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기관 스텐트 삽입과 히스토아크릴 주입법으로 치료한 식도 누공 1례
오동준,조주영,Dong Joon Oh,Joo Young Cho 대한소화기암연구학회 2014 Journal of digestive cancer reports Vol.2 No.1
We report a bronchoesophageal fistula that treat with bronchial stent insertion and histoacryl injection. A 52-year-old man with esophagel cancer was transferred for dysphagia management. At the CT scan that underwent on admission, esophageal cancer with multiple lymph node metastasis was observed. At the gastroduodenoscopy and contrast study, bronchoesophageal fistula was observed. Recurrent stent insertion treatment was failed, and then, By the broncoscopy, covered stent was inserted to right bronchus, and By the endoscopy, fibrin glue and histoacryl was injected in the fistula opening. At the contrast study, contrast leakage was not observed, and the patient was discharged. But, at the 14 days after discharge, the patient was admitted to the emerency room because of cough symptom whenever he eat food. The patient was diagnosed with aspiration pneumonia, we were determined that it is unable to oral intake. The patient received a jejunostomy and antibiotic treatment for aspiration pneumonia. He was discharged after symptomatic improvement.
수핵성형술용 형상기억합금(SMA) 액추에이터 와이어의 열처리 조건 변화가 온도제어 파라미터(t1)에 미치는 영향
오동준(Dong-Joon Oh),김철웅(Cheol-Woong Kim),양영규(Young-Gyu Yang),김태영(Tae-Young Kim),김재정(Jay-Jung Kim) 대한기계학회 2010 大韓機械學會論文集A Vol.34 No.5
차세대 의료기기 시장을 변화시킬 것으로 기대되는 형상기억합금(SMA) 기반의 최소침습용 의료기기는 시술자의 손동작과 같은 유연성과 섬세함을 구현할 수 있는 장점이 있다. 그러나 SMA의 비선형 열전기적 특성으로 인해 SMA 기반 차세대 의료기기 엑추에이터는 자유로운 방향조종 구현이 제한적이고 상용화에 있어서 큰 한계성으로 작용한다. 본 논문은 SMA의 효과적인 온도제어를 위해 전류-온도간의 개방루프 계단응답을 분석하고 1차 미분방정식 해와 비교하여 온도제어에 필요한 파라미터 ?을 도출한 뒤 실험적으로 그 기능을 검증하였다. 또한 ?은 전류를 입력으로 온도를 출력으로 하는 시불변 선형계의 특성함수의 폴(pole)이므로 주파수에 의한 온도제어에 관계된 파라미터인 것으로 나타났다. 본 논문의 결과는 SAM 기반의 차세대 의료기기 액추에이터의 효과적인 위치제어 설계에 응용될 수 있다. Shape Memory Alloy (SMA) has recently received attention in developing implantable surgical equipments and it is expected to lead the future medical device market by adequately imitating surgeons' flexible and delicate hand movement. However, SMA actuators have not been used widely because of their nonlinear behavior called hysteresis, which makes their control difficult. Hence, we propose a parameter, t1, which is necessary for temperature control, by analyzing the open-loop step response between current and temperature and by comparing it with the values of linear differential equations. t1 is a pole of the transfer function in the invariant linear model in which the input and output are current and temperature, respectively; hence, t1 is found to be related to the state variable used for temperature control. When considering the parameter under heat treatment conditions, Tmax was found to assume the lowest value, and t1 was irrelevant to the heat treatment.
Zircaloy-4 피복관의 KEC 파괴인성시험법 개발
오동준(Dong Joon Oh),안상복(Sang Bok Ahn),김도식(Do Sik Kim),주용선(Yong Sun Choo),홍권표(Kwon Pyo Hong) 대한기계학회 2002 대한기계학회 춘추학술대회 Vol.2002 No.3
To define the causes of cladding degradation which can take place during an operation of nuclear power plants, it is required to develop the new fracture toughness test of fuel cladding. The fracture toughness of Zircaloy-4 cladding has been estimated using the recently developed KAERI embedded Charpy (KEC) specimen. Axially notched KEC specimens which were cut directly from fuel claddings, have been tested in a way similar to the standard toughness test method for a Single Edge Bending (SEB) specimen. The results of KEC fracture toughness test at room temperatures were compared with the test data of the previous studis and discussed. In conclusions, even though the KEC fracture toughness test for fuel claddings was easier and more reliable than those developed earlier, the results from the cladding fracture tests were not the material characteristics but the specific fracture parameters which was deeply related to the specification of claddings. In addition, the phenomenon of a thickness yielding was not observed from the fracture surface. It was closely related to the fact that the plane strain condition of the KEC specimen was changed to the plane stress condition during crack advancing. It was also supported by the fractographic evidence that the formation of ductile dimple at the crack initiation became the similar state such as a quasi-cleavage.
디클로로메탄과 초임계 이산화탄소의 혼합용매에서 Simvastatin 약물의 상거동과 초임계 역용매 공정을 이용한 Simvastatin 약물 미세입자의 제조
오동준(Dong-Joon Oh),이병철(Byung-Chul Lee) 한국청정기술학회 2007 청정기술 Vol.13 No.1
고지혈증 치료제로 잘 알려져 있는 난용성 약물인 심바스타틴(simvastatin)을 대상으로 디클로로메탄을 용매로 사용하고 초임계 이산화탄소를 역용매로 사용하는 초임계 역용매 재결정법에 의해 약물 미세입자를 제조할 때, 운전 조건을 설정하는데 활용될 수 있는 가이드 라인을 제공하기 위하여 simvastatin/디클로로메탄/초임계 이산화탄소 3성분계 혼합물의 상거동을 연구하였다. 가변부피 투시 셀이 장착된 고압 상평형 장치를 사용하여 여러 가지 조건에서 3성분계 혼합물의 구름점(cloud point)을 측정함으로서 디클로로메탄과 초임계 이산화탄소의 혼합용매에서 simvastatin의 용해도를 온도, 압력, 용매 조성의 함수로 결정하였다. 주어진 온도에서 Simvastatin 약물의 용해도는 디클로로메탄의 조성과 압력이 증가할수록 온도가 감소할수록 증가하였다. 상거동 데이터를 바탕으로 교반기가 설치된 실린더 모양의 고압 용기에서 초임계 역용매 재결정 공정을 이용해 simvastatin 약물을 미세입자로 제조하는 연구를 수행하였다. 운전 조건인 압력 (8~12 ㎫), 온도 (303.15 K, 313.15 K), 이산화탄소 공급 속도, 교반 속도 (최대 3,000 rpm)를 변화시키면서 simvastatin 미세입자를 제조함으로써 재결정되는 약물 입자의 크기와 모양에 미치는 공정 변수들의 영향을 관찰하였다. Phase behavior of the ternary systems of water-insoluble simvastatin drug, which is well known to be effective drugs for hypercholesterolemia therapy, in solvent mixtures of dichloromethane and supercritical carbon dioxide was investigated to present a guideline of establishing operating conditions in the particle formation of the drugs by a supercritical anti-solvent recrystallization process utilizing clichloromethane as a solvent and carbon dioxide as an anti-solvent. The solubilities of simvastatin in the mixtures of clichloromethane and carbon dioxide were determined as functions of temperature, pressure and solvent composition by measuring the cloud points of the ternary mixtures at various conditions using a high-pressure phase equilibrium apparatus equipped with a variable-volume view cell. The solubility of the drug increased as the dichloromethane composition in solution and the system pressure increases at a fixed temperature. A lower solubility of the drug was obtained at a higher temperature. The second half of this work is focused on the particle formation of the simvastatin drug by a supercritical anti-solvent recrystallization process in a cylindrical high-pressure vessel equipped with an impeller. Microparticles of the simvastatin drug were prepared as functions of pressure (8 ㎫ to 12 ㎫), temperature (303.15 K, 313.15 K), feed flow rate of carbon dioxide, and stirring speed (up to 3000 rpm), in order to observe the effect of those process parameters on the size and shape of the drug microparticles recrystallized.