공기 전색증 고양이에서 Epinephrine과 동시 투여한 Nitroglycerin, Adenosine triphosphate, Sodium nitroprusside가 혈역학 및 혈액가스의 변화에 미치는 영향

우설희,서병태 고려대학교 의과대학 1989 고려대 의대 잡지 Vol.26 No.1

Effects of nitroglycerin (NTG), adenosine triphosphate(ATP) and sodium ni troprusside(SNP) on the hemodynamic and blood gas analysis changes during epinephrine(EPI) infusion in air embolized cats were investigated. Under the general anesthesia with pentobarbital and vecuronium, cats were given 2-2.5 ml/㎏ of air via internal jugular vein and were resuscitated with EPI bolus injection. Thirty two cats were divided into 4 groups of 8 each. Each 4 groups, were administered saline(group 1), NTG(group 2), ATP(group 3) and SNP(group 4) with EPI continuous infusion, respectively The air shadow in the heart of cats was visualized by C-arm image intensifier throught the study and all three vasodilators augmented the removal of air from the heart on C-arm image. All three vasodilators therapy groups produced statistically significant decrease in rate pressure product(p<0.05) but only NTG therapy group decreased heart rate(p<005). Central venous pressure were decreased in all three vasodilators therapy groups but only NTG therapy group was statistically significant(P<0.05) Only NTG therapy group increased both arterial(p<0.05) and venous oxgenation. These results indicate that NTG therapy group produced more prominant hemodynamic and blood oxygenation improvement than the other three groups It is concluded that NTG with vasopressor therapy could be recommended in venous air embolism.

제왕절개술시 흡입마취제에 대한 임상적 비교 연구

공명훈,우설희,서병태 대한마취과학회 1987 Korean Journal of Anesthesiology Vol.20 No.1

The maternal and neonatal effects of 50% O_2 -50% N_2O alone and 50% O_2-5O% N_2O combined with 0.5% halothane or 1% enflurane were studied in 37 parturients undergoing general anesthesia for cesarean section, All patients received thiopental and succinrlcholine for induction and were intubated and ventilated with a tidal volume of 10ml/kg and a rate of 10 breaths/min. until the delivery. Two of 11(18%) patients given O_2-N_2O alone had recall none in those patients receiving a potent inhalation agent had any recall. Blood loss was similar in the two groups. There were no statistically significant differences between groups in induction-todeliverr and uterine incision·to·delivery intervals, the frequencies of Apgar score$lt;7 at and 5 min., maternal and fetal blood gas tensions, and acid-base balance. It is concluded that analgesic concentrations of halothane and enflurane can be safely added to 50% O_2-5O% N_2O to prevent maternal awareness during general anesthesia for cesarean section while maintaining normal maternal and neonatal conditions.

공기 전색증 고양이에서 Epinephrine 과 동시 투여한 Netroglycerin, Adenosine Triphosphate, Sodium Nitroprusside 가 혈역학 및 혈액가스의 변화에 미치는 영향

한성민,서병태,우설희 대한마취과학회 1989 Korean Journal of Anesthesiology Vol.22 No.3

Effects of nitroglycerin (NTC), adenosine triphosphate (ATP) and sodium nitroprusside (SNP) on the hemodynamic and blood gas analysis changes epinephrine (EPI) infusion is air embolized cats were investigated. Under the general anesthesia with pentobarbital and vecuronium cats were given 2~2.5 ml/kg of air via internal jugular vein and were resuscitated with EPI bolus injection. Thirty two cats were divided into 4 groups of 8 each. Each 4 groups, were administered saline (group1), NTG (group 2), ATP (group 3) and SNP (group 4) with EPI continuous infusion, respectively. The air shadow in the heart of cats was visualized C-arm image intensifier throught the study and all three vasodilators augmented the removal of air from the heart on C-arm image. All three vasodilators therapy groups produced statistically significant decrease in rate pressure product (p$lt;0.05) but only NTG therapy group decreased heart rate (p$lt;0.05). Central venous pressure were decreased in all three vasodilators therapy groups but only NTG therapy group was statistically significant (p$lt;0.05). Only NTG therapy group increased both arterial (p$lt;0.05) and venous oxgenation. These results indicate that NTG therapy group produced more prominant hemodynamic and blood oxygenation improvement than the other three groups. It is concluded that NTG with vasopressor therapy coude be recommended in venous air embolism.

Neostigmine Methylsulfate 와 Atropine Sulfate 의 혼합율 및 투여방법이 심박수에 미치는 영향

신정순,장성호,우설희 대한마취과학회 1985 Korean Journal of Anesthesiology Vol.18 No.1

It is common to administrate neostigmiae methylsulfate and atropiae aulfate to counteract the effect of nondepolarising neuromuscular blocker. In case of cardiovascular disease, the effect of bradycardia or tachycardia resultiag from the administration of these drugs may be harmful to the patient. The purpose of this study is to investigate the effects of combinatioa and method of administration of neostigmine methylsulfate and atropine sulfate on heart rate. One hundred and two patients in both sexes were devided into three groups(A, B, C), and each group was devided into three subgroups (AI, AII, AIII, BI, BII, BIII, CI, CII, CIII). In group A, neostigmine methylsulfate and atropine aulfate were mixed and administered intravenously within fifteen seconds. In group B, atropine eulfate was administered thirty seconds after the administration of neostigmine methylsulfate. In group C, the two drugs were mixed and administered over a period of five minutes. In subgroup I the ratio of neostigmine methyliulfate to atropine sulfate was 2: 1(0. 04 mg/kg: 0.02 mg/kg) in subgroup 3 the ratio was 3: 2(0.03 mg/kg: 0. 02 mg/kg), and in subgroup Ⅲ the ratio was 1: 1(0. 02 mg/kg: 0. 02 mg/kg). The heart rate was counted just before, 0. 5 minute, 1 miaute, l. 5 minutes, 2 minutes, 3 minutes, 5 minutes, 10 minutes, 15 minutes, 20 minutes, 25 minutes, 30 minutes after the administration of the drugs. The results were as follows: 1) Initial increase in heart rate was significant in lager atropine ratio. 2) The later decrease in heart rate waa less in larger atropine ratio. 3) The maximal increases in heart rate in groap A and B appeared thirty seconds apart, but there was little difference betweea them. 4) The change ia heart rate was the least in group C.

중증근무력증 환자 마취 8 예 경험

김용철,길찬일,신정순,장진경,임혜자,우설희 대한마취과학회 1983 Korean Journal of Anesthesiology Vol.16 No.3

Myasthenia Gravis is a chronic disease of disputed etiology, possibly an auto-immune reaction to the moter end-plate, characterized by exacerbations and remissions, a rare disease entity in Korea. Myasthenia Gravis has offered many anesthetic problems because it affects respiratory muscles occasionally and bronchial secretion from preoperative anticholinesterase therapy. The chief concern is to ensure adequate respiration both during and after operation. During the year 1976-1982, we have experienced the anesthetic management of 8 patients with myasthenia gravis and thymectomy. From our experiences, we conclude that respiratory care and disuse of relaxants is the key to successful management.

One-Pot Conversion of Trimethylsilyl Ethers into Urethanes Using Chlorosulfonyl Isocyanate: Application to the Synthesis of a Novel Neuromodulator Carisbamate

Guang Ri Dong,Qing Ri Li,우설희,정영훈,김인수 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11

This paper reports a novel synthetic method for the preparation of various urethanes and the application to the synthesis of carisbamate. The reaction of primary (2a, 2e and 2f) or secondary (2g-2i) trimethylsilyl ethers with chlorosulfonyl isocyanate afforded the corresponding urethanes in good yields without affecting the olefin moiety. However, in the case of secondary benzylic trimethylsilyl ether 2j, the corresponding urethane 3j was obtained in low yield. From the difference in reactivity between the primary and secondary benzylic trimethylsilyl ethers, the one-pot synthesis of carisbamate 1 from bis-trimethylsilyl ether 2l was achieved.

전신마취에 있어서 유지수액에 따른 혈당 및 전해질의 변화

문숙희,신정순,장원영,장성호,장진경,우설희 대한마취과학회 1983 Korean Journal of Anesthesiology Vol.16 No.4

Eighty Patients in the state of ASA classification I , II were investigated. Blood samples were collected before, just after, 30 minutes after and 60 minutes after induction of anesthesia. Glucose ana electrolyte changes in relation to maintenance fluids in balanced and halothane anesthesia were as fellows: 1) In both anesthetic techniques bloo4 sugar level stowed increasing tendency according to duration of anesthesia. 2) There were no specific changes in serum electrolytes related to type of anethesia. 3) The administration of D/S ana H/D showed a little increase in Na+ and Cl- level compared to the administration of just DsW. 4) The administration of H/D stowed less increase in K+ level than the administration of D_6W or D/S. 5) Just after induction of anesthesia the K+ level increased a little and decreased gradually thereafter.

척추관 협착증 환자에서 경막외유착 용해술 후 발생한 마미증후군 - 증례 보고 -

이정민(Jeong Min Lee),김형지(Hyung Jee Kim),김동희(Dong Hee Kim),우설희(Seol Hee Woo) 대한통증학회 2001 The Korean Journal of Pain Vol.14 No.2

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