-$HT_{2A}$ receptor gene are related to the development of TD. The 102T/C genotypes were associated with significantly higher AIMS orofacial dyskinesia scores. These findings suggest that the 5-$HT_{2A}$ receptor gene is significantly associated with susceptibility to TD in patients with chronic schizophrenia.