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Propylene Glycol Alginate 製造에 관한 硏究
吳贊烈,金榮祚,李將舜,康東燮,姜永周 濟州大學校 海洋硏究所 1988 해양과환경연구소 연구논문집 Vol.12 No.-
감태 (Eckonia cava)에서 抽出된 알긴酸을 原料로 하여 PGA를 合成하는 最適條件, 原料 알긴酸 및 P.O.(propylene oxide)濃度, 觸媒量 變化 등이 PGA의 遊離 알긴酸 및 에스테르化度에 미치는 영향과 알긴酸 抽出用 原藻의 種類 따른 PGA 合成 適性을 比較 檢討하였다. 原料 알긴酸의 前處理 pH가 상승함에 따라 PGA 내의 遊離 알긴酸 含量은 감소하고 알긴酸나트륨 含量은 증가하며, 에스테르化度는 감소하였다. 最適 前處理 條件은 pH 1.8~2.0, 침지 시간은 6시간이 적당하였다. P.O.濃度가 높을수록 PGA내의 遊離 알긴酸含量이 급격히 감소하였으며, 3.5㏖濃度이상 및 反應 時間 4時間으로 에스테르化度는 80%이상이 얻어졌다. 原料 알긴酸의 濃度는 6~8㏖에 적당하였고, 反應器 容量에 대한 全 反應液의 중량비는 1:10~1:15(W/V)정도가 좋은 것으로 나타냈다. 觸媒量은 PGA 에스테르化度에 큰 영향을 주지 않았으며, 감태가 다른 原藻에 비해 反應性이 높아서 P.O.저농도에서 높은 에스테르化度(80% 이상)를 얻을 수 있었다
섬유아세포(纖維芽細胞)(Balb/c 3T3)의 증식(增殖)에 미치는 신효탁리산(神效托裡散)의 영향(影響)
은재순,전용근,염정열,서은실,소준노,오찬호,Eun, Jae-Soon,Jeon, Young-Keun,Yum, Jeong -Yul,Suh, Eun-Sil,So, June-No,Oh, Chan- Ho 한국생약학회 1993 생약학회지 Vol.24 No.2
The studies were conducted to investigate the effect of Sinhyo-Taklee-San(STS), which is composed of Astragali Radix(AR), Lonicerae Flos(LF), Angelicae gigantis Radix(AGR) and Glycyrrhizae Radix(GR), on the proliferation of fibroblast cell(Balb/c 3T3). STS, GR and glycyrrhizin increased the proliferation of 3T3 cells. The 10% serum obtained from STS, AR, LF, AGR and GR treated mice also increased the proliferation of 3T3 cells markedly. GR, glycyrrhizin and glycyrrhetinic acid inhibited protein synthesis, but did not affect on DNA synthesis.
항암제(抗癌劑) Mitomycin C와 수종(數種) 복합생약(複合生藥)의 병용투여(倂用投與) 효과(I) -보익제(補益劑)-
안문생,김세길,은재순,임종필,염정열,서은실,오찬호,소준노,Ahn, Moon-Saeng,Kim, Sae-Gil,Eun, Jae-Soon,Lim, Jong-Pil,Yum, Jung-Yul,Suh, Eun-Shil,Oh, Chan-Ho,So, June-No 한국생약학회 1992 생약학회지 Vol.23 No.3
The studies were conducted to investigate the combined effects of several combined preparation of crude drugs and mitomycin C(MMC). The combined effects on the proliferation of Molt-4 cells and activation of human lymphocytes were estimated by MTT colorimetric assays. The drugs itself enhanced the proliferation of Molt-4, but the inhibitory action of MMC was not affected by the combined treatment of the drugs and MMC. Among 9 kinds of the drugs, Sip Jeon Dae Bo Tang(SDT), Saeng Maek San(SMS) and Kwi Bi Tang(KBT) did not inhibit the action of MMC, but activated lymphocytes. When the mice were treated by MMC, the number of leukocytes was decreased significantly at the 1st day, but recovered at the 7th day. In the groups of MMC treated with SDT or KBT, the number of leukocytes was increased significantly than the group of MMC treated only at the 3rd day. The combined treatment of SDT, SMS and MMC retained the body weight of mice at the level of normal mice. The SDT, SMS and KBT did not change the number of plaque forming cells(PFC) and the proliferation of T cells. The combined treatment of SDT and MMC increased the number of PFC significantly than the MMC treated group. The combined treatment of SDT, SMS, KBT and MMC increased the T cell proliferation significantly than the MMC treated group. In conclusion, it is suggested that SDT, SMS and KBT can recover the side effects of MMC, such as weight loss, leukopenia and immunosuppression, without any intercalating the anti-proliferative action of MMC in vivo.
글리시르히진이 L1210 세포를 이식한 생쥐의 Lymphocytes Subpopulation 변화에 미치는 영향
은재순(Jae Soon Eun),염정열(Jung Yul Yum),전훈(Hoon Jeon),오찬호(Chan Ho Oh) 대한약학회 2000 약학회지 Vol.44 No.6
We have previously observed that glycyrrhizin(GL) inhibits the proliferation of transplanted-L1210 cells via the production of nitric oxide from peritoneal macrophages. In the present study, we examined the effect of GL on lymphocytes subpopulation change of L1210 cells-transplanted mice. GL increased the population of CD4-CD8+ cells of thymocytes in L1210 cells-transplanted mice and the lucigenin chemiluminescence of human polymorphonuclear cells. These results suggest that the proliferation of transplanted-L1210 cells is partly inhibited by an enhancement of cytotoxic T cells population and phagocytic activity in GL-administered mice.