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오종률,안병철,정신영,이상우,이재태 대한핵의학회 2015 핵의학 분자영상 Vol.49 No.3
Purpose We aimed to develop and validate a simplified, novel quantification method for radioiodine whole-body scans (WBSs) as a predictor for the treatment response in differentiated thyroid carcinoma (DTC) patients with distant metastasis. Methods We retrospectively reviewed serial WBSs after radioiodine treatment from 2008 to 2011 in patients with metastatic DTC. For standardization of TSH simulation, only a subset of patients whose TSH level was fully enhanced (TSH>80 mU/l) was enrolled. The radioiodine scan index (RSI) was calculated by the ratio of tumor-to-brain uptake. We compared correlations between the RSI and TSHstimulated serum thyroglobulin (TSH_s_Tg) level and between the RSI and Tg reduction rate of consecutive radioiodine treatments. Results A total of 30 rounds of radioiodine treatment for 15 patients were eligible. Tumor histology was 11 papillary and 4 follicular subtypes. The TSH_s_Tg level was mean 980 ng/ml (range, 0.5–11,244). The Tg reduction rate after treatment was a mean of −7 % (range, −90 %–210 %). Mean RSI was 3.02 (range, 0.40–10.97). RSI was positively correlated with the TSH_s_Tg level (R2=0.3084, p=0.001) and negatively correlated with the Tg reduction rate (R2=0.2993, p=0.037). The regression equation to predict treatment response was as follows: Tg reduction rate=−14.581×RSI+51.183. Conclusions Use of the radioiodine scan index derived from conventional WBS is feasible to reflect the serum Tg level in patients with metastatic DTC, and it may be useful for predicting the biologic treatment response after radioiodine treatment.
오종률,서지형,장우진,배성일,송인욱,봉진구,정혜연,박소영,배정엽,윤현대 대한핵의학회 2017 핵의학 분자영상 Vol.51 No.3
Purpose We aimed to evaluate the difference in fluorodeoxyglucose (FDG) uptake in sedated healthy subjects after they underwent esophagogastroduodenoscopy (EGD) and colonoscopy procedures. Methods The endoscopy group (n = 29) included healthy subjects who underwent screening via F-18 FDG positron emission tomography/computed tomography (PET/CT) after an EGD and/or colonoscopy under sedation on the same day. The control group (n = 35) included healthy subjects who underwent screening via PET/CT only. FDG uptake in the tongue, uvula, epiglottis, vocal cords, esophagus, stomach, duodenum, liver, cecum, colon, anus, and muscle were compared between the two groups. Results Maximum standardized uptake value (SUVmax) in the tongue, pharynx, larynx, and esophagus did not significantly differ between the endoscopy and control groups. In contrast, mean SUVmax in the whole stomach was 18 % higher in the endoscopy group than in the control group (SUVmax: 2.96 vs. 2.51, P = 0.010). In the lower gastrointestinal track, SUVmax from the cecum to the rectum was not significantly different between the two groups, whereas SUVmax in the anus was 20% higher in the endoscopy group than in the control group (SUVmax: 4.21 vs. 3.50, P = 0.002). SUVmax in the liver and muscle was not significantly different between the two groups. Mean volume of the stomach and mean cross section of the colon was significantly higher in the endoscopy group than in the control group (stomach: 313.28 cm3 vs. 209.93 cm3, P < 0.001, colon: 8.82 cm2 vs. 5.98 cm2, P = 0.001). Conclusions EGD and colonoscopy under sedation does not lead to significant differences in SUVmax in most parts of the body. Only gastric FDG uptake in the EGD subjects and anal FDG uptake in the colonoscopy subjects was higher than uptake in those regions in the control subjects.
Rasmussen 뇌염에서 추적 뇌 자기공명영상과 단일광자단층촬영 소견의 변화
남태승,김병채,오종률,최성민,김명규,조기현,하정민,송호천,김정희 대한치매학회 2009 Dementia and Neurocognitive Disorders Vol.8 No.1
Rasmussen encephalitis (RE) is a chronic inflammatory disorder characterized by progressive neurologic deficits and intractable focal seizures. We report a case of a 37-yr-old man presented with progressive cognitive dysfunction of the right hemisphere. This patient had shown typical clinical and radiological progression of RE for five years, which are demonstrated by the neuropsychological results and serial brain MR- and SPECT images. Rasmussen encephalitis (RE) is a chronic inflammatory disorder characterized by progressive neurologic deficits and intractable focal seizures. We report a case of a 37-yr-old man presented with progressive cognitive dysfunction of the right hemisphere. This patient had shown typical clinical and radiological progression of RE for five years, which are demonstrated by the neuropsychological results and serial brain MR- and SPECT images.
강세령,변병현,오종률,김현식,홍선표,권선영,정아리,송호천,김자혜,조상건,박희정,김영철,안성자,민정준,범희승 대한핵의학회 2014 핵의학 분자영상 Vol.48 No.1
Purpose We evaluated the value of variable 18F-FDG PET/CT parameters for the prediction of disease progression afterconcurrent chemoradiotherapy (CCRT) in patients with inoperablestage III non-small-cell lung cancer (NSCLC). Methods One hundred sixteen pretreatment FDG PET/CTscans of inoperable stage III NSCLC were retrospectivelyreviewed (stage IIIA: 51; stage IIIB: 65). The volume ofinterest was automatically drawn for each primary lung tumor,and PET parameters were assessed as follows: maximumstandardized uptake value (SUVmax), metabolic tumor volume(MTV) using the boundaries presenting SUV intensity exceeding3.0, and the area under the curve of the cumulativeSUV-volume histograms (AUC-CSH), which is known toreflect the tumor heterogeneity. Progression-free survival(PFS), locoregional recurrence-free survival (LRFS), and distantmetastasis-free survival (DMFS) were compared witheach PET and clinical parameters by univariate and multivariatesurvival analysis. Results In the ROC analysis, the optimal cutoff values ofSUVmax, MTV (cm3), and AUC-CSH for prediction of PFSwere determined as 21.5, 27.7, and 4,800, respectively. Inunivariate analysis, PFS was statistically significantly reducedin those with AUC-CSH<4,800 (p =0.004). In multivariateanalysis, AUC-CSH and SUVmax were statistically significantindependent prognostic factors (HR 3.35, 95 % CI 1.79–6.28,p <0.001; HR 0.25, 95%CI 0.09–0.70, p =0.008, respectively). Multivariate analysis showed that AUC-CSH was the mostsignificant independent prognostic factor for LRFS and DMFS(HR 3.27, 95 % CI 1.54–6.94, p =0.002; HR 2.79, 95 % CI1.42–5.50, p =0.003). Conclusions Intratumoral metabolic heterogeneity of primarylung tumor in 18F-FDG PET/CT can predict disease progressionafter CCRT in inoperable stage III NSCLC.